308
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Telomerase activity-independent function of telomerase reverse transcriptase is involved in acrylamide-induced neuron damage

, , , &
Pages 327-335 | Accepted 05 Aug 2013, Published online: 27 Nov 2013

References

  • Adams JM (2004). Ways of dying: multiple pathways to apoptosis. Genes Dev. 17: 2481–2495.
  • Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G (2008). Telomerase does not counteract telomere shortening, but protects mitochondrial function under oxidative stress. J. Cell Sci. 7: 1046–1053.
  • Bonnes-Taourel D, Guérin MC, Torreilles J (1992). Is malonaldehyde a valuable indicator of lipid peroxidation?Biochem. Pharmacol. 44: 985–988.
  • Camello-Almaraz C, Gomez-Pinilla PJ, Pozo MJ, Camello PJ (2006). Mitochondrial reactive oxygen species and Ca2 + signaling. Am. J. Physiol. Cell Physiol. 291: C1082–C1088.
  • Cao XL, Hu XM, Hu JQ, Zheng WX (2011). Myocardin-related transcription factor-A promoting neuronal survival against apoptosis induced by hypoxia/ischemia. Brain Res. 1385: 263–274.
  • Cao Y, Li H, Deb S, Liu JP (2002). TERT regulates cell survival independent of telomerase enzymatic activity. Oncogene21: 3130–3138.
  • Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB (1987). Evaluation of a tetrazolium-based semi-automated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 4: 936–942.
  • Cheng EH, Kirsch DG, Clem RJ, Ravi R, Kastan MB, Bedi A, Ueno K, Hardwick JM (1997). Conversion of Bcl-2 to a bax-like death effector by caspases. Science5345: 1966–1968.
  • Chiodi I, Mondello C (2012). Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. Front. Oncol. 2: 133.
  • Exon JH (2006). A review of the toxicology of acrylamide. J. Toxicol. Environ. Health B Crit. Rev. 9: 397–412.
  • Gordon DM, Santos JH (2010). The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism. J. Nucl. Acids 2010: 390791.
  • Greider CW (1998). Telomerase activity, cell proliferation, and cancer. Proc. Natl. Acad. Sci. USA1: 90–92.
  • Haendeler J, Dröse S, Büchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S (2009). Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler. Thromb. Vasc. Biol. 6: 929–935.
  • Huang XQ, Wang J, Liu JP, Feng H, Liu WB, Yan Q, Liu Y, Sun SM, Deng M, Gong L, Liu Y, Li DW (2005). hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells. Invest. Ophthal. Vis. Sci. 7: 2503–2513.
  • Indran IR, Hande MP, Pervaiz S (2011). hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res. 1: 266–276.
  • Kitazumi I, Tsukahara M (2011). Regulation of DNA fragmentation: the role of caspases and phosphorylation. FEBS J. 278: 427–441.
  • Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT (1997). Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science5336: 294–298.
  • Lee IK, Kang KA, Zhang R, Kim BJ, Kang SS, Hyun JW (2011). Mitochondria protection of baicalen against oxidative damage via induction of manganese superoxide dismutase. Env. Toxicol Pharmacol. 31: 233–241.
  • Li J, Tang B, Qu Y, Mu D (2011). Telomerase reverse transcriptase: a novel neuroprotective mechanism involved in neonatal hypoxic-ischemic brain injury. Int. J. Dev. Neurosci. 8: 867–872.
  • LoPachin RM, Gavin T (2012). Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry. Env. Health Perspec. 12: 1650–1657.
  • Mannaa F, Abdel-Wahhab MA, Ahmed HH, Park MH (2006). Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. J. Appl. Toxicol. 3: 198–206.
  • Martinou JC, Youle RJ (2011). Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell21: 92–101.
  • Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H (2012). Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol. Neurobiol. 2: 227–235.
  • Olsvik PA, Kristensen T, Waagbø R, Rosseland BO, Tollefsen KE, Baeverfjord G, Berntssen MH (2005). mRNA expression of antioxidant enzymes (SOD, CAT and GSH-Px) and lipid peroxidative stress in liver of Atlantic salmon (Salmo salar) exposed to hyperoxic water during smoltification. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 141: 314–323.
  • Park HR, Kim MS, Kim SJ, Park M, Kong KH, Kim HS, Kwack SJ, Kang TS, Kim SH, Kim HS, Lee J (2010). Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Toxicol. Lett. 1: 86–93.
  • Parzefall W (2008). Minireview on the toxicity of dietary acrylamide. Food Chem. Toxicol. 46: 1360–1364.
  • Prasad SN, Muralidhara (2012). Evidence of acrylamide induced oxidative stress and neurotoxicity in Drosophila melanogaster-its amelioration with spice active enrichment: relevance to neuropathy. Neurotoxicology5: 1254–1264.
  • Rahman R, Latonen L, Wiman KG (2005). hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene24: 1320–1327.
  • Santos JH, Meyer JN, Skorvaga M, Annab LA, Van Houten B (2004). Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell3: 399–411.
  • Schmuck G, Mihail F (2004). Effects of the carbamates fenoxycarb, propamocarb and propoxur on energy supply, glucose utilization and SH-groups in neurons. Arch. Toxicol. 78: 330–337.
  • Sharma NK, Reyes A, Green P, Caron MJ, Bonini MG, Gordon DM, Holt IJ, Santos JH (2012). Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucl. Acids Res. 40: 712–725.
  • Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC (2013). Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS One 1: e52989.
  • Tareke E, Rydberg P, Karlsson P, Eriksson M, Tornqvist M (2002). Analysis of acrylamide, a carcinogen formed in heated food-stuffs. J. Agric. Food Chem. 50: 4998–5006.
  • Tsujimoto Y (1998). Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?Genes Cells11: 697–707.
  • Yousef MI, El-Demerdash FM (2006). Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology219: 133–141.
  • Zhao F, Qu Y, Xiong T, Duan Z, Ye Q, Mu D (2012). The neuroprotective role of TERT via an anti-apoptotic mechanism in neonatal rats after hypoxia-ischemia brain injury. Neurosci. Lett. 1: 39–43.
  • Zhu H, Fu W, Mattson MP (2000). The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis. J. Neurochem. 1: 117–124.
  • Zhu YJ, Zeng T, Zhu YB, Yu SF, Wang QS, Zhang LP, Guo X, Xie KQ (2008). Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochem. Res. 11: 2310–2317.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.