Rational design, fabrication, characterization and in vitro testing of biodegradable microparticles that generate targeted and sustained transgene expression in HepG2 liver cells

References

• Abbas AO, Donovan MD, Salem AK. (2008). Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery. J Pharm Sci, 97, 2448–2461.
   PubMed Web of Science ®Google Scholar
• Chen J, Gao X, Hu K, Pang Z, Cai J, Li J, Wu H, Jiang X. (2008). Galactose-poly(ethylene glycol)-polyethylenimine for improved lung gene transfer. Biochem Biophys Res Commun, 375, 378–383.
   PubMed Web of Science ®Google Scholar
• Chumakova OV, Liopo AV, Andreev VG, Cicenaite I, Evers BM, Chakrabarty S, Pappas TC, Esenaliev RO. (2008). Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo. Cancer Lett, 261, 215–225.
   PubMed Web of Science ®Google Scholar
• Cook SE, Park IK, Kim EM, Jeong HJ, Park TG, Choi YJ, Akaike T, Cho CS. (2005). Galactosylated polyethylenimine-graft-poly(vinyl pyrrolidone) as a hepatocyte-targeting gene carrier. J Control Release, 105, 151–163.
   PubMed Web of Science ®Google Scholar
• De Rosa G, Quaglia F, La Rotonda MI, Appel M, Alphandary H, Fattal E. (2002). Poly(lactide-co-glycolide) microspheres for the controlled release of oligonucleotide/polyethylenimine complexes. J Pharm Sci, 91, 790–799.
   PubMed Web of Science ®Google Scholar
• Dunlap DD, Maggi A, Soria MR, Monaco L. (1997). Nanoscopic structure of DNA condensed for gene delivery. Nucleic Acids Res, 25, 3095–3101.
   PubMed Web of Science ®Google Scholar
• Fischer D, Bieber T, Li Y, Elsässer HP, Kissel T. (1999). A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res, 16, 1273–1279.
   PubMed Web of Science ®Google Scholar
• Galindo-Rodriguez S, Allémann E, Fessi H, Doelker E. (2004). Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods. Pharm Res, 21, 1428–1439.
   PubMed Web of Science ®Google Scholar
• Gao G, Vandenberghe LH, Wilson JM. (2005). New recombinant serotypes of AAV vectors. Curr Gene Ther, 5, 285–297.
   PubMed Web of Science ®Google Scholar
• Goforth R, Salem AK, Zhu X, Miles S, Zhang XQ, Lee JH, Sandler AD. (2009). Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma. Cancer Immunol Immunother, 58, 517–530.
   PubMed Web of Science ®Google Scholar
• Hashida M, Hirabayashi H, Nishikawa M, Takakura Y. (1997). Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis. J Control Release, 46, 129–137.
   Web of Science ®Google Scholar
• Hohokabe M, Higuchi Y, Mukai H, Kawakami S, Hashida M. (2007). Hepatocyte-selective gene transfer by galactosylated Protein/Linear Polyethyleneimine/Plasmid DNA complexes in mice. Journal of Biomedical Nanotechnology, 3, 277–284.
   Web of Science ®Google Scholar
• Intra J, Salem AK. (2008). Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. J Control Release, 130, 129–138.
   PubMed Web of Science ®Google Scholar
• Intra J, Salem AK. (2010). Fabrication, characterization and in vitro evaluation of poly(D,L-lactide-co-glycolide) microparticles loaded with polyamidoamine-plasmid DNA dendriplexes for applications in nonviral gene delivery. J Pharm Sci, 99, 368–384.
   PubMed Web of Science ®Google Scholar
• Kang Y, Xie L, Tran DT, Stein CS, Hickey M, Davidson BL, McCray PB Jr. (2005). Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood, 106, 1552–1558.
   PubMed Web of Science ®Google Scholar
• Kim TH, Kim SI, Akaike T, Cho CS. (2005). Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes. J Control Release, 105, 354–366.
   PubMed Web of Science ®Google Scholar
• Kramer MG, Barajas M, Razquin N, Berraondo P, Rodrigo M, Wu C, Qian C, Fortes P, Prieto J. (2003). In vitro and in vivo comparative study of chimeric liver-specific promoters. Mol Ther, 7, 375–385.
   PubMed Web of Science ®Google Scholar
• Krishnamachari Y, Salem AK. (2009). Innovative strategies for co-delivering antigens and CpG oligonucleotides. Adv Drug Deliv Rev, 61, 205–217.
   PubMed Web of Science ®Google Scholar
• Kunath K, von Harpe A, Fischer D, Kissel T. (2003a). Galactose-PEI-DNA complexes for targeted gene delivery: degree of substitution affects complex size and transfection efficiency. J Control Release, 88, 159–172.
   PubMed Web of Science ®Google Scholar
• Kunath K, von Harpe A, Fischer D, Petersen H, Bickel U, Voigt K, Kissel T. (2003b). Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release, 89, 113–125.
   PubMed Web of Science ®Google Scholar
• Midoux P, Mendes C, Legrand A, Raimond J, Mayer R, Monsigny M, Roche AC. (1993). Specific Gene-Transfer Mediated by Lactosylated Poly-L-Lysine into Hepatoma-Cells. Nucleic Acids Res, 21, 871–878.
   PubMed Web of Science ®Google Scholar
• Nandi A, Khakhar DV, Mehra A. (2001). Coalescence in Surfactant-Stabilized Emulsions Subjected to Shear Flow, 2647–2655.
   Google Scholar
• Oh YK, Suh D, Kim JM, Choi HG, Shin K, Ko JJ. (2002). Polyethylenimine-mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA. Gene Ther, 9, 1627–1632.
   PubMed Web of Science ®Google Scholar
• Prabha S, Labhasetwar V. (2004). Critical determinants in PLGA/PLA nanoparticle-mediated gene expression. Pharm Res, 21, 354–364.
   PubMed Web of Science ®Google Scholar
• Sagara K, Kim SW. (2002). A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes. J Control Release, 79, 271–281.
   PubMed Web of Science ®Google Scholar
• Salem AK, Searson PC, Leong KW. (2003). Multifunctional nanorods for gene delivery. Nat Mater, 2, 668–671.
   PubMed Web of Science ®Google Scholar
• Shive MS, Anderson JM. (1997). Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev, 28, 5–24.
   PubMed Web of Science ®Google Scholar
• Sun X, Hai L, Wu Y, Hu HY, Zhang ZR. (2005). Targeted gene delivery to hepatoma cells using galactosylated liposome-polycation-DNA complexes (LPD). J Drug Target, 13, 121–128.
   PubMed Web of Science ®Google Scholar
• Walter E, Moelling K, Pavlovic J, Merkle HP. (1999). Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics. J Control Release, 61, 361–374.
   PubMed Web of Science ®Google Scholar
• Wang SL, Yu FB, Jiang TY, Sun CS, Wang T, Zhang JH. (2008). Design and synthesis of novel galactosylated polymers for liposomes as gene drug carriers targeting the hepatic asialoglycoprotein receptor. J Drug Target, 16, 233–242.
   PubMed Web of Science ®Google Scholar
• Wiethoff CM, Middaugh CR. (2003). Barriers to nonviral gene delivery. J Pharm Sci, 92, 203–217.
   PubMed Web of Science ®Google Scholar
• Wu XS, Wang N. (2001). Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: biodegradation. J Biomater Sci Polym Ed, 12, 21–34.
   PubMed Web of Science ®Google Scholar
• Zanta MA, Boussif O, Adib A, Behr JP. (1997). In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug Chem, 8, 839–844.
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Dahle CE, Baman NK, Rich N, Weiner GJ, Salem AK. (2007a). Potent antigen-specific immune responses stimulated by codelivery of CpG ODN and antigens in degradable microparticles. J Immunother, 30, 469–478.
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Dahle CE, Weiner GJ, Salem AK. (2007b). A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. J Pharm Sci, 96, 3283–3292.
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Intra J, Salem AK. (2007c). Conjugation of polyamidoamine dendrimers on biodegradable microparticles for nonviral gene delivery. Bioconjug Chem, 18, 2068–2076.
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Intra J, Salem AK. (2008). Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. J Microencapsul, 25, 1–12.
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Wang XL, Zhang PC, Liu ZL, Zhuo RX, Mao HQ, Leong KW. (2005). Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes. J Control Release, 102, 749–763.
   PubMed Web of Science ®Google Scholar