230
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Selective ozone concentrations may reduce the ischemic damage after a stroke

, , , &
Pages 612-618 | Received 21 Dec 2011, Accepted 16 Jan 2012, Published online: 14 Feb 2012

References

  • Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P. Stroke. Lancet 2003;362:1211–1224.
  • Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, . Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010;375:1695–1703.
  • Back T. Pathophysiology of the ischemic penumbra–revision of a concept. Cell Mol Neurobiol 1998;18:621–638.
  • Weinberger JM. Evolving therapeutic approaches to treating acute ischemic stroke. J Neurol Sci 2006;249:101–109.
  • Gertz K, Priller J, Kronenberg G, Fink KB, Winter B, Schrock H, . Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res 2006;99:1132–1140.
  • Bak Z, Sjöberg F, Rousseau A, Steinvall I, Janerot-Sjoberg B. Human cardiovascular dose-response to supplemental oxygen. Acta Physiol (Oxf) 2007;191:15–24.
  • Chavez JC, Hurko O, Barone FC, Feuerstein GZ. Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch. Stroke 2009;40:e558–e563.
  • Liu S, Levine SR, Winn HR. Targeting ischemic penumbra: part I - from pathophysiology to therapeutic strategy. J Exp Stroke Trans Med 2010;3:47–55.
  • Kidd PM. Integrated brain restoration after ischemic stroke–medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity. Alternat Med Rev 2009;14:14–35.
  • Lai TW; Shyu WC, Wang YT. Stroke intervention pathways: NMDA receptors and beyond. Trends Mol Med 2011;17:266–275.
  • Iadecola C, Anrather J. Stroke research at a crossroad: asking the brain for directions. Nat Neurosci 2011;14:1363–1368.
  • Clavo B, Catalá L, Pérez, JL, Rodríguez V, Robaina F. Ozone therapy on cerebral blood flow: a preliminary report. Evidence-based Complementary and Alternative Medicine (eCAM) 2004;1:315–319.
  • Clavo B, Suarez G, Aguilar Y, Gutierrez D, Ponce P, Cubero A, . Brain ischemia and hypometabolism treated by ozone therapy. Forsch Komplementärmed 2011;18:283–287.
  • Peralta C, Xaus C, Bartrons R, Leon OS, Gelpi E, Roselló-Catafau J, . Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia-reperfusion. Free Rad Res 2000;33:595–605.
  • Merin O, Attias E, Elstein D, Schwalb H, Bitran D, Zimran A, . Ozone administration reduces reperfusion injury in an isolated rat heart model. J Cardiac Surg 2007;22:339–442.
  • Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, . Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury. E J Pharmacol 2008;581:306–314.
  • Ricci L, Valoti M, Sgaragli G, Frosini M. Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices. Eur J Pharmacol 2007;561:80–84.
  • Ricci L, Valoti M, Sgaragli G, Frosini M. Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage. Eur J Pharmacol 2009; 621:26–32.
  • Ricci L, Valoti M, Sgaragli, Frosini M. Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage. Amino Acids 2011;in press. DOI: 10.1007/s00726-011–0952-9
  • Goldberg MP, Strasser U, Dugan LL. Techniques for assessing neuroprotective drugs in vitro. Int Rev Neurobiol 1997; 40:69–93.
  • Brahma B, Forman RE, Stewart EE, Nicholson C, Rice ME. Ascorbate inhibits edema in brain slices. J Neurochem 2000:74:1263–1270.
  • Travagli V, Zanardi I, Bernini P, Nepi S, Tenori L, Bocci V, . Effects of ozone blood treatment on the metabolite profile of human blood. Int J Toxicol 2010;29:165–174.
  • Mac Gregor DG, Avshalumov MV, Rice .E. Brain edema induced by in vitro ischemia: casual factors and neuroprotection. J Neurochem 2003;85:1402–1411.
  • Cserr HF, De Pasquale M, Nicholson C, Patlak CS, Pettigrew KD, Rice ME, . Extracellular volume decrease while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. J Physiol 1991;442:277–295.
  • De La Cruz JP, Villalobos MA, Sedeno G, Sànchez De La Cuesta F. Effect of propofol on oxidative stress in an vitro model of anoxia-reoxygenation in the rat brain. Brain Res 1998;800:136–144.
  • Lowry O, Rosebrough H, Farr A, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265–275.
  • Calabrese EJ. Hormesis: principles and applications for pharmacology and toxicology. Am J Pharmacol Toxicol 2008;3:56–68.
  • Bocci V, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. J Transl Med 2011;9:66.
  • Di Paolo N, Bocci V, Salvo DP, Palasciano G, Biagioli M, Meini S, . Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. Int J Artif Organs 2005;28:1039–1050.
  • Forman HJ, Dickinson DA, Iles KE. HNE-signaling pathways leading to its elimination. Mol Aspects Med 2003;24:189–194.
  • Iles KE, Liu RM. Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal. Free Radical Bio Med 2005;38:547–556.
  • Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, Kong AN. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 2008;76:1485–1489.
  • Adibhatla RM, Hatcher JF. Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2010;12:125–169.
  • Bocci V. Ozone. A new medical drug. Dordrecht, The Netherlands: Springer; 2011.
  • Bocci V, Borrelli, E, Travagli V, Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev 2009;29:646–682.
  • Travagli V, Zanardi I, Silvietti A, Bocci V. A physicochemical investigation on the effects of ozone on blood. Int J Biol Macromol 2007;41:504–511.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.