1,078
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Design, synthesis, and activity of 2,3-diphosphoglycerate analogs as allosteric modulators of hemoglobin O2 affinity

, , &
Pages 109-115 | Received 05 Jul 2012, Accepted 23 Oct 2012, Published online: 10 Jan 2013

References

  • Astrup P, Rorth M. 1971. Oxygen Affinity of Hemoglobin and Red Cell Acid Base Status. Academic Press: New York.
  • Bakker JC, Berbers GA, Bleeker WK, den Boer PJ, Biessels PT. 1992. Preparation and characterization of cross linked and polymerized hemoglobin solutions. Biomater Artif Cells Immobilization Biotechnol. 20:233–241.
  • Berkowitz DB, Sloss DG. 1995. J Org Chem. 60:7047–7050.
  • Blackburn GM, Kent DE. 1981. A novel synthesis of α- and γ- fluoroalkylphosphonates. J Chem Soc Chem Commun. 11:511–513.
  • Blackburn GM. 1981. Chem Ind (London). 5:134–138.
  • Burke TR Jr.,Smyth MS, Nomizu M, Otaka A, Roller PP. J1993. Org Chem. 58:1336–1340.
  • Caplan NA, Pogson CI, Hayes DJ, Blackburn GM. 1998. Bioorg Med Chem Lett. 8:515–520.
  • Chambers RD, O’Hagan D, Lamont RB, Jain SC. 1990. The difluoromethylenephosphonate moiety as a phosphate mimic: Xray structure of 2-amino-1,1-difluoroethylphosphonic acid. Chem Commun. 15:1053–1054.
  • Engel R. 1977. Chem Rev. 77:349–367.
  • Gould SA, Sehgal LR, Sehgal HL, Moss GS. 1992. Artificial blood: current status of hemoglobin solutions. Crit Care Clin. 8:293–309.
  • Horton H, Moran L, Ochs R, Rawn J, Scrimgeour K. 1993. Principles of Biochemistry. New Jersey: Neil Patterson.
  • Kamber M, Just G. 1985. Can J Chem. 63:825.
  • Kennedy J. 1957. Patent Brit 778,077. Chem Abstr. 51:17980b.
  • Macdonald VW, Winslow RM. 1992. Oxygen Delivery and myocardial function in rabbit hearts perfused with cell-free hemoglobin. J Appl Physiol72:476–483.
  • Moonen K, Laureyn I, Stevens CV. 2004. Chem Rev. 104:6177.
  • Palacios F, Alonso C, de los Santos JM. 2005. Chem Rev. 105:899.
  • Palmer AF, Sun G, Harris DR. 2009. Tangential flow filtration of hemoglobin. Biotechnol Prog. 25:189–199.
  • Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ. 1996. The risk of transfusion-transmitted viral infections. The retrovirus epidemiology donor study. N Engl J Med. 334:1685–1690.
  • Spahn DR. 2000. Current status of artificial oxygen carriers. Adv Drug Deliv Rev. 40:143–151.
  • Stremler KE, Poulter CDJ. 1987. Am Chem Soc. 109:5542–5544 (geranyl diphosphate analogs as FDP synthase pseudo-substrates).
  • Thatcher GRJ, Campbell AS. 1993. J Org Chem. 58:2272–2281.
  • Tozer MJ, Herpin TF. 1996. Tetrahedron. 52:8619–8683.
  • Tsai A, Vandergriff KD, Intalietta M, Winslow RM. 2003. Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics. Am J Physiol Heart Cric Physiol. 285:H1411–H1419.
  • Waschbüsch R, Carran J, Marinetti A, Savignac P. 1997. Chem Rev. 97:3401.
  • Wettstein R, Tsai AG, Winslow RM. 2003. Resuscitation with poly (ethylene glycol)-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. Crit Care Med. 31:1824–1830.
  • Wiemer DF. 1997. Tetrahedron. 53:16609.
  • Winslow RM. 1995. Blood substitutes, a moving target. Nat Med. 1: 1212–1215.
  • Winslow RM. 2003. Current status of blood substitute research towards a new paradigm. J Intern Med. 253:508–517.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.