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Original Article

Genetics of Angiotensin I-Converting Enzyme

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Pages 659-669 | Published online: 03 Jul 2009

References

  • Skeggs L T, Kahn J R, Shumway N P. The preparation and function of the of the hypertensin converting enzyme. J Exp Med 1956; 103: 295–9
  • Erdös E. Angiotensin I- converting enzyme and the changes in our concept through the years. Hypertension (Dallas) 1991; 16: 363–70
  • Jaspard E, Wei L, Alhenc-Gelas F. Differences in properties and enzymatic specificities between two active sites of angiotensin I converting-enzyme. J. Biol. Chem. 1993; 268: 9496–9503
  • Azizi M, Rousseau A, Elan E, Guyenne T T, Michelet S, Grognet J M, Lenfant M, Corvol P, Menad J. Acute ACE inhibition increases the plasma level of the natural stem cell regulator N acetyl-seryl-asparty-lysyl-proline. J. Clin. Invest. 1996; 97: 588–592
  • Cushman D W, Ondetti M A. Inhibitors of angiotensin-converting enzyme. Prog. Med. Chem. 1980; 17: 42–104
  • Marre M, Chatellier G, Leblanc H, Guyenne T T, Menard J, Passa P. Prevention of diabetic nephropathy with enalapril in normotensive diabetics subjects with persistent microalbuminuria. B. M. J. 1988; 297: 1092–1095
  • Lewis E J, Hunsiker L G, Bain R P, Rohde R D. for the Collaborative Study Group. The effect of angiotensin converting-enzyme inhibition on diabetic nephropathy. N. Engl. J. Med. 1993; 329: 1456–1462
  • Maschio G, Alberti D, Janin G, Locatelli F, Mann J FE, Motolese M, Ponticelli C, Ritz E, Ziuchelli P. ACE inhibition in Progressive Renal Insufficiency Study Group: effect of the ACE inhibitor benazepril on the progression of chronic renal insufficiency. N. Engl. J. Med. 1996; 334: 939–945
  • Costerousse O, Jaspard E, Alhenc-Gelas F. Molecular and genetic aspects of dipeptidylcarboxypeptidase I (the angiotensin I converting-enzyme). Expression in the immune system. Advances in Neuroimmunology 1993; 3: 217–224
  • Wei L, Alhenc-Gelas F, Soubrier F, Michaud A, Corvol P, Clauser E. Expression and characterization of recombinant human angiotensin I-converting enzyme. J. Biol. Chem. 1991; 266: 5540–5546
  • Alhenc-Gelas F, Richard J, Courbon D, Warnet J, Corvol P. Ditribution of plasma angiotensin I-converting enzyme levels in healthy men: Relationship to environmental and hormonal parameters. J. Lab. Clin. Med. 1991; 117: 33–39
  • Cambien F, Alhenc-Gelas F, Herberth B, Andre J, Rakotovao R, Gonzales M, Allegrini J, Bloch C. Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy Study. Am. J. Hum. Genet. 1988; 43: 774–780
  • Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Treagear J, Corvol P. Two putative active centers in human angiotensin I converting-enzyme revealed by molecular cloning. Proc. Nat. Acad. Sci. USA 1988; 85: 9386–9390
  • Lattion A L, Soubrier F, Allegrini J, Hubert C, Corvol P, Alhenc-Gelas F. The testicular transcript of angiotensin I-converting enzyme encodes for the ancestral, non duplicated form of the enzyme. FEBS Lett. 1989; 252: 99–104
  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphysm in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990; 86: 1343–1346
  • Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem. J. 1993; 290: 33–40
  • Doria A, Warram J H, Krolewski A S. Genetic predisposition to diabetic nephropathy: evidence for a role of the angiotensin I-converting enzyme gene. Diabetes 1994; 43: 690–695
  • Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1). Nucl Acid Res. 1992; 20: 1433
  • Ludwig E, Corneli P, Anderson J, Marshall H W, Lalouel J M, Ward R H. Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis. Circulation 1995; 91: 2120–4
  • Marre M, Jeunemaïtre J, Gallois Y, Rodier M, Chatellier G, Sert C, Dusselier L, Kahal Z, Chaillous L, Halimi S, Muller R, Sackmann H, Bauduceau B, Bled F, Passa P, Alhenc-Gelas F. Contributions of genetic polymorphisms of the renin angiotensin system to renal complications in insulin dependant diabetes. 1996, for the Genediab Study Group. Submitted.
  • Cushman D, Cheung M. Concentrations of angiotensin-converting enzyme in tissues of rat. Biochim. Biophys. Acta 1971; 65: 250–261
  • Alhenc-Gelas F, Weare J, Johnson R, Erdös E. Measurements of human converting enzyme level by direct radioimmunoassay. J. Lab. Clin. Med. 1983; 101: 83–96
  • Danilov S, Savoie F, Lenoir B, Jeunemaïtre X, Azizi M, Tarnow L, Alhenc-Gelas F. Development of enzyme linked immunoassays for human angiotensin I-converting enzyme suitable for large studies. J. of Hypert. 1996; 14: 709–717
  • Cambien F, Poirier O, Lecerf L, Evans A, Cambou J P, Arveiler D, Luc G., Bard J., Ricard S., Tiret L., Amouyel P., Alhenc-Gelas F., Soubrier F. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641–4
  • Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, Gonzalez M F, Evans A, Arveiller D, Cambou J P, Luc G, Rakotovao P, Ducimetiere P, Soubrier F, Alhenc-Gelas F. Plasma level and ACE gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 1994; 90: 669–76
  • Tiret L, Kee F, Poirier O, Nicaud V, Lecerf L, Evans A, Cambou J P, Arveiller D, Luc G., Amouyel P., Cambien F. Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction. Lancet 1993; 341: 991–2
  • Lindpaintner K, Pfeffer M A, Kreutz R, Stampfer M J, Grodstein F, Lamotte F, Buring T, Hennelens C I. A prospective eveluation of an angiotensin converting enzyme gene polymorphism and the risk of ischemic heart disease. N. Engl. J. of Med. 1995; 333: 458–459
  • Samami N J, Thompson J R, O'Toole L, Channer K, Woods K L. A meta analysis of the association of the deletion allele of the angiotensin converting enzyme gene with myocardial infarction. Circulation 1996; 94: 708–712
  • Marian A J, Yu Q T, Workman R, Greve G, Roberts R. Angiotensin — converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death. Lancet 1993; 342: 1073–5
  • Shunckert H, Hense H W, Holmer S R, Stender M, Perz S, Keil U, Lorell B, Riegger G. Association between a deletion polymorphism of the angiotensin-converting enzyme gene and left ventricular hypertrophy. N. Engl. J. of Med. 1994; 330: 1634–38
  • Marre M, Bernadet P, Gallois Y, Savagner F, Guyene T T, Haliab M, Cambien F, Passa P, Alhenc-Gelas F. Relationship between angiotensin I-converting enzyme gene polymorphism, plasma level and diabetic retinal and renal complications. Diabetes 1994; 43: 384–388
  • Fogarty D G, Maxwell A P, Hughes A, Nevin N C, Doherthy C C. A deletion polymorphism in the angiotensin-converting enzyme gene is a risk factor for diabetic nephropathy. EDTA proceedings. 1994, 117
  • Powrie J K, Watts G F, Ingham J N, Taub N A, Talmud P J, Shaw K M. Role of glycaemic control in development of microalbuminuria in patients with insulin-dependent diabetes. B. M. J. 1994; 309: 1608–1612
  • Tarnow I, Cambien F, Rossing P, Nielsen F S, Hansen B V, Lecerf L, Poirier O, Danilov S, Parving H H. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes 1995; 44: 489–494
  • Schmidt S, Schone N, Ritz E, Diabetic Nephropathy Study Group. Association of ACE gene polymorphism and diabetic nephropathy?. Kidney Int. 1995; 47: 1176–1181
  • Mizuiri S, Hemmi H, Inoue A, Yoshikawa H, Tanegashima M, Fushimi T, Ishigami M, Amagasaki Y, Ohara T, Shimatake H, Hasegawa A. Angiotensin-converting-enzyme polymorphism and development of diabetic nephropathy in non-insulin-dependent diabetes mellitus. Nephron 1995; 70: 455–459
  • Doi Y, Yoshigumi H, Lino K, Yamamoto M, Ichikawa K, Iwase M, Fujishima M. Association between a polymorphism in the angiotensin-converting-enzyme gene and microavascular complications in Japanese patients with NIDDM. Diabetologia 1996; 39: 97–102
  • Dudley C RK, Keavney B, Stratton I M, Turner R C, Ratcliffe P J. U.K. prospective diabetes study XV: relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM. Kidney Int. 1995; 48: 1907–1911
  • Harden P N, Geddes C, Rowe P A, McLlroy J H, Boulton-Jones M, Rodger R SC, Junor B JR, Briggs J D, Connell J MC, Jardine A G. Polymorphisms in angiotensin-converting-enzyme gene and progression og IgA nephropathy. Lancet 1995; 345: 1540–1542
  • Yoshida H, Mitarai T, Kawamura T, Kitajima T, Miyasaki Y, Nagasawa R, Kawaguchi Y, Kubo H, Ichikawa I, Sakai O. Role of the deletion polymorphism of the angiotensin-converting-enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. J. Glin. Invest. 1995; 96: 2162–2169
  • Van Essen G G, Rensma P L, De Zeeuw D, Sluiter W J, Scheffer H, Apperloo A J, De Jong P E. Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy. Lancet 1996; 347: 94–95
  • Lachurie M L, Azizi M, Guyene T T, Alhenc-Gelas F, Menard J. Angiotensin-converting-enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects. Circulation 1995; 91: 2933–2942
  • Ueda S, Elliott H L, Morton J J, Connell J M. Enhanced pressor response to angiotensin I in normotensive men with the deletion genotype (DD) for a angiotensin-converting-enzyme. Hypertension 1995; 25: 1266–1269
  • Jeunemaïtre X, Lifton R P, Hunt S C, Williams R R, Lalouel J M. Absence of linkage between the angiotensin-converting-enzyme locus and human essential hypertension. Nature Genetics 1992; 1: 72–75
  • Danser A H, Koning M M, Admiraal P J, Sassen L M, Derkx F H, Verdouw P D. Production of angiotensin I and II at tissue sites intact pigs. American Journal of Physiology 1992; 263: H429–H437
  • Vane G R. Sites of conversion of angiotensin I. Hypertension, J Genest, E Koine. Springer Verlag, Berlin 1972; 523–532
  • Alhenc-Gelas F, Baussant T, Hubert C, Soubrier F, Corvol P. The angiotensin I-converting enzyme in the kidney. J. Hypertens. 1989; 7: S9–S13
  • Roman R J, Kaldunski M L, Scicli A G, Carretero O A. Influence of kinins and angiotensin II on the regulation of papillary blood flow. Am. J. Physiol. 1988; 255: 801–804
  • Linz W, Wiemer G, Scholkens B A. Role of kinins in the pathophysiology of myocardial ischemia In vitro and in vivo studies. Diabetes 1996; 45 (Suppl.) 1: S51–S58
  • Schunkert H, Dzau V J, Tang S S, Hirsh A T, Apstein C S, Lorell B H. Increased rat cardiac angiotensin enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. J. Clin. Invest. 1990; 86: 1913–1920
  • Johnston C I. Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling. Hypertension 1994; 23: 258–268
  • Challah M, Nicoletti A, Arnal J F, Philippe M, Laboulandine I, Allegrini J, Alhenc-Gelas F, Danilov S, Michel J B. Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension. Cardiovascular Research 1995; 30: 231–239
  • Arnal J F, Battle T, Rasetti C, Challah M, Costerousse O, Vicaut E, Michel J B, Alhenc-Gelas F. ACE in three tunicae of rat aorta: expression in smooth muscle and effect of renovascular hypertension. Am. J. Physiol. 1994; 267: H1777–H1784
  • Vio C P, Alhenc-Gelas F. Differential distribution of angiotensin I converting enzyme in normal and hypertensive rat kidneys. Hypertension 1995; 25: 18

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