References
- Jiang FR, Qian JC, Chen SY, et al. Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress. Pharm Bio 2011;49:856–63
- Wu HJ, Hao J, Wang SQ, et al. Protective effects of ligustrazine on TNF-alpha-induced endothelial dysfunction. Eur J Pharm 2012;574:365–9
- Cheng XC, Liu XY, Xu WF. Research progress of pharmacology of cardiovascular and cerebrovascular of tetramethylpyrazine. Chin J Hosp Pharm 2005;25:661–3
- Lv L, Jiang SS, Xu J, et al. Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase. Clin Exp Pharmacol 2012;39:20–7
- Xu R, Li Y, Huang X. Research progress of tetramethylpyrazine drug metabolism and pharmacokinetics. J Anhui TCM Coll 2002;21:58–61
- Zeng CY, Mei QX. ADRs induced by tetramethylpyrazine: literature analysis of 30 cases. China Pharm 2008;19:1908–10
- Shi J, Wang Y, Luo G. Ligustrazine phosphate ethosomes for treatment of Alzheimer’s disease, in vitro and in animal model studies. AAPS Pharm Sci Tec 2012;13:485–92
- Zhao JH, Ji L, Wang H, et al. Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo. Int J Nanomed 2011;6:1611–19
- Mei D, Mao S, Sun W, et al. Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats. Eur J Pharm Biopharm. 2008;70:874–81
- Wei LJ, Marasinib N, Li G, et al. Development of ligustrazine-loaded lipid emulsion: formulation optimization, characterization and biodistribution. Int J Pharm 2012;437:203–12
- Zhao RL, Hou SX, Mao SJ, et al. Tissue distribution of tetramethylpyrazine intralipid in mice. Central South Pharm 2008;11:264–7
- Washington C. Stability of lipid emulsions for drug delivery. Adv Drug Deliv Rev 1996;20:131–45
- Lou YQ, Zhang H, Cao X, Chen ML. The pharmacokinetics and disposition of tetramethylpyrazine phosphate in dogs and rats. Acta Pharmaceutica Sin 1986;21:481–7
- Jiang J, Jiang GH, Ye YP, Wang SZ. The metabolism of TMPz in vivo. Acta Acad Med Sin 1993;15:79–82
- Chen XM, Xu SJ, Ma YW. Synthesis of 2-hydroxymethyl-3,5,6-trimethyl-pyrazine and observation of its affection on rheologic parameters. Chin J Med Chem 1996;6:254–6
- Chen XM, Cao YX, Li GW, et al. Effect of 2-hydroxymethyl-3,5,6-trimethyl-pyrazine on cardiovascular system. Chin J Pharm 1998;29:258–60
- Nishiwaki S, Nakayama T, Murata M, et al. Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation: macrophage-targeted steroid therapy. Int J Hematol 2012;95:428–33
- Gulati N, Gupta H. Parenteral drug delivery: a review. Recent Pat Drug Deliv Formul 2011;5:133–45
- Date AA, Nagarsenker MS. Parenteral microemulsions: an overview. Int J Pharm, 2008;355:19–30
- Chu T, Zhang Q, Li H, et al. Development of intravenous lipid emulsion of tanshinone IIA and evaluation of its anti-hepatoma activity in vitro. Int J Pharm 2012;424:76–88
- Shen QW, Mao SJ, Wu Y, et al. Synthesis of 2-hydroxy-methyl-3, 5,6-trimethyl-pyrazine pPalmitate and preparation of intravenous emulsion. Chin Pharm J 2009;24:1874–7
- Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84–91
- Tamilvanan S. Oil-in-water lipid emulsions: implications for parenteral and ocular delivering systems. Prog Lipid Res 2004;6:489–533
- Brime B, Moreno MA, Frutos G, et al. Amphotericin B in oil-water lecithin-based microemulsions: formulation and toxicity evaluation. J Pharm Sci 2002;4:1178–85
- Shi S, Chen H, Cui Y, Tang X. Formulation, stability and degradation kinetics of intravenous cinnarizine lipid emulsion. Int J Pharm 2009;373:147–55
- Jumaa M, Kleinebudde P, Muller BW. Physicochemical properties and hemolytic effect of different lipid emulsion formulations using a mixture of emulsifiers. Pharm Acta Helv 1999;6:293–301
- Trotta M, Pattarinob F, Ignoni T. Stability of drug-carrier emulsions containing phosphatidylcholine mixtures. Eur J Pharma Biopharm 2002;53:203–8
- Ishii F, Sasaki I, Ogata H. Effect of phospholipid emulsifiers on physicochemical properties of intravenous fat emulsions and/or drug carrier emulsions. J Pharm Pharmacol 1990;42:513–15
- Gamon BL, Virden JW, Berg JG. The aggregation kinetics of an electrostatically stabilized dipalmitoyl phosphatidylcholine system. J Coil Int Sci 1989;132:125–37
- Chen X, Dong SN. Studies on the metabolites of tetramethylpyrazine in rabbits. Acta Pharmaceutica Sinica 1996;31:617–21
- Yang Y, Li H, Gao K, et al. Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry. J Chrom B 2008;862:119–24
- Liao SL, Kao TK, Chen WY, et al. Tetramethylpyrazine reduces ischemic brain injury in rats. Neurosci Lett 2004;372:40–5
- Kao TK, Ou YC, Kuo JS, et al. Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats. Neurochem Int 2006;48:166–76
- Zhu XL, Xiong LZ, Wang Q, et al. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Neurosci Lett 2009;449:24–7