In situ lyophilisation of nifedipine directly in hard gelatine capsules

References

• Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007;4:403–416.
   PubMed Web of Science ®Google Scholar
• Gomez-Orellana I. Strategies to improve oral drug bioavailability. Expert Opin Drug Deliv 2005;2:419–433.
   PubMed Web of Science ®Google Scholar
• Vippagunta SR, Maul KA, Tallavajhala S, Grant DJ. Solid-state characterization of nifedipine solid dispersions. Int J Pharm 2002;236:111–123.
   PubMed Web of Science ®Google Scholar
• Hecq J, Deleers M, Fanara D, Vranckx H, Amighi K. Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. Int J Pharm 2005;299:167–177.
   PubMed Web of Science ®Google Scholar
• Pattarino F, Giovannelli L, Bellomi S. Effect of poloxamers on nifedipine microparticles prepared by Hot Air Coating technique. Eur J Pharm Biopharm 2007;65:198–203.
   PubMed Web of Science ®Google Scholar
• Stegemann S, Leveiller F, Franchi D, de Jong H, Lindén H. When poor solubility becomes an issue: from early stage to proof of concept. Eur J Pharm Sci 2007;31:249–261.
   PubMed Web of Science ®Google Scholar
• Kesisoglou F, Panmai S, Wu Y. Nanosizing – Oral formulation development and biopharmaceutical evaluation. Adv Drug Delivery Rev 2007;59:631–644.
   PubMed Web of Science ®Google Scholar
• Verma S, Gokhale R, Burgess DJ. A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. Int J Pharm 2009;380:216–222.
   PubMed Web of Science ®Google Scholar
• Tiong N, Elkordy AA. Effects of liquisolid formulations on dissolution of naproxen. Eur J Pharm Biopharm 2009;73:373–384.
   PubMed Web of Science ®Google Scholar
• Zajc N, Obreza A, Bele M, Srcic S. Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method. Int J Pharm 2005;291:51–58.
   PubMed Web of Science ®Google Scholar
• Ohshima H, Miyagishima A, Kurita T, Makino Y, Iwao Y, Sonobe T et al. Freeze-dried nifedipine-lipid nanoparticles with long-term nano-dispersion stability after reconstitution. Int J Pharm 2009;377:180–184.
   PubMed Web of Science ®Google Scholar
• Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000;50:47–60.
   PubMed Web of Science ®Google Scholar
• Sugimoto M, Okagaski T, Narisawa S, Koida Y, Nakajima K. Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water-soluble polymer. Int J Pharm 1998;160:11–19.
   Web of Science ®Google Scholar
• Barichello JM, Morishita M, Takayama K, Chiba Y, Tokiwa S, Nagai T. Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids. Int J Pharm 1999;183:125–132.
   PubMed Web of Science ®Google Scholar
• Srinarong PS, Kouwen S, Visser MR, Hinrichs WLJ, Frijlink HW. Effect of drug-carrier interaction on the dissolution behaviour of solid dispersion tablets. Pharm Dev Tech 2009;1–9.
   PubMed Web of Science ®Google Scholar
• British Pharmacopeia, 2009.
   Google Scholar
• van Drooge DJ, Hinrichs WL, Wegman KA, Visser MR, Eissens AC, Frijlink HW. Solid dispersions based on inulin for the stabilisation and formulation of delta 9-tetrahydrocannabinol. Eur J Pharm Sci 2004;21:511–518.
   PubMed Web of Science ®Google Scholar
• Teagarden DL, Baker DS. Practical aspects of lyophilization using non-aqueous co-solvent systems. Eur J Pharm Sci 2002;15:115–133.
   PubMed Web of Science ®Google Scholar
• Wen H, Morris KR, Park K. Study on the interactions between polyvinylpyrrolidone (PVP) and acetaminophen crystals: partial dissolution pattern change. J Pharm Sci 2005;94:2166–2174.
   PubMed Web of Science ®Google Scholar
• Najib NM, Suleiman MS. The effect of hydrophilic polymers and surface agents on the solubility of indomethacin. Int J Pharm 1985;165–171.
   Google Scholar
• Hörter D, Dressman JB. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv Drug Deliv Rev 2001;46:75–87.
   PubMed Web of Science ®Google Scholar
• Sharma PK, Bhatia SR. Effect of anti-inflammatories on Pluronic F127: micellar assembly, gelation and partitioning. Int J Pharm 2004;278:361–377.
   PubMed Web of Science ®Google Scholar
• Kwon KW, Park MJ, Hwang J, Char K. Effects of alcohol addition on gelation in aqueous solution of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer. Polymer J 2001;33:404–410.
   Web of Science ®Google Scholar
• Wanka G, Hoffmann H, Ulbricht W. Phase diagrams and aggregation behavior of poly(oxyethylene)–poly(oxypropylene)–poly(oxyethylene) triblock copolymers in aqueous solutions. Macromolecules 1994;27:4145–4159.
   Web of Science ®Google Scholar
• van Drooge DJ, Hinrichs WL, Visser MR, Frijlink HW. Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. Int J Pharm 2006;310:220–229.
   PubMed Web of Science ®Google Scholar
• Desai D, Kothari S, Huang M. Solid-state interaction of stearic acid with povidone and its effect on dissolution stability of capsules. Int J Pharm 2008;354:77–81.
   PubMed Web of Science ®Google Scholar
• Innocenzi P, Malfatti L, Piccinini M, Marcelli A. Evaporation-Induced Crystallization of Pluronic F127 Studied in-situ by Time-Resolved Infrared Spectroscopy. J Phy Chem A 2010;114:304–308.
   PubMed Web of Science ®Google Scholar
• López-Molina D, Navarro-Martínez MD, Rojas Melgarejo F, Hiner AN, Chazarra S, Rodríguez-López JN. Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.). Phytochemistry 2005;66:1476–1484.
   PubMed Web of Science ®Google Scholar
• Alhalaweh A, Andersson S, Velaga SP. Preparation of zolmitriptan-chitosan microparticles by spray drying for nasal delivery. Eur J Pharm Sci 2009;38:206–214.
   PubMed Web of Science ®Google Scholar
• Taylor LS, Zografi G. Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. Pharm Res 1997;14:1691–1698.
   PubMed Web of Science ®Google Scholar