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Research Article

The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise

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Pages 821-828 | Received 25 May 2013, Accepted 22 Jul 2013, Published online: 19 Aug 2013

References

  • Knez WL, Coombes JS, Jenkins DG. Ultra-endurance exercise and oxidative damage: implications for cardiovascular health. Sports Med 2006;36:429–441.
  • Powers SK, Nelson WB, Hudson MB. Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 2011;51:942–950.
  • Tauler P, Sureda A, Cases N, Aguilo A, Rodriguez-Marroyo JA, Villa G, et al. Increased lymphocyte antioxidant defences in response to exhaustive exercise do not prevent oxidative damage. J Nutr Biochem 2006;17:665–671.
  • Turner JE, Hodges NJ, Bosch JA, Aldred S. Prolonged depletion of antioxidant capacity after ultraendurance exercise. Med Sci Sports Exerc 2011;43:1770–1776.
  • Droge W, Schulze-Osthoff K, Mihm S, Galter D, Schenk H, Eck HP, et al. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J 1994;8:1131–1138.
  • Staal FJ, Roederer M, Herzenberg LA, Herzenberg LA. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci U S A 1990;87:9943–9947.
  • Gleeson M, Walsh NP. The BASES expert statement on exercise, immunity, and infection. J Sports Sci 2012;30: 321–324.
  • Michalek RD, Crump KE, Weant AE, Hiltbold EM, Juneau DG, Moon EY, et al. Peroxiredoxin II regulates effector and secondary memory CD8+T cell responses. J Virol 2012; 86:13629–13641.
  • Moon EY, Noh YW, Han YH, Kim SU, Kim JM, Yu DY, Lim JS. T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol Lett 2006;102:184–190.
  • Cooper DM, Radom-Aizik S, Schwindt C, Zaldivar F Jr. Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity. J Appl Physiol 2007; 103:700–709.
  • Brinkmann C, Brixius K. Peroxiredoxins and sports: new insights on the antioxidative defense. J Physiol Sci 2013;63:1–5.
  • Wood ZA, Poole LB, Karplus PA. Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 2003;300:650–653.
  • Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 1998;273:6297–6302.
  • Szabo-Taylor KE, Eggleton P, Turner CA, Faro ML, Tarr JM, Toth S, et al. Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. Int J Biochem Cell Biol 2012;44:1223–1231.
  • Van Brussel I, Schrijvers DM, Martinet W, Pintelon I, Deschacht M, Schnorbusch K, et al. Transcript and protein analysis reveals better survival skills of monocyte-derived dendritic cells compared to monocytes during oxidative stress. PLoS One 2012;7:e43357.
  • Phalen TJ, Weirather K, Deming PB, Anathy V, Howe AK, van der Vilet A, et al. Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol 2006;175:779–789.
  • Bast A, Wolf G, Oberbaumer I, Walther R. Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells. Diabetologia 2002;45:867–876.
  • Rabilloud T, Heller M, Gasnier F, Luche S, Rey C, Aebersold R, et al. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. J Biol Chem 2002;277:19396–19401.
  • Dahlan HM, Karsani SA, Rahman MA, Hamid NA, Top AG, Ngah WZ. Proteomic analysis reveals that treatment with tocotrienols reverses the effect of H(2)O(2) exposure on peroxiredoxin expression in human lymphocytes from young and old individuals. J Nutr Biochem 2012;23:741–751.
  • Jang HH, Lee KO, Chi YH, Jung BG, Park SK, Park JH, et al. Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function. Cell 2004;117:625–635.
  • Drake SK, Bourdon E, Wehr NB, Levine RL, Backlund PS, Yergey AL, Rouault TA. Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation. Dev Neurosci 2002;24:114–124.
  • Friguet B. Oxidized protein degradation and repair in ageing and oxidative stress. FEBS Lett 2006;580:2910–2916.
  • Mars M, Govender S, Weston A, Naicker V, Chuturgoon A. High intensity exercise: a cause of lymphocyte apoptosis?Biochem Biophys Res Commun 1998;249:366–370.
  • Simpson RJ. Aging, persistent viral infections, and immunosenescence: can exercise “make space”?Exerc Sport Sci Rev 2011;39:23–33.
  • Reichhold S, Neubauer O, Ehrlich V, Knasmuller S, Wagner KH. No acute and persistent DNA damage after an Ironman triathlon. Cancer Epidemiol Biomarkers Prev 2008; 17:1913–1919.
  • Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med 2008;44:153–159.
  • Sahlin K, Shabalina IG, Mattsson CM, Bakkman L, Fernstrom M, Rozhdestvenskaya Z, et al. Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle. J Appl Physiol 2010;108:780–787.
  • Bishop NC, Fitzgerald C, Porter PJ, Scanlon GA, Smith AC. Effect of caffeine ingestion on lymphocyte counts and subset activation in vivo following strenuous cycling. Eur J Appl Physiol 2005;93:606–613.
  • Gleeson M, Pyne DB, Austin JP, Lynn FJ, Clancy RL, McDonald WA, Fricker PA. Epstein-Barr virus reactivation and upper-respiratory illness in elite swimmers. Med Sci Sports Exerc 2002;34:411–417.
  • Effros RB, Dagarag M, Spaulding C, Man J. The role of CD8+T-cell replicative senescence in human aging. Immunol Rev 2005;205:147–157.
  • Lorre K, Kasran A, Van VF, de Boer M, Ceuppens JL. Interleukin-1 and B7/CD28 interaction regulate interleukin-6 production by human T cells. Clin Immunol Immunopathol 1994;70:81–90.
  • Boyce WT, Chesney M, Alkon A, Tschann JM, Adams S, Chesterman B, et al. Psychobiologic reactivity to stress and childhood respiratory illnesses: results of two prospective studies. Psychosom Med 1995;57:411–422.
  • Marumoto M, Suzuki S, Hosono A, Arakawa K, Shibata K, Fuku M, et al. Changes in thioredoxin concentrations: an observation in an ultra-marathon race. Environ Health Prev Med 2010;15:129–134.
  • Moghaddam DA, Heber A, Capin D, Kreutz T, Opitz D, Lenzen E, et al. Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes. Wien Med Wochenschr 2011;161:511–518.
  • Brinkmann C, Chung N, Schmidt U, Kreutz T, Lenzen E, Schiffer T, et al. Training alters the skeletal muscle antioxidative capacity in non-insulin-dependent type 2 diabetic men. Scand J Med Sci Sports 2012;22:462–470.

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