A herbal medicine, saikokaryukotsuboreito, improves serum testosterone levels and affects sexual behavior in old male mice

References

• Mäkinen JI, Huhtaniemi I. Androgen replacement therapy in late-onset hypogonadism: current concepts and controversies - a mini-review. Gerontology 2011;57:193–202
   PubMedGoogle Scholar
• Araujo AB, Wittert GA. Endocrinology of the aging male. Best Pract Res Clin Endocrinol Metab 2011;25:303–19
   PubMed Web of Science ®Google Scholar
• Wu FC, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010;363:123–35
   PubMed Web of Science ®Google Scholar
• Morales A, Lunenfeld B; International Society for the Study of the Aging Male. Investigation, treatment and monitoring of late-onset hypogonadism in males. Official recommendations of ISSAM. International Society for the Study of the Aging Male. Aging Male 2002;5:74–86
   PubMedGoogle Scholar
• Nieschlag E, Swerdloff R, Behre HM, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations. Eur Urol 2005;48:1–4
   PubMed Web of Science ®Google Scholar
• Wang C, Nieschlag E, Swerdloff R, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males. Int J Androl 2009;32:1–10
   Google Scholar
• Neaves WB, Johnson L, Porter JC, et al. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 1984;59:756–63
   PubMed Web of Science ®Google Scholar
• Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men:longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002;87:589–98
   PubMed Web of Science ®Google Scholar
• Wu FC, Tajar A, Pye SR, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab 2008;93:2737–45
   PubMed Web of Science ®Google Scholar
• Matsumoto AM. Andropause: clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci 2002;57:M76–99
   PubMed Web of Science ®Google Scholar
• Kenny AM, Bellantonio S, Gruman CA, et al. Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 2002;57:M321–5
   PubMed Web of Science ®Google Scholar
• Isidori AM, Giannetta E, Gianfrilli D, et al. Effects of testosterone on sexual function in men: results of a meta-analysis. Clin Endocrinol (Oxf) 2005;63:381–94
   PubMed Web of Science ®Google Scholar
• Srinivas-Shankar U, Roberts SA, Connolly MJ, et al. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010;95:639–50
   PubMed Web of Science ®Google Scholar
• Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010;95:2536–59
   PubMed Web of Science ®Google Scholar
• McGill JJ, Shoskes DA, Sabanegh ES. Androgen deficiency in older men:indications, advantages, and pitfalls of testosterone replacement therapy. Cleve Clin J Med 2012;79:797–806
   Google Scholar
• Mizoguchi K, Yuzurihara M, Ishige A, et al. Saiko-karyukotsu-borei-to, a herbal medicine, ameliorates chronic stress-induceddepressive state in rotarod performance. Pharmacol Biochem Behav 2003;75:419–25
   PubMed Web of Science ®Google Scholar
• Kanba S, Yamada K, Mizushima H, Asai M. Use of herbal medicine for treating psychiatric disorders in Japan. Psychiatry Clin Neurosci 1998;52:S331–3
   PubMedGoogle Scholar
• Sarai K. Oriental medicine as therapy for resistant depression: use of some herbal drugs in the far east (Japan). Prog Neuropsychopharmacol Biol Psychiatry 1992;16:171–80
   PubMedGoogle Scholar
• Tsujimura A, Takada S, Matsuoka Y, et al. Clinical trial of treatment with saikokaryukotsuboreito for eugonadal patients with late-inset hypogonadism-related symptoms. Aging Male 2008;11:95–9
   PubMed Web of Science ®Google Scholar
• Tsujimura A, Miyagawa Y, Okuda H, et al. Change in cytokine levels after administration of saikokaryuukotsuboreito or testosterone in patients with symptoms of late-onset hypogonadism. Aging Male 2011;14:76–81
   PubMed Web of Science ®Google Scholar
• Benelli A, Bertolini A, Zoli M, et al. Pharmacological manipulation of brain galaninergic system and sexual behavior in male mice. Psychopharmacology (Berlin) 2002;160:325–30
   Google Scholar
• Clemens LG, Wee BE, Weaver DR, et al. Retention of masculine sexual behavior following castration in male B6D2F1 mice. Physiol Behav 1988;42:69–76
   Google Scholar
• Huhtaniemi I. Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment. Asian J Androl 2014;16:192–202
   PubMed Web of Science ®Google Scholar
• Taylor MF, Woolveridge I, Metcalfe AD, et al. Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate:role of the Bcl-2 family members. J Endocrinol 1998;157:317–26
   PubMed Web of Science ®Google Scholar
• Corona G, Isidori AM, Buvat J, et al. Testosterone supplementation and sexual function:a meta-analysis study. J Sex Med 2014;11:1577–92
   PubMed Web of Science ®Google Scholar
• Michihara S, Shin N, Watanabe S, et al. A Kampoformula, saikokaryukotsuboreito, improves serum testosterone levels of castrated mice and its possible mechanism. Aging Male 2013;16:17–21
   Web of Science ®Google Scholar
• Clark JT, Kalra SP, Kalra PS. Effects of a selective alpha 1-adrenoceptor agonist, methoxamine, on sexual behavior and penile reflexes. Physiol Behav 1987;40:747–53
   Google Scholar
• Walsh LP, McCormick C, Martin C, et al. Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ Health Perspect 2000;108:769–76
   PubMed Web of Science ®Google Scholar
• Premalatha R, Jubendradass R, Srikumar K, et al. Gibberellic acid acts as an agonist of steroidogenesis in male rats. Andrologia 2013. [Epub ahead of print]
   Google Scholar