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Original Article: Research

CCR4 + T cell recruitment to the skin in mycosis fungoides: potential contributions by thymic stromal lymphopoietin and interleukin-16

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Pages 440-449 | Received 04 Feb 2014, Accepted 24 Apr 2014, Published online: 06 Jun 2014

References

  • Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005;105:3768–3785.
  • Kaech SM, Wherry EJ, Ahmed R. Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol 2002;2:251–262.
  • Kopf M, Le Gros G, Bachmann M, et al. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993;362:245–248.
  • Campbell JJ, Clark RA, Watanabe R, et al. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 2010;116:767–771.
  • Clark RA, Watanabe R, Teague JE, et al. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med 2012;4:117ra117.
  • Kim EJ, Hess S, Richardson SK, et al. Immunopathogenesis and therapy of cutaneous T cell lymphoma. J Clin Invest 2005;115:798–812.
  • Imai T, Nagira M, Takagi S, et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 1999;11:81–88.
  • Gobert M, Treilleux I, Bendriss-Vermare N, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 2009;69:2000–2009.
  • D’Ambrosio D, Albanesi C, Lang R, et al. Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion. J Immunol 2002;169:2303–2312.
  • Spadoni I, Iliev ID, Rossi G, et al. Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis. Mucosal Immunol 2012;5:184–193.
  • Reich K, Hugo S, Middel P, et al. The maturation-dependent production of interleukin-16 is impaired in monocyte-derived dendritic cells from atopic dermatitis patients but is restored by inflammatory cytokines TNF-alpha and IL-1beta. Exp Dermatol 2004;13:740–747.
  • Saenz SA, Taylor BC, Artis D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol Rev 2008;226:172–190.
  • Zhang K, Shan L, Rahman MS, et al. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2007;293:L375–L382.
  • Ying S, O’Connor B, Ratoff J, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005;174:8183–8190.
  • Laberge S, Ernst P, Ghaffar O, et al. Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma. Am J Respir Cell Mol Biol 1997;17:193–202.
  • Frezzolini A, Paradisi M, Zaffiro A, et al. Circulating interleukin 16 (IL-16) in children with atopic/eczema dermatitis syndrome (AEDS): a novel serological marker of disease activity. Allergy 2002;57:815–820.
  • Nagy G, Gaspar K, Irinyi B, et al. Association between serum IL-16 levels and the degree of sensitization in patients with atopic dermatitis. Int Arch Allergy Immunol 2011;156:69–74.
  • Wu KG, Li TH, Chen CJ, et al. Correlations of serum interleukin-16, total IgE, eosinophil cationic protein and total eosinophil counts with disease activity in children with atopic dermatitis. Int J Immunopathol Pharmacol 2011;24:15–23.
  • Angelova-Fischer I, Hipler UC, Bauer A, et al. Significance of interleukin-16, macrophage-derived chemokine, eosinophil cationic protein and soluble E-selectin in reflecting disease activity of atopic dermatitis—from laboratory parameters to clinical scores. Br J Dermatol 2006;154:1112–1117.
  • Angelova-Fischer I, Bauer A, Hipler UC, et al. The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. Br J Dermatol 2005;153:767–773.
  • Belloni Fortina A, Tonin E, Pigozzi B, et al. IL-16 serum level in children with atopic dermatitis. Int J Immunopathol Pharmacol 2006;19:841–845.
  • Parada NA, Cruikshank WW, Danis HL, et al. IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. Cell Immunol 1996;168:100–106.
  • McFadden C, Morgan R, Rahangdale S, et al. Preferential migration of T regulatory cells induced by IL-16. J Immunol 2007;179:6439–6445.
  • Liu C, Mills J, Dixon K, et al. IL-16 signaling specifically induces STAT6 activation through CD4. Cytokine 2007;38:145–150.
  • Middel P, Reich K, Polzien F, et al. Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease. Gut 2001;49:795–803.
  • Richmond J, Tuzova M, Parks A, et al. Interleukin-16 as a marker of Sezary syndrome onset and stage. J Clin Immunol 2011;31:39–50.
  • Richmond JM, Lee J, Green DS, et al. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells. J Immunol 2012;189:5586–5595.
  • Blaschke V, Reich K, Middel P, et al. Expression of the CD4 + cell-specific chemoattractant interleukin-16 in mycosis fungoides. J Invest Dermatol 1999;113:658–663.
  • Asadullah K, Haeussler-Quade A, Gellrich S, et al. IL-15 and IL-16 overexpression in cutaneous T-cell lymphomas: stage-dependent increase in mycosis fungoides progression. Exp Dermatol 2000;9: 248–251.
  • Egawa G, Kabashima K. Skin as a peripheral lymphoid organ: revisiting the concept of skin-associated lymphoid tissues. J Invest Dermatol 2011;131:2178–2185.
  • Kallinich T, Muche JM, Qin S, et al. Chemokine receptor expression on neoplastic and reactive T cells in the skin at different stages of mycosis fungoides. J Invest Dermatol 2003;121: 1045–1052.
  • Lynch EA, Heijens CA, Horst NF, et al. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol 2003;171:4965–4968.
  • Campbell JJ, Clark RA, Watanabe R, et al. Sezary syndrome and MF arise from distinct T cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 2010;116:767–771.
  • Ferenczi K, Fuhlbrigge RC, Pinkus J, et al. Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol 2002; 119:1405–1410.
  • Curiel-Lewandrowski C, Yamasaki H, Si CP, et al. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest 2011;121:4838–4849.
  • Center DM, Cruikshank WW, Zhang Y. Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription. J Immunol 2004;172: 1654–1660.
  • Ziegler SF, Artis D. Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol 2010;11:289–293.
  • Miyagaki T, Sugaya M, Fujita H, et al. Increased serum thymic stromal lymphopoietin levels in patients with cutaneous T cell lymphoma. Clin Exp Dermatol 2009;34:539–540.
  • Alloo A, DeSimone JA, Kupper TS. Mycosis fungoides presenting at the site of a transdermal estradiol patch. J Am Acad Dermatol 2012;67:e207–e208.
  • Meyer N, Mazereeuw-Hautier J, Launay F, et al. Cutaneous T cell lymphoma complicating severe atopic dermatitis. Is making a diagnosis the main challenge? Dermatology 2009;218:168–171.
  • Dumortier A, Durham AD, Di Piazza M, et al. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One 2010;5:e9258.
  • Demehri S, Morimoto M, Holtzman MJ, et al. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol 2009;7:e1000067.
  • Humme D, Lukowsky A, Sterry W. Diagnostic tools in mycosis fungoides. G Ital Dermatol Venereol 2010;145:375–384.
  • Jawed SI, Myskowski PL, Horwitz S, et al. Primary cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am Acad Dermatol 2014;70:205 e201–e216; quiz e221–e202.
  • Chang DK, Sui J, Geng S, et al. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Mol Cancer Ther 2012;11:2451–2461.
  • Han T, Abdel-Motal UM, Chang DK, et al. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One 2012;7:e44455.

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