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Research Article

Ufasomes nano-vesicles-based lyophilized platforms for intranasal delivery of cinnarizine: preparation, optimization, ex-vivo histopathological safety assessment and mucosal confocal imaging

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Pages 706-715 | Received 18 Mar 2015, Accepted 28 Apr 2015, Published online: 21 May 2015

References

  • Gebicki JM, Hicks M. Ufasomes are stable particles surrounded by unsaturated fatty acid membranes. Nature 1973;243:232–234
  • Naik PV, Dixit SG. Ufasomes as plausible carriers for horizontal gene transfer. J Disper Sci Technol 2008;29:804–808
  • Sharma A, Arora S. Formulation and in vitro evaluation of ufasomes for dermal administration of methotrexate. ISRN Pharm 2012;2012:873653
  • Dhillon V, Sharma S, Jain S, et al. Formulation characterization and evaluation of new topical 5-fu by drug entrapment in oleic acid vesicles. Am J Pharmtech Res 2011;1:1–16
  • Verma S, Bhardwaj A, Vij M, et al. Oleic acid vesicles: a new approach for topical delivery of antifungal agent. Artif Cells Nanomed Biotechnol 2014;42:95–101
  • Zakir F, Vaidya B, Goyal AK, et al. Development and characterization of oleic acid vesicles for the topical delivery of fluconazole. Drug Deliv 2010;17:238–248
  • Sharma A, Kumar V, Dhillon V, et al. Evaluation of transdermal permeability of zidovudine entrapped in oleic acid vesicles. Indo Global J Pharm Sci 2011;1:21–35
  • Fan Y, Fang Y, Ma L. The self-crosslinked ufasome of conjugated linoleic acid: investigation of morphology, bilayer membrane and stability. Colloids Surf B Biointerfaces 2014;123C:8–14
  • Almeida AJ, Florindo HF. Nanostructures overcoming the nasal barrier: physiological considerations and mechanistic issues. In: Alonso MJ, Csaba NS, eds. Nanostructured biomaterials for overcoming biological barriers. Cambridge (MA): RSC Publishing; 2012:117–132
  • Ali J, Ali M, Baboota S, et al. Potential of nanoparticulate drug delivery systems by intranasal administration. Curr Pharm Des 2010;16:1644–1653
  • Ugwoke MI, Agu RU, Verbeke N, Kinget R. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv Drug Deliv Rev 2005;57:1640–1665
  • Alsarra IA, Hamed AY, Alanazi FK. Acyclovir liposomes for intranasal systemic delivery: development and pharmacokinetics evaluation. Drug Deliv 2008;15:313–321
  • Alsarra IA, Hamed AY, Alanazi FK. Vesicular systems for intranasal drug delivery. Neuromethods 2010;45:175–203
  • Arumugam K, Subramanian GS, Mallayasamy SR, et al. A study of rivastigmine liposomes for delivery into the brain through intranasal route. Acta Pharm 2008;58:287–297
  • Seju U, Kumar A, Sawant KK. Development and evaluation of olanzapine loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies. Acta Biomater 2011;7:4169–4176
  • Salama HA, Mahmoud AA, Kamel AO, et al. Brain delivery of olanzapine by intranasal administration of transfersomal vesicles. J Liposome Res 2012;22:336–345
  • Salama HA, Mahmoud AA, Kamel AO, et al. Phospholipid based colloidal poloxamer-nanocubic vesicles for brain targeting via the nasal route. Colloids Surf B Biointerfaces 2012;100:146–154
  • Scholtz AW, Schwarz M, Baumann W, et al. Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study. Clin Ther 2004;26:866–877
  • Li BQ, Yang GQ, Fang SH, et al. Effect of route of administration on the pharmacokinetics and toxicokinetics of cinnarizine in dogs. Eur J Pharm Sci 2010;40:197–201
  • Curić A, Reul R, Möschwitzer J, Fricker G. Formulation optimization of itraconazole loaded PEGylated liposomes for parenteral administration by using design of experiments. Int J Pharm 2013;448:189–197
  • Montgomery DC. Design and analysis of experiments. 5th ed. New York (NY): Wiley; 2000
  • Montgomery DC, Myers RH. Response surface methodology: process and product optimization using designed experiments. 2nd ed. Hoboken (NJ): Wiley; 2002
  • Singh G, Pai RS, Devi VK. Optimization of pellets containing solid dispersion prepared by extrusion/spheronization using central composite design and desirability function. J Young Pharm 2012;4:146–156
  • Pandya VM, Patel JK, Patel DJ. Formulation and optimization of nanosuspensions for enhancing simvastatin dissolution using central composite design. Dissolution Technol 2011;18:40–45
  • Higuchi WI. Analysis of data on the medicament release from ointments. J Pharm Sci 1962;51:802–804
  • Shamma RN, Elsayed I. Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization. J Liposome Res 2013;23:244–254
  • Manne N, Yadav KS, Kumar SH, et al. Design and evaluation of a lyophilized liposomal gel of an antiviral drug for intravaginal delivery. J Appl Polym Sci 2014;31:39804–39813
  • Abdelbary GA, Tadros MI. Brain targeting of olanzapine via intranasal delivery of core–shell difunctional block copolymer mixed nanomicellar carriers: in vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies. Int J Pharm 2013;452:300–310
  • Bancroft D, Steven A, Turner R. 2007. Theory and practice of histological techniques. 6th ed. New York (NY): Churchill Livingstone
  • Vila A, Gill H, McCallion O, Alonso MJ. Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J Control Release 2004;98:231–244
  • Hathout RM, Nasr M. Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies. Colloids Surf B Biointerfaces 2013;110:254–260
  • Shamma RN, Aburahma MH. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia. Int J Nanomed 2014;9:5449–5460
  • Kumbhar DD, Pokharkar VB. Engineering of a nanostructured lipid carrier for the poorly water-soluble drug, bicalutamide: physicochemical investigations. Colloids Surf A Physicochem Eng Asp 2013;416:32–42
  • Nasr M, Mansour S, Mortada ND, Elshamy AA. Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. J Microencapsul 2008;25:499–512
  • Moribe K, Maruyama K, Iwatsuru M. Molecular localization and state of Amphotericin B in PEG liposomes. Int J Pharm 1999;193:97–106
  • Manosroi A, Wongtrakul P, Manosroi J, et al. Characterization of vesicles prepared with various non ionic surfactants mixed with cholesterol. Coll Surf B Biointerfaces 2003;30:129–138
  • Coderch L, Fonollosa J, Pera MD, et al. Influence of cholesterol on membrane fluidity by EPR: relationship with percutaneous absorption. J Control Release 2000;68:85–95
  • Ramana LN, Sethuraman S, Ranga U, Krishnan UM. Development of a liposomal nanodelivery system for nevirapine. J Biomed Sci 2010;17:57–65
  • Zeisig R, Shimada K, Hirota S, Arndt D. Effect of sterical stabilization on macrophage uptake in vitro and on thickness of the fixed aqueous layer of liposomes made from alkylphosphocholines. Biochim Biophys Acta Biomembrane 1996;1285:237–245
  • Abdelbary GA, Aburahma MH. Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain. J Liposome Res 2014;24:1–15
  • Mosharraf M, Nystrom C. Solubility characterization of practically insoluble drugs using the Coulter counter principle. Int J Pharm 1995;122:57–67
  • Glavas-Dodov M, Goracinova K, Mladenovska K, Fredro-Kumbaradzi E. Release profile of lidocaine HCl from topical liposomal gel formulation. Int J Pharm 2002;242:381–384
  • Hathout R, Mansour S, Mortada ND, Guinedi AS. Liposomes as ocular delivery system for acetzolamide: in vitro and in vivo studies. AAPS Pharm Sci Tech 2007;8:E1–E2
  • Lim WM, Rajinikanth PS, Mallikarjun C, Kang YB. Formulation and delivery of itraconazole to the brain using a nanolipid carrier system. Int J Nanomed 2014;9:2117–2126
  • Janicki S, Jankowski J, Szulc J, et al. The effect of cryoprotectants on the physical properties of large liposomes containing sodium diclofenac. Acta Pol Pharm 2002;59:187–191
  • Charlton S, Jones NS, Davis SS, Illum L. Distribution and clearance of bioadhesive formulations from the olfactory region in man: effect of polymer type and nasal delivery device. Eur J Pharm Sci 2007;30:295–302
  • Aburahma MH, Abdelbary GA. Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation. Int J Pharm 2012;422:139–150
  • Bruschi ML1, Jones DS, Panzeri H, et al. Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J Pharm Sci 2007;96:2074–2089
  • Lang S, Rothen-Rutishauser B, Perriard JC, et al. Permeation and pathways of human calcitonin (hCT) across excised bovine nasal-mucosa. Peptides 1998;19:599–607
  • Marttin E, Verhoef JC, Cullander C, et al. Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: effects of absorption enhancers. Pharm Res 1997;14:631–637
  • Deli MA. Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. Biochim Biophys Acta 2009;1788:892–910

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