372
Views
17
CrossRef citations to date
0
Altmetric
Original Article

Preparation and characterization of Δ9-tetrahydrocannabinol-loaded biodegradable polymeric microparticles and their antitumoral efficacy on cancer cell lines

, , , , , & show all
Pages 710-718 | Received 10 Mar 2013, Accepted 23 May 2013, Published online: 18 Jun 2013

References

  • Mechoulam R, Peters M, Murillo-Rodriguez E, et al. Cannabidiol – recent advances. Chem Biodivers 2007;4:1678–92
  • Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br J Pharmacol 2008;153:199–215
  • Izzo AA, Borrelli F, Capasso R, et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009;30:515–27
  • Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 2009;156:397–411
  • Guzmán M. Cannabinoids: potential anticancer agents. Nat Rev Cancer 2003;3:745–55
  • Ben Amar M. Cannabinoids in medicine: a review of their therapeutic potential. J Ethnopharmacol 2006;105:1–25
  • Hanuš LO. Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Med Res Rev 2009;29:213--71
  • Parolaro D, Massi P. Cannabinoids as potential new therapy for the treatment of gliomas. Expert Rev Neurother 2008;8:37–49
  • Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 2003;42:327–60
  • Ohlsson A, Lindgren JE, Andersson S, et al. Single-dose kinetics of deuterium-labelled cannabidiol in man after intravenous administration and smoking. Biomed Environ Mass Spectrom 1986;149:495–9
  • Mannila J, Järvinen T, Järvinen K, et al. Precipitation complexation method produces cannabidiol/beta-cyclodextrin inclusion complex suitable for sublingual administration of cannabidiol. J Pharm Sci 2007;96:312–19
  • Doyle E, Spence AA. Cannabis as a medicine? Br J Anaesth 1995;74:359–61
  • Mattes RDShaw LM, Edling-Owens J, et al. Bypassing the first-pass effect for the therapeutic use of cannabinoids. Pharmacol Biochem Behav 1993;44:745–7
  • Hazekamp A, Verpoorte R. Structure elucidation of the tetrahydrocannabinol complex with randomly methylated [beta]-cyclodextrin. Eur J Pharm Sci 2006;29:340–7
  • Ohlsson A, Lindgren JE, Wahlen A, et al. Plasma delta-9-tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clin Pharmacol Ther 1980;28:409–16
  • Garrett ER, Tsau J. Stability of tetrahydrocannabinols I. J Pharm Sci 1974;63:1563–74
  • Grotenhermen F. Cannabinoids for therapeutic use. Designing systems to increase efficacy and reliability. Am J Drug Deliv 2004;24:229–40
  • Thomas BF, Compton DR, Martin BR. Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency. J Pharmacol Exp Ther 1990;255:624–30
  • van Drooge D-J, Hinrichs WLJ, Dickhoff BHJ, et al. Spray freeze drying to produce a stable Δ9-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation. Eur J Pharm Sci 2005;26:231–40
  • Mechoulam R. Marihuana chemistry. Science 1970;168:1159–66
  • Munjal M, ElSohly MA, Repka MA. Chemical stabilization of a Delta9-Tetrahydrocannabinol prodrug in polymeric matrix systems produced by a hot-melt method: role of microenvironment pH. AAPS PharmSciTech 2006;7:E1--E12
  • Garrett ER, Hunt A. Physicochemical properties, solubility, and protein binding of D9-tetrahydrocannabinol. J Pharm Sci 1974;63:1056–64
  • Jarho P, Pate DW, Brenneisen R, et al. Hydroxypropyl-beta-cyclodextrin and its combination with hydroxypropyl-methylcellulose increases aqueous solubility of delta9-tetrahydrocannabinol. Life Sci 1998;63:PL381–4
  • Wilson DM, Peart J, Martin BR, et al. Physiochemical and pharmacological characterization of a Δ9-THC aerosol generated by a metered dose inhaler. Drug Alcohol Depend 2002;67:259–67
  • Hernán Pérez de la Ossa D, Ligresti A, Gil-Alegre ME, et al. Poly-ε-caprolactone microspheres as a drug delivery system for cannabinoid administration: development, characterization and in vitro evaluation of their antitumoral efficacy. J Controlled Release 2012;161:927–32
  • Alexander A, Smith PF, et al. Cannabinoids in the treatment of cancer. Cancer Lett 2009;285:6–12
  • Guzmán M, et al. Effects on cell viability. Handb Exp Pharmacol 2005;168:627–42
  • Patsos HAHicks DJ, Greenhough A. Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans 2005;33:712–14
  • Ligresti A, Bisogno T, et al. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 2003;125:677–87
  • Caffarel MM, Moreno-Bueno G, Cerutti C, et al. JunD is involved in the antiproliferative effect of [Delta]9-tetrahydrocannabinol on human breast cancer cells. Oncogene 2008;27:5033–44
  • Walsh D, Nelson K, Mahmoud F, et al. Established and potential therapeutic applications of cannabinoids in oncology. Support Care Cancer 2003;11:137–43
  • Mechoulam R. Chemistry of cannabis. Handbook Exp Pharmacol 1981;55:119–34
  • Gill EW, Jones G. Brain levels of Δ1-THC and its metabolites in mice. Biochem Pharmacol 1972;21:2237–48
  • Shi Y, Li LC. Current advances in sustained-release systems for parenteral drug delivery. Expert Opin Drug Deliv 2005;2:1039–58
  • Sinha VR, Bansal K, et al. Poly-[epsilon]-caprolactone microspheres and nanospheres: an overview. Int J Pharm 2004;278:1–23
  • Li Z, Li Q, Simon S, et al. Formulation of spray-dried phenytoin loaded poly(ε-caprolactone) microcarrier intended for brain delivery to treat epilepsy. J Pharm Sci 2007;96:1018–30
  • Ligresti A, Moriello AS, Starowicz K, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006;318:1375–87
  • Repka MA, Munjal M, ElSohly MA, et al. Temperature stability and bioadhesive properties of delta-9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems. Drug Dev Ind Pharm 2006;32:21–32
  • Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123–33
  • Barcia E, Herradón C, Herrero-Vanrell R. Biodegradable additives modulate ganciclovir release rate from PLGA microspheres destined to intraocular administration. Lett Drug Design Discov 2005;2:148–9
  • Martínez-Sancho C, Herrero-Vanrell R, Negro S. Poly(D,L-lactide-co-glycolide) microspheres for long-term intravitreal delivery of aciclovir: influence of fatty and non-fatty additives. J Microencapsul 2003;20:799–810
  • Mu L, Feng SS. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol®): PLGA nanoparticles containing vitamin E TPGS. J Controlled Release 2003;86:33–48
  • Forrest ML, Won C-Y, Malick AW, et al. In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(ε-caprolactone) micelles. J Controlled Release 2006;110:370–7
  • Menei P, Boisdron-Celle M, Croué A, et al. Effect of stereotactic implantation of biodegradable 5-fluorouracil-loaded microspheres in healthy and C6 glioma-bearing rats. Neurosurgery 1996;39:117–23

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.