A novel allele of HWP1, isolated from a clinical strain of Candida albicans with defective hyphal growth and biofilm formation, has deletions of Gln/Pro and Ser/Thr repeats involved in cellular adhesion

References

• Odds FC. Pathogenesis of candidosis. Candida and Candidosis. A Review and Bibliography, 2nd ed. London: Bailliere Tindall, 1988: 252–278.
   Google Scholar
• Calderone R. Introduction and historical perspectives. Calderone RA. Candida and Candidiasis. Washington, DC: ASM Press, 2002: 3–13.
   Google Scholar
• Calderone R. Taxonomy and biology of Candida. Calderone RA. Candida and Candidiasis. Washington, DC: ASM Press, 2002: 15–27.
   Google Scholar
• Lo HJ, Köhler J, DiDomenico B, . Nonfilamentous C. albicans mutants are avirulent. Cell 1997; 90:939–949.
   PubMed Web of Science ®Google Scholar
• Sharkey LL, McNemar MD, Saporito-Irwin SM, Sypherd PS, Fonzi WA. HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J Bacteriol 1999; 181:5273–5279.
   PubMed Web of Science ®Google Scholar
• Braun BR, Johnson AD. TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 2000; 155:57–67.
   PubMed Web of Science ®Google Scholar
• Liu H. Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 2001; 4:728–735.
   PubMed Web of Science ®Google Scholar
• Hoyer LL. The ALS gene family of Candida albicans. Trends Microbiol 2001; 9:176–180.
   PubMed Web of Science ®Google Scholar
• Zhao X, Oh SH, Cheng G, . ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiol 2004; 150:2415–2428.
   PubMed Web of Science ®Google Scholar
• Hoyer LL, Payne TL, Bell M, Myers AM, Scherer S. Candida albicans ALS3 and insights into the nature of the ALS gene family. Curr Genet 1998; 33:451–459.
   PubMedGoogle Scholar
• Sheppard DC, Yeaman MR, Welch WH, . Functional and structural diversity in the Als protein family of Candida albicans. J Biol Chem 2004; 279:30480–30489.
   PubMed Web of Science ®Google Scholar
• Staab J, Bradway S, Fidel P, Sundstrom P. Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 1999; 283:1535–1538.
   PubMed Web of Science ®Google Scholar
• Tsuchimori N, Sharkey LL, Fonzi WA, . Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells. Infect Immun 2000; 68:1997–2002.
   PubMedGoogle Scholar
• Nobile CJ, Andes DR, Nett JE, . Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog 2006; 2:e63–
   PubMed Web of Science ®Google Scholar
• Nobile CJ, Nett JE, Andes DR. Mitchell AP. Function of Candida albicans adhesin Hwp1 in biofilm formation. Eukaryot Cell 2006; 5:1604–1610.
   PubMed Web of Science ®Google Scholar
• Calderone R, Gow N. Host recognition by Candida species. Calderone RA. Candida and Candidiasis. Washington, DC: ASM Press, 2002: 67–106.
   Google Scholar
• Douglas LJ. Candida biofilms and their role in infection. Trends Microbiol 2003; 11:30–36.
   PubMed Web of Science ®Google Scholar
• Baillie GS, Douglas LJ. Effect of growth rate on resistance of Candida albicans biofilms to antifungal agents. Antimicro Agents Chemother 1998; 42:1900–1905.
   PubMed Web of Science ®Google Scholar
• Soustre J, Rodier MH, Imbert-Bouyer S, Daniault G, Imbert C. Caspofungin modulates in vitro adherence of Candida albicans to plastic coated with extracellular matrix proteins. J Antimicro Chemother 2004; 48:1–4.
   Google Scholar
• Mateus C, Crow SA Jr, Ahearn DG. Adherence of Candida albicans to silicone induces immediate enhanced tolerance to fluconazole. Antimicro Agents Chemother 2004; 48:3358–3366.
   PubMed Web of Science ®Google Scholar
• Staab J, Sundstrom P. Genetic organization and sequence analysis of the hypha-specific cell wall protein gene HWP1 of Candida albicans. Yeast 1998; 14:681–686.
   PubMed Web of Science ®Google Scholar
• Li X, Yan Z, Xu J. Quantitative variation of biofilms among strains in natural populations of Candida albicans. Microbiol 2003; 149:353–362.
   PubMed Web of Science ®Google Scholar
• Jin Y, Yip HK, Samaranayake YH, Yau JY, Samaranayake LP. Biofilm-forming ability of Candida albicans is unlikely to contribute to high levels of oral yeast carriage in cases of human immunodeficiency virus infection. J Clin Microbiol 2003; 41:2961–2967.
   PubMed Web of Science ®Google Scholar
• Cowen LE, Anderson JB, Kohn LM. Evolution of drug resistance in Candida albicans. Annu Rev Microbiol 2002; 56:139–165.
   PubMed Web of Science ®Google Scholar
• Samaranayake YH, Samaranayake LP, Yau JY, . Adhesion and cell-surface-hydrophobicity of sequentially isolated genetic isotypes of Candida albicans in an HIV-infected Southern Chinese cohort. Mycoses 2003; 46:375–383.
   PubMed Web of Science ®Google Scholar
• Lockhart SR, Daniels KJ, Zhao R, Wessels D, Soll DR. Cell biology of mating in Candida albicans. Eukaryot Cell 2003; 2:49–61.
   PubMedGoogle Scholar
• Jones T, Federspiel NA, Chibana H, . The diploid genome sequence of Candida albicans. Proc Natl Acad Sci USA 2004; 101:7329–7334.
   PubMed Web of Science ®Google Scholar
• Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhauser J. Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene. Mol Microbiol 2002; 44:1351–1366.
   PubMedGoogle Scholar
• Sanz M, Valle R, Roncero C. Promoter heterozygosity at the Candida albicans CHS7 gene is translated into differential expression between alleles. FEMS Yeast Res 2007; 7:993–1003.
   PubMedGoogle Scholar
• Hawser SP, Douglas LJ. Biofilm formation by Candida species on surface of catheter materials in vitro. Infect Immun 1994; 62:915–921.
   PubMed Web of Science ®Google Scholar
• Wach A, Pick H, Philppsen P. Procedures for isolating yeast DNA for different purposes. Johnston John R. Molecular Genetics of Yeast. Oxford: IRL Press at Oxford University Press, 1994: 10–11.
   Google Scholar
• Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd. New York: Cold Spring Harbor Laboratory Press, 1989.
   Google Scholar
• Ewing B, Green P. Base-calling of automated sequencer traces using phred. II. Error probabilities. Genome Res 1998; 8:186–194.
   PubMed Web of Science ®Google Scholar
• Ewing B, Hillier L, Wendl MC, Green P. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res 1998; 8:175–185.
   PubMed Web of Science ®Google Scholar
• Gordon D, Abajian C, Green P. Consed: a graphical tool for sequence finishing. Genome Res 1998; 8:195–202.
   PubMed Web of Science ®Google Scholar
• Santos MA, Tuite MF. The CUG codon is decoded in vivo as serine and not leucine in Candida albicans. Nucleic Acids Res 1995; 23:1481–1486.
   PubMed Web of Science ®Google Scholar
• Servant F, Bru C, Carrere S, . ProDom: automated clustering of homologous domains. Brief Bioinform 2002; 3:246–251.
   PubMedGoogle Scholar
• Staab J, Ferrer C, Sundstrom P. Developmental expression of a tandemly repeated, proline-and glutamine-rich amino acid motif on hyphal surfaces on Candida albicans. J Biol Chem 1996; 271:6298–6305.
   PubMed Web of Science ®Google Scholar
• Garnier J, Robson B. Prediction of Protein Structure and the Principles of Protein Conformation. New York: Plenum Press, 1989.
   Google Scholar
• Hube B, Monod M, Schofield DA, Brown AJ, Gow NA. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 1994; 14:87–99.
   PubMed Web of Science ®Google Scholar
• White TC, Agabian N. Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors. J Bacteriol 1995; 177:5215–5221.
   PubMed Web of Science ®Google Scholar
• Richard ML, Nobile CJ, Bruno VM, Mitchell AP. Candida albicans biofilm-defective mutants. Eukaryot Cell 2005; 4:1493–1502.
   PubMedGoogle Scholar
• Kumamoto CA. A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Proc Natl Acad Sci USA 2005; 102:5576–5581.
   PubMed Web of Science ®Google Scholar
• Bartolome C, Maside X, Yi S, Grant AL, Charlesworth B. Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda. Genetics 2005; 169:1495–1507.
   PubMedGoogle Scholar
• Loewe L, Charlesworth B, Bartolome C, Noel V. Estimating selection on nonsynonymous mutations. Genetics 2006; 172:1079–1092.
   PubMedGoogle Scholar
• McGraw EA, Merritt DJ, Droller JN, O'Neill SL. Wolbachia density and virulence attenuation after transfer into a novel host. Proc Natl Acad Sci USA 2002; 99:2918–2923.
   PubMed Web of Science ®Google Scholar
• Dyddahl MF, Stofer A. Parasite local adaptation: Red quenn versus Suicide King. Trends Ecol Evol 2003; 18:523–530.
   Google Scholar
• Zhao X, Pujol C, Soll DR, Hoyer LL. Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9. Microbiol 2003; 149:2947–2960.
   PubMed Web of Science ®Google Scholar
• Zhang N, Harrex AL, Holland BR, . Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 is a hypermutable contingency locus. Genom Res 2003; 13:2005–2017.
   PubMed Web of Science ®Google Scholar
• Sato M, Watari J, Shinotsuka K. Genetic instability in flocculation of bottom-fermentating yeast. J Am Soc Brew Chem 2001; 59:107–110.
   Google Scholar
• Verstrepen KJ, Reynolds TB, Fink GR. Origins of variation in the fungal cell surface. Nat Rev Microbiol 2004; 2:533–540.
   PubMed Web of Science ®Google Scholar
• Nandi PK. Protein conformation and disease. Vet Res 1996; 27:373–382.
   PubMedGoogle Scholar
• Staab J, Bahn Y, Tai C, Cook P, Sundstrom P. Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification. J Biol Chem 2004; 279:40737–40747.
   PubMed Web of Science ®Google Scholar
• Tiley KA, Benjamin RE, Bagorogoza KE, . Tyrosine cross-links: Molecular basis of gluten structure and function. J Agric Food Chem 2001; 49:2627–2632.
   PubMedGoogle Scholar
• Suzuki K. Roles of sexual cell agglutination in yeast mass mating. Genes Genet Syst 2003; 78:211–219.
   PubMedGoogle Scholar
• Couture-Tosi E, Delacroix H, Mignot T, . Structural analysis and evidence for dynamic emergence of Bacillus anthracis S-layer networks. J Bacteriol 2002; 184:6448–6456.
   PubMedGoogle Scholar
• Espinel-Ingroff A, Kish CJ, Kerkering T, . Collaborative comparison of broth macrodilution and microdilution antifungal susceptibility tests. J Clin Microbiol 1992; 30:3138–3145.
   PubMed Web of Science ®Google Scholar
• Pfaller M, Vu Q, Lancaster M, . Multisite reproducibility of colorimetric broth microdilution method for antifungal susceptibility testing of yeast isolates. J Clin Microbiol 1994; 32:1625–1628.
   PubMed Web of Science ®Google Scholar
• Gillum A, Tsay E, Kirsch D. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 1984; 198:179–182.
   PubMedGoogle Scholar
• Garnier J, Osguthorpe DJ, Robson B. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol 1978; 120:97–120.
   PubMed Web of Science ®Google Scholar
• Hoop T, Woods K. Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci USA 1981; 78:3824–3828.
   PubMedGoogle Scholar
• Emini EA, Hughes JV, Perlow DS, Boger J. Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 1985; 55:836–839.
   PubMed Web of Science ®Google Scholar