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Review Article

The signaling pathway of stromal cell-derived factor-1 and its role in kidney diseases

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Pages 85-91 | Received 17 Aug 2013, Accepted 11 Nov 2013, Published online: 04 Dec 2013

References

  • Kollet O, Vagima Y, D'Uva G, et al. Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors. Leukemia 2013;27:2006--15
  • Cencioni C, Capogrossi MC, Napolitano M. The SDF-1/CXCR4 axis in stem cell preconditioning. Cardiovasc Res 2012;94:400–07
  • Lewellis SW, Knaut H. Attractive guidance: how the chemokine SDF1/CXCL12 guides different cells to different locations. Semin Cell Dev Biol 2012;23:333–40
  • Xue B, Wu W, Huang K, et al. Stromal cell-derived factor-1 (SDF-1) enhances cells invasion by αvβ6 integrin-mediated signaling in ovarian cancer. Mol Cell Biochem 2013;380:177–84
  • Shen HB, Gu ZQ, Jian K, et al. CXCR4-mediated Stat3 activation is essential for CXCL12- induced cell invasion in bladder cancer. Tumour Biol 2013;34:1839–45
  • Gil M, Seshadri M, Komorowski MP, et al. Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breastcancer metastases. Proc Natl Acad Sci U S A 2013;110:E1291–300
  • Takabatake Y, Sugiyama T, Kohara H, et al. The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol 2009;20:1714–23
  • Sayyed SG, Hägele H, Kulkarni OP, et al. Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia 2009;52:2445–54
  • Liu H, Wu R, Jia RP, et al. Ischemic preconditioning increases endothelial progenitor cell number to attenuate partial nephrectomy-inducedischemia/reperfusion injury. PLoS One 2013;8:e55389
  • Huang C, Gu H, Zhang W, et al. SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 2011;301:H1496–505
  • Wang HP, Liu CW, Chang HW, et al. Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats. Mol Biol Rep 2013;40:2347–55
  • Darisipudi MN, Kulkarni OP, Sayyed SG, et al. Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease. Am J Pathol 2011;179:116–24
  • Launay O, Paul S, Servettaz A, et al. Control of humoral immunity and auto-immunity by the CXCR4/CXCL12 axis in lupus patients following influenza vaccine. Vaccine 2013;31:3492–501
  • Wehler TC, Graf C, Altherr K, et al. SDF1β expression in renal cell carcinoma correlates with grading and infiltration by CD8+ T-cells. Anticancer Res 2011;31:2797–803
  • Vadlamudi HC, Yalavarthi PR, Balambhaigari RY, et al. Receptors and ligands role in colon physiology and pathology. J Recept Signal Transduct Res 2013;33:1–9
  • Chetram MA, Hinton CV. PTEN regulation of ERK1/2 signaling in cancer. J Recept Signal Transduct Res 2012;32:190–5
  • Costantini S, Raucci R, De Vero T, et al. Common structural interactions between the receptors CXCR3, CXCR4 and CXCR7 complexed with their natural ligands, CXCL11 and CXCL12, by a modeling approach. Cytokine 2013;64:316--21
  • Casoni F, Hutchins BI, Donohue D, et al. SDF and GABA interact to regulate axophilic migration of GnRH neurons. J Cell Sci 2012;125:5015–25
  • Hatfield KJ, Reikvam H, Bruserud Ø. The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia. Curr Med Chem 2010;17:4448–61
  • Bouzaffour M, Dufourcq P, Lecaudey V, et al. Fgf and Sdf-1 pathways interact during zebrafish fin regeneration. PLoS One 2009;4:e5824
  • Ngo HT, Leleu X, Lee J, et al. SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. Blood 2008;112:150–8
  • Benamar K, Geller EB, Adler MW. First in vivo evidence for a functional interaction between chemokine and cannabinoid systems in the brain. J Pharmacol Exp Ther 2008;325:641–5
  • Juarez J, Baraz R, Gaundar S, et al. Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia. Haematologica 2007;92:450–9
  • Ryser MF, Ugarte F, Lehmann R, et al. S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. Mol Immunol 2008;46:166–71
  • Valenzuela-Fernández A, Palanche T, Amara A, et al. Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans. J Biol Chem 2001;276:26550–8
  • Yuan L, Zhang H, Liu J, et al. Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration. Mol Cancer 2013;12:12–18
  • Xie J, Wang W, Si JW, et al. Notch signaling regulates CXCR4 expression and the migration of mesenchymal stem cells. Cell Immunol 2013;281:68–75
  • Li J, Liu S, Li W, et al. Vascular smooth muscle cell apoptosis promotes transplant arteriosclerosis through inducing the production of SDF-1α. Am J Transplant 2012;12:2029–43
  • Ahn IE, Ju JH, Lee SY, et al. Upregulation of stromal cell-derived factor by IL-17 and IL-18 via a phosphatidylinositol 3-kinase-dependent pathway. Scand J Immunol 2012;76:433–9
  • Asano S, Kitatani K, Taniguchi M, et al. Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway. Mol Cell Biol 2012;32:3242–52
  • Du MR, Zhou WH, Piao HL, et al. Cyclosporin A promotes crosstalk between human cytotrophoblast and decidual stromal cell through up-regulating CXCL12/CXCR4 interaction. Hum Reprod 2012;27:1955–65
  • Pan CH, Chen CW, Sheu MJ, et al. Salvianolic acid B inhibits SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor. Vascul Pharmacol 2012;56:98–105
  • Obermajer N, Muthuswamy R, Odunsi K, et al. PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. Cancer Res 2011;71:7463–70
  • Anjard C, Su Y, Loomis WF, et al. The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium. Eukaryot Cell 2011;10:956–63
  • Shanmugam MK, Manu KA, Ong TH, et al. Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. Int J Cancer 2011;129:1552–63
  • Hsu WH, Chen CN, Huang HI, et al. Urokinase induces stromal cell-derived factor-1 expression in human hepatocellular carcinoma cells. J Cell Physiol 2012;227:697–704
  • Santiago B, Calonge E, Del Rey MJ, et al. CXCL12 gene expression is upregulated by hypoxia and growth arrest but not by inflammatory cytokines in rheumatoid synovial fibroblasts. Cytokine 2011;53:184–90
  • Ryser MF, Ugarte F, Lehmann R, et al. S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. Mol Immunol 2008;46:166–71
  • McCandless EE, Budde M, Lees JR, et al. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. J Immunol 2009;183:613–20
  • Tamura M, Sato MM, Nashimoto M. Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells. Int J Biochem Cell Biol 2011;43:760–7
  • Leone V, D'Angelo D, Rubio I, et al. MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha. J Clin Endocrinol Metab 2011;96:E1388–98
  • Munk R, Ghosh P, Ghosh MC, et al. Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS One 2011;6:e24667
  • Seeger FH, Rasper T, Fischer A, et al. Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair. Circ Res 2012;111:854–62
  • Lee E, Han J, Kim K, et al. CXCR7 mediates SDF1-induced melanocyte migration. Pigment Cell Melanoma Res 2013;26:58–66
  • Young K, Conley B, Romero D, et al. BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood 2012;120:4263–73
  • Huang WS, Chen CN, Sze CI, et al. Visfatin induces stromal cell-derived factor-1 expression by β1 integrin signaling in colorectal cancer cells. J Cell Physiol 2013;228:1017–24
  • Torregroza I, Holtzinger A, Mendelson K, et al. Regulation of a vascular plexus by gata4 is mediated in zebrafish through the chemokine sdf1a. PLoS One 2012;7:e46844
  • Warner JA, Zwezdaryk KJ, Day B, et al. Human cytomegalovirus infection inhibits CXCL12-mediated migration and invasion of human extravillous cytotrophoblasts. Virol J 2012;9:255--64
  • Tu H, Zhou Z, Liang Q, et al. CXCR4 and SDF-1 production are stimulated by hepatocyte growth factor and promote glioma cell invasion. Onkologie 2009;32:331–6
  • Ceradini DJ, Kulkarni AR, Callaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004;10:858–64
  • Chen YY, Malik M, Tomkowicz BE, et al. BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells. Blood 2008;111:5182–6
  • Lin HH, Chen YH, Chiang MT, et al. Activator protein-2α mediates carbon monoxide- induced stromal cell-derived factor-1α expression andvascularization in ischemic heart. Arterioscler Thromb Vasc Biol 2013;33:785–94
  • Schiraldi M, Raucci A, Muñoz LM, et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 andsignaling via CXCR4. J Exp Med 2012;209:551–63
  • Zagzag D, Esencay M, Mendez O, et al. Hypoxia- and vascular endothelial growth factor- induced stromal cell-derived factor-1alpha/CXCR4 expression inglioblastomas: one plausible explanation of Scherer's structures. Am J Pathol 2008;173:545–60
  • Semerad CL, Christopher MJ, Liu F, et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 2005;106:3020–7
  • Berthebaud M, Rivière C, Jarrier P, et al. RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes. Blood 2005;106:2962–8
  • Charnaux N, Brule S, Hamon M, et al. Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/CXCL12. FEBS J 2005;272:1937–51
  • Luo Y, Cai J, Xue H, et al. SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors. Neurosci Lett 2006;398:291–5
  • Pan F, Ma S, Cao W, et al. SDF-1α upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines. Mol Biol Rep 2013;40:4139–46
  • Xue B, Wu W, Huang K, et al. Stromal cell-derived factor-1 (SDF-1) enhances cells invasion by αvβ6 integrin-mediated signaling in ovariancancer. Mol Cell Biochem 2013;380:177–84
  • Zhang D, Shao S, Shuai H, et al. SDF-1α reduces fibronectin expression in rat mesangial cells induced by TGF-β1 and high glucose throughPI3K/Akt pathway. Exp Cell Res 2013;319:1796–803
  • Herberg S, Shi X, Johnson MH, et al. Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derivedmesenchymal stem cells. PLoS One 2013;8:e58207
  • Li W, Kohara H, Uchida Y, et al. Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell 2013;24:359–71
  • Tung SY, Chang SF, Chou MH, et al. CXC chemokine ligand 12/stromal cell-derived factor- 1 regulates cell adhesion in human colon cancer cells byinduction of intercellular adhesion molecule-1. J Biomed Sci 2012;19:91–8
  • Singh AP, Arora S, Bhardwaj A, et al. CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions. J Biol Chem 2012;287:39115–24
  • Zhao HB, Tang CL, Hou YL, et al. CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells. PLoS One 2012;7:e38375
  • Heinrich EL, Lee W, Lu J, et al. Chemokine CXCL12 activates dual CXCR4 and CXCR7- mediated signaling pathways in pancreatic cancer cells. J Transl Med 2012;10:68–73
  • Liu X, Duan B, Cheng Z, et al. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell 2011;2:845–54
  • Liu G, Lu P, Li L, et al. Critical role of SDF-1α-induced progenitor cell recruitment and macrophage VEGF production in the experimentalcorneal neovascularization. Mol Vis 2011;17:2129–38
  • Chen HT, Tsou HK, Hsu CJ, et al. Stromal cell-derived factor-1/CXCR4 promotes IL-6 production in human synovial fibroblasts. J Cell Biochem 2011;112:1219–27
  • Monterrubio M, Mellado M, Carrera AC, et al. PI3Kgamma activation by CXCL12 regulates tumor cell adhesion and invasion. Biochem Biophys Res Commun 2009;388:199–204
  • Pi X, Wu Y, Ferguson JE III, et al. SDF-1alpha stimulates JNK3 activity via eNOS- dependent nitrosylation of MKP7 to enhance endothelial migration. Proc Natl Acad Sci U S A 2009;106:5675–80
  • Matsushita Y, Ohya S, Suzuki Y, et al. Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1alpha in Jurkat T cells. Am J Physiol Cell Physiol 2009;296:C1079–85
  • Hernandez L, Smirnova T, Kedrin D, et al. The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res 2009;69:3221–7
  • Lu DY, Tang CH, Yeh WL, et al. SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia. Eur J Pharmacol 2009;613:146–54
  • Lai TH, Fong YC, Fu WM, et al. Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells. J Cell Physiol 2009;218:334–42
  • Luo Y, Lathia J, Mughal M, et al. SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons. J Biol Chem 2008;283:24789–800
  • Scupoli MT, Donadelli M, Cioffi F, et al. Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways. Haematologica 2008;93:524–32
  • Huang YC, Hsiao YC, Chen YJ, et al. Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-kappaB-dependent pathway in human lung cancer cells. Biochem Pharmacol 2007;74:1702–12
  • Chalasani SH, Sabol A, Xu H, et al. Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. J Neurosci 2007;27:973–80
  • Luo C, Pan H, Mines M, et al. CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis. J Biol Chem 2006;281:30081–93
  • Zhao D, Li XP, Gao M, et al. Stromal cell-derived factor 1alpha stimulates human endometrial carcinoma cell growth through the activation of both extracellular signal- regulated kinase 1/2 and Akt. Gynecol Oncol 2006;103:932–7
  • Bartolomé RA, Molina-Ortiz I, Samaniego R, et al. Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res 2006;66:248–58
  • Chinni SR, Sivalogan S, Dong Z, et al. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. Prostate 2006;66:32–48
  • Wang JF, Park IW, Groopman JE. Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood 2000;95:2505–13
  • Nicolai J, Burbassi S, Rubin J, et al. CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. Cell Death Dis. 2010;1:e33
  • Hosogane N, Huang Z, Rawlins BA, et al. Stromal derived factor-1 regulates bone morphogenetic protein 2-induced osteogenic differentiation of primarymesenchymal stem cells. Int J Biochem Cell Biol 2010;42:1132–41
  • Yin Q, Jin P, Liu X, et al. SDF-1α inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways. Mol Biol Rep 2011;38:9–16
  • Huang CY, Lee CY, Chen MY, et al. Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. J Cell Physiol 2009;221:204–12
  • Heinisch S, Kirby LG. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology 2010;58:501–14
  • Guyon A, Skrzydelski D, Rovère C, et al. Stromal-cell-derived factor 1alpha/CXCL12 modulates high-threshold calcium currents in rat substantia nigra. Eur J Neurosci 2008;28:862–70
  • Wendt MK, Drury LJ, Vongsa RA, et al. Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. Gastroenterology 2008;135:508–17
  • Gao H, Priebe W, Glod J, et al. Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium. Stem Cells 2009;27:857–65
  • Rehman AO, Wang CY. CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex. Int J Oral Sci 2009;1:105–18
  • Ping YF, Yao XH, Jiang JY, et al. The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling. J Pathol 2011;224:344–54
  • Rehman AO, Wang CY. SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB. J Biol Chem 2008;283:19888–94
  • Chinni SR, Yamamoto H, Dong Z, et al. CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. Mol Cancer Res 2008;6:446–57
  • Tögel F, Isaac J, Hu Z, et al. Renal SDF-1 signals mobilization and homing of CXCR4- positive cells to the kidney after ischemic injury. Kidney Int 2005;67:1772–84
  • Oliver JA, Maarouf O, Cheema FH, et al. SDF-1 activates papillary label-retaining cells during kidney repair from injury. Am J Physiol Renal Physiol 2012;302:F1362–73
  • Stokman G, Stroo I, Claessen N, et al. SDF-1 provides morphological and functional protection against renal ischaemia/reperfusion injury. Nephrol Dial Transplant 2010;25:3852–9
  • Liu N, Patzak A, Zhang J. CXCR4-overexpressing bone marrow-derived mesenchymal stem cells improve repair of acute kidney injury. Am J Physiol Renal Physiol 2013 [Epub ahead of print]
  • Wang L, Chen W, Gao L, et al. High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma. World J Surg Oncol 2012;10:212--20
  • Wang L, Huang T, Chen W, et al. Silencing of CXCR4 by RNA interference inhibits cell growth and metastasis in human renal cancer cells. Oncol Rep 2012;28:2043–8
  • Wang L, Wang L, Yang B, et al. Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis. Clin Exp Metastasis 2009;26:1049–54
  • Vielhauer V, Anders HJ, Schlöndorff D. Chemokines and chemokine receptors as therapeutic targets in lupus nephritis. Semin Nephrol 2007;27:81–97
  • Gao C, Huan J. SDF-1 plays a key role in chronic allograft nephropathy in rats. Transplant Proc 2008;40:1674–78
  • Balabanian K, Couderc J, Bouchet-Delbos L, et al. Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus. J Immunol 2003;170:3392–400
  • Petruzziello-Pellegrini TN, Yuen DA, Page AV, et al. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice. J Clin Invest 2012;122:759–76

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