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Research Article

Preparation of pH-dependent modified-release pellets of urapidil to improve its bioavailability

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Pages 212-218 | Received 02 Sep 2009, Accepted 04 Jan 2010, Published online: 15 Feb 2010

References

  • Lecomte F Siepmann J Walther M MacRae RJ Bodmeier R. PH-sensitive polymer blends used as coating materials to control drug release from spherical beads: Elucidation of the underlying mass transport mechanisms. Pharm Res 2005;22:1129–1141.
  • Ittner KP Pawlik M Zimmermann M Taeger K Faerber L. Urapidil enhance subcutaneous tissue oxygen tension during convective rewarming of mildly hypothermic rats. J Therm Biol 2005;31:144–148.
  • Doolet M Goa KL. Urapidil, a reappraisal of its use in the management of hypertension. Drugs 1998;56:929–955.
  • CA, calculated using advanced chemistry development (ACD/Labs) software V8.14.for solaris (1994-2008 ACD/Labs)
  • Sathe P Song Y Shah VP. In-vitro dissolution profile comparison: Statistics and analysis model dependent approach. Pharm Res 1998;13:1799–1803.
  • Petereit HU Weisbrod W. Formulation and process considerations affecting the stability of solid dosage forms formulated with methacrylate copolymers. Eur J Pharm Biopharm 1998;47:15–25.
  • Lecomte F Siepmann J Walther M MacRae RJ Bodmeier R. Polymer blends used for the coating of multiparticulates: Comparison of aqueous and organic coating techniques. Pharm Res 2004;21:882–890.
  • Lecomte F Siepmann J Walther M MacRae RJ Bodmeier R. Blends of enteric and GIT-insoluble polymers used for film coating: physicochemical characterization and drug release patterns. J Control Release 2004;89:457–471.
  • Wu C McGinity JW. Influence of an enteric polymer on drug release rates of theophylline from pellets coated with Eudragit® RS 30D. Pharm Dev Technol 2003;8:103–110.
  • Siepmann F Siepmann J Walther M MacRae RJ Bodmeier R. Blends of aqueous polymer dispersions used for pellet coating: Importance of the particle size. J Control Release 2005;105:226–239.
  • Thoma K Ziegler I. The pH-independent release of fenoldopam from pellets with insoluble film coats. Eur J Pharm Biopharm 1998;46:105–113.
  • Hu LD Liu Y Tang X Zhang Q. Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets. Eur J Pharm Biopharm 2006;64:185–192.
  • Wang BQ. 2000. The investigation of sustained-release urapidil capsules. Thesis. Shenyang Pharmaceutical University.
  • Frenning G Tunón A Alderborn G, Modelling of drug release from coated granular pellets. J Control Release 2003;92:113–123.
  • Pillay V Fassihi R. Evaluation and comparison of dissolution data derived from different modified release dosage forms: An alternative method. J Control Release 1998;55:45–55.
  • Song HT Guo T Zhang RH Zheng CL Ma Y Li X Bi KS Tang X. Preparation of the traditional Chinese medicine compound recipe heart protecting musk pH-dependent gradient-release pellets. Drug Dev Ind Pharm 2002;28:1261–1273.
  • Huyghebaert N Vermeire A Remon JP. In vitro evaluation of coating polymers for enteric coating and human ileal targeting. Int J Pharm 2005;298:26–37.
  • Lehmann K. Acrylic latices from redispersable powder for peroral and transdermal drug formulations. Drug Dev Ind Pharm 1986;12:265–287.
  • Ritschel WA. Biopharmaceutic and pharmacokinetic aspects in the design of controlled release peroral drug delivery systems. Drug Dev Ind Pharm 1989;15:1073–1103.
  • Peter JW Lisbeth L. Colonic drug delivery. Drug Dev Ind Pharm 1997;23:893–913.
  • Costa P Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Biopharm 2001;13:123–133.

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