Advanced search
Publication Cover
Leukemia & Lymphoma Volume 56, 2015 - Issue 10
Submit an article Journal homepage
460
Views
10
CrossRef citations to date
0
Altmetric
Original Articles: Research

DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts

Li YangDepartment of Hematology, Tongji Hospital affiliated by Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
,
Ya'Nan LiuDepartment of Hematology, Tongji Hospital affiliated by Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
,
Li ZhuDepartment of Hematology, Tongji Hospital affiliated by Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
&
Min XiaoDepartment of Hematology, Tongji Hospital affiliated by Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, ChinaCorrespondence[email protected]
Pages 2914-2922 | Received 10 Oct 2014, Accepted 31 Jan 2015, Published online: 06 Jul 2015

References

  • Cancer T, Atlas G. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013;368:2059–2074.
  • Estey EH. Acute myeloid leukemia: 2013 update on risk-stratification and management. Am J Hematol 2013;88:318–327.
  • Falini B, Gionfriddo I, Cecchetti F, et al. Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy? Blood Rev 2011;25:247–254.
  • Itzykson R, Solary E. An evolutionary perspective on chronic myelomonocytic leukemia. Leukemia 2013;27:1441–1450.
  • Thol F, Damm F, Ludeking A, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol 2011;29:2889–2896.
  • Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2011;44:23–31.
  • Shlush LI, Zandi S, Mitchell A, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 2014;506: 328–333.
  • Im AP, Sehgal AR, Carroll MP, et al. DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia 2015;29:516.
  • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Enlg J Med 2010;363:2424–2433.
  • Xu J, Wang Y-Y, Dai Y-J, et al. DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells. Proc Natl Acad Sci USA 2014;111:2620–2625.
  • Kelly LM, Englmeier U, Lafon I, et al. MafB is an inducer of monocytic differentiation EMBO J 2000;19:1987–1997.
  • Gemelli C, Montanari M, Tenedini E, et al. Virally mediated MafB transduction induces the monocyte commitment of human CD34 + hematopoietic stem/progenitor cells. Cell Death Differ 2006;13:1686–1696.
  • Lutherborrow M, Bryant A, Jayaswal V, et al. Expression profiling of cytogenetically normal acute myeloid leukemia identifies microRNAs that target genes involved in monocytic differentiation. Am J Hematol 2011;86:2–11.
  • Lu Q, Chen Y, Wang H, et al. DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia. Cancer Cell Int 2013;13:1.
  • Scott CS, Richards SJ, Master PS, et al. Flow cytometric analysis of membrane CD11b, CD11c and CD14 expression in acute myeloid leukaemia: relationships with monocytic subtypes and the concept of relative antigen expression. Eur J Haematol 1990;44:24–29.
  • Marcucci G, Metzeler KH, Schwind S, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol 2012;30:742–750.
  • Gemelli C, Orlandi C, Zanocco Marani T, et al. The vitamin D3/Hox-A10 pathway supports MafB function during the monocyte differentiation of human CD34 + hemopoietic progenitors. J Immunol 2008;181:5660–5672.
  • Kim SJ, Zhao H, Hardikar S, et al. A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood 2013;122:4086–4089.
  • Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, et al. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell 2014;25:442–454.
  • Eychène A, Rocques N, Pouponnot C. A new MAFia in cancer. Nat Rev Cancer 2008;8:683–693.
  • Pouponnot C, Sii-Felice K, Hmitou I, et al. Cell context reveals a dual role for Maf in oncogenesis. Oncogene 2006;25: 1299–1310.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.