Design of oral insulin delivery systems

References

• Adams G, Wang N, Cui Y. (2005). Future alternative therapies in a quest to halt aberrations in diabetes mellitus. Biomed Pharmacother, 59: 296–301.
   PubMed Web of Science ®Google Scholar
• Anita L, Santani DD. (2007). Pulsatile drug delivery systems. Ind J Pharm Sci, 69(4): 489–497.
   Google Scholar
• Aoki Y, Morishita M, Takayama K. (2005a). Role of mucous/glycocalyx layers in insulin permeation across the rat ileal membrane. Int J Pharm, 297: 98–109.
   PubMed Web of Science ®Google Scholar
• Aoki Y, Morishita M, Asai K, Akikusa B, Hosoda S, Takayama K. (2005b). Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane. Pharm Res, 22(11): 1854–1862.
   PubMed Web of Science ®Google Scholar
• Arnolds S, Heise T. (2007). Inhaled insulin. Best Pract Clin Endocrinol Metab, 21(4): 555–571.
   PubMed Web of Science ®Google Scholar
• Bai JPF, Chang LL. (1996). Effects of enzyme inhibitors and insulin concentration on transepithelial transport of insulin in rats. J Pharm Pharmacol, 48: 1078–1082.
   PubMed Web of Science ®Google Scholar
• Baker JC, Hanquier JM. (1997). Acylated insulin analogs. US Patent 5693609.
   Google Scholar
• Banerjee D, Flanagan PR, Cluett J, Valberg LS. (1986). Transferrin receptors in the human gastrointestinal tract. Relationships to body iron stores. Gastroenterology, 91: 861–869.
   PubMed Web of Science ®Google Scholar
• Belchetz P, Hammond P. (2004). Mosby’s Color Atlas and Text of Diabetes and Endocrinology. Spain: Elsevier Ltd.
   Google Scholar
• Bernkop-Schnürch A. (1998). The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J Control Release, 52: 1–16.
   PubMed Web of Science ®Google Scholar
• British Pharmacopoeia (1998). Human Insulin (pp. 725–727 ), Vol. I. London: The Stationery Office Ltd.
   Google Scholar
• Calceti P, Salmaso S, Walker G, Bernkop-Schnürch A. (2004). Development and in vivo evaluation of an oral insulin-PEG delivery system. Eur J Pharm Sci, 22: 315–323.
   PubMed Web of Science ®Google Scholar
• Cano-Cebrián M.J, Zornoza T, Granero L, Polache A. (2005). Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery. Curr Drug Deliv, 2: 9–22.
   PubMedGoogle Scholar
• Carino GP, Mathiowitz E. (1999). Oral insulin delivery. Adv Drug Deliv Rev, 35: 249–257.
   PubMed Web of Science ®Google Scholar
• Chan KK, Mei H. (2000). Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells. US Patent 6159931.
   Google Scholar
• Cheng K, Lim L-Y. (2004). Insulin-loaded calcium pectinate nanoparticles: Effects of pectin molecular weight and formulation pH. Drug Dev Ind Pharm, 30(4): 359–367.
   PubMed Web of Science ®Google Scholar
• Chu JS. (2003). Advances in colon-specific drug delivery systems employing the CODES™. The Drug Delivery Companies Report Autumn/Winter 36–40.
   Google Scholar
• Cui F, Shi K, Zhang L, Tao A, Kawashima Y. (2006). Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. J. Control Release, 114: 242–250.
   PubMed Web of Science ®Google Scholar
• Damgé C, Maincent P, Ubrich N. (2007). Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control Release, 117: 163–170.
   PubMed Web of Science ®Google Scholar
• Delie F. (1998). Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv. Drug Deliv. Rev. 34: 221–233.
   Google Scholar
• Ertl B, Heigl F, Wirth M, Gabor F. (2000). Lectin-mdiated bioadhesion: preparation, stability and Caco-2 binding of wheat germ agglutinin-functionalized poly(D, L-lactic-co-glycolic acid)-microspheres. J Drug Target, 8(3): 173–184.
   PubMed Web of Science ®Google Scholar
• Fasano A. (1998). Innovative strategies for the oral delivery of drugs and peptides. Trends Biotechnol, 16(4): 152–157.
   PubMed Web of Science ®Google Scholar
• Flood T. (2006). Advances in insulin delivery systems and devices: Beyond the vial and syringe. Insulin, 1(3): 99–108.
   Google Scholar
• Foss A.C, Goto T, Morishita M, Peppas NA. (2004). Development of acrylic-based copolymers for oral insulin delivery. Eur J Pharm Biopharm, 57: 163–169.
   PubMed Web of Science ®Google Scholar
• Gabor F, Schwarzbauer A, Wirth M. (2002). Lectin-mediated drug delivery: Binding and uptake of BSA-WGA conjugates using the Caco-2 model. Int J Pharm, 237: 227–239.
   PubMed Web of Science ®Google Scholar
• Grabovac V, Föger F, Bernkop-Schnürch A. (2008). Design and in vivo evaluation of a patch delivery system for insulin based on thiolated polymers. Int J Pharm 348: 169–174.
   PubMed Web of Science ®Google Scholar
• Graves PM, Eisenbarth GS. (1999). Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus. Adv Drug Del Rev, 35: 143–156.
   PubMed Web of Science ®Google Scholar
• Hinds KD, Kim SW. (2002). Effects of PEG conjugation on insulin properties. Adv Drug Deliv Rev, 54(4): 505–530.
   PubMed Web of Science ®Google Scholar
• Hinds KD, Campbell KM, Holland KM, Lewis DH, Piché CA, Schmidt PG. (2005). PEGylated insulin in PLGA microparticles. In vivo and in vitro analysis. J Control Release, 104: 447–460.
   PubMed Web of Science ®Google Scholar
• Hite P.F, Barnes AM, Johnston PE. (2006). Exhuberance over Exubera. Clin Diabet, 24(3): 110–114.
   Google Scholar
• Hollander P.A. (2007). Evolution of a pulmonary insulin delivery system (Exubera) for patients with diabetes. Medscape General Med, 9(1): 45.
   PubMedGoogle Scholar
• Hosny EA, Al-Shora HI, Elmazar MMA. (2002). Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on relative hypoglycemia of diabetic beagle dogs. Int J Pharm 237: 71–76.
   PubMed Web of Science ®Google Scholar
• Hou Z, Zhang Z, Zhang C, Huang M. (2004). Use of natural plant exudates (Sanguis Draxonis) for sustained oral insulin delivery with dramatic reduction of glycemic effects in diabetic rats. J. Controll Release, 97: 467–475.
   PubMed Web of Science ®Google Scholar
• Hovgaard Lars, Jacobs H, Wilson DE, Kim SW. (1996). Stabilization of insulin by alkylmaltosides. B. Oral absorption in vivo in rats. Int J Pharm, 132: 115–121.
   Web of Science ®Google Scholar
• Irache JM, Durrer C, Duchêne D, Ponchel G. (1994). In vitro study of lectin-latex conjugates for specific bioadhesion. J Control Release, 31: 181–188.
   Web of Science ®Google Scholar
• Jain S, Hreczuk-Hirst D.H, McCormack B, Mital M, Epenetos A, Laing P, Gregoriadis G. (2003). Polysialylated insulin: synthesis, characterization and biological activity in vivo. Biochim Biophys Acta, 1622: 42–49.
   PubMed Web of Science ®Google Scholar
• Jasti BR, Marasanapalle V, Li X. (2002). Barriers to the delivery of proteins and peptides. American Pharmaceutical Review.
   Google Scholar
• Jeandidier N, Boivin S. (1999). Current status and future prospects of parenteral insulin regimens, strategies and delivery systems for diabetes treatment. Adv Drug Deliv Rev, 35: 179–198.
   PubMed Web of Science ®Google Scholar
• Kajii T, Hori T, Hayashi M, Awazu S. (1986). Effect of salicylic acid on the permeability of plasma membrane of the small intestine of the rat: fluorescence spectroscopic approach to elucidate the mechanism of promoted drug absorption. J Pharm Sci, 75(5): 475–478.
   PubMed Web of Science ®Google Scholar
• Katsuma M, Watanabe S, Kawai H, Takemura S, Sako K. (2006). Effects of absorption promoters on insulin absorption through colon-targeted delivery. Int J Pharm, 307: 156–162.
   PubMed Web of Science ®Google Scholar
• Kim JJ, Park K. (2001). Modulated insulin delivery from glucose-;sensitive hydrogel dosage forms. J Control Release, 77: 39–47.
   PubMed Web of Science ®Google Scholar
• Kim B-Y, Jeong JH, Park K, Kim J-D. (2005). Bioadhesive interaction and hypoglycemic effect of insulin loaded lectin-microparticle conjugates in oral insulin delivery system. J Control Release, 102: 525–538.
   PubMed Web of Science ®Google Scholar
• King H, Aubert RE, Herman WH. (1998). Global burden of diabetes, 1995–2025. Diabetes Care, 21(9): 1414–1431.
   PubMed Web of Science ®Google Scholar
• Krauland AH, Guggi D, Bernkop-Schnürch A. (2004). Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats. J Control Release, 95: 547–555.
   PubMed Web of Science ®Google Scholar
• Lacombe O, Woodley J, Solleux C, Delbos J-M, Boursier-Neyret C, Houin G. (2004). Localization of drug permeability along the rat small intestine, using markers of the paracellular, transcellular and some transporter routes. Eur J Pharm Sci, 23: 385–391.
   PubMed Web of Science ®Google Scholar
• Lehr C-M. (2000). Lectin-mediated drug delivery: the second generation of bioadhesives. J Control Release, 65: 19–29.
   PubMed Web of Science ®Google Scholar
• Li J, Yang L, Ferguson S.M, Hudson TJ, Watanabe S, Katsuma M, Fix JA. (2002). In vitro evaluation of dissolution behaviour for a colon-specific drug delivery system (CODES™) in multi-pH media using United States Pharmacopeia apparatus II and III. AAPS Pharm Sci Tech 3(4): article 33.
   PubMedGoogle Scholar
• Li M-G, Lu W-L, Wang J-C, Zhang X, Wang X-Q, Zheng A-P, Zhang Q. (2007). Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats. Int J Pharm, 329: 182–191.
   PubMed Web of Science ®Google Scholar
• Lim C-J, Shen W-C. (2005). Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs. J Control Release, 106: 273–286.
   PubMed Web of Science ®Google Scholar
• Lin Y-H, Chen C-T, Liang H-F, Kulkarni AR, Lee P-W, Chen C-H, Sung H-W. (2007). Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnol. 18: doi: 10.1088/0957-4484/18/10/105102.
   Web of Science ®Google Scholar
• Lubben IMVD, Konings FAJ, Borchard G, Verhoef JC, Junginger HE. (2001). In vivo uptake of chitosan microparticles by murine peyer’s patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry. J Drug Target, 9(1): 39–47.
   PubMed Web of Science ®Google Scholar
• Ma Z, Lim L-Y. (2003). Uptake of chitosan and associated insulin in Caco-2 cell monolayers: A comparison between chitosan molecules and chitosan nanoparticles. Pharm Res 20(11): 1812–1819.
   PubMed Web of Science ®Google Scholar
• Ma Z, Lim TM, Lim L-Y. (2005). Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int J Pharm 293: 271–280.
   PubMed Web of Science ®Google Scholar
• Mandal TK. (2005). Inhaled insulin for diabetes mellitus. Am J Health-Syst Pharm 62(13): 1359–1364.
   PubMed Web of Science ®Google Scholar
• Mastrandrea LD, Quattrin T. (2006). Clinical evaluation of inhaled insulin. Adv Drug Deliv Rev, 58: 1061–1075.
   PubMed Web of Science ®Google Scholar
• Morishita M, Goto T, Peppas NA, Joseph JI, Torjman M.C, Munsick C, Nakamura K, Yamagata T, Takayama K, Lowman AM. (2004). Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption. J Control Release, 97: 115–124.
   PubMed Web of Science ®Google Scholar
• Morishita M, Goto T, Nakamura K, Lowman AM, Takayama K, Peppas NA. (2006). Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats. J Control Release, 110: 587–594.
   PubMed Web of Science ®Google Scholar
• Moslemi P, Najafabadi AR, Tajerzadeh H. (2003). A rapid and sensitive method for simultaneous determination of insulin and A21-desamido insulin by high performance liquid chromatography. J Pharm Biomed Anal, 33: 45–51.
   PubMed Web of Science ®Google Scholar
• Muranushi N, Mack E, Kim SW. (1993). The effects of fatty acids and their derivatives on the intestinal absorption of insulin in rat. Drug Dev Ind Pharm, 19(8): 929–941.
   Web of Science ®Google Scholar
• Musabayane CT, Munjeri O, Bwititi P, Osim EE. (2000). Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin-diabetic rats. J Endocrinol,, 164: 1–6.
   PubMed Web of Science ®Google Scholar
• Nakamura K, Murray RJ, Joseph JI, Peppas NA, Morishita M, Lowman AM. (2004). Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics. J Control Release, 95: 589–599.
   PubMed Web of Science ®Google Scholar
• Pan Y, Li Y-J, Zhao H-Y, Zheng J-M, Xu H, Wei, G, Hao J-S, Cui F-D. (2002). Bioadhesive polysaccharide in protein delivery system: chitoan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm, 249: 139–147.
   PubMed Web of Science ®Google Scholar
• Patton JS, Bukar J, Nagarajan S. (1999) Inhaled insulin. Adv Drug Deliv Rev, 35: 235–247.
   PubMed Web of Science ®Google Scholar
• Peppas NA, Kavimandan NJ. (2006). Nanoscale analysis of protein and peptide absorption: Insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles. Eur J Pharm Sci, 29(3–4): 183–197.
   PubMed Web of Science ®Google Scholar
• Pillai, O, Panchagnula R. (2001). Insulin therapies-past, present and future. Drug Discov. Today, 6(20): 1056–1061.
   Google Scholar
• Ramkissoon-Ganorkar C, Liu F, Baudyš M, Kim SW. (1999). Modulating insulin-release profile from pH/thermosensitive polymeric beads through polymer molecular weight. J Control Release, 59: 287–298.
   PubMed Web of Science ®Google Scholar
• Rosa G.D, Iommelli R, Rotonda M.I.L, Miro A, Quaglia F. (2000). Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J Control Release, 69: 283–295.
   PubMed Web of Science ®Google Scholar
• Saffran M, Pansky B, Budd GC, Williams FE. (1997). Insulin and gastrointestinal tract. J Control Release, 46: 89–98.
   Web of Science ®Google Scholar
• Sajeesh S, Sharma CP. 2006 Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int J Pharm, 325: 147–154.
   PubMed Web of Science ®Google Scholar
• Sarmento B, Ribeiro A, Veiga F, Ferreira D. (2006). Development and characterization of new insulin containing polysaccharide nanoparticles. Coll. Surf B: Biointerf, 53(2): 193–202.
   PubMed Web of Science ®Google Scholar
• Schultz SG. (1977). Some properties and consequences of low resistance paracellular pathways across the small intestine: The advantages of being “leaky”. In M. Kramer and F. Lauterbach (eds.), Intestin Permeat Ex Med, 391: 382–392.
   Google Scholar
• Shah D, Shen WC. (1996). Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells. J Pharm Sci, 85(12): 1306–1311.
   PubMed Web of Science ®Google Scholar
• Shao Z, Li Y, Krishnamoorthy R, Chermak T, Mitra AK. (1993). Differential effects of anionic, cationic, nonionic, and physiologic surfactants on the dissociation, α-chymotryptic degradation, and enteral absorption of insulin hexamers. Pharm Res, 10(2): 243–251.
   PubMed Web of Science ®Google Scholar
• Suzuka T, Tata N, Sakai K, Nishihata T. (1988). The effect of salicylate concentration on the uptake of salicylate and cefmetazole into rat isolated small intestine epithelial cells. J Pharm Pharmacol, 40(7): 469–472.
   PubMed Web of Science ®Google Scholar
• Szabo S, Trier JS, Frankel PW. (1981). Sulfhydryl compounds may mediate gastric cytoprotection. Science, 214: 200–202.
   PubMed Web of Science ®Google Scholar
• Takei I, Kasatani T. (2004). Future therapy of diabetes mellitus. Biomed Pharmacother, 58: 578–581.
   PubMed Web of Science ®Google Scholar
• Tao SL, Desai TA. (2005) Gastrointestinal patch systems for oral drug delivery. Drug Discovery Today, 10(13): 909–915.
   PubMed Web of Science ®Google Scholar
• Teply BA, Tong R, Jeong S.Y, Luther G, Sherifi I, Yim C.H, Khademhosseini A, Farokhzad OC, Langer RS, Cheng J. (2008). The use of charged-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials, 29: 1216–1223.
   PubMed Web of Science ®Google Scholar
• Wan J, Taub ME, Shah D, Shen WC. (1992) Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canin kidney cells. J Biol Chem, 267(19): 13446–13450.
   PubMed Web of Science ®Google Scholar
• Wikipedia (2008) Inhalable insulin.
   Google Scholar
• Whitehead K, Shen Z, Mitragotri S. (2004). Oral delivery of macromolecules using intestinal patches: application for insulin delivery. J. Control Release, 98: 37–45.
   PubMed Web of Science ®Google Scholar
• WHO. (1999). Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. World Health Organization, Department of Noncommunicable Disease Surveillance, Geneva.
   Google Scholar
• Wong TW. (2009). Chitosan and its use in design of insulin delivery system. Recent Pat Drug Deliv Formulation, 3: 8–25.
   PubMedGoogle Scholar
• Xia CQ, Shen W-C. (2001) Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2 cells and increases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res, 18(2): 191–195.
   PubMed Web of Science ®Google Scholar
• Yamagata T, Morishita M, Kavimandan N.J, Nakamura K, Fukuoka Y, Takayama K, Peppas N.A. 2006 Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids. J Control Release, 112: 343–349.
   PubMed Web of Science ®Google Scholar
• Yin L, Fei L, Cui F, Tang C, Yin C. (2007). Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks. Biomaterials, 28: 1258–1266.
   PubMed Web of Science ®Google Scholar
• Yin L, Ding JY, Fei L, He M, Cui F, Tang C, Yin C. (2008). Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles. Int J Pharm, 350: 220–229.
   PubMed Web of Science ®Google Scholar