The Visualization of Neuronal Benzodiazepine Receptors in the Brain by Autoradiography and Immunohistochemistry

References

• Haefely W. The biological basis of benzodiazepine actions. The benzodiazepines today - two decades of research and clinical experience. J. Psychoact. Drugs 1983; 15: 19–39
   PubMed Web of Science ®Google Scholar
• Möhler H., Richards J. G. Receptors for anxiolytic drugs. Anxiolytics : Neurochemical, Behavioural and Clinical Perspectives, J. B. Malick, S. J. Enna, H. I. Yamamura. Raven Press, New York 1983; 15–40
   Google Scholar
• Braestrup C., Nielsen M. Benzodiazepine receptors. Handbook of Psychopharmacology, L. L. Iversen, S. D. Iversen, S. H. Snyder. Plenum Press, New York 1983; 17: 285–294
   Google Scholar
• Haefely W., Kyburz E., Gerecke M., Möhler H. Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure-activity relationship of their agonists and antagonists. Advances in Drug Res., in press
   Google Scholar
• Haefely W., Polc P., Pieri L., Schaffner R., Laurent J. P. Neuropharmacology of benzodiazepines : synaptic mechanisms and neural basis of action. The Benzodiazepines : From Molecular Biology to Clinical Practice, E. Costa. Raven Press, New York 1983; 21–66
   Google Scholar
• Polc P., Bonetti E. P., Schaffner R., Haefely W. A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, β-carbolines and phenobarbitone. Naunyn-Schmiedeberg's Arch.Pharmacol. 1982; 321: 260–264
   Google Scholar
• Haefely W. Pharmacological profile of two benzodiazepine partial agonists : Ro 16-6028 and Ro 17-1812. Clinical Neuropharmacology, in press
   Google Scholar
• Barker J. L., Gratz E., Owen D. G., Study R. E. Pharmacological effects of clinically important drugs on the excitability of cultured mouse spinal neurons. Actions and Interactions of GABA and Benzodiazepines, N. G. Bowery. Raven Press, New York 1984; 203–216
   Google Scholar
• Wamsley J. K., Palacios J. M. Receptor mapping by histo-chemistry. Handbook of Neurochemistry 2nd, A. Lajtha, 1983; 2: 27–51
   Google Scholar
• Young W. S., III, Kuhar M. J. A new method for receptor auto-radiography : [3H]opioid receptors in rat brain. Brain Res. 1979; 179: 255–270
   PubMed Web of Science ®Google Scholar
• Palacios J. M. Receptor autoradiography : the last ten years, this volume. 1984
   Google Scholar
• Pazos A., Cortés R., Palacios J. M. Quantitative receptor autoradiography : application to the characterization of multiple receptor subtypes, this volume. 1984
   Google Scholar
• Young W. S., III, Kuhar M. J. The light microscopic radio-histochemistry of drug and neurotransmitter receptors using diffusible ligands. Current Trends in Morphological Techniques, J. E. Johnson. C.R.C. Press, Boca Raton, Florida 1981; 119–136
   Google Scholar
• Herkenham M., Pert C. Light microscopic localization of brain opiate receptors : a general autoradiographic method which preserves tissue quality. J.Neurosci. 1982; 2: 1129–1149
   PubMed Web of Science ®Google Scholar
• Rainbow T. C., Bleisch W., Biegon A., McEwen B. S. Quantitative densitometry of neurotransmitter receptors. J. Neurosci. Methods 1982; 5: 127–138
   PubMed Web of Science ®Google Scholar
• Penney J. B., Pan H. S., Young A. B., Frey K. A., Dauth G. W. Quantitative autoradiography of [3H]muscimol binding in rat brain. Science 1981; 214: 1036–1038
   PubMed Web of Science ®Google Scholar
• Young W. S., III, Kuhar M. J. Radiohistochemical localization of benzodiazepine receptors in rat brain. J.Pharm.Exp.Ther. 1980; 212: 337–346
   PubMed Web of Science ®Google Scholar
• Schoch P., Richards J. G., Häring P., Takacs B., Stähli C., Staehelin T., Haefely W., Möhler H. A purified GABA/benzodiazepine receptor : immunohistochemistry and structural analysis with monoclonal antibodies, in preparation
   Google Scholar
• Richards J. G., Möhler H. Benzodiazepine receptors and their ligands. Mechanisms of Drug Action, G. N. Woodruff. Macmillan Press, in press
   Google Scholar
• Roberts E. Interrelationships of GABA neurons explored by immunocytochemical techniques. Interactions between putative neurotransmitters in the brain, S. Garattini, J. F. Pujol, R. Samanin. Raven Press, New York 1978; 89–107
   Google Scholar
• Möhler H., Okada T., Heitz Ph., Ulrich J. Biochemical identification of the site of action of benzodiazepines in human brain by 3H-diazepam binding. Life Sci. 1978; 22: 985–986
   PubMed Web of Science ®Google Scholar
• Möhler H., Okada T. Benzodiazepine receptors : demonstration in the central nervous system. Science 1977; 198: 849–851
   PubMed Web of Science ®Google Scholar
• Squires R. R., Braestrup C. Benzodiazepine receptors in rat brain. Nature 1977; 266: 732–734
   PubMed Web of Science ®Google Scholar
• Richards J. G., Möhler H. Benzodiazepine receptors. Neuropharmacology 1984; 23: 233–242
   PubMed Web of Science ®Google Scholar
• Ribak C. E., Vaughn J. E., Saito K., Barber R., Roberts E. Glutamate decarboxylase localization in neurons of the olfactory bulb. Brain Res. 1977; 126: 1–18
   PubMed Web of Science ®Google Scholar
• Ishikawa K., Watabe S., Goto N. Laminal distribution of γ-aminobutyric acid (GABA) in the occipital cortex of rats : evidence as a neurotransmitter. Brain Res. 1983; 277: 361–364
   PubMed Web of Science ®Google Scholar
• Fallon J. H., Loughlin S. E., Ribak C. E. The islands of Calleja complex of rat basal forebrain. III. Histochemical evidence for a striato-pallidal system. J.Comp. Neurol. 1983; 218: 91–120
   PubMed Web of Science ®Google Scholar
• Ribak C. E., Vaughn J. E., Saito K. Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport. Brain Res. 1978; 140: 315–332
   PubMed Web of Science ®Google Scholar
• Ribak C. E., Vaughn J. E., Saito K., Barber R., Roberts E. Immunocytochemical localization of glutamate decarboxylase in rat substantia nigra. Brain Res. 1976; 116: 287–298
   PubMed Web of Science ®Google Scholar
• Young W. S., III, Kuhar M. J. Autoradiographic localization of benzodiazepine receptors in the brains of humans and animals. Nature 1979; 280: 393–395
   Web of Science ®Google Scholar
• Niehoff D. L., Whitehouse P. J. Multiple benzodiazepine receptors : autoradiographic localization in normal human amygdala. Brain Res. 1983; 276: 237–245
   PubMed Web of Science ®Google Scholar
• Palacios J. M., personal communication
   Google Scholar
• Palacios J. M., Young W. S., III, Kuhar M. Autoradiographic localization of γ-aminobutyric acid (GABA) receptors in the rat cerebellum. Proc.Natl.Acad.Sci. USA 1980; 77: 670–674
   PubMed Web of Science ®Google Scholar
• Palacios J. M., Wamsley J. J., Kuhar M. J. High affinity GABA receptors - Autoradiographic localization. Brain Res. 1981; 222: 285–307
   PubMed Web of Science ®Google Scholar
• Wamsley J. K., Gee K. W., Yamamura H. I. Comparison of the distribution of convulsant/barbiturate and benzodiazepine receptors using light microscopic autoradiography. Life Sci. 1983; 33: 2321–2329
   PubMed Web of Science ®Google Scholar
• Möhler H., Richards J. G. Agonist and antagonist benzodiazepine receptor interaction in vitro. Nature 1981; 294: 763–764
   PubMed Web of Science ®Google Scholar
• Honoré T., Nielsen M., Braestrup C. Barbiturate shift as a tool for determination of efficacy of benzodiazepine-receptor ligands. Eur.J.Pharmac. 1984; 100: 103–107
   PubMed Web of Science ®Google Scholar
• Unnerstall J. R., Kuhar M. J., Niehoff D. L., Palacios J. M. Benzodiazepine receptors are coupled to a subpopulation of γ-aminobutyric acid (GABA) receptors: evidence from a quantitative autoradiographic study. J.Pharm.Exp.Ther. 1981; 218: 797–804
   PubMed Web of Science ®Google Scholar
• Chang R. S.L., Snyder S. H. Benzodiazepine receptors: labeling in intact animals with [3H]flunitrazepam. Eur.J.Pharmac. 1978; 48: 213–218
   PubMed Web of Science ®Google Scholar
• Williamson M. J., Paul S. M., Skolnick P. Demonstration of [3H]diazepam binding to benzodiazepine receptors in vivo. Life Sci. 1978; 23: 1935–1940
   PubMed Web of Science ®Google Scholar
• Mennini T., Garattini S. Benzodiazepines receptor binding in vivo: pharmacokinetic and pharmacological significance. Benzodiazepine Recognition Site Ligands: Biochemistry and Pharmacology, G. Biggio, E. Costa. Raven Press, New York 1983; 189–199
   Google Scholar
• Hunt P., Husson J.-M., Raynaud J.-P. A radioreceptor assay for benzodiazepines. J.Pharm.Pharmac. 1979; 31: 448–451
   PubMed Web of Science ®Google Scholar
• Lund J. Radioreceptor assay for benzodiazepines in biological fluids using a new drug and stable receptor preparation. Scand. J.Clin.Lab.Invest. 1981; 41: 275–280
   PubMed Web of Science ®Google Scholar
• Möhler H., Battersby M. K., Richards J. G. Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label. Proc.Natl.Acad.Sci. USA. 1980; 77: 1666–1670
   PubMed Web of Science ®Google Scholar
• Möhler H., Richards J. G., Wu J.-Y. Autoradiographic localization of benzodiazepine receptors in immunocytochemically identified γ-aminobutyrergic synapses. Proc.Natl.Acad.Sci. USA 1981; 78: 1935–1938
   PubMed Web of Science ®Google Scholar
• Möhler H., Sieghart W., Richards J. G., Hunkeler W. Photoaffinity labeling of benzodiazepine receptors with a partial inverse agonist. Eur.J.Pharmacol., in press
   Web of Science ®Google Scholar
• Comar D., Mazière M., Cepeda C., Godot J.-M., Meinini C., Naquet R. The kinetics and displacement of [11C]flunitrazepam in the brain of the living baboon. Eur.J.Pharmac. 1981; 75: 21–26
   PubMed Web of Science ®Google Scholar
• Mazière M., Prenant Ch., Sastre J., Crouzet M., Comar D., Hantraye P., Kaisima M., Guibert B., Naquet R. 11C-Ro 15-1788 et 11C-flunitrazepam, deux coordinats pour 1'étude par tomographie par positrons des sites de liaison des benzodiazépines. C.R. Acad.Sc. Paris, T.296 Série 1983; 111: 871–876
   Google Scholar
• Mintum M. A., Raichlle M. E., Kilbourn M. R., Wooten G. F., Welch M. J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol. 1984; 15: 217–227
   PubMed Web of Science ®Google Scholar
• Schoch P., Möhler H. Purified benzodiazepine receptor retains modulation by GABA. Eur.J.Pharmacol. 1983; 95: 323–324
   PubMed Web of Science ®Google Scholar
• Schoch P., Häring P., Takacs B., Stähli C., Möhler H. A GABA/benzodiazepine complex from bovine brain: purification, reconstitution and immunological characterization (this volume)
   Google Scholar
• Sigel E., Stephenson F. A., Mamalaki C., Barnard E. A. A γ-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex: purification and partial characterization. J.Biol.Chem. 1983; 258: 6965–6969
   PubMed Web of Science ®Google Scholar
• Sigel E., Stephenson F. A., Mamalaki C., Barnard E. A. The purified GABA/benzodiazepine/barbiturate receptor complex: four types of ligand-binding sites, and the interactions between them, are preserved in a single isolated protein complex (this volume)
   Google Scholar
• Häring P., Stähli C., Schoch P., Takacs B., Staehelin T., Möhler H. Characterization of the brain GABA/benzodiazepine receptor with monoclonal antibodies, in preparation
   Google Scholar