Physical activity on endothelial and erectile dysfunction: a literature review

References

• Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 2002;90:40L–8L
   PubMed Web of Science ®Google Scholar
• Sudano I, Spieker LE, Hermann F, et al. Protection of endothelial function: targets for nutritional and pharmacological interventions. J Cardiovasc Pharmacol 2006;47:S136–50
   Google Scholar
• Félétou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 2006;291:H985–1002
   PubMed Web of Science ®Google Scholar
• Guay AT. ED2: erectile dysfunction = endothelial dysfunction. Endocrinol Metab Clin North Am 2007;36:453–63
   PubMedGoogle Scholar
• NIH Consensus Conference on Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270:83–90
   PubMedGoogle Scholar
• Kendirci M, Nowfar S, Hellstrom WJ. The impact of vascular risk factors on erectile function. Drugs Today 2005;41:65–74
   PubMedGoogle Scholar
• Pedersen BK, Saltin B. Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 2006;16:3–63
   PubMed Web of Science ®Google Scholar
• Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol 2012;2:1143–211
   PubMed Web of Science ®Google Scholar
• Teng NI, Shahar S, Rajab NF, et al. Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. Aging Male 2013;16:177–83
   PubMed Web of Science ®Google Scholar
• Wonisch W, Falk A, Sundl I, et al. Oxidative stress increases continuously with BMI and age with unfavourable profiles in males. Aging Male 2012;15:159–65
   PubMed Web of Science ®Google Scholar
• Snyder SH, Bredt DS. Biological roles of nitric oxide. Sci Am 1992;266:68–71, 74–77
   PubMed Web of Science ®Google Scholar
• Chen K, Pittman RN, Popel AS. Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal 2008;10:1185–98
   PubMed Web of Science ®Google Scholar
• Burnett AL. Role of nitric oxide in the physiology of erection. Biol Reprod 1995;52:485–9
   PubMed Web of Science ®Google Scholar
• Rongen GA, Smits P, Thien T. Endothelium and the regulation of vascular tone with emphasis on the role of nitric oxide. Physiology, pathophysiology and clinical implications. Neth J Med 1994;44:26–35
   PubMed Web of Science ®Google Scholar
• Doumas M, Douma S. Sexual dysfunction in essential hypertension: myth or reality? J Clin Hypertens 2006;8:269–74
   Google Scholar
• Wierzbicki AS, Solomon H, Lumb PJ, et al. Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. Atherosclerosis 2006;185:421–5
   PubMedGoogle Scholar
• Solomon H, Wierzbicki AS, Lumb PJ, et al. Cardiovascular risk factors determine erectile and arterial function response to sildenafil. Am J Hypertens 2006;19:915–9
   PubMedGoogle Scholar
• Agarwal A, Nandipati KC, Sharma RK, et al. Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction. J Androl 2006;27:335–47
   PubMedGoogle Scholar
• Sáenz de Tejada I, Angulo J, Cellek S, et al. Pathophysiology of erectile dysfunction. J Sex Med 2005;2:26–39
   PubMed Web of Science ®Google Scholar
• Billups KL, Kaiser DR, Kelly AS, et al. Relation of C-reactive protein and other cardiovascular risk factors to penile vascular disease in men with erectile dysfunction. Int J Impot Res 2003;15:231–6
   PubMed Web of Science ®Google Scholar
• Condorelli RA, Calogero AE, Vicari E, et al. Endothelial progenitor cells and erectile dysfunction: a brief review on diagnostic significance and summary of our experience. Aging Male 2013;16:29–32
   PubMed Web of Science ®Google Scholar
• Linet OI, Ogrinc FG. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. New Engl J Med 1996;334:873–7
   PubMed Web of Science ®Google Scholar
• Padma-Nathan H, Hellstrom WJ, Kaiser FE, et al. Treatment of men with erectile dysfunction with transurethral alprostadil. New Engl J Med 1997;336:1–7
   PubMed Web of Science ®Google Scholar
• Leoni LA, Leite GS, Wichi RB, Rodrigues B. Sildenafil: two decades of benefits or risks? Aging Male 2013;16:85–91
   PubMed Web of Science ®Google Scholar
• Raja SG, Nayak SH. Sildenafil: emerging cardiovascular indications. Ann Thorac Surg 2004;78:1496–506
   PubMed Web of Science ®Google Scholar
• Kontaras K, Varnavas V, Kyriakides ZS. Does sildenafil cause myocardial infarction or sudden cardiac death? Am J Cardiovasc Drugs 2008;8:1–7
   PubMedGoogle Scholar
• Lee TM, Chen CC, Chung TH, Chang NC. Effect of sildenafil on ventricular arrhythmias in post-infarcted rat hearts. Eur J Pharmacol 2012;690:124–32
   PubMedGoogle Scholar
• Corbin JD, Francis SH. Pharmacology of phosphodiesterase-5 inhibitors. Int J Clin Pract 2002;56:453–9
   PubMed Web of Science ®Google Scholar
• Wallis RM, Corbin JD, Francis SH, Ellis P. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 1999;83:3C–12C
   PubMed Web of Science ®Google Scholar
• Vlachopoulos C, Terentes-Printzios D, Ioakeimidis N, et al. PDE5 inhibitors in non-urological conditions. Curr Pharm Des 2009;15:3521–39
   PubMedGoogle Scholar
• Frantzen J, Speel TG, Kiemeney LA, Meuleman EJ. Cardiovascular risk among men seeking help for erectile dysfunction. Ann Epidemiol 2006;16:85–90
   PubMed Web of Science ®Google Scholar
• Montorsi F, Padma-Nathan H, Glina S. Erectile function and assessments of erection hardness correlate positively with measures of emotional well-being, sexual satisfaction, and treatment satisfaction in men with erectile dysfunction treated with sildenafil citrate (Viagra). Urology 2006;68:26–37
   PubMedGoogle Scholar
• Morris JN, Heady JA, Raffle PAB, et al. Coronary heart-disease and physical activity of work. Lancet 1953;262:1111–20
   PubMedGoogle Scholar
• Paffenbarger RS, Wolf PA, Notkin J, Thorne MC. Chronic disease in former college students: I. Early precursors of fatal coronary heart disease. Am J Epidemiol 1966;83:314–28
   PubMed Web of Science ®Google Scholar
• Leon AS, Connett J, Jacobs DR Jr, Rauramaa R. Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial. JAMA 1987;258:2388–95
   PubMed Web of Science ®Google Scholar
• Clarkson P, Montgomery HE, Mullen MJ, et al. Exercise training enhances endothelial function in young men. J Am Coll Cardiol 1999;33:1397–85
   Google Scholar
• Higashi Y, Sasaki S, Kurisu S, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects. Circulation 1999;100:1194–202
   PubMed Web of Science ®Google Scholar
• Laufs U, Urhausen A, Werner N, et al. Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur J Cardiovasc Prev Rehabil 2005;12:407–14
   PubMed Web of Science ®Google Scholar
• Van Craenenbroeck EM, Vrints CJ, Haine SE, et al. A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile. J Appl Physiol (1985) 2008;104:106–13
   Google Scholar
• Hambrecht R, Fiehn E, Weigl C, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998;98:2709–15
   PubMed Web of Science ®Google Scholar
• Hambrecht R, Hilbrich L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000;35:706–13
   PubMed Web of Science ®Google Scholar
• Lavrencic A, Salobir BG, Keber I. Physical training improves flow-mediated dilation in patients with the polymetabolic syndrome. Arterioscler Thromb Vasc Biol 2000;20:551–5
   PubMed Web of Science ®Google Scholar
• Maiorana A, O’Discroll G, Cheetham C, et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 2001;38:860–6
   PubMed Web of Science ®Google Scholar
• Vona M, Rossi A, Capodaqlio P, et al. Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction. Am Heart J 2004;147:1039–46
   PubMed Web of Science ®Google Scholar
• Steiner S, Niessner A, Zieqler S, et al. Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 2005;18:305–10
   Google Scholar
• Benjamin EJ, Larson MG, Keyes MJ, et al. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation 2004;109:613–9
   PubMed Web of Science ®Google Scholar
• Adams V, Linke A, Breuckmann F, et al. Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners. Eur J Cardiovasc Prev Rehabil 2008;15:602–7
   PubMedGoogle Scholar
• Möbius-Winkler S, Hilberg T, Menzel K, et al. Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals. J Appl Physiol (1985) 2009;107:1943–50
   PubMed Web of Science ®Google Scholar
• Navasiolava NM, Dignat-George F, Sabatier F, et al. Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers. Am J Physiol Heart Circ Physiol 2010;299:H248–56
   PubMed Web of Science ®Google Scholar
• Ribeiro F, Alves AJ, Duarte JA, Oliveira J. Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation? Int J Cardiol 2010;141:214–21
   PubMed Web of Science ®Google Scholar
• Derby CA, Mohr BA, Goldstein I, et al. Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology 2000;56:302–6
   PubMed Web of Science ®Google Scholar
• Esposito K, Ciotola M, Giugliano F, et al. Effects of intensive lifestyle changes on erectile dysfunction in men. J Sex Med 2009;6:243–50
   PubMed Web of Science ®Google Scholar
• Esposito K, Giugliano F, Di Palo C, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004;291:2978–84
   PubMed Web of Science ®Google Scholar
• Bacon CG, Mittleman MA, Kawachi I, et al. A prospective study of risk factors for erectile dysfunction. J Urol 2006;176:217–21
   PubMed Web of Science ®Google Scholar
• Cheng JY, Ng EM, Ko JS, Chen RY. Physical activity and erectile dysfunction: meta-analysis of population-based studies. Int J Impot Res 2007;19:245–52
   PubMed Web of Science ®Google Scholar
• Janiszewski PM, Janssen I, Ross R. Abdominal obesity and physical inactivity are associated with erectile dysfunction independent of body mass index. J Sex Med 2009;6:1990–8
   PubMed Web of Science ®Google Scholar
• Kratzik CW, Lackner JE, Märk I, et al. How much physical activity is needed to maintain erectile function? Results of the Androx Vienna Municipality Study. Eur Urol 2009;55:509–16
   PubMed Web of Science ®Google Scholar
• Maio G, Saraeb S, Marchiori A. Physical activity and PDE5 inhibitors in the treatment of erectile dysfunction: results of a randomized controlled study. J Sex Med 2010;7:2201–8
   PubMed Web of Science ®Google Scholar
• Giugliano F, Maiorino M, Bellastella G, et al. Determinants of erectile dysfunction in type 2 diabetes. Int J Impot Res 2010;22:204–9
   PubMed Web of Science ®Google Scholar
• Agostini LC, Netto JM, Miranda MV Jr, Figueiredo AA. Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years. Int J Impot Res 2011;23:115–21
   PubMed Web of Science ®Google Scholar
• La Vignera S, Condorelli R, Vicari E, et al. Aerobic physical activity improves endothelial function in the middle-aged patients with erectile dysfunction. Aging Male 2011;14:265–72
   PubMed Web of Science ®Google Scholar
• Pohjantähti-Maaroos H, Palomäki A, Hartikainen J. Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis. BMC Cardiovasc Disord 2011;11:36
   PubMed Web of Science ®Google Scholar
• Hsiao W, Shrewsberry AB, Moses KA, et al. Exercise is associated with better erectile function in men under 40 as evaluated by the International Index of Erectile Function. J Sex Med 2012;9:524–30
   PubMed Web of Science ®Google Scholar
• Billups KL, Bank AJ, Padma-Nathan H, et al. Erectile dysfunction is a marker for cardiovascular disease: results of the minority health institute expert advisory panel. J Sex Med 2005;2:40–50
   Web of Science ®Google Scholar