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The European Journal of Contraception & Reproductive Health Care Volume 16, 2011 - Issue 2
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Original Research Articles

Inhibition of ovulation by NOMAC/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17β-oestradiol: A double-blind, randomised, dose-finding pilot study

Nathalie Chabbert-Buffet Obstetrics and Gynaecology Unit, Hôpital Tenon AP-HP, and ER-9, UPMC Université Paris 06, Paris, France
,
Didier Chassard SGS Aster, Paris, France
,
Edith Ochsenbein Laboratoire Théramex SAM, Monaco
,
Jean-Louis Thomas Laboratoire Théramex SAM, MonacoCorrespondence[email protected]
&
Sophie Christin-Maitre AP-HP Endocrinology Department, Hôpital Saint Antoine and ER-9, UPMC Université Paris 06, Paris, France
Pages 76-84 | Published online: 21 Feb 2011

References

  • Sitruk-Ware R. New progestagens for contraceptive use. Hum Reprod Update 2006;12:169–78.
  • Mashchak CA, Lobo RA, Dozono-Takano R, et al. Comparison of pharmacodynamic properties of various estrogen formulations. Am J Obstet Gynecol 1982;144:511–8.
  • Calaf i Alsina J. After 50 years of ethinylestradiol, another oestrogen in combined oral contraceptives. Eur J Contracept Reprod Health Care 2010;15:1–3.
  • Couzinet B, Young J, Brailly S, et al. The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor. J Clin Endocrinol Metab 1996;81: 4218–23.
  • Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 2005;8 (Suppl. 1):3–63.
  • Dorangeon P, Thomas JL, Choisy H, et al. Effects of nomegestrol acetate on carbohydrate metabolism. Diabete Metab 1993;19:441–5.
  • Basdevant A, Pelissier C, Conard J, et al. Effects of nomegestrol acetate (5 mg/d) on hormonal, metabolic and hemostatic parameters in premenopausal women. Contraception 1991;44:599–605.
  • Conard J, Basdevant A, Thomas JL, et al. Cardiovascular risk factors and combined estrogen-progestin replacement therapy: a placebo-controlled study with nomegestrol acetate and estradiol. Fertil Steril 1995;64:957–62.
  • Bazin B, Thevenot R, Bursaux C, et al. Effect of nomegestrol acetate, a new 19-nor-progesterone derivative, on pituitary-ovarian function in women. Br J Obstet Gynaecol 1987;94:1199–204.
  • Chretien FC, Dubois R. Effect of nomegestrol acetate on spinability, ferning and mesh dimension of midcycle cervical mucus. Contraception 1991;43:55–65.
  • Couzinet B, Young J, Kujas M, et al. The antigonadotropic activity of a 19-nor-progesterone derivative is exerted both at the hypothalamic and pituitary levels in women. J Clin Endocrinol Metab 1999;84:4191–6.
  • Anderson F. Kinetics and pharmacology of estrogens in pre- and postmenopausal women. Int J Fertil Menopausal Stud 1993;38(Suppl. 1):55–64.
  • Wenzl R, Bennink HC, van Beek A, et al. Ovulation inhibition with a combined oral contraceptive containing 1 mg micronized 17 beta-estradiol. Fertil Steril 1993;60:616–9.
  • Csemiczky G, Dieben T, Coeling Bennink HJ, Landgren BM. The pharmacodynamic effects of an oral contraceptive containing 3 mg micronized 17 beta-estradiol and 0.150 mg desogestrel for 21 days, followed by 0.030 mg desogestrel only for 7 days. Contraception 1996;54:333–8.
  • Sullivan H, Furniss H, Spona J, et al. Effect of 21-day and 24-day oral contraceptive regimens containing gestodene (60 microg) and ethinyl estradiol (15 microg) on ovarian activity. Fertil Steril 1999;72:115–20.
  • Serfaty D, Christin-Maitre S, Ochsenbein E, et al. Comparison of two regimens of new monophasic oral contraceptive combining 17 beta-estradiol and nomegestrol acetate. Int J Gynecol Obstet 2009;107 (Suppl. 2): S623.
  • Gaussem P, Alhenc-Gelas M, Thomas J-L, et al. Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17ß-estradiol, compared with those of levonorgestrel/ethinyl estradiol: A double-blind, randomized study. Thromb Haemost 2011;105(3): [Epub ahead of print].

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