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Original Article: Research

Up-regulation of connexin-43 expression in bone marrow mesenchymal stem cells plays a crucial role in adhesion and migration of multiple myeloma cells

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Pages 211-218 | Received 23 Jan 2014, Accepted 03 Apr 2014, Published online: 16 Jun 2014

References

  • Hideshima T, Mitsiades C, Tonon G, et al. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007;7:585–598.
  • Podar K, Chauhan D, Anderson KC. Bone marrow micro- environment and the identification of new targets for myeloma therapy. Leukemia 2009;23:10–24.
  • Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008;455:406–410.
  • Yang FC, Ingram DA, Chen S, et al. Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit dependent bone marrow. Cell 2008;135:437–448.
  • Raaijmakers MH, Mukherjee S, Guo S, et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010;464:852–857.
  • Katz BZ. Adhesion molecules-The lifelines of multiple myeloma cells. Semin Cancer Biol 2010;20:186–195.
  • Basak GW, Srivastava AS, Malhotra R, et al. Multiple myeloma bone marrow niche. Curr Pharm Biot 2009;10:335–346.
  • Sugiyama T, Kohara H, Noda M, et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977–988.
  • Rosendaal M, Green CR, Rahman A, et al. Up-regulation of the connexin43 + gap junction network in haemopoietic tissue before the growth of stem cells. J Cell Sci 1994;107:29–37.
  • Cancelas JA, Koevoet WLM, Koning AE, et al. Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood 2000;96:498–505.
  • Kandouz M, Batist G. Gap junctions and connexins as therapeutic targets in cancer. Expert Opin Ther Targets 2010;14:681–692.
  • Jose AC, Wendy LMK, Alexandra EK, et al. Connexin 43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood 2000;96:498–505.
  • Montecino-Rodriquez E, Leathers H, Dorshkind K. Expression of connexin 43 (Cx43)is critical for normal hematopoiesis. Blood 2000;96:917– 924.
  • Presley CA, Lee AW, Kastl B, et al. Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy. Cell Commun Adhes 2005;12:307–317.
  • Machtaler S, Dang-Lawson M, Choi K, et al. The gap junction protein Cx43 regulates B-lymphocyte spreading and adhesion. J Cell Sci 2011;124:2611–2621.
  • Laird DW, Fisturis P, Batist G, et al. Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Cancer Res 1999;59:4104–4110.
  • Noguchi M, Nomate K, Watanabe JI, et al. Disruption of gap junctional intercellular communication in human renal cancer cell lines. Urology 1999;53:218–222.
  • McLachlan E, Shao Q, Laird DW. Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol 2007;218:107–121.
  • Daniel-Wojcik A, Misztal K, Bechyne I, et al. Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. Intl J Oncol 2008;3:309–315.
  • Li Z, Zhou Z, Donahue HJ. Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential. Clin Exp Metastasis 2008;25:265–272.
  • Qiang YW, Chen Y, Stephens O, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008;112: 196–207.
  • Oshima T, Abe M, Asano J, et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 2005;106:3160–3165.
  • Monica H, Ulrike H, Martin K, et al. Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK. Br J Haematol 2007;138:446–458.
  • Sanz-Rodríguez F, Hidalgo A, Teixidó J. Chemokine stromal cell-derived factor-1 modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood 2001;97:346–351.
  • Hideshima T, Nakamura N, Chauhan D, et al. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene 2001;20:5991–6000.
  • Tassone P, Neri P, Carrasco DR, et al. A clinically relevant SCID-hu in vivo model of human multiple myeloma. Blood 2005; 106:713–716.
  • Yaccoby S, Wezeman MJ, Zangari M, et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006;91:192–199.
  • Zhang X, Liu Y, Si YJ, et al. Effect of Cx43 gene-modified leukemic bone marrow stromal cells on the regulation of Jurkat cell line in vitro. Leuk Res 2012;36:198–204.
  • Liu Y, Zhang X, Li ZJ, et al. Up-regulation of Cx43 expression and GJIC function in acute leukemia bone marrow stromal cells post-chemotherapy. Leuk Res 2010;34:631–640.
  • Véliz LP, González FG, Duling BR, et al. Functional role of gap junctions in cytokine-induced leukocyte adhesion to endo- thelium in vivo. Am J Physiol Heart Circ Physiol 2008;295: H1056–H1066.
  • Roccaro AM, Sacco A, Ungari M, et al. In vivo targeting of stromal-derived factor-1 as a strategy to prevent myeloma cell dissemination to distant bone marrow niches. Blood 2012;120(Suppl.1): Abstract 440.
  • Schajnovitz A, Itkin T, D’Uva G, et al. CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nat Immunol 2011;12:391–398.
  • Dar A, Kollet O, Lapidot T. Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice. Exp Hematol 2006;34:967–975.

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