6
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Insulin Receptor Sub-Types in a Human Lymphoid-Derived Cell Line (IM-9): Differential Regulation by Insulin, Dexamethasone and Monensin

&
Pages 813-829 | Published online: 26 Sep 2008

References

  • Jonas H. A., Newman J. D., Harrison L. C. An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors. Proc. Natl. Acad. Sci. USA. 1986; 83: 4124–4128
  • Jonas H. A., Cox A. J., Harrison L. C. Delineation of atypical receptors from classical insulin and type I IGF receptors in human placenta. Biochem. J. 1989; 257: 101–108
  • Jonas H. A., Cox A. J. Insulin-like growth factor binding to the atypical insulin receptors of a human lymphoid-derived cell line (IM-9). Biochem. J. 1990; 266: 737–742
  • Hintz R. L., Thorsson A. V., Enberg G., Hall K. IGF-II binding on human lymphoid cells: demonstration of a common high affinity receptor for insulin-like peptides. Biochem. Biophys. Res. Commun. 1984; 118: 774–782
  • Tollefsen S. E., Thompson K., Petersen D. J. Separation of the high affinity insulin-like growth factor I receptor from low affinity binding sites by affinity chromatography. J. Biol. Chem. 1987; 262: 16461–16469
  • Misra P., Hintz R. L., Rosenfeld R. Structural and immunological characterization of insulin-like growth factor II binding to IM-9 cells. J. Clin. Endocrinol. Metab. 1986; 63: 1400–1405
  • Soos M. A., Siddle K. Immunological relationships between receptors for insulin and insulin-like growth factor I: evidence for structural heterogeneity of insulin of insulin-like growth factor I receptors involving hybrids with insulin receptors. Biochem. J. 1989; 263: 553–563
  • Jonas H. A. Heterogeneity of receptors for insulin and insulin-like growth factor I: evidence for receptor sub-types. Receptor Biochemistry and Methodology, J. C. Venter, L. C. Harrison. Alan R. Liss, New York 1988; vol. 12B: 19–36
  • Jonas H. A., Eckardt G. S., Clark S. Expression of atypical and classical insulin receptors in Chinese hamster ovary cells transfected with cloned cDNA for the human insulin receptor. Endocrinology 1990; 127: 1301–1309
  • Kosmakos F. C., Roth J. Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. J. Biol. Chem. 1980; 255: 9860–9869
  • Rosenfeld R. G., Hintz R. L., Dollar L. A. Insulin-induced loss of insulinlike growth factor I Receptors on IM-9 lymphocytes. Diabetes 1982; 31: 375–381
  • Kasuga M., Kahn C. R., Hedo J. A., Van Obberghen E., Yamada K. M. Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc. Natl. Acad. Sci. USA. 1981; 78: 6917–6921
  • Fantus I. G., Saviolakis G. A., Hedo J. A., Gorden P. Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes. J. Biol. Chem. 1982; 257: 8277–8283
  • McDonald A. R., Maddux B. A., Okabayashi Y., Wong K. Y., Hawley D. M., Logsdon C. D., Goldfine I. D. Regulation of insulin-receptor mRNA levels by glucocorticoids. Diabetes, 36: 779–781
  • Jacobs S., Kull F. C., Cuatrecasas P. Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors. Proc. Natl. Acad. Sci. USA., 80: 1228–1231
  • Carpentier J-L., Dayer J-M., Lang U., Silverman R., Orci L., Gorden P. Down-regulation and recycling of insulin receptors. effect of monensin on IM-9 lymphocytes and U-937 monocyte-like cells. J. Biol. Chem. 1984; 259: 14190–14195
  • Scatchard G. The attraction of proteins for small molecules and ions. Ann. NY. Acad Sci. 1949; 51: 660–672
  • Svoboda M. E., Van Wyk J. J., Klapper D. G., Fellows R. E., Grissom F. E., Schlueter R. J. Purification of somatomedin C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins. Biochemistry 1980; 19: 790–797
  • Thompson M. A., Cox A. J., Whitehead R. H., Jonas H. A. Autocrine regulation of human tumor cell proliferation by insulin-like growth factor II: an in-Vitro model. Endocrinology 1990; 126: 3033–3042
  • Baxter R. C., De Mellow J. S.M. Measurement of insulin-like growth factor-II by radioreceptor assay using ovine placental membranes. Clin. Endocrinol. 1986; 24: 267–278
  • Munson P. J., Rodbard D. LIGAND: A versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 1980; 107: 220–239
  • Wardzala L. J., Simpson I. A., Rechler M. M., Cushman S. W. Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. J. Biol. Chem. 1984; 259: 8378–8883
  • Rechler M. M., Nissley S. P. The nature and regulation of the receptors for insulin-like growth factors. Annu. Rev. Physiol. 1985; 47: 425–442
  • Rouiller D. G., McElduff A., Hedo J. A., Gorden P. Induction of the insulin proreceptor by hydrocortisone in cultured lymphocytes (IM-9 line). J. Clin. Invest. 1985; 76: 645–649
  • Maassen J. A., Krans H. M. J., Möller W. The effect of insulin, serum and dexamethasone on mRNA levels for the insulin receptor in the human lymphoblastoic cell line IM-9. Biochim. Biophys. Acta 1987; 930: 72–78
  • McDonald A. R., Goldfine I. D. Glucocorticoid regulation of insulin receptor gene transcription in IM-9 lymphocytes. J. Clin. Invest. 1988; 81: 499–504
  • Rouiller D. G., McKeon C., Taylor S. I., Gorden P. Hormonal regulation of insulin receptor gene expression. Hydrocortisone and insulin act by different mechanisms. J. Biol. Chem. 1988; 263: 13185–13190
  • Rouiller D. G., Gorden P. Homologous down-regulation of the insulin receptor is associated with increased receptor biosynthesis in cultured human lymphocytes. Proc. Natl. Acad. Sci. USA. 1987; 84: 126–130
  • Crettaz M., Kahn C. R. Insulin receptor regulation and desensitization in rat hepatoma cells. Concomitant changes in receptor number and in binding affinity. Diabetes 1984; 33: 477–485

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.