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Original Article

Deletion Variants within the NF-kB Activation Domain of the LMP1 Oncogene in Acquired Immunodeficiency Syndrome-Related Large Cell Lymphomas, in Prelymphomas and Atypical Lymphoproliferations

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Pages 239-250 | Received 28 Aug 1996, Published online: 01 Jul 2009

References

  • Henle G., Henle W., Diehl V. Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc. Natl. Acad. Sci. USA 1968; 59: 94–101
  • Epstein M.A., Achong B.G., Barr Y.M. Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet 1964; 702–703
  • Fahraeus R., Fu H.L., Ernberg I., Finke J., Rowe M., Klein G., Falk K., Nilsson E., Yaday M., Busson P., Tursz T., Kallin B. Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma. Int. J. Cancer 1988; 42: 329–338
  • Brousset P., Butet V., Chittal S., Selves J., Delsol G. Comparison of in situ hybridization using different nonisotopic probes for detection of Epstein-Barr virus in nasopharyngeal carcinoma and immunohistochemical correlation with anti-latent membrane protein antibody. Lab. Invest. 1992; 67: 457–464
  • Crawford D.H., Thomas J.A., Janossy G., Sweny P., Fernando O.N., Moorhead J.F., Thompson J.H. Epstein-Barr virus nuclear antigen positive lymphoma after cyclosporin a treatment in patient with renal allograft. Lancet 1980; 1355–1356
  • Hamilton-Dutoit S.J., Rea D., Raphael M., Sandvej K., Delecluse H.J., Gisselbrecht G., Marelle L., van Krieken J. H. H. M., Pallesen G. Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related Non-Hodgkin's lymphoma. Blood 1993; 82: 619–624
  • Weiss L.M., Movahed L.A., Warnke R.A., Sklar J. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N. Engl. J. Med. 1989; 320: 502–506
  • Knecht H., Sahli R., Shaw P., Meyer C., Bachmann E., Odermatt B.F. Detection of Epstein-Barr virus DNA by polymerase chain reaction in lymph node biopsies from patients with angioimmunoblastic lymphadenopathy. Br. J. Haematol. 1990; 75: 610–614
  • Bankier A.T., Deininger P.L., Satchwell S.C., Baer R., Farrell P.J., Barrell G.B. DNA sequence analysis of the EcoR1 Dhet fragment of B95–8 Epstein-Barr virus containing the terminal repeat sequences. Mol. Biol, Med. 1983; 1: 425–145
  • Fennewald S., van Santen V., Kieff E. Nucleotide sequence of a mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein. J. Virol 1984; 51: 411–419
  • Hennessy K., Fennewald S., Hummel M., Cole T., Kieff E. A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection. Proc. Natl. Acad. Sci. USA 1984; 81: 7207–7211
  • Deacon E.M., Pallesen G., Niedobitek G., Crocker J., Brooks L., Rickinson A.B., Young L.S. Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in malignant cells. J. Exp. Med. 1993; 177: 339–349
  • Chen F., Hu L.F., Ernberg I., Klein G., Winberg G. Coupled transcription of Epstein-Barr virus latent memhrane protein (LMP)-1 and LMP-2B genes in nasopharyngeal carcinomas. J. Gen. Virol. 1995; 76: 131–138
  • Tierney R.J., Steven N., Young L.S., Rickinson A.B. Epstein-Barr virus latency in blood mononuclear cells: Analysis of viral gene transcription during primary infection and in the carrier state. J. Virol. 1994; 68: 7374–7385
  • Thomas J.A., Hotchin N.A., Allday M.J., Amlot P., Rose M., Yacoub M., Crawford D.H. Immunohistology of Epstein-Baar virus-associated antigens in B cell disorders from immunocompromised individuals. Transplantation 1990; 49: 944–953
  • Wang D., Liebowitz D., Kieff E. An EBV membrane protein expressed in immortalized lymphocytes transforms estahlished rodent cells. Cell 1988; 43: 831–840
  • Fuhraeus R., Rymo L., Rhim J.S., Klein G. Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus. Nature 1990; 345: 437–449
  • Dawson C.W., Rickinson A.B., Young L.S. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation. Nature 1990; 344: 777–780
  • Peng M., Lundgren E. Transient expression of the Epstein-Barr virus LMP1 gene in human primary B cells induces cellulat- activation and DNA synthesis. Oncogene 1992; 7: 1775–1782
  • Henderson S., Rowe M., Gregory C., Croom-Carter D., Wang F., Lonpnecker R., Kieff E., Rickinson A. Induction or bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 1991; 65: 1107–1115
  • Mosialos G., Birkenbach M., Yalamanchili R., Van Arsdale T., Ware C., Kieff E. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 1995; 80: 380–399
  • Mitchell T., Sugden R. Stimulation of NF-kB-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus. J. Virol. 1995; 69: 2068–2976
  • Huen D.S., Henderson S.A., Croon-Carter D., Rowe M. The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kB and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Ontogene 1995; 10: 549–560
  • Herrero J.A., Mathew P., Paya C.V. LMP-1 activates NP-kB by targeting the inhibitory molecule IkBα. J. Virol. 1095; 69: 2168–2174
  • Baeuerle P.A., Henkel T. Function and activation of NF-kB in the immune system. Annu. Rev. Immunol. 1994; 12: 141–179
  • Hu L.F., Zabarovsky E.R., Chen F., Cao S.F., Ernberg I., Klein G., Winberg G. Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma. J. Gen. Virol. 1991; 72: 2399–2400
  • Chang Y.S., Su I.J., Chung P.J., Shu C.H., Ng C.K., Wu S.J., Liu S.T. Detection ot en Epstein-Barr-virus variant in T-cell-lymphoma tissues identical to the distinct strain observed in nasopharyngeal carcinoma in the Taiwanes population. Int. J. Cancer 1995; 62: 673–677
  • Knecht H., Bachmann E., Brousset P., Sandvej K., Nadal D., Bachmann F., Odermatt B.F., Delsol G., Pallesen G. Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma. Blood 1993; 82: 2937–2942
  • Knecht H., Bachmann E., Joske D. J. L., Sahli R., Emery-Goodman A., Casanova J.L., Zilic M., Bachmann F., Odermatt B.F. Molecular anaylsis of the LMP (latent membrane protein) oncogene in Hodgkin's disease. Leukemia 1993; 7: 580–585
  • Knecht H., Bachmann E., Brousset P., Rothenberger S., Einsele If., Lestou V.S., Delsol C., Bachmann F., Ambros P.F., Odermatt R.F. Mutational hot spots within the carboxy terminal region of the LMP1 oncogene of Epstein-Barr virus are frequent in lymphoproliferative disorders. Oncogene 1995; 10: 523–528
  • Santon A., Manzanal A.I., Campo E., Bellas C. Deletions in the Epstein-Barr virus latent membrane prtrtein- 1 oncogene in Hodgkin's disease. J. Clin. Pathol.: Mol. Pathol. 1995; 48: M184–M187
  • Knecht H., Raphael M., McQuain C., Kothenberger S., Pihan G., Bachmann E., Ryan S., Kittler E. L. W., Quesenberry P.J., Schlaifer D., Woda B.A., Brousset P. Deletion variants within the NF-kB activation domain of the LMP1 oncogene prevail in AIDS-related large cell lymphomas and HIV-negative atypical lymphoproliferations. Blood 1996; 87: 876–881
  • Palefsky J.M., Berline J., Penarandu M.E., Lennette E.T., Greenspan D., Greenspan J.S. Sequence variation of latent membrane protein-1 of Epstein-Barr virus strains associated with hairy leukoplakia. J. Infect. Dis. 1996; 173: 710–714
  • Walling D.M., Clark N.M., Markovitz D.M., Frank T.S., Braun D.K., Eisenberg E., Krutchkoff D.J., Felix D.H., Raab-Traub N. Epstein-Barr cirus coinfection and recombination in non-human immunodeficiency virus association. ated oral hairy leukoplakia. J. Infect. Dis. 1995; 171: 1122–1130
  • Berger C., McQuain C., Sullivan J., Nadal D., Quesenberry P.J., Knecht H. The LMP1 30 base pair deletion variant with enhanced oncogenic activity prevails in acute infectious mononucleosis and EBV-associated tonsillar hyperplasia. Blood 1996, Abstr. (in press)
  • Knecht H., McQuain C., Martin J., Drexler H.G., Rothenberger S., Berger C., Bachmann E., Kittler E. L. W., Odermati B.F., Quesenberry P.J. Expression of the LMP1 oncoprotein in the EBV negative Hodgkin's disease cell line L-428 is associated with Reed-Sternberg cell morphology. Oncogene 1996; 13: 947–953
  • Li S.N., Chang Y.S., Liu S.T. Effect of a 10-amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus. Oncogene 1996; 12: 2129–2135
  • Sandvej K., Peh S.C., Andresen B.S., Pallesen G. Identification of potential hot spots in the carboxy-termind part of the Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases: High frequency of a 30-bp deletion in Malaysian and Danish peripheral T-cell lymphomas. Blood 1994; 84: 4053–4060
  • Vasef M.A., Kamel O.W., Chen Y.Y., Medeiros J., Weiss L.M., Abbot S.D. Detection of Epstein-Barr virus in multiple sites involved by Hodgkin's disease. Am. J. Pathol. 1995; 147: 1408–1415
  • Kingma D.W., Weiss W.B., Jaffe E.S., Kumar S., Frekko K., Raffeld M. Epstein-Barr virus latent membrane protein-1 oncogene deletions: correlations with malignancy in Epstein-Barr virus-associated lymphoproliferative disorders and malignant lymphomas. Blood 1996; 88: 242–251
  • Chen W.C., Chen Y.Y., Bacchi M.M., Bacchi C.E., Alvarenga M. W. L. M. Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. Am. J. Pathol. 1996; 148: 17–23
  • Brousset P., Schlaifer D., Meggetto F., Bachmann E., Rothenberger S., Delsol G., Knecht H. Persistance of the same viral strain in early and late relapses of Epstein-Barr virus associated Hodgkin's disease. Blood 1994; 84: 2441–2451
  • Knecht H., Martius F., Bachmann E., Hoffmann T., Zimmermann D.R., Rothenberger S., Sandvej K., Wegmann W., Hurwitz N., Odermatt B.F., Kummer H., Pallesen G. A deletion mutant of the LMP1 oncogene of Epstein-Barr virus is associated with transformation of angioimmunoblastic lymphadenopathy into B-immunoblastic lymphoma. Leukemia 1995; 9: 458–465
  • Kershaw G.R., McQuain C., Berger C., Pihan G., Odermatt B.F., Quesenberry P.J., Woda B.A., Knecht H. Selective outgrowth of a posttransplant B-immunoblastic lymphoma expressing a LMP1 deletion variant. 1996, (Submitted)
  • Klein C., Rothenberger S., Niemeyer C., Bachmann E., Odermatt B., Boehm N., Brandis M., Knecht H. EBV-associated lymphoproliferative syndrome with a distinct 69 hase-pair deletion in the LMP-1 oncogene. Br. J. Haematol. 1995; 91: 938–940
  • Larcher C., McQuain C., Berger C., Mitterer M., Huemer H.P., Quesenberry P.J., Knecht H. Epstein-Barr virus associated persistent polyclonal B-cell lymphocytosis with a distinct 69 base pair deletion in the LMP-1 oncogene. Ann. Haematol. 1996, (in press)
  • Grunewald V., Bonnet M., Martel Renoir D., Cochet C., Joab I. Heterogeneity within the Epstein-Barr virus transactivator, zebra, derived from nasopharyngeal carcinoma. Epstein-Barr Virus & Associated Diseases 1994; 208, (Abstract)
  • Chen M.L., Tsai C.N., Liang C.L., Shu C.H., Hang C.R., Sulitzeanu D., Liu S.T., Chang Y.S. Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population. Oncogene 1992; 7: 2131–2140
  • Trivedi P., Hu L.F., Chen F., Christensson B., Masucci M.G., Klein G., Winberg G. Epstein-Barr virus (EBV)-encoded membrane protein LMP1 from a nasopharyngeal carcinoma is non-immunogenic in a murine model system, in contract to a B cell-derived homologue. Eur. J. Cancer 1994; 30A: 84–88
  • Hu L.F., Chen F., Zheng X., Ernberg I., Cao S.L., Christensson B., Klein G., Winberg G. Clonability and tumorigenicity of human epithelial cells expressing the EBV encoded membrane protein LMP1. Oncogene 1993; 8: 1575–1583
  • Pallesen G., Hamilton-Dutoit S.J., Rowe M., Young L.S. Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet 1991; i: 320–322
  • Herbst H., Dallenhach F., Hummel M., Niedobitek G., Pileri S., Muller-Lantzsch N., Stein H. Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells. Proc. Natl. Acad Sci. USA 1991; 88: 4766–4770
  • Hammarskjold M.L., Simurada M.C. Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kB activity. J. Virol. 1992; 66: 6496–6501
  • Laherty C.D., Hu H.M., Opipari A.W., Wang F., Dixit V.M. The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kB. J. Biol. Chem. 1992; 267: 24157–24160
  • Rothenberger S., Bachmann E., Knecht H. Natural 30 bp and 69 bp deletion variants of the LMP1 oncogene do stimulate NK-kB-mediated transcription. Oncogene 1996, (manuscript in revision)
  • Van de Stolpe A., Caldenhoven E., Stade B.G., Koenderman L., Raaijmakers J. A. M., Johnson R.P., van der Saag P.T. 12-O-tetradecanoylphorbol-13-acetate-and tumor necrosis factor α-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. J. Biol. Chem. 1994; 269: 6185–6192
  • Martin J., Sugden B. Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal association. J. Virol. 1991; 65: 3246–3258
  • Liu Y.-J., Joshua D.E., Williams G.T., Smith C.A., Gordon J., MacLennan I. C. M. Mechanism of antigen-driven selection in germinal centres. Nature 1989; 342: 929–931
  • Liu Y.J., Malisan F., de Bouteiller O., Guret C., Lebecque S., Banchereau J., Mills F.C., Max E.E., Martinez-Valdez H. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunity 1996; 4: 241–250
  • Carbone A., Tirelli U., Gloghini A., Volpe R., Boiocchi M. Human immunodeficiency virus-associated systemic lymphomas may he subdivided into two main groups according to Epstein-Barr viral latent gene expression. J. Clin. Oncol. 1993; 11: 1674–1681
  • Hamilton-Dutoit S.J., Raphael M., Audouin J., Diebold J., Lisse I., Pedersen C., Oksenhendler E., Marelle L., Pallesen G. In situ demonstration of Epstein-Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site. Blood 1993; 82: 69–624
  • Moorthy R.K., Thorley-Lawson D.A. All three domains of the Epstein-Barr virus-encoded latent membrane protein LMP-1 are required for transformation of Rat-1 fibroblasts. J. Virol. 1993; 67: 1638–1646
  • Seto E., Benedict Yen T.S., Matija Peterlin B., Ou J.-H. Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc. Natl. Acad. Sci. USA 1988; 85: 8286–8290
  • Sun S.-C., Elwood J., Beraud C., Greene W.C. Human T-cell leukemia virus type 1 tax activation of NF-kB/Rel involves phosphorylation and degradation of IkBα and RelA (p65)-mediated induction of the c-rel gene. Mol. & Cell. Biol. 1994; 14: 7377–7384
  • Kanno T., Franzoso G., Siebenlist U. Human T-cell leukemia virus type 1 Tax-protein-mediated activation of NF-kB from p100 (NF-kB2)-inhibited cytoplasmic reservoirs. Proc. Natl. Acad. Sci USA 1994; 91: 12634–12638
  • Gruss H.-J., Brach M.A., Drexler H.G., Bonifer R., Mertelsmann R.H. Expression of cytokine genes, cytokine receptor genes, and transcription factors in cultured Hodgkin and Reed-Sternberg cells. Cancer Res. 1992; 52: 3353–3360
  • Bargou R.C., Leng C., Krappmann D., Emmerich F., Mapara M.K., Bommert K., Royer H.D., Scheidereit C., Doerken B. High-level nuclear NF-kB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 1996; 87: 4340–4347
  • Gruss H.J., Ulrich D., Dower S.K., Herrtmann F., Brach M.A. Activation of Hodgkin cells via the CD30 receptor induces autocrine secretion of interleukin-6 engaging the NF-kB transcription factor. Blood 1996; 87: 2443–2449
  • Baker S.J., Reddy E.P. Transducers of life nnd death: TNF receptor superfamily and associated proteins. Oncogene. 1996; 12: 1–9

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