Gastroretentive systems – a proposed strategy to modulate anthocyanin release and absorption for the management of diabetes

References

• Adisakwattana S, Yibchok-Anun S, Charoenlertkul P, Wongsasiripat N. (2011). Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. J Clin Biochem Nutr 49:36–41
   PubMed Web of Science ®Google Scholar
• Al-Awwadi N, Azay J, Poucheret P, et al. (2004). Antidiabetic activity of red wine polyphenolic extract, ethanol, or both in streptozotocin-treated rats. J Agric Food Chem 52:1008–16
   PubMed Web of Science ®Google Scholar
• Asgary S, RafieianKopaei M, Sahebkar A, et al. (2016). Anti-hyperglycemic and anti-hyperlipidemic effects of Vaccinium myrtillus fruit in experimentally induced diabetes (antidiabetic effect of Vaccinium mirtillus fruit). J Sci Food Agric 96:764–8
   PubMed Web of Science ®Google Scholar
• Ataie-Jafari A, Hosseini S, Karimi F, Pajouhi M. (2008). Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women: a pilot study. Nutr Food Sci 38:355–60
   Google Scholar
• Banaszewski K, Park E, Edirisinghe I, et al. (2013). A pilot study to investigate bioavailability of strawberry anthocyanins and characterize postprandial plasma polyphenols absorption patterns by Q-TOF LC/MS in humans. J Berry Res 3:113–26
   Google Scholar
• Banini AE, Boyd LC, Allen JC, et al. (2006). Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Nutrition 22:1137–45
   PubMed Web of Science ®Google Scholar
• Battiston L, Macagno A, Passamonti S, et al. (1999). Specific sequence-directed anti-bilitranslocase antibodies as a tool to detect potentially bilirubin-binding proteins in different tissues of the rat. FEBS Lett 453:351–5
   PubMed Web of Science ®Google Scholar
• Bechgaard H, Ladefoged K. (1978). Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets. J Pharm Pharmacol 30:690–2
   PubMed Web of Science ®Google Scholar
• Boddupalli BM, Mohammed ZNK, Nath RA, Banji D. (2010). Mucoadhesive drug delivery system: an overview. J Adv Pharm Technol Res 1:381–7
   PubMedGoogle Scholar
• Bomma R, Veerabrahma K. (2013). Development of gastroretentive drug delivery system for cefuroxime axetil: in vitro and in vivo evaluation in human volunteers. Pharm Dev Technol 18:1230–7
   PubMed Web of Science ®Google Scholar
• Brogna A, Ferrara R, Bucceri AM, et al. (1998). Gastric emptying rates of solid food in relation to body mass index: an ultrasonographic and scintigraphic study. Eur J Radiol 27:258–63
   PubMed Web of Science ®Google Scholar
• Brouillard R, Delaporte B. (1977). Chemistry of anthocyanin pigment. 2. Kinetic and thermodynamic study of proton transfer, hydration, and tautomeric reactions of malvidin 3-glucoside. J Am Chem Soc 99:8461–8
   Web of Science ®Google Scholar
• Brouillard R, Dubois J-E. (1977). Mechanisms of the structural transformations of anthocyanins in acidic media. J Am Chem Soc 99:1359–64
   Web of Science ®Google Scholar
• Brouwer IA, van Dusseldorp M, West CE, et al. (1999). Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J Nutr 129:1135–9
   PubMed Web of Science ®Google Scholar
• Buckles DC, Sarosiek I, McMillin C, McCallum RW. (2004). Delayed gastric emptying in gastroesophageal reflux disease: reassessment with new methods and symptomatic correlations. Am J Med Sci 327:1–4
   PubMed Web of Science ®Google Scholar
• Cassidy A, Mukamal KJ, Liu L, et al. (2013). High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 127:188–96
   PubMed Web of Science ®Google Scholar
• Cassidy A, O’Reilly ÉJ, Kay C, et al. (2011). Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 93:338–47
   PubMed Web of Science ®Google Scholar
• Chambers BK, Camire ME. (2003). Can cranberry supplementation benefit adults with type 2 diabetes? Diabetes Care 26:2695–6
   PubMed Web of Science ®Google Scholar
• Charron CS, Kurilich AC, Clevidence BA, et al. (2009). Bioavailability of anthocyanins from purple carrot juice: effects of acylation and plant matrix. J Agric Food Chem 57:1226–30
   PubMed Web of Science ®Google Scholar
• Chen R, Meseck M, McEvoy RC, Woo SLC. (2000). Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells. Gene Ther 7:1802–9
   PubMed Web of Science ®Google Scholar
• Choi M-K, Park S-J, Eom SH, Kang M-H. (2013). Anti-diabetic and hypolipidemic effects of purple-fleshed potato in streptozotocin-induced diabetic rats. Food Sci Biotechnol 22:1–6
   Google Scholar
• Clark GWB, Jamieson IR, Hinder RA, et al. (1993). The relationship between gastric pH and the emptying of solid, semisolid and liquid meals. Neurogastroenterol Motil 5:273–9
   Google Scholar
• Clarke GM, Newton JM, Short MB. (1995). Comparative gastrointestinal transit of pellet systems of varying density. Int J Pharm 114:1–11
   Web of Science ®Google Scholar
• Code CF, Marlett JA. (1975). The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol (Lond) 246:289–309
   Google Scholar
• Czank C, Cassidy A, Zhang Q, et al. (2013). Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study. Am J Clin Nutr 97:995–1003
   PubMed Web of Science ®Google Scholar
• Davis DW. (1968). Method of swallowing a pill, US Patent No. 3,418,999. Washington (DC): US Patent and Trademark Office
   Google Scholar
• Davis SS. (2005). Formulation strategies for absorption windows. Drug Discov Today 10:249–57
   PubMed Web of Science ®Google Scholar
• Davis SS, Stockwell AF, Taylor MJ, et al. (1986). The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm Res 3:208–13
   PubMed Web of Science ®Google Scholar
• de Wever I, Eeckhout C, Vantrappen G, Hellemans J. (1978). Disruptive effect of test meals on interdigestive motor complex in dogs. Am J Physiol 235:E661–5
   PubMed Web of Science ®Google Scholar
• Delgado-Vargas F, Jiménez AR, Paredes-López O. (2000). Natural pigments: carotenoids, anthocyanins, and betalains-characteristics, biosynthesis, processing, and stability. Crit Rev Food Sci Nutr 40:173–289
   PubMed Web of Science ®Google Scholar
• Devereux JE, Newton JM, Short MB. (1990). The influence of density on the gastrointestinal transit of pellets. J Pharm Pharmacol 42:500–1
   PubMed Web of Science ®Google Scholar
• Dooley CP, Di Lorenzo C, Valenzuela JE. (1992). Variability of migrating motor complex in humans. Dig Dis Sci 37:723–8
   PubMed Web of Science ®Google Scholar
• Elias MM, Lunazzi GC, Passamonti S, et al. (1990). Bilitranslocase localization and function in basolateral plasma membrane of renal proximal tubule in rat. Am J Physiol 259:F559–64
   PubMed Web of Science ®Google Scholar
• Faas H, Steingoetter A, Feinle C, et al. (2002). Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans – a magnetic resonance imaging study. Alim Pharmacol Ther 16:217–24
   PubMed Web of Science ®Google Scholar
• Fallatah B, AzizShehry A, Abdelsamad L, et al. (2013). Comparison study of gastric emptying after performing sleeve gastrectomy with two differente techniques. Global J Surg 1:53–6
   Google Scholar
• Fang J. (2014). Some anthocyanins could be efficiently absorbed across the gastrointestinal mucosa: extensive presystemic metabolism reduces apparent bioavailability. J Agric Food Chem 62:3904–11
   PubMed Web of Science ®Google Scholar
• Faramarzi S, Pacifico S, Yadollahi A, et al. (2015). Red-fleshed apples: old autochthonous fruits as a novel source of anthocyanin antioxidants. Plant Foods Hum Nutr 70:324–30
   PubMed Web of Science ®Google Scholar
• Faria A, Fernandes I, Norberto S, et al. (2014). Interplay between anthocyanins and gut microbiota. J Agric Food Chem 62:6898–902
   PubMed Web of Science ®Google Scholar
• Felgines C, Texier O, Besson C, et al. (2007). Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. Br J Nutr 98:1126–31
   PubMed Web of Science ®Google Scholar
• Fernandes I, de Freitas V, Reis C, Mateus N. (2012). A new approach on the gastric absorption of anthocyanins. Food Funct 3:508–16
   PubMed Web of Science ®Google Scholar
• Ferrars RM, Czank C, Zhang Q, et al. (2014). The pharmacokinetics of anthocyanins and their metabolites in humans. Br J Pharmacol 171:3268–82
   PubMed Web of Science ®Google Scholar
• Fischer UA, Jaksch AV, Carle R, Kammerer DR. (2013). Influence of origin source, different fruit tissue and juice extraction methods on anthocyanin, phenolic acid, hydrolysable tannin and isolariciresinol contents of pomegranate (Punica granatum L.) fruits and juices. Eur Food Res Technol 237:209–21
   Web of Science ®Google Scholar
• Fleschhut J, Kratzer F, Rechkemmer G, Kulling SE. (2005). Stability and biotransformation of various dietary anthocyanins in vitro. Eur J Nutr 45:7–18
   PubMed Web of Science ®Google Scholar
• Foster MC, Leapman RD, Li MX, Atwater I. (1993). Elemental composition of secretory granules in pancreatic islets of Langerhans. Biophys J 64:525–32
   PubMed Web of Science ®Google Scholar
• Galante P, Mosthaf L, Kellerer M, et al. (1995). Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle. Diabetes 44:646–51
   PubMed Web of Science ®Google Scholar
• Gentilcore D, Chaikomin R, Jones KL, et al. (2006). Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes. J Clin Endocrinol Metab 91:2062–7
   PubMed Web of Science ®Google Scholar
• Grace MH, Ribnicky DM, Kuhn P, et al. (2009). Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 16:406–15
   PubMed Web of Science ®Google Scholar
• Gravena C, Mathias PC, Ashcroft SJH. (2002). Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. J Endocrinol 173:73–80
   PubMed Web of Science ®Google Scholar
• Guo H, Ling W. (2015). The update of anthocyanins on obesity and type 2 diabetes: experimental evidence and clinical perspectives. Rev Endocr Metab Disord 16:1–13
   PubMed Web of Science ®Google Scholar
• Guo H, Ling W, Wang Q, et al. (2007). Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats. Plant Foods Hum Nutr 62:1–6
   PubMed Web of Science ®Google Scholar
• Hardoff R, Sula M, Tamir A, et al. (2001). Gastric emptying time and gastric motility in patients with Parkinson’s disease. Mov Disord 16:1041–7
   PubMed Web of Science ®Google Scholar
• He J, Wallace TC, Keatley KE, et al. (2009). Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat. J Agric Food Chem 57:3141–8
   PubMed Web of Science ®Google Scholar
• Hectors TLM, Vanparys C, Pereira-Fernandes A, et al. (2012). Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: new endpoints for toxicity testing? Toxicol Lett 212:180–9
   PubMed Web of Science ®Google Scholar
• Henriksen I, Green KL, Smart JD, et al. (1996). Bioadhesion of hydrated chitosans: an in vitro and in vivo study. Int J Pharm 145:231–40
   Web of Science ®Google Scholar
• Heo HJ, Lee CY. (2005). Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells. J Agric Food Chem 53:1984–9
   PubMed Web of Science ®Google Scholar
• Hidalgo M, Martin-Santamaria S, Recio I, et al. (2012). Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites. Genes Nutr 7:295–306
   PubMed Web of Science ®Google Scholar
• Hoelzel F. (1930). The rate of passage of inert materials through the digestive tract. Am J Physiol 92:466–97
   Google Scholar
• Hoggard N, Cruickshank M, Moar K-M, et al. (2013). A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modified glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle. J Nutr Sci 2:e22
   PubMedGoogle Scholar
• Hunt JN, Spurrell WR. (1951). The pattern of emptying of the human stomach. J Physiol (Lond) 113:157–68
   Google Scholar
• Hutson WR, Roehrkasse RL, Wald A. (1989). Influence of gender and menopause on gastric emptying and motility. Gastroenterology 96:11–17
   PubMed Web of Science ®Google Scholar
• Ibrahim HK. (2009). A novel liquid effervescent floating delivery system for sustained drug delivery. Drug Discov Ther 3:168–75
   PubMedGoogle Scholar
• Ichikawa M, Kato T, Kawahara M, et al. (1991). A new multiple-unit oral floating dosage system. II: in vivo evaluation of floating and sustained-release characteristics with p-aminobenzoic acid and isosorbide dinitrate as model drugs. J Pharm Sci 80:1153–6
   PubMed Web of Science ®Google Scholar
• International Diabetes Federation. (2013). IDF Diabetes Atlas. Brussels: Author
   Google Scholar
• Ishihara H, Maechler P, Gjinovci A, et al. (2003). Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5:330–5
   PubMed Web of Science ®Google Scholar
• Iwai K, Onodera A, Matsue H. (2004). Inhibitory effects of Viburnum dilatatum Thunb. (Gamazumi) on oxidation and hyperglycemia in rats with streptozotocin-induced diabetes. J Agric Food Chem 52:1002–7
   PubMed Web of Science ®Google Scholar
• Jackson SJ, Leahy FE, McGowan AA, et al. (2004). Delayed gastric emptying in the obese: an assessment using the non-invasive (13)C-octanoic acid breath test. Diabetes Obes Metab 6:264–70
   PubMed Web of Science ®Google Scholar
• Jankowski A, Jankowska A, Niedworok J. (2000). The effect of anthocyanin dye from grapes on experimental diabetes. Folia Med Cracov 41:5–15
   PubMedGoogle Scholar
• Jayaprakasam B, Olson LK, Schutzki RE, et al. (2006). Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in cornelian cherry (Cornus mas). J Agric Food Chem 54:243–8
   PubMed Web of Science ®Google Scholar
• Jayaprakasam B, Vareed SK, Olson LK, Nair MG. (2005). Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 53:28–31
   PubMed Web of Science ®Google Scholar
• Joseph NJ, Lakshmi S, Jayakrishnan A. (2002). A floating-type oral dosage form for piroxicam based on hollow polycarbonate microspheres: in vitro and in vivo evaluation in rabbits. J Control Release 79:71–9
   PubMed Web of Science ®Google Scholar
• Kahn BB. (1998). Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92:593–6
   PubMed Web of Science ®Google Scholar
• Kay CD, Mazza G, Holub BJ. (2005). Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr 135:2582–8
   PubMed Web of Science ®Google Scholar
• Keane KM, Bell PG, Lodge JK, et al. (2015). Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro. Eur J Nutr. [Epub ahead of print]. doi: 10.1007/s00394-015-0988-9
   Google Scholar
• Kelsey N, Hulick W, Winter A, et al. (2011). Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress. Nutr Neurosci 14:249–59
   PubMed Web of Science ®Google Scholar
• Krepinsky J, Ingram AJ, Clase CM. (2000). Prolonged sulfonylurea-induced hypoglycemia in diabetic patients with end-stage renal disease. Am J Kidney Dis 35:500–5
   PubMed Web of Science ®Google Scholar
• Kubo W, Konno Y, Miyazaki S, Attwood D. (2004). In situ gelling pectin formulations for oral sustained delivery of paracetamol. Drug Dev Ind Pharm 30:593–9
   PubMed Web of Science ®Google Scholar
• Kurilich AC, Clevidence BA, Britz SJ, et al. (2005). Plasma and urine responses are lower for acylated vs nonacylated anthocyanins from raw and cooked purple carrots. J Agric Food Chem 53:6537–42
   PubMed Web of Science ®Google Scholar
• Li D, Zhang Y, Liu Y, et al. (2015). Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. J Nutr 145:742–8
   PubMed Web of Science ®Google Scholar
• Liang L, Wu X, Zhao T, et al. (2012). In vitro bioaccessibility and antioxidant activity of anthocyanins from mulberry (Morus atropurpurea Roxb.) following simulated gastro-intestinal digestion. Food Res Int 46:76–82
   Web of Science ®Google Scholar
• Lin HC, Zhao X-T, Wang L. (1996). Fat absorption is not complete by midgut but is dependent on load of fat. Am J Physiol 271:G62–7
   PubMed Web of Science ®Google Scholar
• Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. (1997). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Delivery Rev 23:3–25
   Web of Science ®Google Scholar
• Liu Y, Zhang D, Wu Y, et al. (2014). Stability and absorption of anthocyanins from blueberries subjected to a simulated digestion process. Int J Food Sci Nutr 65:440–8
   PubMed Web of Science ®Google Scholar
• Lorena SLS, Tinois E, Hirata ES, et al. (2000). Scintigraphic study of gastric emptying and intragastric distribution of a solid meal: gender differences. Arq Gastroenterol 37:102–6
   PubMedGoogle Scholar
• Maestro A, Terdoslavich M, Vanzo A, et al. (2010). Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter. Cardiovasc Res 85:175–83
   PubMed Web of Science ®Google Scholar
• Martineau LC, Couture A, Spoor D, et al. (2006). Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Phytomedicine 13:612–23
   PubMed Web of Science ®Google Scholar
• Matsui T, Ebuchi S, Kobayashi M, et al. (2002). Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J Agric Food Chem 50:7244–8
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Ito K, Yonekura K, et al. (2007). Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans. J Agric Food Chem 55:2489–96
   PubMed Web of Science ®Google Scholar
• McDougall GJ, Dobson P, Smith P, et al. (2005). Assessing potential bioavailability of raspberry anthocyanins using an in vitro digestion system. J Agric Food Chem 53:5896–904
   PubMed Web of Science ®Google Scholar
• Md S, Ahuja A, Khar RK, et al. (2011). Gastroretentive drug delivery system of acyclovir-loaded alginate mucoadhesive microspheres: formulation and evaluation. Drug Deliv 18:255–64
   PubMed Web of Science ®Google Scholar
• Mistiaen W, Blockx P, Van Hee R, et al. (2001). The effect of stress on gastric emptying rate measured with a radionuclide tracer. Hepatogastroenterology 49:1457–60
   Web of Science ®Google Scholar
• Miyazaki Y, Yakou S, Takayama K. (2008). Comparison of gastroretentive microspheres and sustained-release preparations using theophylline pharmacokinetics. J Pharm Pharmacol 60:693–8
   PubMed Web of Science ®Google Scholar
• Moore JG, Christian PE, Coleman RE. (1981). Gastric emptying of varying meal weight and composition in man. Dig Dis Sci 26:16–22
   PubMed Web of Science ®Google Scholar
• Mullen W, Edwards CA, Serafini M, Crozier A. (2008). Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. J Agric Food Chem 56:713–19
   PubMed Web of Science ®Google Scholar
• Muraki I, Imamura F, Manson JE, et al. (2013). Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. BMJ 347:f5001
   PubMed Web of Science ®Google Scholar
• Nathan DM, Buse JB, Davidson MB, et al. (2009). Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32:193–203
   PubMed Web of Science ®Google Scholar
• Nedachi T, Kanzaki M. (2006). Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes. Am J Physiol Endocrinol Metab 291:E817–28
   PubMed Web of Science ®Google Scholar
• Ochi M, Tominaga K, Tanaka F, et al. (2008). Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats. Life Sci 82:862–8
   PubMed Web of Science ®Google Scholar
• Olausson EA, Alpsten M, Larsson A, et al. (2008). Small particle size of a solid meal increases gastric emptying and late postprandial glycaemic response in diabetic subjects with gastroparesis. Diabetes Res Clin Pract 80:231–7
   PubMed Web of Science ®Google Scholar
• Oliveira J, Fernandes V, Miranda C, et al. (2006). Color properties of four cyanidin-pyruvic acid adducts. J Agric Food Chem 54:6894–903
   PubMed Web of Science ®Google Scholar
• Pascual-Teresa S, Moreno DA, García-Viguera C. (2010). Flavanols and anthocyanins in cardiovascular health: a review of current evidence. Int J Mol Sci 11:1679–703
   PubMed Web of Science ®Google Scholar
• Passamonti S, Terdoslavich M, Margon A, et al. (2005). Uptake of bilirubin into HepG2 cells assayed by thermal lens spectroscopy. Function of bilitranslocase. FEBS J 272:5522–35
   PubMed Web of Science ®Google Scholar
• Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. (2003). The stomach as a site for anthocyanins absorption from food. FEBS Lett 544:210–13
   PubMed Web of Science ®Google Scholar
• Proteggente AR, Pannala AS, Paganga G, et al. (2002). The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition. Free Rad Res 36:217–33
   PubMed Web of Science ®Google Scholar
• Read NW, Al-Janabi MN, Holgate AM, et al. (1986). Simultaneous measurement of gastric emptying, small bowel residence and colonic filling of a solid meal by the use of the gamma camera. Gut 27:300–8
   PubMed Web of Science ®Google Scholar
• Rojo LE, Ribnicky D, Logendra S, et al. (2012). In vitro and in vivo anti-diabetic effects of anthocyanins from maqui berry (Aristotelia chilensis). Food Chem 131:387–96
   PubMed Web of Science ®Google Scholar
• Rouge N, Allémann E, Gex-Fabry M, et al. (1998). Comparative pharmacokinetic study of a floating multiple-unit capsule, a high-density multiple-unit capsule and an immediate-release tablet containing 25 mg atenolol. Pharm Acta Helv 73:81–7
   PubMedGoogle Scholar
• Saier MH. (2000). A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev 64:354–411
   PubMed Web of Science ®Google Scholar
• Samieri C, Sun Q, Townsend MK, et al. (2014). Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr 100:1489–97
   PubMed Web of Science ®Google Scholar
• Santos AC, Veiga F, Ribeiro AJ. (2011). New delivery systems to improve the bioavailability of resveratrol. Expert Opin Drug Deliv 8:973–90
   PubMed Web of Science ®Google Scholar
• Sasaki R, Nishimura N, Hoshino H, et al. (2007). Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol 74:1619–27
   PubMed Web of Science ®Google Scholar
• Saxena A, Gaur K, Singh V, et al. (2014). Floating microspheres as drug delivery system. AJPPS 1:27–36
   Google Scholar
• Schelleman H, Han X, Brensinger CM, et al. (2014). Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol 78:639–48
   PubMed Web of Science ®Google Scholar
• Seymour EM, Singer AAM, Kirakosyan A, et al. (2008). Altered hyperlipidemia, hepatic steatosis, and hepatic peroxisome proliferator-activated receptors in rats with intake of tart cherry. J Med Food 11:252–9
   PubMed Web of Science ®Google Scholar
• Shaikh R, Singh TRR, Garland MJ, et al. (2011). Mucoadhesive drug delivery systems. J Pharm BioAllied Sci 3:89–100
   PubMed Web of Science ®Google Scholar
• Shakyaa R, Thapa P, Saha RN. (2013). In vitro and in vivo evaluation of gastroretentive floating drug delivery system of ofloxacin. Asian J Pharm Sci 8:191–8
   Google Scholar
• Singh BN, Kim KH. (2000). Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release 63:235–59
   PubMed Web of Science ®Google Scholar
• Soppimath KS, Kulkarni AR, Rudzinski WE, Aminabhavi TM. (2001). Microspheres as floating drug-delivery systems to increase gastric retention of drugs. Drug Metab Rev 33:149–60
   PubMed Web of Science ®Google Scholar
• Sottocasa GL, Lunazzi GC, Tiribelli C. (1989). Isolation of bilitranslocase, the anion transporter from liver plasma membrane for bilirubin and other organic anions. Meth Enzymol 174:50–7
   PubMed Web of Science ®Google Scholar
• Stalmach A, Edwards CA, Wightman JD, Crozier A. (2012). Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans. Mol Nutr Food Res 56:497–509
   PubMed Web of Science ®Google Scholar
• Steingoetter A, Fox M, Treier R, et al. (2006). Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study. Scand J Gastroenterol 41:1155–64
   PubMed Web of Science ®Google Scholar
• Stull AJ, Cash KC, Johnson WD, et al. (2010). Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr 140:1764–8
   PubMed Web of Science ®Google Scholar
• Surwit RS, Kuhn CM, Cochrane C, et al. (1988). Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37:1163–7
   PubMed Web of Science ®Google Scholar
• Törrönen R, Kolehmainen M, Sarkkinen E, et al. (2012a). Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr 96:527–33
   PubMed Web of Science ®Google Scholar
• Törrönen R, McDougall GJ, Dobson G, et al. (2012b). Fortification of blackcurrant juice with crowberry: impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects. J Funct Foods 4:746–56
   Web of Science ®Google Scholar
• Törrönen R, Sarkkinen E, Tapola N, et al. (2010). Berries modify the postprandial plasma glucose response to sucrose in healthy subjects. Br J Nutr 103:1094–7
   PubMed Web of Science ®Google Scholar
• Takahashi A, Okazaki Y, Nakamoto A, et al. (2014). Dietary anthocyanin-rich haskap phytochemicals inhibit postprandial hyperlipidemia and hyperglycemia in rats. J Oleo Sci 63:201–9
   PubMed Web of Science ®Google Scholar
• Takikawa M, Inoue S, Horio F, Tsuda T. (2010). Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr 140:527–33
   PubMed Web of Science ®Google Scholar
• Talavéra S, Felgines C, Texier O, et al. (2003). Anthocyanins are efficiently absorbed from the stomach in anesthetized rats. J Nutr 133:4178–82
   PubMed Web of Science ®Google Scholar
• Tang M, Alvani K, Tester RF. (2010). Production and utilisation of gastric rafts from polysaccharide combinations to induce satiety: a preliminary study. Nutr Food Sci 40:155–65
   Google Scholar
• Tarozzi A, Morroni F, Hrelia S, et al. (2007). Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. Neurosci Lett 424:36–40
   PubMed Web of Science ®Google Scholar
• Tarozzi A, Morroni F, Merlicco A, et al. (2010). Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity. Neurosci Lett 473:72–6
   PubMed Web of Science ®Google Scholar
• Tsuda T, Horio F, Uchida K, et al. (2003). Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133:2125–30
   PubMed Web of Science ®Google Scholar
• Urbain J-LC, Siegel JA, Charkes ND, et al. (1989). The two-component stomach: effects of meal particle size on fundal and antral emptying. Eur J Nucl Med 15:254–9
   PubMedGoogle Scholar
• Urquhart J, Theeuwes F. (1984). Drug delivery system comprising a reservoir containing a pluratility of tiny pills, US Patent No. 4,434,153. Washington (DC): US Patent and Trademark Office
   Google Scholar
• van Dam RM, Naidoo N, Landberg R. (2013). Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: review of recent findings. Curr Opin Lipidol 24:25–33
   PubMed Web of Science ®Google Scholar
• Vanzo A, Vrhovsek U, Tramer F, et al. (2011). Exceptionally fast uptake and metabolism of cyanidin 3-glucoside by rat kidneys and liver. J Nat Prod 74:1049–54
   PubMed Web of Science ®Google Scholar
• Vincent R, Roberts A, Frier M, et al. (1995). Effect of bran particle size on gastric emptying and small bowel transit in humans: a scintigraphic study. Gut 37:216–19
   PubMed Web of Science ®Google Scholar
• Vitaglione P, Donnarumma G, Napolitano A, et al. (2007). Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr 137:2043–8
   PubMed Web of Science ®Google Scholar
• Wallace TC. (2011). Anthocyanins in cardiovascular disease. Adv Nutr 2:1–7
   PubMed Web of Science ®Google Scholar
• Wang L-S, Stoner GD. (2008). Anthocyanins and their role in cancer prevention. Cancer Lett 269:281–90
   PubMed Web of Science ®Google Scholar
• Wedick NM, Pan A, Cassidy A, et al. (2012). Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 95:925–33
   PubMed Web of Science ®Google Scholar
• Wei H. (2014). Postprandial plasma polyphenol profile and bioavailability of anthocyanins in insulin resistant humans after consuming multiple doses of strawberries beverage with a meal. Chicago (IL): Illinois Institute of Technology
   Google Scholar
• Wiggins HS, Dawson AM. (1961). An evaluation of unabsorbable markers in the study of fat absorption. Gut 2:373–6
   PubMed Web of Science ®Google Scholar
• Woerle HJ, Albrecht M, Linke R, et al. (2008). Impaired hyperglycemia-induced delay in gastric emptying in patients with type 1 diabetes deficient for islet amyloid polypeptide. Diabetes Care 31:2325–31
   PubMed Web of Science ®Google Scholar
• Wu T, Yu Z, Tang Q, et al. (2013). Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice. Food Funct 4:1654–61
   PubMed Web of Science ®Google Scholar
• Zunino SJ. (2009). Type 2 diabetes and glycemic response to grapes or grape products. J Nutr 139:1794S–800S
   PubMed Web of Science ®Google Scholar