405
Views
12
CrossRef citations to date
0
Altmetric
Original Articles: Clinical

Chronic myeloid leukemia with e14a3 BCR-ABL transcript: analysis of characteristics and prognostic significance

, , , , , , , , , , & show all
Pages 3343-3347 | Received 07 Apr 2014, Accepted 29 Mar 2015, Published online: 19 Jun 2015

References

  • Bernards A, Rubin CM, Westbrook CA, et al. The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. Mol Cell Biol 19877:3231–3236.
  • Ghavamzadeh A, Alimoghaddam K, Jahani M, et al. Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia. Arch Iran Med 2008;11:247–251.
  • Arana-Trejo RM, Sánchez ER, Ignacio-Ibarra G, et al. BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML). Clin Lab Haematol 2002;24:145–150.
  • Goh HG, Hwang JY, Kim SH, et al. Comprehensive analysis of BCR-ABL transcript types in Korean CML patients using a newly developed multiplex RT-PCR. Transl Res 2006;148:249–256.
  • Ravandi F, Cortes J, Albitar M, et al. Chronic myelogenous leukemia with p185 (BCR/ABL) expression: characteristics and clinical significance. Br J Haematol 1999;107:581–586.
  • Cross NCP .Standardisation of molecular monitoring for chronic myeloid leukaemia. Best Pract Res Clin Haematol 2009;22:355–365.
  • Kim J, Park TS, Lyu CJ, et al. BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet 2009;189:132–137.
  • Al-Ali HK, Leiblein S, Kovacs I, et al. CML with an e1a3 BCR-ABL fusion: rare, benign, and a potential diagnostic pitfall. Blood 2002;100:1092–1093.
  • Tiribelli M, Tonso A, Ferrero D, et al. Lack of SH3 domain does not imply a more severe clinical course in Ph+ chronic myeloid leukemia patients. Blood 2000;95:4019–4020.
  • Roman J, Jimenez A, Barrios M, et al. E1A3 as a unique, naturally occurring BCR–ABL transcript in an indolent case of chronic myeloid leukaemia. Br J Haematol 2001;114:635–637.
  • Iwata S, Mizutani S, Nakazawa S, et al. Heterogeneity of the breakpoint in the ABL gene in cases with BCR/ABL transcript lacking ABL exon a2. Leukemia 1994;8:1696–1702.
  • Kim J, Park TS, Lyu CJ, et al. BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet 2009;189:132–137.
  • Fujisawa S, Nakamura S, Naito K, et al. A variant transcript, e1a3, of the minor BCR–ABL fusion gene in acute lymphoblastic leukemia: case report and review of the literature. Int J Hematol 2008;87: 184–18.
  • Jinawath N, Norris-Kirby A, Smith BD, et al. A rare e14a3 (b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia: diagnostic challenges in clinical laboratory practice. J Mol Diagn 2009;11: 359–363.
  • Nieborowska-Skorska M, Wasik MA, Slupianek A, et al. Signal transducer and activator of transcription (STAT) 5 activation by BCR/ABL is dependent on intact Src homology (SH) 3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med 1999; 189:1229–1242.
  • Gross A W, Zhang X, Ren R. Bcr-Abl with an SH3 deletion retains the ability to induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy[J]. Mol Cell Biol 1999;19:6918–6928.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.