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Letters to the Editor

Novel STAT5B–RARA fusion transcript in acute promyelocytic leukemia: identification and treatment response

, , , , , , , , , , , , & show all
Pages 2731-2734 | Received 19 Aug 2014, Accepted 10 Jan 2015, Published online: 11 Feb 2015

References

  • de The H, Lavau C, Marchio A, et al. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 1991;66:675–684.
  • Borowitz MJ, Bene MC, Harris NL, et al. Acute leukemias of ambiguous lineage. In Swerdlow SH, Campo E, Harris NL, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008:150–155.
  • De Braekeleer E, Douet-Guilbert N, De Braekeleer M, et al. RARa fusion genes in acute promyelocytic leukemia:a review. Expert Rev Hematol 2014;7:347–357.
  • Chen Y, Li S, Zhou C, et al.TBLR1 fuses to retinoid acid recepror α in a variant (3;17)(q26;q21) translocation of acute promyelocytic leukemia. Blood 2014;124:936–934.
  • Arnould C, Philippe C, Bourdon V, et al. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Hum Mol Genet 1999;8:1741–1749.
  • Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011;118:5593–5603.
  • Gallagher RE, Mak S, Paietta E, et al. Identification of a second acute promyelocytic leukemia (APL) patient with the STAT5b-RARa fusion gene among PML-RARa-negative Eastern Cooperative Oncology Group (ECOG) APL Protocol Registrants. Blood 2004;104(Suppl. 1): Abstract 3005.
  • Kusakabe M, Suzukawa K, Nanmoku T, et al. Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding. Eur J Haematol 2008;80:444–447.
  • Iwanaga E, Nakamura M, Nanri T, et al. Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA. Eur J Haematol 2009;83:499–501.
  • Qiao C, Zhang SJ, Chen LJ, et al. Identification of the STAT5B-RARalpha fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, c-Kit and C/EBPalpha mutation. Eur J Haematol 2011;86:442–446.
  • Jovanovic JV, Rennie K, Culligan D, et al. Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia. Front Oncol 2011;1:35.
  • Chen H, Pan J, Yao L, et al. Acute promyelocytic leukemia with a STAT5b-RARalpha fusion transcript defined by array-CGH, FISH, and RT-PCR. Cancer Genet 2012;205:327–331.
  • Strehl S, Konig M, Boztug H, et al. All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene. Leukemia 2013;27: 1606–1610.
  • Zelent A, Guidez F, Melnick A, et al. Translocations of the RARa gene in acute promyelocytic leukemia. Oncogene 2001; 20:7186–7203.
  • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010;115:453–474.

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