Effects of prenatal exposure to diclofenac sodium and saline on the optic nerve of 4- and 20-week-old male rats: a stereological and histological study

References

• Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley PF, Isakson P, Markowska AL (2001). Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J. Neurosci. 21: 8198–8209.
   PubMed Web of Science ®Google Scholar
• Bohn MC, Friedrich VL Jr (1982). Recovery of myelination in rat optic nerve after developmental retardation by cortisol. J. Neurosci. 2: 1292–1298.
   PubMed Web of Science ®Google Scholar
• Breder CD, Dewitt D, Kraig RP (1995). Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol. 355: 296–315.
   PubMed Web of Science ®Google Scholar
• Canan S, Aktas A, Ulkay MB, Colakoglu S, Ragbetli MC, Ayyildiz M, Geuna S, Kaplan S (2008). Prenatal exposure to a non-steroidal anti-inflammatory drug or saline solution impairs sciatic nerve morphology: a stereological and histological study. Int. J. Dev. Neurosci. 26: 733–738.
   PubMed Web of Science ®Google Scholar
• Capone ML, Tacconelli S, Di Francesco L, Sacchetti A, Sciulli MG, Patrignani P (2007). Pharmacodynamic of cyclooxygenase inhibitors in humans. Prostagl. Lipid Mediat. 82: 85–94.
   PubMed Web of Science ®Google Scholar
• Cappon GD, Cook JC, Hurtt ME (2003). Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res. B Dev. Reprod. Toxicol. 68: 47–56.
   PubMed Web of Science ®Google Scholar
• Carp HJ, Fein A, Nebel L (1988). Effect of diclofenac on implantation and embryonic development in the rat. Eur. J. Obstet. Gynecol. Reprod. Biol. 28: 273–277.
   PubMed Web of Science ®Google Scholar
• Chan LY, Chiu PY, Siu SS, Lau TK (2001). A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model. Hum. Reprod. 16: 2390–2393.
   PubMed Web of Science ®Google Scholar
• Chan LY, Chiu PY, Siu NS, Wang CC, Lau TK (2002). Diclofenac-induced embryotoxicity is associated with increased embryonic 8-isoprostaglandin F2alpha level in rat whole embryo culture. Reprod. Toxicol. 16: 841–844.
   PubMed Web of Science ®Google Scholar
• Chen WJ, Edwards RB (2003). Prenatal nicotine exposure does not cause Purkinje cell loss in the developing rat cerebellar vermis. Neurotoxicol. Teratol. 25: 633–637.
   PubMed Web of Science ®Google Scholar
• Chen WJ, King KA, Lee RE, Sedtal CS, Smith AM (2006). Effects of nicotine exposure during prenatal or perinatal period on cell numbers in adult rat hippocampus and cerebellum: a stereology study. Life Sci. 79: 2221–2227.
   PubMed Web of Science ®Google Scholar
• Clarke AS, Wittwer DJ, Abbott DH, Schneider ML (1994). Long-term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys. Dev. Psychobiol. 27: 257–269.
   PubMed Web of Science ®Google Scholar
• Cui JG, Kuroda H, Chandrasekharan NV, Pelaez RP, Simmons DL, Bazan NG, Lukiw WJ (2004). Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem. Res. 29: 1731–1737.
   PubMed Web of Science ®Google Scholar
• Dawood MY (1993). Nonsteroidal anti-inflammatory drugs and reproduction. Am. J. Obstet. Gynecol. 169: 1255–1265.
   PubMed Web of Science ®Google Scholar
• Ericson A, Källén B (2001). Nonsteroidal anti-inflammatory drugs in early pregnancy. Reprod. Toxicol. 15: 371–375.
   PubMed Web of Science ®Google Scholar
• Fu Q, Hue J, Li S (2007). Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition. J. Neurosci. 27: 4154–4164.
   PubMed Web of Science ®Google Scholar
• Gao XQ, Yang CX, Chen GJ, Wang GY, Chen B, Tan SK, Liu J, Yuan QL (2010). Ginsenoside Rb1 regulates the expressions of brain-derived neurotrophic factor and caspase-3 and induces neurogenesis in rats with experimental cerebral ischemia. J. Ethnopharmacol. 132: 393–399.
   PubMed Web of Science ®Google Scholar
• Geuna S, Tos P, Battiston B, Guglielmone R (2000). Verification of the two-dimensional disector, a method for the unbiased estimation of density and number of myelinated nerve fibers in peripheral nerves. Ann. Anat. 182: 23–34.
   PubMed Web of Science ®Google Scholar
• Geuna S, Tos P, Guglielmone R, Battiston B, Giacobini-Robecchi MG (2001). Methodological issues in size estimation of myelinated nerve fibers in peripheral nerves. Anat. Embryol. 204: 1–10.
   PubMedGoogle Scholar
• Gokcimen A, Ragbetli MC, Bas O, Tunc AT, Aslan H, Yazici AC, Kaplan S (2007). Effect of prenatal exposure to an anti-inflammatory drug on neuron number in cornu ammonis and dentate gyrus of the rat hippocampus: a stereological study. Brain Res. 1127: 185–192.
   PubMed Web of Science ®Google Scholar
• Gómez-Lechón MJ, Ponsoda X, O’Connor E, Donato T, Castell JV, Jover R (2003). Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem. Pharmacol. 66: 2155–2167.
   PubMed Web of Science ®Google Scholar
• Green GA (2001). Understanding NSAIDs: from aspirin to COX-2. Clin. Cornerstone 3: 50–60.
   PubMedGoogle Scholar
• Gundersen HJ (1986). Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microsc. 143: 3–45.
   PubMed Web of Science ®Google Scholar
• Gundersen HJ, Jensen EB, Kieu K, Nielsen J (1999). The efficiency of systematic sampling in stereology- reconsidered. J. Microsc. 193: 199–211.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Gutteridge JM (1985). The importance of free radicals and catalytic metal ions in human diseases. Mol. Asp. Med. 8: 89–193.
   PubMed Web of Science ®Google Scholar
• Huizink AC (2000). Prenatal Stress and its Effects on Infant Development, Utrecht University.147–169.
   Google Scholar
• Inoue A, Muranaka S, Fujita H, Kanno T, Tamai H, Utsumi K (2004). Molecular mechanism of diclofenac- induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free Rad. Biol. Med. 37: 1290–1299.
   PubMed Web of Science ®Google Scholar
• Inuzuka T, Quarles RH, Trapp BD, Heath JW (1988). Analysis of myelin proteins in sympathetic peripheral nerve of adult rats. Brain Res. 466: 191–199.
   PubMed Web of Science ®Google Scholar
• Kannangara TS, Lucero MJ, Gil-Mohapel J, Drapala RJ, Simpson JM, Christie BR, van Praag H (2011). Running reduces stress and enhances cell genesis in aged mice. Neurobiol. Aging 32: 2279–2286.
   PubMed Web of Science ®Google Scholar
• Kaplan S, Canan S, Aslan H, Unal B, Sahin B (2001). A simple technique to measure the movements of the microscope stage along the x and y axes for stereological methods. J. Microsc. 203: 321–325.
   PubMed Web of Science ®Google Scholar
• Kaplan S, Gokyar A, Unal B (2005). A simple technique for localizing consecutive fields for disector pairs in light microscopy: application to neuron counting in rabbit spinal cord following spinal cord injury. J. Neurosci. Methods 145: 277–284.
   PubMed Web of Science ®Google Scholar
• Kaplan S, Geuna S, Ronchi G, Ulkay MB, von Bartheld CS (2010). Calibration of the stereological estimation of the number of myelinated axons in the rat sciatic nerve: a multicenter study. J. Neurosci. Methods 187: 90–99.
   PubMed Web of Science ®Google Scholar
• Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P (1996). Cox-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 93: 2317–2321.
   PubMed Web of Science ®Google Scholar
• Knabe W, Obermayer B, Kuhn HJ, Brunnett G, Washausen S (2009). Apoptosis and proliferation in the trigeminal placode. Brain Struct. Funct. 214: 49–65.
   PubMed Web of Science ®Google Scholar
• Kudo C, Kori M, Matsuzaki K, Yamai K, Nakajima A, Shibuya A, Niwa H, Kamisaki Y, Wada K (2003). Diclofenac inhibits proliferation and differentiation of neural stem cells. Biochem. Pharmacol. 66: 289–295.
   PubMed Web of Science ®Google Scholar
• Kuwabara T (1975). Development of the optic nerve of the rat Invest. Ophthal. Vis. Sci. 14: 732–745.
   Google Scholar
• Larsen JO (1998). Stereology of nerve cross sections. J. Neurosci. Methods 85: 107–118.
   PubMed Web of Science ®Google Scholar
• Liu LY, Fei XW, Li ZM, Zhang ZH, Mei YA (2005). Diclofenac, a nonsteroidal anti-inflammatory drug, activates the transient outward K+ current in rat cerebellar granule cells. Neuropharmacology 48: 918–926.
   PubMed Web of Science ®Google Scholar
• Milusheva E, Baranyi M, Kittel A, Fekete A, Zelles T, Vizi ES, Sperlágh B (2008). Modulation of dopaminergic neurotransmission in rat striatum upon in vitro and in vivo diclofenac treatment. J. Neurochem. 105: 360–368.
   PubMed Web of Science ®Google Scholar
• Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR (1993). Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 90: 11693–11697.
   PubMed Web of Science ®Google Scholar
• Mulder EJH, Robles de Medina PG, Huizink AC, Van den Berg BRH , Buitelaar JK, Visser GHA (2002). Prenatal maternal stress: effects on pregnancy and the (unborn) child. Early Hum. Dev. 70 3–14.
   PubMed Web of Science ®Google Scholar
• Odaci E, Cihan OF, Aslan H, Ragbetli MC, Kaplan S (2010). Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: a stereological study. Int. J. Dev. Neurosci. 28: 145–151.
   PubMed Web of Science ®Google Scholar
• Orhan H, Sahin G (2001). In vitro effects of NSAIDS and paracetamol on oxidative stress-related parameters of human erythrocytes. Exp. Toxicol. Pathol. 53: 133–140.
   PubMedGoogle Scholar
• Østensen ME, Skomsvoll JF (2004). Anti-inflammatory pharmacotherapy during pregnancy. Expert Opin. Pharmacol. 5: 571–580.
   PubMed Web of Science ®Google Scholar
• Pascucci RA (2002). Use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors: indications and complications. J. Am. Osteopath. Assoc. 102: 487–489.
   PubMedGoogle Scholar
• Ragbetli MC, Ozyurt B, Aslan H, Odaci E, Gokcimen A, Sahin B, Kaplan S (2007). Effect of prenatal exposure to diclofenac sodium on Purkinje cell numbers in rat cerebellum: a stereological study. Brain Res. 1174: 130–135.
   PubMed Web of Science ®Google Scholar
• Russell RI (2001). Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions. Postgrad. Med. J. 77: 82–88.
   PubMed Web of Science ®Google Scholar
• Schmitz C, Otto U, Korr H (2000). More cerebellar granule cells following prenatal low-dose X-irradiation. Brain Res. 872: 250–253.
   PubMed Web of Science ®Google Scholar
• Schneider ML, Roughton EC, Koehler AJ, Lubach GR (1999). Growth development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. Child Dev. 70: 263–274.
   PubMed Web of Science ®Google Scholar
• Siu KL, Lee WH (2004). Maternal diclofenac sodium ingestion and severe neonatal pulmonary hypertension. J. Paediat. Child Health 40: 152–153.
   PubMed Web of Science ®Google Scholar
• Siu SSN, Yeung JHK, Lau TK (2000). Study on placental transfer of diclofenac in first trimester of human pregnancy. Hum. Reprod. 15: 2423–2425.
   PubMed Web of Science ®Google Scholar
• Trapp BD, Quarles RH (1982). Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin. J. Cell Biol. 92: 877–882.
   PubMed Web of Science ®Google Scholar
• Weinstock M (1997). Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis?. Neurosci. Biobehav. Rev. 21: 1–10.
   PubMed Web of Science ®Google Scholar
• Van den Veyver IB, Moise KJ Jr (1993). Prostaglandin synthetase inhibitors in pregnancy. Obstet. Gynecol. Surv. 48: 493–502.
   PubMedGoogle Scholar
• Vane JR, Flower RJ, Botting RM (1990). History of aspirin and its mechanism of action. Stroke 21, suppl. 12: 12–23.
   Web of Science ®Google Scholar
• Vane JR, Bakhle YS, Botting RM (1998). Cyclooxygenases 1 and 2. Ann. Rev. Pharmacol. Toxicol. 38: 97–120.
   PubMed Web of Science ®Google Scholar
• Yamagata K, Andreasson KI, Kaufmann WE (1993). Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11: 371–386.
   PubMed Web of Science ®Google Scholar
• Zacharaki T, Sophou S, Giannakopoulou A, Dinopoulos A, Antonopoulos J, Parnavelas JG, Dori I (2000). Natural and lesion-induced apoptosis in the dorsal lateral geniculate nucleus during development. Brain Res. 1344: 62–76.
   Google Scholar