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Research Article

Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and in situ intestinal permeability studies

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Pages 740-747 | Received 13 Jan 2014, Accepted 21 Feb 2014, Published online: 27 Mar 2014

References

  • Alzoubi K, Khabour O, Al-Azzam S, Mayyas F. (2013). The role of multidrug resistance-1 (MDR1) variants in response to fexofenadine among Jordanians. Int J Clin Pharmacol Ther 51:880–7
  • Bezerra DP, de Castro FO, Alves AP, et al. (2008). In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. J Appl Toxicol 28:156–63
  • Bhardwaj RK, Glaeser H, Becquemont L, et al. (2002). Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302:645–50
  • Cao F, Gao Y, Wang M, et al. (2013). Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for pepT1-mediated transport: synthesis, intestinal permeability, and pharmacokinetics. Mol Pharm 10:1378–87
  • Craig D, Barker S, Banning D, Booth S. (1995). An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm 114:103–10
  • Devani M, Ashford M, Craig DQ. (2004). The emulsification and solubilisation properties of polyglycolysed oils in self-emulsifying formulations. J Pharm Pharmacol 56:307–16
  • Ee GC, Lim CM, Rahmani M, et al. (2010). Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. Molecules 15:2398–404
  • Gao P, Morozowich W. (2006). Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs. Expert Opin Drug Deliv 3:97–110
  • Han Y, Chin Tan TM, Lim L-Y. (2008). In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol Appl Pharmacol 230:283–9
  • Huo X, Huang L, Liu S, et al. (2011). Study on the rat intestinal absorption of rapamycin formulated in self-microemulsifying drug delivery system by single-pass intestinal perfusion technique. Chin Hosp Pharm J 31:217–21
  • Kim M-S, Kim J-S, Park HJ, et al. (2011). Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process. Int J Nanomed 6:2997–3009
  • Kommuru T, Gurley B, Khan M, Reddy I. (2001). Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm 212:233–46
  • Li P, Ghosh A, Wagner RF, et al. (2005). Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. Int J Pharm 288:27–34
  • Luo Z, Liu Y, Zhao B, et al. (2013). Ex vivo and In situ approaches used to study intestinal absorption. J Pharmacol Toxicol methods 68:208–16
  • Neslihan Gursoy R, Benita S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 58:173–82
  • Pattanaik S, Hota D, Prabhakar S, et al. (2006). Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. Phytother Res 20:683–6
  • Porter CJ, Trevaskis NL, Charman WN. (2007). Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 6:231–48
  • Pouton CW. (1985). Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification. Int J Pharm 27:335–48
  • Pouton CW. (1997). Formulation of self-emulsifying drug delivery systems. Adv Drug Delivery Rev 25:47–58
  • Rahman MA, Hussain A, Hussain MS, et al. (2013). Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS). Drug Dev Ind Pharm 39:1–19
  • Rege BD, Kao JP, Polli JE. (2002). Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur J Pharm Sci 16:237–46
  • Samiei N, Mangas-Sanjuan V, Gonz Lez-Álvarez I, et al. (2013). Ion-pair strategy for enabling Amifostine oral absorption: rat in situ and in vivo experiments. Eur J Pharm Sci 49:499–504
  • Shao B, Tang J, Ji H, et al. (2010). Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis Extracts) by self-emulsifying drug delivery systems. Drug Dev Ind Pharm 36:1356–63
  • Shoba G, Joy D, Joseph T, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta medica 64:353–6
  • Singh DV, Godbole MM, Misra K. (2013). A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors. J Mol Model 19:227–38
  • Six K, Verreck G, Peeters J, et al. (2004). Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast- and slow-dissolving polymers. J Pharm Sci 93:124–31
  • Srinivasan K. (2007). Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr 47:735–48
  • Sunila E, Kuttan G. (2004). Immunomodulatory and antitumor activity of Piper longum Linn and piperine. J Ethnopharmacol 90:339–46
  • Suresh D, Srinivasan K. (2007). Studies on the in vitro absorption of spice principles–Curcumin, capsaicin and piperine in rat intestines. Food Chem Toxicol 45:1437–42
  • Suresh D, Srinivasan K. (2010). Tissue distribution, elimination of capsaicin, piperine, curcumin following oral intake in rats. Indian J Med Res 131:682–91
  • Tang J, Sun J, Cui F, et al. (2008). Self-emulsifying drug delivery systems for improving oral absorption of ginkgo biloba extracts. Drug Deliv 15:477–84
  • Tang J, Wang Y, Wang D, et al. (2013). Key Structure of Brij for Overcoming Multidrug Resistance in Cancer. Biomacromolecules 14:424–30
  • Veerareddy P, Vobalaboina V. (2008). Pharmacokinetics and tissue distribution of piperine lipid nanospheres. Pharmazie 63:352–5
  • Veerareddy P, Vobalaboina V, Nahid A. (2004). Formulation and evaluation of oil-in-water emulsions of piperine in visceral leishmaniasis. Pharmazie 59:194–7
  • Wang X, Peng W, Zhang Q, et al. (2010). Pharmacokinetics of piperine capsules in healthy volunteers. J Cent South Univ T 8:513–16
  • Wu Z, Xia X, Huang X. (2012). Determination of equilibrium solubility and apparent oil/water partition coefficient of piperine. J Jinan Univ 33:473–6
  • Yap SP, Yuen KH. (2004). Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. Int J Pharm 281:67–78
  • Yoncheva K, Calleja P, Ag Eros M, et al. (2012). Stabilized micelles as delivery vehicles for paclitaxel. Int J Pharm 436:258–64
  • Zhang P, Liu Y, Feng N, Xu J. (2008). Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm 355:269–76
  • Zhang Z, Gao F, Jiang S, et al. (2013). Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats. Int J Pharm 452:374–81

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