A review of biodegradable polymeric systems for oral insulin delivery

References

• Ahn S, Lee IH, Lee E, et al. (2013). Oral delivery of an anti-diabetic peptide drug via conjugation and complexation with low molecular weight chitosan. J Control Release 170:226–32
   PubMed Web of Science ®Google Scholar
• Alonso MJ. (2004). Nanomedicines for overcoming biological barriers. Biomed Pharmacother 58:168–72
   PubMed Web of Science ®Google Scholar
• Bakhru SH, Furtado S, Morello AP, et al. (2013). Oral delivery of proteins by biodegradable nanoparticles. Adv Drug Delivery Rev 65:811–21
   PubMed Web of Science ®Google Scholar
• Čalija B, Cekić N, Savić S, et al. (2011). An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen. Arch Pharmacal Res 34:919–29
   PubMed Web of Science ®Google Scholar
• Chalasani KB, Russell-Jones GJ, Jain AK, et al. (2007a). Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release 122:141–50
   PubMed Web of Science ®Google Scholar
• Chalasani KB, Russell-Jones GJ, Yandrapu SK, et al. (2007b). A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin. J Control Release 117:421–9
   PubMed Web of Science ®Google Scholar
• Chan AW, Neufeld RJ. (2010). Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics. Biomaterials 31:9040–7
   PubMed Web of Science ®Google Scholar
• Chen MC, Mi FL, Liao ZX, et al. (2013). Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. Adv Drug Deliv Rev 65:865–79
   PubMed Web of Science ®Google Scholar
• Chen MC, Sonaje K, Chen KJ, et al. (2011). A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 32:9826–38
   PubMed Web of Science ®Google Scholar
• Chuang EY, Lin KJ, Su FY, et al. (2013). Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery. J Control Release 169:296–305
   PubMed Web of Science ®Google Scholar
• Cone RA. (2009). Barrier properties of mucus. Adv Drug Delivery Rev 61:75–85
   PubMed Web of Science ®Google Scholar
• Cui F, He C, Yin L, et al. (2007). Nanoparticles incorporated in bilaminated films: a smart drug delivery system for oral formulations. Biomacromolecules 8:2845–50
   PubMed Web of Science ®Google Scholar
• Cui F, Shi K, Zhang L, et al. (2006). Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J Control Release 114:242–50
   PubMed Web of Science ®Google Scholar
• Cui FD, Tao AJ, Cun DM, et al. (2007). Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J Pharm Sci 96:421–7
   PubMed Web of Science ®Google Scholar
• Cui FY, Qian F, Zhao Z, et al. (2009). Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles. Biomacromolecules 10:1253–8
   PubMed Web of Science ®Google Scholar
• Damge C, Maincent P, Ubrich N. (2007). Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release 117:163–70
   PubMed Web of Science ®Google Scholar
• Damge C, Socha M, Ubrich N, et al. (2010). Poly(epsilon-caprolactone)/eudragit nanoparticles for oral delivery of aspart-insulin in the treatment of diabetes. J Pharm Sci 99:879–89
   PubMed Web of Science ®Google Scholar
• Degim Z, Unal N, Essiz D, et al. (2004). The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer. Life Sci 75:2819–27
   PubMed Web of Science ®Google Scholar
• des Rieux A, Pourcelle V, Cani PD, et al. (2013). Targeted nanoparticles with novel non-peptidic ligands for oral delivery. Adv Drug Deliv Rev 65:833–44
   PubMed Web of Science ®Google Scholar
• Gao X, Cao Y, Song X, et al. (2013a). Biodegradable, pH-responsive carboxymethyl cellulose/poly(acrylic acid) hydrogels for oral insulin delivery. Macromol Biosci 14:1–11
   Google Scholar
• Gao X, He C, Xiao C, et al. (2013b). Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin. Polymer 54:1786–93
   Web of Science ®Google Scholar
• Han L, Zhao Y, Yin L, et al. (2012). Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery. AAPS PharmSciTech 13:836–45
   PubMed Web of Science ®Google Scholar
• He C, Yin L, Tang C, et al. (2012). Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs. Biomaterials 33:8569–78
   PubMed Web of Science ®Google Scholar
• He P, Liu H, Tang Z, et al. (2013). Poly(ester amide) blend microspheres for oral insulin delivery. Int J Pharm 455:259–66
   PubMed Web of Science ®Google Scholar
• He P, Tang Z, Lin L, et al. (2012). Novel biodegradable and pH-sensitive poly(ester amide) microspheres for oral insulin delivery. Macromol Biosci 12:547–56
   PubMed Web of Science ®Google Scholar
• Hsieh CT, Hsieh TJ, El-Shazly M, et al. (2012). Synthesis of chalcone derivatives as potential anti-diabetic agents. Bioorg Med Chem Lett 22:3912–15
   PubMed Web of Science ®Google Scholar
• Hu S, Niu M, Hu F, et al. (2013). Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media. Int J Pharm 441:693–700
   PubMed Web of Science ®Google Scholar
• Hurkat P, Jain A, Jain A, et al. (2012). Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery. J Nanopart Res. doi: http://dx.doi.org/10.1007/s11051-012-1219-4
   Web of Science ®Google Scholar
• Jin Y, Song Y, Zhu X, et al. (2012). Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials 33:1573–82
   PubMed Web of Science ®Google Scholar
• Jose S, Fangueiro JF, Smitha J, et al. (2012). Cross-linked chitosan microspheres for oral delivery of insulin: taguchi design and in vivo testing. Colloids Surf B 92:175–9
   PubMed Web of Science ®Google Scholar
• Jose S, Fangueiro JF, Smitha J, et al. (2013). Predictive modeling of insulin release profile from cross-linked chitosan microspheres. Eur J Med Chem 60:249–53
   PubMed Web of Science ®Google Scholar
• Jugminder S, Chawla MMA. (2002). Biodegradable poly(o-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen. Int J Pharm 249:127–38
   PubMed Web of Science ®Google Scholar
• Kebede A, Singh AK, Rai PK, et al. (2013). Controlled synthesis, characterization, and application of iron oxide nanoparticles for oral delivery of insulin. Lasers Med Sci 28:579–87
   PubMed Web of Science ®Google Scholar
• Khutoryanskiy VV. (2011). Advances in mucoadhesion and mucoadhesive polymers. Macromol Biosci 11:748–64
   PubMed Web of Science ®Google Scholar
• Kim BY, Jeong JH, Park K, et al. (2005). Bioadhesive interaction and hypoglycemic effect of insulin-loaded lectin-microparticle conjugates in oral insulin delivery system. J Control Release 102:525–38
   PubMed Web of Science ®Google Scholar
• Kita-Tokarczyk K, Grumelard J, Haefele T, et al. (2005). Block copolymer vesicles – using concepts from polymer chemistry to mimic biomembranes. Polymer 46:3540–63
   Web of Science ®Google Scholar
• Lassalle V, Ferreira ML. (2010). PLGA based drug delivery systems (DDS) for the sustained release of insulin: insight into the protein/polyester interactions and the insulin release behavior. J Chem Technol Biotechnol 85:1588–96
   Web of Science ®Google Scholar
• Li P, Nielsen HM, Fano M, et al. (2013). Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems. J Pharm Sci 102:2689–98
   PubMed Web of Science ®Google Scholar
• Lin YH, Chen CT, Liang HF, et al. (2007). Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnology 18:1–11
   Web of Science ®Google Scholar
• Lin YH, Sonaje K, Lin KM, et al. (2008). Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J Control Release 132:141–19
   PubMed Web of Science ®Google Scholar
• Ling SS, Magosso E, Khan NA, et al. (2006). Enhanced oral bioavailability and intestinal lymphatic transport of a hydrophilic drug using liposomes. Drug Dev Ind Pharm 32:335–45
   PubMed Web of Science ®Google Scholar
• Liu Y, Kong M, Feng C, et al. (2013). Biocompatibility, cellular uptake and biodistribution of the polymeric amphiphilic nanoparticles as oral drug carriers. Colloids Surf B 103:345–53
   PubMed Web of Science ®Google Scholar
• Lopes MA, Abrahim BA, Cabral LM, et al. (2014). Intestinal absorption of insulin nanoparticles: contribution of M cells. Nanomedicine 10:1139–51
   PubMed Web of Science ®Google Scholar
• Marais E, Hamman J, Plessis L, et al. (2013). Eudragit(R) L100/N-trimethylchitosan chloride microspheres for oral insulin delivery. Molecules 18:6734–47
   PubMed Web of Science ®Google Scholar
• Maroni A, Del Curto MD, Serratoni M, et al. (2009). Feasibility, stability and release performance of a time-dependent insulin delivery system intended for oral colon release. Eur J Pharm Biopharm 72:246–51
   PubMed Web of Science ®Google Scholar
• Martins S, Sarmento B, Souto EB, et al. (2007). Insulin-loaded alginate microspheres for oral delivery – effect of polysaccharide reinforcement on physicochemical properties and release profile. Carbohydr Polym 69:725–731
   Web of Science ®Google Scholar
• Minimol PF, Paul W, Sharma CP. (2013). PEGylated starch acetate nanoparticles and its potential use for oral insulin delivery. Carbohydr Polym 95:1–8
   PubMed Web of Science ®Google Scholar
• Mueller C, Verroken A, Iqbal J, et al. (2011). Thiolated chitosans: in vitro comparison of mucoadhesive properties. J Appl Polym Sci 126:5046–55
   Google Scholar
• Mukhopadhyay P, Sarkar K, Chakraborty M, et al. (2013). Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model. Mater Sci Eng C 33:376–82
   PubMed Web of Science ®Google Scholar
• Niu M, Lu Y, Hovgaard L, et al. (2011). Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation. Int J Nanomed 6:1155–66
   PubMed Web of Science ®Google Scholar
• Niu M, Lu Y, Hovgaard L, et al. (2012). Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. Eur J Pharm Biopharm 81:265–72
   PubMed Web of Science ®Google Scholar
• Prego C, Torres D, Fernandez-Megia E, et al. (2006). Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree. J Control Release 111:299–308
   PubMed Web of Science ®Google Scholar
• Qian F, Cui FY, Ding J, et al. (2006). Chitosan graft copolymer nanoparticles for oral protein drug delivery: preparation and characterization. Biomacromolecules 7:2722–7
   PubMed Web of Science ®Google Scholar
• Reis CP, Ribeiro AJ, Houng S, et al. (2007). Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity. Eur J Pharm Biopharm 30:392–7
   Web of Science ®Google Scholar
• Reix N, Parat A, Seyfritz E, et al. (2012). In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles. Int J Pharm 437:213–20
   PubMed Web of Science ®Google Scholar
• Rekha MR, Sharma CP. (2013). Oral delivery of therapeutic protein/peptide for diabetes – future perspectives. Int J Pharm 440:48–62
   PubMed Web of Science ®Google Scholar
• Sarmento B, Ribeiro A, Veiga F, et al. (2007a). Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res 24:2198–206
   PubMed Web of Science ®Google Scholar
• Sarmento B, Ribeiro AJ, Veiga F, et al. (2007b). Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation. J Nanosci Nanotechnol 7:2833–41
   PubMed Web of Science ®Google Scholar
• Shahbazi MA, Santos HA. (2013). Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication. Currt Drug Metab 14:28–56
   PubMed Web of Science ®Google Scholar
• Shelma R, Sharma CP. (2011). Submicroparticles composed of amphiphilic chitosan derivative for oral insulin and curcumin release applications. Colloids Surf B 88:722–8
   PubMed Web of Science ®Google Scholar
• Singh B, Chauhan N. (2009). Modification of psyllium polysaccharides for use in oral insulin delivery. Food Hydrocolloid 23:928–35
   Web of Science ®Google Scholar
• Sonaje K, Chen YJ, Chen HL, et al. (2010a). Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials 31:3384–94
   PubMed Web of Science ®Google Scholar
• Sonaje K, Lin KJ, Wang JJ, et al. (2010b). Self-assembled pH-sensitive nanoparticles: a platform for oral delivery of protein drugs. Adv Funct Mater 20:3695–700
   Web of Science ®Google Scholar
• Sonaje K, Lin KJ, Wey SP, et al. (2010c). Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-responsive nanoparticles vs. subcutaneous injection. Biomaterials 31:6849–58
   PubMed Web of Science ®Google Scholar
• Sonia TA, Sharma CP. (2011). In vitro evaluation of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan for oral insulin delivery. Carbohydr Polym 84:103–9
   Web of Science ®Google Scholar
• Sonia TA, Sharma CP. (2012). An overview of natural polymers for oral insulin delivery. Drug Discov Today 17:784–92
   PubMed Web of Science ®Google Scholar
• Su FY, Lin KJ, Sonaje K, et al. (2012). Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery. Biomaterials 33:2801–11
   PubMed Web of Science ®Google Scholar
• Sun Y, Wan A. (2007). Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules. J Appl Polym Sci 105:552–61
   Web of Science ®Google Scholar
• Sung HW, Sonaje K, Liao ZX, et al. (2012). pH-Responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc Chem Res 45:619–29
   PubMed Web of Science ®Google Scholar
• Viehof A, Javot L, Beduneau A, et al. (2013). Oral insulin delivery in rats by nanoparticles prepared with non-toxic solvents. Int J Pharm 443:169–74
   PubMed Web of Science ®Google Scholar
• Wang XQ, Zhang, Q. (2012). pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. Eur J Pharm Biopharm 82:219–29
   PubMed Web of Science ®Google Scholar
• Werle M, Loretz B, Entstrasser D, et al. (2007). Design and evaluation of a chitosan-aprotinin conjugate for the peroral delivery of therapeutic peptides and proteins susceptible to enzymatic degradation. J Drug Target 15:327–33
   PubMed Web of Science ®Google Scholar
• Woitiski CB, Sarmento B, Carvalho RA, et al. (2011). Facilitated nanoscale delivery of insulin across intestinal membrane models. Int J Pharm 412:123–31
   PubMed Web of Science ®Google Scholar
• Wong TW. (2010). Design of oral insulin delivery systems. J Drug Target 18:79–92
   PubMed Web of Science ®Google Scholar
• Wu ZM, Guo XD, Zhang LJ, et al. (2012a). Solvent mediated microstructures and release behavior of insulin from pH-sensitive nanoparticles. Colloids Surf B 94:206–12
   PubMed Web of Science ®Google Scholar
• Wu ZM, Ling L, Zhou LY, et al. (2012b). Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery. Nanoscale Res Lett 7:299. doi:10.1186/1556-276X-7-299
   PubMed Web of Science ®Google Scholar
• Wu ZM, Zhou L, Guo XD, et al. (2012c). HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. Int J Pharm 425:1–8
   PubMed Web of Science ®Google Scholar
• Xiong XY, Li QH, Li YP, et al. (2013). Pluronic P85/poly(lactic acid) vesicles as novel carrier for oral insulin delivery. Colloids Surf B 111:282–8
   PubMed Web of Science ®Google Scholar
• Xiong XY, Li YP, Li ZL, et al. (2007). Vesicles from pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery. J Control Release 120:11–17
   PubMed Web of Science ®Google Scholar
• Xiong XY, Tam KC, Gan LH. (2006). Polymeric nanostructures for drug delivery applications based on pluronic copolymer systems. J Nanosci Nanotechnol 6:2638–50
   PubMed Web of Science ®Google Scholar
• Yang J, Sun H, Song C. (2012). Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles. Diabetes Obes Metab 14:358–64
   PubMed Web of Science ®Google Scholar
• Yin L, Ding J, He C, et al. (2009). Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 30:5691–700
   PubMed Web of Science ®Google Scholar
• Yun Y, Cho YW, Park K. (2013). Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery. Adv Drug Deliv Rev 65:822–32
   PubMed Web of Science ®Google Scholar
• Zhang N, Ping QN, Huang GH, et al. (2005). Investigation of lectin-modified insulin liposomes as carriers for oral administration. Int J Pharm 294:247–59
   PubMed Web of Science ®Google Scholar
• Zhang X, Ma GH, Su ZG, et al. (2011a). Novel poly(L-lysine) particles for gene delivery. J Control Release 152:184–6
   Web of Science ®Google Scholar
• Zhang X, Qi J, Lu Y, et al. (2014). Biotinylated liposomes as potential carriers for the oral delivery of insulin. Nanomedicine 10:167–76
   PubMed Web of Science ®Google Scholar
• Zhang X, Sun M, Zheng A, et al. (2012). Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration. Eur J Pharm Biopharm 45:632–8
   Web of Science ®Google Scholar
• Zhang Y, Wei W, Lv P, et al. (2011b). Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. Eur J Pharm Biopharm 77:11–19
   PubMed Web of Science ®Google Scholar
• Zhang Z, Shan H, Chen L, et al. (2013). Synthesis of pH-responsive starch nanoparticles grafted poly(l-glutamic acid) for insulin controlled release. Eur Polym J 49:2082–91
   Web of Science ®Google Scholar
• Zhao X, Shan C, Zu Y, et al. (2013). Preparation, characterization, and evaluation in vivo of Ins-SiO(2)-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin. Int J Pharm 454:278–84
   PubMed Web of Science ®Google Scholar
• Zhu S, Qian F, Zhang Y, et al. (2007). Synthesis and characterization of PEG modified N-trimethylaminoethylmethacrylate chitosan nanoparticles. Eur Polym J 43:2244–53
   Web of Science ®Google Scholar