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Research Article

Aerosol-based efficient delivery of azithromycin to alveolar macrophages for treatment of respiratory infections

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Pages 1361-1365 | Received 31 Mar 2012, Accepted 13 Jun 2012, Published online: 20 Jul 2012

References

  • Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010;375:1545–1555.
  • Waterer G, Wunderink R. Respiratory infections: a current and future threat. Respirology 2009;14:651–655.
  • Wong SS, Yuen KY. Antiviral therapy for respiratory tract infections. Respirology 2008;13:950–971.
  • Ferrari G, Langen H, Naito M, Pieters J. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 1999;97:435–447.
  • Greub G, Raoult D. Microorganisms resistant to free-living amoebae. Clin Microbiol Rev 2004;17:413–433.
  • Harb OS, Gao LY, Abu Kwaik Y. From protozoa to mammalian cells: a new paradigm in the life cycle of intracellular bacterial pathogens. Environ Microbiol 2000;2:251–265.
  • Doganay M. Listeriosis: clinical presentation. FEMS Immunol Med Microbiol 2003;35:173–175.
  • Ellner JJ, Goldberger MJ, Parenti DM. Mycobacterium avium infection and AIDS: a therapeutic dilemma in rapid evolution. J Infect Dis 1991;163:1326–1335.
  • Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C. Tuberculosis. Lancet 2003;362:887–899.
  • Nara C, Tateda K, Matsumoto T, Ohara A, Miyazaki S, Standiford TJ et al. Legionella-induced acute lung injury in the setting of hyperoxia: protective role of tumour necrosis factor-alpha. J Med Microbiol 2004;53:727–733.
  • Tärnvik A, Berglund L. Tularaemia. Eur Respir J 2003;21:361–373.
  • Tsai MH, Huang YC, Chen CJ, Lin PY, Chang LY, Chiu CH et al. Chlamydial pneumonia in children requiring hospitalization: effect of mixed infection on clinical outcome. J Microbiol Immunol Infect 2005;38:117–122.
  • Roig J, Casal J, Gispert P, Gea E. 13–Antibiotic therapy of community-acquired pneumonia (CAP) caused by atypical agents. Med Mal Infect 2006;36:680–689.
  • Vergis EN, Indorf A, File TM Jr, Phillips J, Bates J, Tan J et al. Azithromycin vs cefuroxime plus erythromycin for empirical treatment of community-acquired pneumonia in hospitalized patients: a prospective, randomized, multicenter trial. Arch Intern Med 2000;160:1294–1300.
  • Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990;25 Suppl A:73–82.
  • Longo G, Valenti C, Gandini G, Ferrara L, Bertesi M, Emilia G. Azithromycin-induced intrahepatic cholestasis. Am J Med 1997;102:217–218.
  • Antonini JM, Reasor MJ. Accumulation of amiodarone and desethylamiodarone by rat alveolar macrophages in cell culture. Biochem Pharmacol 1991;42 Suppl:S151–S156.
  • Kohno Y, Yoshida H, Suwa T, Suga T. Uptake of clarithromycin by rat lung cells. J Antimicrob Chemother 1990;26:503–513.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–254.
  • Hunt C, Macgregor R, Siegel R. Engineering Targeted In Vivo Drug Delivery. I. The Physiological and Physicochemical Principles Governing Opportunities and Limitations. Pharm Res 1986;3:333–334.
  • Muto C, Liu P, Chiba K, Suwa T. Pharmacokinetic-pharmacodynamic analysis of azithromycin extended release in Japanese patients with common respiratory tract infectious disease. J Antimicrob Chemother 2011;66:165–174.
  • Baldwin DR, Honeybourne D, Wise R. Pulmonary disposition of antimicrobial agents: methodological considerations. Antimicrob Agents Chemother 1992;36:1171–1175.
  • Wang F, Daugherty B, Keise LL, Wei Z, Foley JP, Savani RC et al. Heterogeneity of claudin expression by alveolar epithelial cells. Am J Respir Cell Mol Biol 2003;29:62–70.
  • Campbell L, Abulrob AN, Kandalaft LE, Plummer S, Hollins AJ, Gibbs A et al. Constitutive expression of p-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures. J Pharmacol Exp Ther 2003;304:441–452.
  • Zaman GJ, Versantvoort CH, Smit JJ, Eijdems EW, de Haas M, Smith AJ et al. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res 1993;53:1747–1750.
  • Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 1987;84:265–269.
  • Togami K, Chono S, Morimoto K. Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages. Biopharm Drug Dispos 2011;32:389–397.
  • Vazifeh D, Abdelghaffar H, Labro MT. Effect of telithromycin (HMR 3647) on polymorphonuclear neutrophil killing of Staphylococcus aureus in comparison with roxithromycin. Antimicrob Agents Chemother 2002;46:1364–1374.
  • Mouton JW, Dudley MN, Cars O, Derendorf H, Drusano GL. Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs. Int J Antimicrob Agents 2002;19:355–358.
  • Mouton JW, Dudley MN, Cars O, Derendorf H, Drusano GL. Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update. J Antimicrob Chemother 2005;55:601–607.
  • Miyashita N, Fukano H, Yoshida K, Niki Y, Matsushima T. In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae. J Antimicrob Chemother 2003;52:497–499.
  • Dubois J, St-Pierre C. Comparative in vitro activity and post-antibiotic effect of gemifloxacin against Legionella spp. J Antimicrob Chemother 2000;45 Suppl 1:41–46.
  • Krishnan MY, Manning EJ, Collins MT. Comparison of three methods for susceptibility testing of Mycobacterium avium subsp. paratuberculosis to 11 antimicrobial drugs. J Antimicrob Chemother 2009;64:310–316.

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