Genetic Effects of Marijuana

References

• The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects, S. Agurell, W. L. Dewey, R. E. Willette. Academic Press., Orlando 1984
   Google Scholar
• Agurell S., Gillespie H., Halldin M., Hollister L. E., Johansson E., Lindgren J. E., Ohlsson A., Szirmai M., Widen M. A review of recent studies on the pharmacokinetics and metabolism of delta-1-tetrahydro-cannabinal, cannabidiol and cannabinol in man. Marihuana, D. J. Harvey. IRL Press., Oxford 1985; 84: 49–62
   Google Scholar
• Ashby J. Screening chemicals for mutagenicity: Practices and pitfalls. Mutagenicity: New Horizons in Genetic Toxicology, J. A. Heddle. Academic Press., Orlando 1982; 1–33
   Google Scholar
• Blevins R. D., Regan J. D. 9Tetrahydrocannabinol. Effect on macro-molecular synthesis in human and other mammalian cells. Arch. Toxicol 1976; 35: 127–135
   PubMed Web of Science ®Google Scholar
• Braude D. Pharmacology of Marihuana, M. C. Braude, S. Szara. Raven Press., New York 1976; 1 and 2
   Google Scholar
• Braude M.C. Genetic and Perinatal Effects of Abused Substances, M. C. Braude, A. M. Zimmerman. Academic Press., Orlando 1987
   Google Scholar
• Busch F. W., Seid D. A., Wei E. T. Mutagenic activity of marihuana smoke codensates. Cancer Lett. 1979; 6: 319–324
   PubMed Web of Science ®Google Scholar
• Carchman R. A., Harris L. S., Munson A. E. The inhibition of DNA synthesis by cannabinoids. Cancer Res. 1976; 36: 95–100
   PubMed Web of Science ®Google Scholar
• Chiesara E., Cutrufello R., Rizzi R. Chromosome damage in heroin-marijuana and marijuana addicts. Arch. Toxicol. Suppl. 1983; 6: 128–130
   PubMedGoogle Scholar
• Dalterio S., Badr F., Bartke A., Mayfield D. Cannabinoids in male mice: Effects on fertility and spermatogenesis. Science 1982; 216: 315–316
   PubMed Web of Science ®Google Scholar
• Dorrance D., Janiger O., Teplitz R. L. In vivo effects of illicit hallucinogens on human lymphocyte chromosomes. J. Am. Med. Assoc. 1970; 212: 1488–1491
   PubMed Web of Science ®Google Scholar
• Freireich E. J., Gehan E. A., Rall D. P., Schmidt L. H., Skipper H. E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother. Rep. 1966; 50: 219–244
   PubMedGoogle Scholar
• Gaoni Y., Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J. Am. Chem. Soc. 1964; 86: 1646–1647
   Web of Science ®Google Scholar
• Generoso W. M., Cain K. T., Cornett C. V., Shelby M. D. Tests for induction of dominant-lethal mutations and heritable translocations with Δ9-tetra-hydrocannabinol in male mice. Mutat. Res. 1985; 143: 51–53
   PubMed Web of Science ®Google Scholar
• Gilmour D. G., Blood A. D., Lele K. P., Robbins E. S., Maximilian C. Chromosomal aberrations in users of psychoactive drugs. Arch. Gen. Psychiatry 1971; 24: 268–272
   PubMed Web of Science ®Google Scholar
• Harvey D. J. Chemistry, metabolism, and pharmacokinetics of the cannabinoids. Marihuana in Science and Medicine, G. G. Nahas. Raven Press., New York 1984; 37–107
   Google Scholar
• Braude D. Marihuana 84, D. J. Harvey. IRL Press., Oxford 1985
   Google Scholar
• Heddle J. A. A rapid in vivo test for chromosomal damage. Mutat. Res. 1973; 18: 187–190
   PubMed Web of Science ®Google Scholar
• Heddle J. A., Bruce W. R. On the use of multiple assays for mutagenicity, especially the micronucleus, Salmonella, and sperm abnormality assays. Progress in Genetic Toxicology, D. Scott, B. A. Bridges, F. H. Sobel. Elsevier/North-Holland., New York 1977; 265–274
   Google Scholar
• Henrich R. T., Nogawa T., Morishima A. In vitro induction of segregational errors of chromosomes by natural cannabinoids in normal human lymphocytes. Environ. Mutgenesis 1980; 2: 139–147
   Google Scholar
• Herha J., Obe G. Chromosomal damage in chronic users of cannabis: In vivo investigation with two-day lymphocyte cultures. Pharmakopsychiatrie 1974; 7: 328–337
   Google Scholar
• Hoffmann D., Brunnemann K. D., Gori G. B., Wynder E. L. On the carcinogenicity of marijuana smoke. Recent Advances in Phytochemistry, V. C. Runeckles. Plenum., New York 1975; 63–86
   Google Scholar
• Issidorides M. R. Observations in chronic hashish users: Nuclear aberrations in blood and sperm and abnormal acrosomes in spermatosa. Marihuana: Biological Effects, G. G. Nahas, W.D.M. Paton. Pergamon., New York 1979; 377–388
   Google Scholar
• Kolodny R. C., Masters W. H., Kilodner R. M., Toro G. Depression of plasma testosterone levels after chronic intensive marijuana use. N. Engl. J. Med. 1974; 290: 872–874
   PubMed Web of Science ®Google Scholar
• Legator M. S., Au W. W. Need to reassess the genetic toxicology of drugs of abuse. Genetic and Perinatal Effects of Abused Substances, M. C. Braude, A. M. Zimmerman. Academic Press., Orlando 1987; 3–26
   Google Scholar
• Legator M. S., Weber E., Connor T., Stoeckel M. Failure to detect mutagenic effects of Δ9-tetrahydrocannabinol in the dominant-fethal test, host-mediated assay, blood urine studies and cytogenetic evaluation with mice. Pharmacology of Marihuana, M. C. Braude, S. Szara. Raven., New York 1976; 699–709
   Google Scholar
• Leuchtenberger C., Leuchtenberger R., Schneider A. Effects of marihuana and tobacco smoke on human lung physiology. Nature (London) 1973a; 241: 137–139
   PubMed Web of Science ®Google Scholar
• Leuchtenberger C., Leuchtenberger R., Ritter U., Inui H. Effects of marihuana and tobacco smoke on DNA and chromosomal complement in human lung explants. Nature (London) 1973b; 242: 403–404
   PubMed Web of Science ®Google Scholar
• Leuchtenberger C., Leuchtenberger R., Chapus L. Difference in response to vitamin C between marihuana and tobacco smoke exposed human cell cultures. Marihuana: Biological Effects, G. G. Nahas, W.D.M. Paton. Pergamon., Oxford 1979; 209–218
   Google Scholar
• Mc Clean D. K., Zimmerman A. M. Action of Δ9-tetrahydrocannabinol on cell division and macromolecular synthesis in division-synchronized protozoa. Pharmacology 1976; 14: 317–321
   Web of Science ®Google Scholar
• Martin P. A., Throburn M. J., Bryant S. A. In vivo and in vitro studies on the cytogenetic effects of Cannabis sativa in rats and men. Teratology 1974; 9: 81–85
   PubMedGoogle Scholar
• Matsuyama S. S., Yen F. S., Jarvik L. F., Sparkes R. S., Fu T. K., Fisher H., Reccius N., Frank I. M. Marihuana exposure in vivo and human lymphocyte chromosomes. Mutat. Res. 1977; 48: 255–266
   PubMed Web of Science ®Google Scholar
• Mechoulam R. Cannabinoid chemistry. Marihuana: Chemistry, Pharmacology, Metabolism and Chemical Effects, R. Mechoulam. Academic Press., New York 1973; 1–99
   Google Scholar
• Mon M. J., Jansing R. L., Doggett S., Stein J. L., Stein G. S. Influence of Δ9-Tetrahydrocannabinol on cell proliferation and macromolecular biosynthesis in human cells. Biochem. Pharmacol 1978; 27: 1759–1765
   PubMed Web of Science ®Google Scholar
• Mon M. J., Haas A. E., Stein J. L., Stein G. S. Influence of psychoactive and nonpsychoactive cannabinoids on cell proliferation and macromolecular biosynthesis in human cells. Biochem. Pharmacol. 1981a; 30: 31–43
   PubMed Web of Science ®Google Scholar
• Mon M. J., Haas A., Stein J. L., Stein G. S. Influence of psychoactive and nonpsychoactive cannabinoids on chromatin structure and function in human cells. Biochem. Pharmacol. 1981b; 30: 45–58
   PubMed Web of Science ®Google Scholar
• Morishima A. Effects of cannabis and natural cannabinoids on chromosomes and ova. Marijuana Effects on the Endocrine and Reproductive Systems, M. C. Braude, J. P. Ludford. NIDA Res. Monogr. 1984; 44: 25–45
   Google Scholar
• Morishima A., Henrich R. T., Jou S., Nahas G. G. Errors of chromosome segregation induced by olivetol, a compound with the structure of C-ring common to cannabinoids: Formation of bridges and multipolar divisions. Marihuana: Chemistry, Biochemistry and Cellular Effects, G. G. Nahas, W. D.M. Patton, J. E. Idanpaan-Heikkila. Springer-Verlag., Berlin and New York 1976a; 265–271
   Google Scholar
• Morishima A., Milstein M. M., Henrich R. T., Nahas G. G. Effects of marihuana smoking cannabinoids and olivetol on replication of human lymphocytes: Formation of micronuclei. Pharmacology of Marihuana, M. C. Braude, S. Szara. Raven., New York 1976b; 2: 711–722
   Google Scholar
• Morishima A., Henrich R. T., Jayaraman J., Nahas G. G. Hypoploid metaphases in cultured lymphocytes of marihuana smokers. Marihuana: Biological Effects, G. G. Nahas, W. D. Paton. Pergamon., Oxford 1979; 371–376
   Google Scholar
• Braude D. Marihuana: Biological Effects, G. G. Nahas, W.D.M. Patton. Pergamonn Press., Oxford 1919
   Google Scholar
• Nahas G. G., Paton W. D.M., Idanpaan-Heikkila J. E. Marihuana Chemistry, Biochemistry and Cellular Effects. Springer-Verlag, New York 1976
   Google Scholar
• Nichols W. W., Miller R. C., Heneen W., Bradt C., Hollister L., Kanter S. Cytogenetic studies on human subjects receiving marihuana and Δ9-tetrahydrocannabinol. Mutat. Res. 1974; 26: 413–417
   PubMed Web of Science ®Google Scholar
• Palmer S. L., Meyerhof G., Zimmerman A. M. Effects of Δ9-tetrahydrocannabinol on some aspects of mitotic organization. J. Cell Biol. 1981; 91((2)), Part 2: 319a (Abstr.)
   Web of Science ®Google Scholar
• Rosenkrantz H. The immune response and marihuana. Marihuana, Chemistry Biochemistry and Cellular Effects, G. G. Nahas, W.D.M. Paton, J. E. Idanpaan-Heikkila. Springer-Verlag., New York 1976; 441–456
   Google Scholar
• Rosenkrantz H., Fleischman R. W. Effects of cannabis on the lungs. Marihuana: Biological Effects, G. G. Nahas, W.D.M. Paton. Pergamon., New York 1979; 279–299
   Google Scholar
• Seid D. A., Wei E. T. Mutagenic activity of marihuana smoke condensates. Pharmacologist 1979; 21: 204
   Google Scholar
• Stein G. S., Stein J. L. Effects of cannabinoids on gene expression. Marijuana Effects on the Endocrine and Reproductive Systems, M. C. Braude, J. P. Ludford. NIDA Res. Monogr. 1984; 44: 5–24
   Google Scholar
• Stein G., Stein J., Green L. Applications of molecular genetics to cannabinoid research. Genetic and Perinatal Effects of Abused Substances, M. C. Braude, A. M. Zimmerman. Academic Press., Orlando 1987; 69–93
   Google Scholar
• Stenchever M. A., Allen M. The effect of delta-9-tetrahydrocannabinol on the chromosomes of human lymphocytes in vitro. Am. J. Obsete. Gynecol. 1972; 114: 819–821
   PubMed Web of Science ®Google Scholar
• Stenchever M. A., Kunysz T. J., Allen M. A. Chromosome breakage in users of marihuana. Am. J. Obstet. Gynecol. 1974; 118: 106–113
   PubMed Web of Science ®Google Scholar
• Stenchever M. A., Parks K. J., Stenchever M. R. Effects of Δ8-tetrahydrocannabinol, Δ9-tetrahydrocannabinol, and crude marihuana on human cells in tissue culture. Marihuana: Chemistry, Biochemistry and Cellular Effects, G. G. Nahas. Springer-Verlag., New York 1976; 257–263
   Google Scholar
• Thomas J., Tilak S., Zimmerman S., Zimmerman A. M. Action of Δ9-tetrahydrocannabinol on the pool of acid soluble nucleotides. Cytobios 1984; 40: 71–85
   PubMedGoogle Scholar
• Tilak S. K., Zimmerman A. M. Effects of cannabinoids on macromolecular synthesis in isolated spermatogenic cells. Pharmacology 1984; 29: 343–350
   PubMed Web of Science ®Google Scholar
• Turner C. E. Marihuana and cannabis: Research, why the conflict. Marihuana, D. J. Harvey. IRL Press., Oxford 1985; 82: 31–36.
   Google Scholar
• Von Ledebur M., Schmid W. The micronucleus test. Methodological aspects. Mutat. Res. 1973; 19: 109–117
   PubMed Web of Science ®Google Scholar
• Van Wehner F. C., Rensburg S. J., Thiel P. G. Mutagenicity of marijuana and transkei tobacco smoke condensates in the Samonella/microsome assay. Mutat. Res. 1980; 77: 135–142
   PubMed Web of Science ®Google Scholar
• Wyrobek A. J., Bruce W. R. Chemical induction of sperm abnormalities in mice. Proc. Natl. Acad. Sci. USA 1975; 72: 4425–4429
   PubMed Web of Science ®Google Scholar
• Zimmerman A. M., Bruce W. R., Zimmerman S. Effects of cannabinoids on sperm morphology. Pharmacology 1979; 18: 143–148
   PubMed Web of Science ®Google Scholar
• Zimmerman A. M., Murer-Orlando M. L., Richer C. L. Effects of cannabinoids on spermatogenesis in vivo. Cytobios 1986; 45: 7–15
   PubMedGoogle Scholar
• Zimmerman A. M., Yesoda Raj A. Influence of cannabinoids on somatic cells. in vivo. Pharmacology 1980; 21: 277–287
   Google Scholar
• Zimmerman A. M., Stitch H., San R. Nonmutagenic action of cannabinoids in vitro. Pharmacology 1978; 16: 333–343
   PubMed Web of Science ®Google Scholar
• Zimmerman A. M., Zimmerman S. Cytogenetic studies of cannabinoid effects. Genetic and Perinatal Effects of Abused Substances, M. C. Braude, A. M. Zimmerman. Academic Press., Orlando 1987; 95–111
   Google Scholar