253
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Nuclear transcription factor-kappa beta-dependent ultrastructural alterations within the placenta and systemic inflammatory activation in pregnant patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome: a case–control study

, , , , , , , & show all
Pages 281-291 | Received 13 Jun 2012, Accepted 04 May 2013, Published online: 01 Aug 2013

REFERENCES

  • Sibai BM. Preeclampsia as a cause of preterm and late preterm (nearterm) births. Semin Perinatol 2006;30:16–19
  • Weinstein L. Syndrome of hemolysis, elevated liver enzymes and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 1982;142:159–67
  • Ciantar E, Walker JJ. Pre-eclampsia, severe pre-eclampsia and hemolysis, elevated liver enzymes and low platelets syndrome: what is new? Womens Health (Lond Engl) 2011;7:555–69
  • Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001;357:53–6
  • Molvarec A, Rigó J Jr, Bõze T, et al. Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. Thromb Haemost 2009;101:305–11
  • Madách K, Molvarec A, Rigó J, et al. Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Eur J Obstet Gynecol Reprod Biol 2008;139:133–8
  • Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499–506
  • Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol 1998;179:80–6
  • Brennan ML, Hazen SL. Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment. Curr Opin Lipidol 2003;14:353–9
  • Teran E, Escudero C, Moya W, et al. Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia. Int J Gynaecol Obstet 2001;3:243–9
  • Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225–60
  • Ali S, Mann DA. Signal transduction via the NF-kappaB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct 2004;22:67–79
  • National High Blood Pressure Education Program Working Group. Report on High Blood Pressure in Pregnancy. National Institutes of Health Publication No. 00-3029. Washington, DC: National Institutes of Health, 2000
  • Bosco C, Parra M, Barja P, et al. Increased immunohistochemical expressión of thrombomodulin at placental perivascular myofibroblast in severe preeclampsia (PE). Histol Histophatol 2005;20:1045–55
  • Budwit-Novotny DA, McCarty KS, Cox EB, et al. Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. Cancer Res 1986;46:5419–25
  • Wei H, Frenkel K. Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 1993;14:1195–201
  • Yuan HT, Haig D, Ananth Karumanchi S. Angiogenic factors in the pathogenesis of preeclampsia. Curr Top Dev Biol 2005;71:297–312
  • Ramma W, Ahmed A. Is inflammation the cause of pre-eclampsia? Biochem Soc Trans 2011;39:1619–27
  • Can M, Sancar E, Harma M, et al. Inflammatory markers in preeclamptic patients. Clin Chem Lab Med 2011;49:1469–72
  • de Oliveira LG, Karumanchi A, Sass N. Preeclampsia: oxidative stress, inflammation and endothelial dysfunction. Rev Bras Ginecol Obstet 2010;32:609–16
  • Greer IA, Dawes J, Johnston TA, Calder AA. Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension. Obstet Gynecol 1991;78:28–32
  • Tosun M, Celik H, Avci B, et al. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med 2010;23:880–6
  • Madazli R, Aydin S, Uludag S, et al. Maternal plasma levels of cytokines in normal and preeclamptic pregnancies and their relationship with diastolic blood pressure and fibronectin levels. Acta Obstet Gynecol Scand 2003;82:797–802
  • Guven MA, Coskun A, Ertas IE, et al. Association of maternal serum CRP, IL-6, TNF-alpha, homocysteine, folic acid and vitamin B12 levels with the severity of preeclampsia and fetal birth weight. Hypertens Pregnancy 2009;28:190–200
  • Roberts JM, Gammill HS. Preeclampsia: recent insights. Hypertension 2005;46:1243–9
  • Terrone DA, Rinehart BK, May WL, et al. Leukocytosis is proportional to HELLP syndrome severity: evidence for an inflammatory form of preeclampsia. South Med J 2000;93:768–71
  • Halim A, Kanayama N, El Maradny E, et al. Immunohistological study in cases of HELLP syndrome and acute fatty liver of pregnancy. Gynecol ObstetInvest 1996;41:106–12
  • Haeger M, Unander AM, Bengtsson A. Enhanced anaphylatoxin and terminal C5b-9 complement formation in patients with HELLP syndrome. Obstet Gynecol 1990;76:698–702
  • Zusterzeel PLM, Wanten GJA, Peters WHM, et al. Neutrophil oxygen radical production in preeclampsia with HELLP syndrome. Eur J Obstet Gynecol 2001;99:213–18
  • Riordan SM, Williams R. Acute liver failure: targeted artificial and hepatocyte-based support of liver regeneration and reversal of multiorgan failure. J Hepatol 2000;32:63–76
  • Siebenlist U, Brown K, Claudio E. Control of lymphocyte development by nuclear factor-kappaB. Nat Rev Immunol 2005;5:435–45
  • Centlow M, Wingren C, Borrebaeck C, et al. Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays. J Pregnancy. 2011;2011:472354 (1--12)
  • Landi B, Tranquilli AL. HELLP syndrome and placental inflammatory pathology. Minerva Ginecol 2008;60:389–98
  • Benedetto C, Marozio L, Tancredi A, et al. Biochemistry of HELLP syndrome. Adv Clin Chem 2011;53:85–104
  • Maeda S, Omata M. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci 2008;99:836–42
  • Salgado SS, Salgado MKR. Structural changes in pre-eclamptic and eclamptic placentas – an ultrastructural study. J Coll Physicians Surg Pak 2011;21:482–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.