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Original Article

Synthesis, characterization and pH-controllable methotrexate release from biocompatible polymer/silica nanocomposite for anticancer drug delivery

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Pages 155-163 | Received 28 May 2013, Accepted 20 Aug 2013, Published online: 10 Oct 2013

References

  • Bitar A, Ahmad NM, Fessi H, Elaissari A. (2012). Silica-based nanoparticles for biomedical applications. Drug Discov Today 17:1147--54
  • Carino IS, Pasqua L, Testa F, et al. (2007). Silica-based mesoporous materials as drug delivery system for methotrexate release. Drug Deliv 14:491–5
  • Chruściel J, Ślusarski L. (2003). Synthesis of nanosilica by the sol-gel method and its activity toward polymers. Mater Sci 21:461–9
  • Colilla M, González B, Vallet-Regí M. (2013). Mesoporous silica nanoparticles for the design of smart delivery nanodevices. Biomater Sci 1:114–34
  • Deng Z, Zhen Z, Hu X, et al. (2011). Hollow chitosan–silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy. Biomatter 32:4976–86
  • Gan Q, Lu X, Yuan Y, et al. (2011). A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica. Biomater 32:1932–42
  • Gao Q, Xu Y, Wu D, et al. (2010). Synthesis, characterization, and in vitro pH-controllable drug release from mesoporous silica spheres with switchable gates. Langmuir 26:17133–8
  • Gao Y, Chen Y, Ji X, et al. (2011). Controlled intracellular release of doxorubicin in multidrug-resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles. ACS Nano 5:9788–98
  • He Q, Gao Y, Zhang L, et al. (2011). A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomatter 32:7711–20
  • He Q, Shi J. (2011). Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility. J Mater Chem 21:5845–55
  • Jafarzadeh M, Rahman I, Sipaut C. (2009). Synthesis of silica nanoparticles by modified sol–gel process: the effect of mixing modes of the reactants and drying techniques. J sol-gel Sci Technol 50:328–36
  • Kang H, Kim J-D, Han S-H, Chang I-S. (2002). Self-aggregates of poly (2-hydroxyethyl aspartamide) copolymers loaded with methotrexate by physical and chemical entrapments. J Control Release 81:135–44
  • Knežević NŽ, Trewyn BG, Lin VSY. (2011). Light-and pH-responsive release of doxorubicin from a mesoporous silica-based nanocarrier. Chem Eur J 17:3338–42
  • Li L, Takemura G, Li Y, et al. (2006). Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy. Circ 113:535–43
  • Liu F, Eisenberg A. (2003). Preparation and pH triggered inversion of vesicles from poly (acrylic acid)-b lock-polystyrene-b lock-Poly (4-vinyl pyridine). ACS 125:15059–64
  • Mahkam M. (2012). Synthesis and characterization of novel positive-charge functionalized silica nanoparticles for oral drug delivery. IJAPBC 1:275--80
  • Mahkam M, Hosseinzadeh F, Galehassadi M. (2012). Preparation of ionic liquid functionalized silica nanoparticles for oral drug delivery. J Biomater Nanobiotechnol 3:391–5
  • Meng H, Xue M, Xia T, et al. (2010). Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. ACS 132:12690–7
  • Muhammad F, Guo M, Qi W, et al. (2011). pH-Triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids. ACS 133:8778–81
  • Najafi M, Yousefi Y, Rafati A. (2012). Synthesis, characterization and adsorption studies of several heavy metal ions on amino-functionalized silica nano hollow sphere and silica gel. Sep Purif Technol 85:193–205
  • Ramteke K, Dhole S, Patil S. (2012). Transdermal drug delivery system: a review. J Adv Sci Res 3:22--35
  • Salehi R, Irani M, Rashidi M-R, et al. (2013). Stimuli-responsive nanofibers prepared from poly (N-isopropylacrylamide-acrylamide-vinylpyrrolidone) by electrospinning as an anticancer drug delivery. Des Monomers Polym 16:515–27
  • Singh N, Karambelkar A, Gu L, et al. (2011). Bioresponsive mesoporous silica nanoparticles for triggered drug release. ACS 133:19582–5
  • Singh R, Lillard Jr JW. (2009). Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–23
  • Tung W-L, Hu S-H, Liu D-M. (2011). Synthesis of nanocarriers with remote magnetic drug release control and enhanced drug delivery for intracellular targeting of cancer cells. Acta Biomater 7:2873–82
  • Vadia N, Rajput S. (2012). Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement. Eur J Pharm Sci 45:8–18
  • Wen H, Guo J, Chang B, Yang W. (2013). pH-responsive composite microspheres based on magnetic mesoporous silica nanoparticle for drug delivery. Eur J Pharm Biopharm. 84:91--8
  • Xi J, Qin J, Fan L. (2012). Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery. Int J Nanomedicine 7:5235
  • Xue M, Zhong X, Shaposhnik Z, et al. (2011). pH-operated mechanized porous silicon nanoparticles. J Am Chem Soc 133:8798–801
  • Yan EY, Ding Y, Chen CJ, et al. (2009). Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments. Chem Commun 19: 2718--20

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