Intermediate and High Grade Non Hodgkin's Lymphoma in the Elderly

References

• Hodgkin T. On some morbid appearances of the absorbant glands and spleen. Med Chic Trans 1832; 17: 68–114
   PubMedGoogle Scholar
• Oliver J. The relation of Hodgkin's disease to lymphosarcoma and endothelioma. J Med Res 1913; 29: 191–207
   PubMedGoogle Scholar
• Mallory F. B. P. The principles of pathologic histology. WB Saunders, Philadelphia 1914; 333
   Google Scholar
• Herbert P. A., Miller F. R., Erf L. A. The relationship of Hodgkin's disease, lymphosarcoma and reticulum cell sarcoma. Am J Pathol 1945; 21: 233–253
   PubMedGoogle Scholar
• Ginsberg S. Lymphosarcoma and Hodgkin's disease:biologic characteristics. Ann Intern Med 1934; 8: 14–36
   Google Scholar
• Berman L. Malignant Lymphomas, their classification and relation to leucemia. Blood 1953; 8: 195–210
   PubMed Web of Science ®Google Scholar
• Rappaport H., Winter W. J., Hicks E. B. Follicular lymphoma: a reevaluation of its position in the scheme of malignant lymphoma based on a survey of 253 cases. Cancer 1956; 31: 806
   Google Scholar
• Lukes R. J., Collins R. D. lmmunologic characterization of human malignant lymphomas. Cancer 1974; 34: 1488–1503
   PubMed Web of Science ®Google Scholar
• Lennert K., Mohri N., Stein H., Kaizerling E. Histopathology of malignant lymphomas. Br J Haematol 1975; 31: 193–203
   PubMed Web of Science ®Google Scholar
• Bennett M. H., Farrer‐Brown G., Henry K., Jelliffe A. M. Classification of non‐Hodgkin's lymphomas. Lancet 1974; 2: 405
   Web of Science ®Google Scholar
• Dorfman R. F. Classification of non‐Hodgkin's lymphoma. Lancet 1974; 1: 1295
   PubMed Web of Science ®Google Scholar
• Mathe G., Rappaport H., O'Conor G. T., et al. Histological and cytological typing of neoplastic diseases of hematopoietic and lymphoid tissues. WHO International Histological Classification of tumours. Geneva 1976, no 14
   Google Scholar
• Gerard‐Marchant R., Hamlin I., lennert K., et al. Classification of non‐Hodgkin's lymphomas. Lancet 1974; 2: 406
   Web of Science ®Google Scholar
• Rosenberg S. A., Berard C. W., Brown B. W., et al. National Cancer Institute sponsered study of classifications of non‐Hodgkin's lymphomas:summary and description of a working formulation for clinical usage. Cancer 1982; 49: 2112–2135
   PubMed Web of Science ®Google Scholar
• Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K., Cleary M. L., Delsol G., De Wolf Peeters C., Falini B., Garter K. C., et al. A revised European‐American classification of lymphoid neoplasms:a proposal from the International Lymphoma study Group. Blood 1994; 84(5)1361
   PubMed Web of Science ®Google Scholar
• Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K., Cleary M. L., Delsol G., De Wolf Peeters C., Falini B., Gatter K. C., et al. Lymphoma classification proposakclarification. Blood 1995; 85(3)857
   PubMed Web of Science ®Google Scholar
• Hiddemann W., longo D. L., Coiffier B., Fisher R. I., Cabanillas F., Cavalli F., Nadler L. M., De Vita V. T., Lister A., Armitrage J. O. Lymphoma classification‐The gap between biology and clinical management is closing. Blood 1996; 88: 4085
   PubMed Web of Science ®Google Scholar
• Pittaluga S., Bijnens L., Teodorovic I., Hagenbeek A., Meerwaldt J. H., Somers R., Thomas J., Noordijk E. M., De Wolf Peeters C. Clinical analysis of 670 cases in two trials of the European Organization for the Research and Treatment of Cancer lymphoma Cooperative Group subtyped according to the Revised European‐American Classification of Lymphoid Neoplasms: a comparison with the Working Formulation. Blood 1996; 87(10)4358
   PubMed Web of Science ®Google Scholar
• Meijer C. J. L. M., van der Valk P., de Bruin P. C., Willemze R. The revised European‐American Lymphoma (REAL) classification of non‐Hodgkin's lymphoma: A missed opportunity?. Blood 1995; 85(7)1971–2
   PubMed Web of Science ®Google Scholar
• Begg C. B., Cohen J. L., Ellerton J. Are the elderly predisposed to toxicity from cancer chemotherapy? An investigation using data from the Eastern Cooperative Oncology Group. Cancer Clin Trials 1980; 3: 369–374
   PubMedGoogle Scholar
• Hall S. W. Cancer:Special considerations in older patients. Geriatrics 1984; 39: 74–78
   PubMed Web of Science ®Google Scholar
• Yancik R., Ries R. G. Cancer in the aged. An epidemiologic perspective on treatment issues. Cancer 1991; 68: 2502–2510
   PubMed Web of Science ®Google Scholar
• Schouten L. J., van den Brandt P. A., Jager J. J. Koppejan‐Rensenbrink Incidentie van kanker in midden en zuid limburg 1986–1991. Regionale kankerregistratie 1994; 5: 3–1
   Google Scholar
• Sonneveld P., Hop W., Mulder A. H., Michiels J. J., Blijham G., et al. Full dose chemotherapy for non‐hodgkin's lymphoma in the elderly. Sem in Hematol 1994; 31(2)9–12
   PubMed Web of Science ®Google Scholar
• Visser O., Coebergh J. W. W., Schouten L. J. Incidence of cancer in the Netherlands. 1991, third report of the Netherlands cancer registry
   Google Scholar
• Devesa S. S., Fears T. Non‐Hodgkin's lymphoma time trends:United States and international data. Cancer Res 1992; 52: 543–544
   Google Scholar
• Baranovsky A., Myers M. H. Cancer incidence and survival in patients 65 years of age and older. Cancer J for Clinicians 1986; 36: 26–41
   PubMed Web of Science ®Google Scholar
• Miller B. A., Ries L. A. G., Hankey B. F., et al. Cancer Statistics review: 1973–1989, National Cancer Institute. NIH Pub.No.92–2789 1992; 17: 1–6
   Google Scholar
• Weisenburger D. D. Epidemiology of non‐Hodgkin's lymphoma:recent findings regarding an emerging epidemic. Ann Oncol 1994; 5(suppl. 1)S19–S24
   Google Scholar
• Whisler R. L., Williams J. W., Jr, Newhouse Y. G. Human B cell proliferative responses during aging. Reduced RNA synthesis and DNA replication after signal transduction by surface immunoglobulins compared to B cell‐antigenic determinants CD20 and CD40. Mech Aging Dev 1991; 61: 209–222
   PubMed Web of Science ®Google Scholar
• Rabkin C. S., Biggar R. J., Horm J. W. Increasing incidence of cancers associated with the human immunodeficiency virus epidemic. Int J Cancer 1991; 47: 692–696
   PubMed Web of Science ®Google Scholar
• Gail M. H., Pluda J. M., Rabkin C. S., et al. Projections of the incidence of non‐Hodgkin's lymphoma related to acquired immunodeficiency syndrome. J Nat Cancer Inst 1991; 83: 695–701
   PubMed Web of Science ®Google Scholar
• Russo C., Schwab R., Weksler M. E. Immune dysregulation associated with aging. Immunol Infec Dis 1990; 2: 211–216
   Google Scholar
• Tsongas T. A. Occupational factors in the epidemiology of chemically induced lymphoid and hemopoietic cancers. Toxicology of the blood and bone marrow, R. D. Irons. Raven Press, New York 1985; 149–177
   Google Scholar
• Cantor K. P. Farming and mortality from non‐Hodgkin's lymphomas case‐control study. Int J Cancer 1982; 29: 239–47
   PubMed Web of Science ®Google Scholar
• Scherr P. A., Mueller N. Non‐Hodgkin's lymphoma. Cancer epidemiology and prevention2nd ed., D. Schottenfeld, J. F. Fraumeni. Oxford press, New York 1993
   Google Scholar
• Scherr P. A., Hutchison G. B., Neiman R. S. Non‐Hodgkin's lymphoma and occupational exposure. Cancer Res 1992; 52: 5503c–5509
   PubMedGoogle Scholar
• Pearce N., Bethwaite P. Increasing incidence of non‐Hodgkin's lymphoma:Occupational and environmental factors. Cancer Res 1992; 52: 5496s–5500s, supl
   PubMed Web of Science ®Google Scholar
• Morrison H. I., Wilkens K., Semenciw R., et al. Herbicides and cancer. J Natl Cancer Inst 1992; 84: 1866–1874
   PubMed Web of Science ®Google Scholar
• Zahm S. H., Blair A. Pesticides and non‐Hodgkin's lymphoma. Cancer Res 1992; 52: 5485s–5488s, suppl
   PubMed Web of Science ®Google Scholar
• Hoar S. K., Blair A., Holmes F. F., et al. Agricultural herbicides use and the risk of lymphoma and soft tissue sarcoma. J Am med Assoc 1986; 256: 1141–1147
   PubMed Web of Science ®Google Scholar
• Brandt L., Kristofferson W., Olsson H., et al. Relation between occupational exposure to organic solvents and chromosome aberrations in non‐Hodgkin's lymphoma. Eur J haematol 1989; 42: 298–302
   PubMed Web of Science ®Google Scholar
• Linet M. S., McLaughlin J. K., Hsing A. W., et al. Is cigarette smoking a risk factor for non‐Hodgkin's lymphoma or multiple myeloma? Results from the Lutheran Brotherhood Cohort Study. Leuk Res 1992; 16: 621–624
   PubMed Web of Science ®Google Scholar
• John E. M., Savitz D. A., Sandler D. P. Prenatal exposure to parents smoking and childhood cancer. Am J Epidemiol 1991; 133: 123–132
   PubMed Web of Science ®Google Scholar
• Lichtman S. M. Lymphoma in the older patient. Sem in Oncol 1995; 22(1)25–28
   PubMed Web of Science ®Google Scholar
• Repetto L., Vercelli M., Simoni C., et al. Comorbidity amoung elderly patients with with and without cancer. Proc Am Soc Clin Oncol 1994; 13: 467a
   Google Scholar
• Vose J. M., Armitage J. O., Weisenberger D. D., et al. The importance of age in survival of patients treated with chemotherapy for aggressive non‐Hodgkin's lymphoma. J Clin Oncol 1988; 6: 1838–1844
   PubMed Web of Science ®Google Scholar
• Dixon D. O., Neilan B., Jones S., et al. Effect of age on therapeutic outcome in advanced diffuse histiocytic lym‐homa:The Southwest Oncology experience. J Clin Oncol 1986; 4: 295–305
   PubMed Web of Science ®Google Scholar
• The International Non‐Hodgkin's lymphoma Prognostic Factors Project A predictive model for aggressive non‐Hodgkin's lymphoma. N Engl J Med 1993; 329: 987–94
   PubMed Web of Science ®Google Scholar
• Armitage J. O., Potter J. E. Aggressive chemotherapy for diffuse histocytic lymphoma in the elderly:increased complications with advancing age. J Am Geriat Soc 1984; 32: 269–273
   PubMed Web of Science ®Google Scholar
• Hoskens P. J., Ng V., Spinelli J. J., et al. Prognostic variables in patients with diffuse large‐cell lymphoma treated with MACOP.‐B. J Clin Oncol 1991; 9: 220–226
   PubMed Web of Science ®Google Scholar
• Coiffier B., Gisselbrecht C., Vose J. M., et al. Prognostic factors in aggressive maligant lymphoma and validation of a prognostic index that could identify patients requiring a more intensive therapy. J Clin Oncol 1991; 9: 211–219
   PubMed Web of Science ®Google Scholar
• Solal‐Celigny P., Chastang C., Herrera A., et al. Age as a mean prognostic factors in adult aggressive non hodgkin's lymphoma. Am J Med 1987; 83: 1075–1079
   PubMed Web of Science ®Google Scholar
• Balducci L., Phillips D. M., Davis K. M., et al. Systemic treatment of cancer in elderly. Arch Gerontol Ger 1988; 7: 115–150
   Google Scholar
• Plunkett W., Gandhi V. Cellular pharmacodynamics of anticancer drugs. Sem Oncol 1993; 20: 50–63
   PubMed Web of Science ®Google Scholar
• Zhan Z., Sandor V. A., Gamelin E., Regis J., Dickstein B., Wilson W., Fojo A. T., Bates S. E. Expression of the multidrug resistance‐associated protein gene in refractory lym‐phoma:Quantitation by a validated polymerase chain reaction assay. Blood 1997; 89(10)3795–3800
   PubMed Web of Science ®Google Scholar
• Almquist K. C., Loe D. W., Hipfner D. R., Mackie J. E., Cole S. P., Deeley R. G. Characterization of the M(r) 190,000 multidrug resistance protein. Cancer Res 1995; 55: 102
   PubMed Web of Science ®Google Scholar
• Harrison D. J. Molecular mechanisms of drug resistance in tumors. J Pathol 1995; 175: 7
   PubMed Web of Science ®Google Scholar
• Schouten H. C., Sanger W. G., Weisenburger D. D., Anderson J., Armitrage J. O. Chromosomal abnormalities in untreated patients with non‐Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome. Blood 1990; 75: 1841–1847
   PubMed Web of Science ®Google Scholar
• Levine E. G., Arthur D. C., Frizzera G., Peterson B. A., Hurd D. D., Bloomfield C. D. Cytogenetic abnormalities predict clinical outcome in non‐Hodgkin's lymphoma. Ann Intern Med 1988; 108: 14
   PubMed Web of Science ®Google Scholar
• Offit K., Wong G., Filippa D. A., Tao Y., Chaganti R. S. K. Cytogenetic analysis of 434 consecutively ascertained specimens of non‐Hodgkin's lymphoma xlinical correlations. Blood 1991; 77: 1508
   PubMed Web of Science ®Google Scholar
• Shipp M. A. Prognostic factors in aggressive Non‐Hodgkin's lymphoma:who has “high‐risk” disease?. Blood 1994; 83(5)1165–1173
   PubMed Web of Science ®Google Scholar
• de Rijke J. M., Schouten L. J., Schouten H. C., Jager J. J., Koppe‐jan A. G., van den Brandt P. A. Age‐specific differences in the diagnostics and treatment of cancer patients aged 50 years and older in the province of Limburg, the Netherlands. Ann Oncol 1996; 7: 677–685
   PubMed Web of Science ®Google Scholar
• Carbone A., Volpe R., Gloghini A., et al. Non‐Hodgkin's lymphoma in the elderly. Pathologic features at presentation. Cancer 1990; 66: 1991–1994
   PubMed Web of Science ®Google Scholar
• Ansell S. M., Falkson G., van der Merwe R., et al. Chronological age is a multifactorial prognostic variable in patients with non‐Hodgkin's lymphoma. Ann Oncol 1992; 3(1)45–50
   PubMed Web of Science ®Google Scholar
• Neilly I. J., Ogston M., Bennett B., Dawson A. A. High grade non‐Hodgkin's lymphoma in the elderly‐12 year experience in the grampian region of Scotland. Hematol Oncol 1995; 13: 99–106
   PubMed Web of Science ®Google Scholar
• D'Amore F., Brincker H., Christensen B. E. Non‐Hodgkin's lymphoma in the elderly. A study of 602 patients aged 70 or older from a Danish population based registry. Ann Oncol 1992; 3: 379–386
   PubMed Web of Science ®Google Scholar
• Goss P., Burkes R., Rudinskas L., King M., et al. A phase II trial of prednisone, oral etoposide and novantrone (PEN) as initial treatment of non‐Hodgkin's lymphoma in elderly patients. Leukemia Lymphoma 1995; 18: 145–152
   PubMed Web of Science ®Google Scholar
• Tirelli U., Zagonel V., Serraino D., Thomas J., Hoerni B., Tangury A., Ruhl U., et al. Non‐Hodgkin's lymphomas in 137 patients aged 70 years or older. A retrospective European organization for research and treatment of cancer lymphoma group study. J Clin Oncol 1988; 6(11)1708–1713
   PubMed Web of Science ®Google Scholar
• Heinz R., Pawlicki M., Losonczy H., Varbiro M., et al. Initial chemotherapy with an age adjusted CHOP schedule in non‐Hodgkin lymphomas with unfavourable prognosis: A study of the IGCI. Haematologica (Pavia) 1986; 71: 473–479
   PubMedGoogle Scholar
• Grogan L., Corbally N., Dervan P. A., Byrne A., Carney D. N. Comparable prognostic factors and survival in elderly patients with aggressive non‐Hodgkin's lymphoma treated with standard dose adriamycin based regimens. Ann Oncol 1994; 5(suppl 2)S47–51
   PubMedGoogle Scholar
• Cohen H. J. Geriatric Principles of Treatment Applied to Medical Oncology:An Overview. Sem in Oncol 1995; 22(1)1–2
   PubMed Web of Science ®Google Scholar
• Balducci L., Parker M., Sexton W., Tantranond P. Pharmacology of antineoplastic agents in the elderly patient. Sem in Oncol 1989; 16(1)76–84
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J. Elimination half‐life of drugs:value and limitations. Ann Rev Med 1985; 36: 421–427
   PubMed Web of Science ®Google Scholar
• Cohen H. J. Biology of aging as related to cancer. Cancer 1993; 71: 2092–2100
   Google Scholar
• Sweet D. L., Kinzie J., Gaeke M. E., Golomb H. M., Ferguson D. L., Ultmann J. E. Survival of patients with localized diffuse histiocytic lymphoma. Blood 1981; 58: 1218–1223
   PubMed Web of Science ®Google Scholar
• Bessell E. M., Coutts A., Fletcher J., Toghil P. J., Moloney A. J., Ellis I. O., Hulman G., Jenkins D. Non‐Hodgkin's lymphoma in elderly patients:a phase II study of MCOP Chemotherapy in patients aged 70 years or over with intermediate or high‐grade histology. Eur J Cancer 1994; 30A(9)1337–1341
   PubMed Web of Science ®Google Scholar
• Sonneveld P., de Ridder M., van der Lelie H., Nieuwenhuis K., et al. Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non‐Hodgkin's lymphoma using CHOP VS CNOP chemotherapy. J Clin Oncol 1995; 13: 2530–2539
   PubMed Web of Science ®Google Scholar
• McKelvey E. M., Gottlieb J. A., Wilson H. E., et al. Hydroxy‐ldaunomicin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 1976; 38: 11484–11493
   Web of Science ®Google Scholar
• Fisher R. I. Treatment of aggressive non Hodgkin's lymphomas. Cancer 1994; 74: 2657–61
   PubMed Web of Science ®Google Scholar
• Fisher R. I., Gaynor E. R., Dahlberg S., Oken M. M., Grogan T. M., Mize E. M., Glick J. H., Coltman C. A., Miller T. P. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non Hodgkin's lymphoma. N Engl J Med 1993; 328: 1002–6
   PubMed Web of Science ®Google Scholar
• Orlandi E., Lazzarino M., Brusamolino E., et al. Non‐Hodgkin's lymphoma in elderly:The impact of advanced age on therapeutic options and clinical results. Haematologica 1991; 76: 204–208
   PubMed Web of Science ®Google Scholar
• Meyer R. M., Browman G. P., Samosh M. L., Benger A. M., Bryant‐lukosius, et al. Randomized phase II comparison of standard CHOP with weekly CHOP in elderly patients with non‐hodgkin's lymphoma. J Clin Oncol 1995; 13: 2386–2393
   PubMed Web of Science ®Google Scholar
• Young W. A., Greco F. A., Greer J. P., Hainsworth J. D. Aggressive Non‐Hodgkin's lymphoma in the elderly:an effective, well tolerated treatment regimen containing extended schedule etoposide. J Nat Cancer Inst 1994; 17: 1346–7
   Web of Science ®Google Scholar
• Bertini M., Freilone R., Vitolo U., Botto B., Pizzuti M., et al. P‐VEBEC:A new 8 weekly schedule with or without rG‐CSF for elderly patients with aggressive non‐Hodgkin's lymphoma (NHL). Ann Oncol 1994; 5: 895–900
   PubMed Web of Science ®Google Scholar
• O'Reilly S. E., Conners J. M., Howdle S., et al. In search of an optimal regimen for elderly people with advanced‐stage diffuse large cell lymphoma:Results of a phase II study of P/DOCE chemotherapy. J Clin Oncol 1993; 11: 2250–2257
   PubMed Web of Science ®Google Scholar
• Zizani P. L., Bendandi M., Gherlinzoni F., et al. VNCOP‐B regimen in the treatment of high grade non‐Hodgkin's lymphoma in the elderly. Haematologica 1993; 78: 378–82
   PubMedGoogle Scholar
• Martelli M., Guglieimi C., Coluzzi S., Avvisati G., Amadori S., et al. P‐VABEC:a prospective study of a new weekly chemotherapy regimen for elderly aggressive non‐Hodgkin's lymphoma. J Clin Oncol 1993; 1: 2362–2369
   Google Scholar
• Tirelli U., Zagonel V., Errante D., et al. A prospective study of a new combination chemotherapy regimen in patients older than 70 years with unfavourable non‐Hodgkin's lymphoma. J Clin Oncol 1992; 10: 228–236
   PubMed Web of Science ®Google Scholar
• Salvagno L., Contu A., Bianco A. A combination of mitoxantrone, etoposide and prednisone in elderly patients with non‐Hodgkin's lymphoma. Ann Oncol 1992; 3: 833–837
   PubMed Web of Science ®Google Scholar
• O'Reilly S. E., Klimo P., Connors J. M. Low dose ACOP‐B and VABE weekly chemotherapy for elderly patients with advanced stage diffuse large cell lymphoma. J Clin Oncol 1991; 9: 741–747
   PubMed Web of Science ®Google Scholar
• Tigaud J. D., Demolombe S., Bastion Y., et al. Ifosfamide continous infusion plus etoposide in the treatment of elderly patients with aggressive lymphoma. A phase II study. Hematol Oncol 1991; 9: 225–233
   PubMed Web of Science ®Google Scholar
• McMaster M. L., Johnson D. H., Greer J. P., et al. A brief‐duration combination chemotherapy for elderly with poor prognosis non‐Hodgkin's lymphoma. Cancer 1991; 67: 1487–1492
   PubMed Web of Science ®Google Scholar
• Zagonel V., Tirelli U., Carbone A., et al. Combination chemotherapy specifically devised for elderly patients with unfavourable non‐Hodgkin's lymphoma. Cancer Invest 1990; 8: 577–582
   PubMed Web of Science ®Google Scholar
• Sonneveld P., Michels J. J. Full dose chemotherapy in elderly patients with non‐Hodgkin's lymphoma:a feasable study using a mitoxantrone containing regimen. Br J Cancer 1990; 62: 105–108
   PubMed Web of Science ®Google Scholar
• Tirelli U., Carbone A., Zagonel V., et al. Non‐Hodgkin's lymphoma in the elderly:prospective studies with specifically devised chemotherapy regimens in 66 patients. Eur J Cancer Clin Oncol 1987; 23: 535–540
   PubMedGoogle Scholar
• O'Connell M. J., Earle J. D., Harrington D. P., et al. Initial chemotherapy doses for elderly patients with malignant lymphoma. J Clin Oncol 1986; 4: 1418
   PubMed Web of Science ®Google Scholar
• Ruys C. D., Dekker A. W., van Kempen‐Harteveld M. L., van Baarlen J., Hordijk C. J. Treatment of localized non Hodgkin's lymphoma of the head and neck. Cancer 1994; 74(2)703–707
   PubMed Web of Science ®Google Scholar
• Martelli M., De Sanctis V., Avvisati G., Mandelli F. Current guidelines for the management of aggressive non‐Hodgkin's lymphoma. Drugs 1997; 53(6)957–972
   PubMed Web of Science ®Google Scholar
• Tondini C., Zanini M., Lombardi F., Bengala C., Rocca A., Giardini R., Buzzoni R., Valagussa P., Bonadonna G. Combined modality treatment with primary CHOP chemotherapy followed by locoregional irradiation in stage 1 or II histologically aggressive non Hodgkin's lymphomas. J Clin Oncol 1993; 11(4)720–21
   PubMed Web of Science ®Google Scholar
• Munck J. N., Dhermain F., Koscielny S., Girinsky T., Carde P., Bosq J., Decaudin D., Julieron M., Cosset J. M., Hayat M. Alternating chemotherapy and radiotherapy for limited stage intermediate and high grade non Hodgkin's lymphoma; long term results for 96 patients with tumors > 5 cm. Ann Oncol 1996; 7(9)925–931
   PubMed Web of Science ®Google Scholar
• Vose J. M., Armitage J. O. The present status of therapy for patients with aggressive non Hodgkin's lymphoma. Ann Oncol 1991; 2(suppl 2)171–176
   PubMedGoogle Scholar
• Hiddemann W. Non Hodgkin's lymphoma‐current status of therapy and future perspectives. Eur J Cancer 1995; 31A(13–14)2141–2145
   PubMed Web of Science ®Google Scholar
• Vose J. M. Cytokine use in the older patient. Sem in Oncol 1995; 22(1)6–8
   PubMed Web of Science ®Google Scholar
• Zauber N. P., Zauber A. G. Hematologic data of healthy very old people. JAMA 1987; 257: 2181–2184
   PubMed Web of Science ®Google Scholar
• Zagonel V., Barbare R., Merola M. Ac., et al. Cost benefit of granulocyte colony‐stimulating factor administration in older patients with non hodgkin's lymphoma treated with combination chemotherapy. Ann Oncol 1994; 5(suppl 2)S127–132
   PubMedGoogle Scholar
• Chatta G. S., Price T. H., Allen R. C., Dale D. C. Effects of in vivo recombinant methionyl human granulocyte colony stimulating factor on the neutrophil response and perpheral blood colony forming cells in healthy young and elderly adult volunteers. Blood 1994; 84(9)2923–2929
   PubMed Web of Science ®Google Scholar
• Coiffier B. What treatment for elderly patients with aggressive lymphoma. Ann Oncol 1994; 873–875
   PubMed Web of Science ®Google Scholar
• Epelbaum R., Haim N., Leviov M., et al. Full dose CHOP chemotherapy in elderly patients with non‐Hodgkin's lymphoma. Acta Oncol 1995; 34(1)87–91
   PubMed Web of Science ®Google Scholar
• Armitage J. O. Treatment of non Hodgkin's lymphoma. New Engl J Med 1993; 328(14)1023–1030
   PubMed Web of Science ®Google Scholar
• Bastion V., Blay J. Y., Divine M., Brice P., Bordessoule D., et al. Elderly patients with aggressive non‐Hodgkin's lymphoma: disease presentation, response to treatment, and survival‐A groupe d'etude des lymphomes de l'adulte study on 453 patients older than 69 years. J Clin Oncol 1997; 15(8)2945–2953
   PubMed Web of Science ®Google Scholar
• Crowther D., Wagstaff J. Management of high grade non Hodgkin's lymphoma in adults. Bailliere's Clinical Hematology 1987; vol 1(1)157–183
   Google Scholar
• The Non Hodgkin's lymphoma classification project. A clinical eveluation of the international lymphoma study group classification of Non‐Hodgkin's lymphoma. Blood 1997; 89(11)3909–3918
   PubMed Web of Science ®Google Scholar
• The Non Hodgkin's lymphoma classification project. Effect of age on the characteristics and clinical behaviour of non‐Hodgkin's lymphoma patients. Ann Oncol 1997; 8: 973–978
   PubMed Web of Science ®Google Scholar
• Tirelli U., Errante D., Van Klabbeke M., Teodorovic I., et al. CHOP is the standard regimen in patients greater than or equal to 70 years of age with intermediate grade and high grade non Hodgkin's lymphoma. Results of a randomized study of the European lymphoma cooperative study group. J Clin Oncol 1998; 16: 27–34
   PubMed Web of Science ®Google Scholar