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Original Article: Clinical

Assessment of clonality in T-cell large granular lymphocytic leukemia: flow cytometric T cell receptor Vβ repertoire and T cell receptor gene rearrangement

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Pages 324-331 | Received 18 Jan 2014, Accepted 29 Apr 2014, Published online: 17 Jul 2014

References

  • Loughran TP Jr. Clonal diseases of large granular lymphocytes. Blood 1993;82:1–14.
  • Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Oncologist 2006;11:263–273.
  • Loughran TP Jr, Kadin ME, Starkebaum G, et al. Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia. Ann Intern Med 1985;102:169–175.
  • Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2008.
  • Ryan DK, Alexander HD, Morris TC. Routine diagnosis of large granular lymphocytic leukemia by Southern blot and polymerase chain reaction analysis of clonal T cell receptor gene rearrangement. Mol Pathol 1997;50:77–81.
  • Melenhorst JJ, Sorbara L, Kirby M, et al. Large granular lymphocyte leukemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8(+) lymphocyte populations. Br J Haematol 2001;112:189–194.
  • Morice WG, Kimlinger T, Katzmann JA, et al. Flow cytometric assessment of TCR-Vβ expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: a comparison with conventional T-cell immunophenotyping and molecular genetic techniques. Am J Clin Pathol 2004;121:373–383.
  • Feng B, Jorgensen JL, Hu Y, et al. TCR-Vβ flow cytometric analysis of peripheral blood for assessing clonality and disease burden in patients with T cell large granular lymphocyte leukemia. J Clin Pathol 2010;63:141–146.
  • Koskela HL, Eldfors S, Ellonen P, et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012;366: 1905–1913.
  • Jerez A, Clemente MJ, Makishima H, et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 2012;120: 3048–3057.
  • Kwong YL, Wong KF, Liang RH, et al. Pure red cell aplasia: clinical features and treatment results in 16 cases. Ann Hematol 1996;72: 137–140.
  • Zhang D, Loughran TP Jr. Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment. Hematology Am Soc Hematol Educ Program 2012;652–659.
  • Brinkman K, van Dongen JJ, van Lom K, et al. Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vβ antibodies. Leukemia 1998;12: 150–154.
  • Langerak AW, van Den Beemd R, Wolvers-Tettero IL, et al. Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβ T-cell proliferations. Blood 2001;98: 165–173.
  • van Dongen JJ, Langerak AW, Brüggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003;17: 2257–2317.
  • Qiu ZY, Fan L, Wang L, et al. STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. J Hematol Oncol 2013;6:82–84.
  • Hodges E, Krishna MT, Pickard C, et al. Diagnostic role of tests for T cell receptor (TCR) genes. J Clin Pathol 2003;56:1–11.
  • Wlodarski MW, O’Keefe C, Howe EC, et al. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood 2005;106:2769–2780.
  • van den Beemd R, Boor PP, van Lochem EG, et al. Flow cytometric analysis of the Vβ repertoire in healthy controls. Cytometry 2000;40:336–345.
  • Bromberg JF, Wrzeszczynska MH, Devgan G, et al. Stat3 as an oncogene. Cell 1999;98:295–303.
  • Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995;82:241–250.
  • Posnett DN, Sinha R, Kabak S, et al. Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 1994;179:609–618.

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