845
Views
79
CrossRef citations to date
0
Altmetric
Research Article

Preparation and Characterization of Agarose Hydrogel Nanoparticles for Protein and Peptide Drug Delivery

&
Pages 135-142 | Received 28 Aug 1996, Accepted 29 Nov 1996, Published online: 27 Sep 2008

References

  • Pitt C. G. The controlled parenteral delivery of polypeptides and proteins. Int. J. Pharm 1990; 59: 173–196
  • Selby H. H., Wynne W. H. Agar. Industrial Gums, R. L. Whistler. Academic Press, New York 1973; 29–49
  • Lindenbaum E. S., Tendler M., Beach D. Serum-free cell culture medium induces acceleration of wound healing in guinea-pigs. Bums 1995; 21(2)110–115
  • Iwata H., Kobayashi K., Takagi T., Oka T., Yang H., Amemiya H., Tsuji T., Ito F. Feasibility of agarose microbeads with xenogeneic islets as a bioartificial pancreas. J. Biomed. Mater. Res 1994; 28(9)1003–1011
  • Upadrashta S. M., Haglund B. O., Sundelof L. O. Diffusion and concentration profiles of drugs in gels. J. Pharm. Sci 1993; 82(11)1094–1098
  • Haglund B. O., Upadrashta S. M., Neau S. H., Cutrera M. A. Dissolution controlled drug release from agarose beads. Drug Dev. Ind. Pharm 1994; 20(6)947–959
  • Wang N., Wu X. S., Mesiha M. A new method for the preparation of protein-loaded agarose nano-spheres. Pharm. Res 1995; 12: S-257
  • Wang N., Wu X. S. Preparation of agarose nanospheres. Transactions of the Fifth World Bio-materials Congress. Toronto, OntarioCanada June 2–7, 1996; 162
  • Wang N., Wu X. S. Agarose nanospheres for protein drug delivery. Proc. Int. Symp. Control. Rel. Bioact. Mater 1996; 23: 829–830
  • Kreuter J. Nanoparticles—Preparation and applications. Microcapsules and Nanoparticles in Medicine and Pharmacy, M. Donbrow. CRC Press, Boca Raton, FL 1992; 125–148
  • Kreuter J. Nanoparticle-based drug delivery systems. J. Control. Rel 1991; 16: 169–176
  • Yoshioka T., Hashida M., Muranishi S., Sezaki H. Specific delivery of mitomycin C to the liver, spleen and lung: Nano- and microspherical carriers of gelatin. Int. J. Pharm 1981; 81: 131–141
  • Tabata Y., Ikada Y. Macrophage activation through phagocytosis of muramyl dipeptide encapsulated in gelatin microspheres. J. Pharm. Pharmacol 1987; 39: 698–704
  • Verrijk R., Smolders I. J. H., McVie J. G., Begg A. C. Polymer-coated albumin microspheres as carriers for intravascular tumour targeting of cisplatin. Cancer Chemother. Pharmacol 1991; 29: 117–121
  • Hjerten S. The preparation of agarose spheres for chromatography of molecules and particles. Biochim. Biophys. Acta 1964; 79: 393–398
  • Rinaudo M. Gelation of polysaccharides. J. Intell. Mater. Syst. Struct 1993; 4: 210–215
  • Guiseley K. B. Chemical and physical properties of algal polysaccharides used for cell immobilization. Enzyme Microb. Technol 1989; 11: 706–716
  • Tarcha P. J. Polymers for Controlled Drug Delivery. CRC Press, Boca Raton, FL 1991; 16–20
  • Lee P. I. Kinetics of drug release from hydrogel matrix. J. Control. Rel 1985; 2: 277–288
  • Peppas N. A. Hydrogels in Medicine and Pharmacy. CRC Press, Boca Raton, FL 1987; Vols. 1–3
  • Baker R. W. Controlled Release of Biologically Active Agents. Wiley & Sons, New York 1987
  • Lee P. I. Interpretation of drug-release kinetics from hydrogel matrices in terms of time-dependent diffusion coefficients. Controlled-Release Technology: Pharmaceutical Applications, P. I. Lee, W. R. Good. ACS, Washington, DC 1987; 72–73
  • Crank J. The Mathematics of Diffusion2nd ed. Oxford Press, London 1975

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.