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Research Article

Synovitis biomarkers: ex vivo characterization of three biomarkers for identification of inflammatory osteoarthritis

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Pages 547-556 | Received 15 Jul 2015, Accepted 22 Sep 2015, Published online: 10 Feb 2016

References

  • Alaaeddine N, DiBattista JA, Pelletier JP, et al. (1997). Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha. J Rheumatol 24:1985–94
  • Ayral X, Pickering EH, Woodworth TG, et al. (2005). Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage/OARS, Osteoarthritis Res Soc 13:361–7
  • Barascuk N, Veidal SS, Larsen L, et al. (2010). A novel assay for extracellular matrix remodeling associated with liver fibrosis: an enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen. Clin Biochem 43:899–904
  • Bay-Jensen AC, Platt A, Byrjalsen I, et al. (2014). Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study. Semin Arthritis Rheum 43:470–8
  • Beekhuizen M, Bastiaansen-Jenniskens YM, Koevoet W, et al. (2011). Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture. Arthritis Rheum 63:1918–27
  • Beffa CD, Slansky E, Pommerenke C, et al. (2013). The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification. PLoS One 8:e72494
  • Blom AB, van Lent PL, Libregts S, et al. (2007). Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. Arthritis Rheum 56:147–57
  • Bondeson J, Wainwright SD, Lauder S, et al. (2006). The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther 8:R187
  • Bottini N, Firestein GS. (2012). Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol 9:1–10
  • Chang SK, Noss EH, Chen M, et al. (2011). Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci USA 108:8402–7
  • Daghestani HN, Pieper CF, Kraus VB. (2015). Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis. Arthritis Rheumatol (Hoboken, N.J.) 67:956–65
  • De Lange-Brokaar BJE, Ioan-Facsinay A, van Osch GJVM, et al. (2012). Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage/OARS, Osteoarthritis Res Soc 20:1484–99
  • Fox DB, Warnock JJ. (2011). Cell-based meniscal tissue engineering: a case for synoviocytes. Clin Orthop Relat Res 469:2806–16
  • Hansen NUB, Genovese F, Leeming DJ, et al. (2015). The importance of extracellular matrix for cell function and in vivo likeness. Exp Mol Pathol 98:286–94
  • Hardy RS, Hulso C, Liu Y, et al. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Res Ther 15:R24
  • Juarez M, Filer A, Buckley CD. (2012). Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer. Swiss Med Wkly 142:w13529
  • Karsdal MA, Christiansen C, Ladel C, et al. (2014). Osteoarthritis – a case for personalized health care? Osteoarthritis Cartilage/OARS, Osteoarthritis Res Soc 22:7–16.
  • Kiener HP, Watts GFM, Cui Y, et al. (2010). Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture. Arthritis Rheum 62:742–52
  • Lambert C, Dubuc J-E, Montell E, et al. (2014). Gene expression pattern of cells from inflamed and normal areas of osteoarthritis synovial membrane. Arthritis Rheumat (Hoboken, N.J.) 66:960–8
  • Leeming D, He Y, Veidal S, et al. (2011). A novel marker for assessment of liver matrix remodeling: an enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope (C1M). Biomark Biochem Indicat Exposure Response Susceptib Chem 16:616–28
  • Nair A, Kanda V, Bush-Joseph C, et al. (2012). Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum 64:2268–77
  • Noss EH, Brenner MB. (2008). The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunol Rev 223:252–70
  • Pasternak B, Aspenberg P. (2009). Metalloproteinases and their inhibitors – diagnostic and therapeutic opportunities in orthopedics. Acta Orthopaed 80:693–703
  • Pessler F, Dai L, Diaz-Torne C, et al. (2008). The synovitis of “non-inflammatory” orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis. Ann Rheum Dis 67:1184–7
  • Remst DFG, Blom AB, Vitters EL, et al. (2014). Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis. Arthritis Rheumatol (Hoboken, N.J.) 66:647–56
  • Ríos DL, López C, Álvarez ME, et al. (2015). Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide. BMC Musculoskelet Disord 16:153
  • Scanzello CR, Goldring SR. (2012). The role of synovitis in osteoarthritis pathogenesis. Bone 51:249–57
  • Siebuhr AS, Bay-Jensen AC, Leeming DJ, et al. (2013). Serological identification of fast progressors of structural damage with rheumatoid arthritis. Arthritis Res Ther 15:R86
  • Siebuhr AS, Petersen KK, Arendt-Nielsen L, et al. (2014). Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover. Osteoarthritis Cartilage/OARS, Osteoarthritis Res Soc 22:44–50
  • Smith MD. (2011). The normal synovium. Open Rheumatol J 5:100–6
  • Sondergaard BC, Henriksen K, Wulf H, et al. (2006). Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthritis Cartilage/OARS, Osteoarthritis Res Soc 14:738–48
  • Sun S, Bay-Jensen A-C, Karsdal MA, et al. (2014). The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases. BMC Musculoskelet Disord 15:93
  • Tian J, Chen J-W, Gao J-S, et al. (2013). Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway. Rheumatol Int 33:1829–35
  • Tolboom TCA, Pieterman E, van der, Laan WH, et al. (2002). Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10. Ann Rheum Dis 61:975–80
  • Ultaigh SNA, Saber TP, McCormick J, et al. (2011). Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures. Arthritis Res Ther 13:R33
  • van Buul GM, Villafuertes E, Bos PK, et al. (2012). Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture. Osteoarthritis Cartilage/OARS, Osteoarthritis Res Soc 20:1186–96
  • Veidal SS, Vassiliadis E, Barascuk N, et al. (2010). Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis. Liver Int 30:1293–304
  • Winchester R, Su F, Ritchlin C. (1993). Alteration of synoviocytes by inflammation – the source of a persistent non-immunologic drive in synovitis: analysis of levels of mRNA expression by a simple multi-gene assay. Clin Exp Rheumatol 11:S87–90
  • Wynn TA, Barron L. (2010). Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30:245–57