Role of NADPH oxidase in host defense against aspergillosis

References

• Reeves EP, Lu H, Jacobs HL, . Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 2002; 416: 291–297.
   PubMed Web of Science ®Google Scholar
• Marciano BE, Rosenzweig SD, Kleiner DE, . Gastrointestinal involvement in chronic granulomatous disease. Pediatrics 2004; 114: 462–468.
   PubMed Web of Science ®Google Scholar
• Graham DB, Stephenson LM, Lam SK, . An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med 2007; 204: 2889–2897.
   Google Scholar
• Mocsai A, Abram CL, Jakus Z, . Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 2006; 7: 1326–1333.
   PubMed Web of Science ®Google Scholar
• Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003; 197: 1107–1117.
   PubMed Web of Science ®Google Scholar
• Abo A, Pick E, Hall A, . Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature 1991; 353: 668–670.
   PubMed Web of Science ®Google Scholar
• Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 1991; 254: 1512–1515.
   PubMed Web of Science ®Google Scholar
• Winkelstein JA, Marino MC, Johnston RB Jr, . Chronic granulomatous disease: report on a national registry of 368 patients. Medicine (Baltimore) 2000; 79: 155–169.
   PubMed Web of Science ®Google Scholar
• Segal BH, DeCarlo ES, Kwon-Chung KJ, . Aspergillus nidulans infection in chronic granulomatous disease. Medicine (Baltimore) 1998; 77: 345–354.
   PubMed Web of Science ®Google Scholar
• Liese J, Kloos S, Jendrossek V, . Long-term follow-up and outcome of 39 patients with chronic granulomatous disease. J Pediatr 2000; 137: 687–693.
   PubMed Web of Science ®Google Scholar
• van den Berg JM, van Koppen E, Ahlin A, . Chronic granulomatous disease: the European experience. PLoS ONE 2009; 4: e5234.
   PubMed Web of Science ®Google Scholar
• Rosen-Wolff A, Soldan W, Heyne K, . Increased susceptibility of a carrier of X-linked chronic granulomatous disease (CGD) to Aspergillus fumigatus infection associated with age- related skewing of lyonization. Ann Hematol 2001; 80: 113–115.
   PubMed Web of Science ®Google Scholar
• Gallin JI, Buescher ES, Seligmann BE, . NIH conference. Recent advances in chronic granulomatous disease. Ann Intern Med 1983; 99: 657–674.
   PubMed Web of Science ®Google Scholar
• Dennis CG, Greco WR, Brun Y, . Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Antimicrob Agents Chemother 2006; 50: 422–427.
   PubMed Web of Science ®Google Scholar
• Chang YC, Segal BH, Holland SM, Miller GF, Kwon-Chung KJ. Virulence of catalase-deficient Aspergillus nidulans in p47(phox)-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease. J Clin Invest 1998; 101: 1843–1850.
   PubMedGoogle Scholar
• Walsh TJ, Schaufele RL, Sein T, . Reduced expression of galactomannan antigenemia in patients with invasive aspergillosis and chronic granulomatous disease or Job's syndrome. Paper presented at: Infectious Disease Society of America 40th annual meeting 2002; Chicago, IL.
   Google Scholar
• Zarember KA, Sugui JA, Chang YC, Kwon-Chung KJ, Gallin JI. Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion. J Immunol 2007; 178: 6367–6373.
   PubMed Web of Science ®Google Scholar
• Cornish EJ, Hurtgen BJ, McInnerney K, . Reduced nicotinamide adenine dinucleotide phosphate oxidase-independent resistance to Aspergillus fumigatus in alveolar macrophages. J Immunol 2008; 180: 6854–6867.
   PubMed Web of Science ®Google Scholar
• Tkalcevic J, Novelli M, Phylactides M, . Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity 2000; 12: 201–210.
   PubMed Web of Science ®Google Scholar
• Brinkmann V, Reichard U, Goosmann C, . Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532–1535.
   PubMed Web of Science ®Google Scholar
• Bianchi M, Hakkim A, Brinkmann V, . Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 2009; 114: 2619–2622.
   PubMed Web of Science ®Google Scholar
• Fuchs TA, Abed U, Goosmann C, . Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 2007; 176: 231–241.
   PubMed Web of Science ®Google Scholar
• Garlanda C, Hirsch E, Bozza S, . Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 2002; 420: 182–186.
   PubMed Web of Science ®Google Scholar
• Jaillon S, Peri G, Delneste Y, . The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 2007; 204: 793–804.
   PubMed Web of Science ®Google Scholar
• D'Angelo C, De Luca A, Zelante T, . Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J Immunol 2009; 183: 4609–4618.
   PubMed Web of Science ®Google Scholar
• Siddiqui S, Anderson VL, Hilligoss DM, . Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease. Clin Infect Dis 2007; 45: 673–681.
   PubMed Web of Science ®Google Scholar
• Bignell E, Negrete-Urtasun S, Calcagno AM, . Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun 2005; 73: 5204–5207.
   PubMed Web of Science ®Google Scholar
• Morgenstern DE, Gifford MA, Li LL, Doerschuk CM, Dinauer MC. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J Exp Med 1997; 185: 207–218.
   PubMed Web of Science ®Google Scholar
• Schappi M, Deffert C, Fiette L, . Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice. J Pathol 2008; 214: 434–444.
   PubMed Web of Science ®Google Scholar
• Brown GD, Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 2001; 413: 36–37.
   PubMed Web of Science ®Google Scholar
• Netea MG, Gow NA, Munro CA, . Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest 2006; 116: 1642–1650.
   PubMed Web of Science ®Google Scholar
• LeibundGut-Landmann S, Gross O, Robinson MJ, . Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007; 8: 630–638.
   PubMed Web of Science ®Google Scholar
• Gross O, Gewies A, Finger K, . Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006; 442: 651–656.
   PubMed Web of Science ®Google Scholar
• Gross O, Poeck H, Bscheider M, . Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009; 459: 433–436.
   PubMed Web of Science ®Google Scholar
• Gersuk GM, Underhill DM, Zhu L, Marr KA. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol 2006; 176: 3717–3724.
   PubMed Web of Science ®Google Scholar
• Hohl TM, Van Epps HL, Rivera A, . Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog 2005; 1: e30.
   PubMed Web of Science ®Google Scholar
• Steele C, Rapaka RR, Metz A, . The beta-glucan receptor Dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog 2005; 1: e42.
   PubMed Web of Science ®Google Scholar
• Aimanianda V, Bayry J, Bozza S, . Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 2009; 460: 1117–1121.
   PubMed Web of Science ®Google Scholar
• Werner JL, Metz AE, Horn D, . Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol 2009; 182: 4938–4946.
   PubMed Web of Science ®Google Scholar
• Stark MA, Huo Y, Burcin TL, . Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005; 22: 285–294.
   PubMed Web of Science ®Google Scholar
• Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 2009; 9: 556–567.
   PubMed Web of Science ®Google Scholar
• Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007; 25: 221–242.
   PubMed Web of Science ®Google Scholar
• Zelante T, De Luca A, D'Angelo C, Moretti S, Romani L. IL-17/Th17 in anti-fungal immunity: what's new? Eur J Immunol 2009; 39: 645–648.
   PubMed Web of Science ®Google Scholar
• Romani L, Fallarino F, De Luca A, . Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 2008; 451: 211–215.
   PubMed Web of Science ®Google Scholar
• Glocker EO, Hennigs A, Nabavi M, . A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med 2009; 361: 1727–1735.
   PubMed Web of Science ®Google Scholar
• Ferwerda B, Ferwerda G, Plantinga TS, . Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 2009; 361: 1760–1767.
   PubMed Web of Science ®Google Scholar
• Pollock JD, Williams DA, Gifford MA, . Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 1995; 9: 202–209.
   PubMed Web of Science ®Google Scholar
• Zenaro E, Donini M, Dusi S. Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, mannose receptor, and DC-SIGN. J Leukoc Biol 2009; 86: 1393–1401.
   PubMed Web of Science ®Google Scholar
• Manicassamy S, Ravindran R, Deng J, . Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med 2009; 15: 401–409.
   PubMed Web of Science ®Google Scholar
• Segal BH, Han W, Bushey JJ, . NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE 2010; 5: e9631.
   PubMed Web of Science ®Google Scholar
• Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007; 47: 89–116.
   PubMed Web of Science ®Google Scholar
• Gelderman KA, Hultqvist M, Pizzolla A, . Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. J Clin Invest 2007; 117: 3020–3028.
   PubMedGoogle Scholar
• George-Chandy A, Nordstrom I, Nygren E, . Th17 development and autoimmune arthritis in the absence of reactive oxygen species. Eur J Immunol 2008; 38: 1118–1126.
   PubMedGoogle Scholar
• Cheng P, Corzo CA, Luetteke N, . Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008; 205: 2235–2249.
   PubMed Web of Science ®Google Scholar
• Jancic C, Savina A, Wasmeier C, . Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol 2007; 9: 367–378.
   Google Scholar
• Savina A, Jancic C, Hugues S, . NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 2006; 126: 205–218.
   PubMed Web of Science ®Google Scholar
• Mantegazza AR, Savina A, Vermeulen M, . NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells. Blood. 2008 Dec 1; 112(12): 4712–22.
   PubMedGoogle Scholar
• Corzo CA, Cotter MJ, Cheng P, . Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 2009; 182: 5693–5701.
   PubMed Web of Science ®Google Scholar
• Montagnoli C, Fallarino F, Gaziano R, . Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 2006; 176: 1712–1723.
   PubMed Web of Science ®Google Scholar
• Maghzal GJ, Thomas SR, Hunt NH, Stocker R. Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. J Biol Chem 2008; 283: 12014–12025.
   PubMedGoogle Scholar
• Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 2007; 56: 2936–2946.
   PubMed Web of Science ®Google Scholar
• Snelgrove RJ, Edwards L, Williams AE, Rae AJ, Hussell T. In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection. J Immunol 2006; 177: 5509–5516.
   PubMedGoogle Scholar
• Geiszt M, Kopp JB, Varnai P, Leto TL. Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci USA 2000; 97: 8010–8014.
   PubMed Web of Science ®Google Scholar
• Kawahara T, Kuwano Y, Teshima-Kondo S, . Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. J Immunol 2004; 172: 3051–3058.
   PubMed Web of Science ®Google Scholar
• Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol 2004; 5: 818–827.
   PubMed Web of Science ®Google Scholar
• Pagano PJ, Clark JK, Cifuentes-Pagano ME, . Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II. Proc Natl Acad Sci USA 1997; 94: 14483–14488.
   PubMed Web of Science ®Google Scholar
• Lavigne MC, Malech HL, Holland SM, Leto TL. Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells. Circulation 2001; 104: 79–84.
   PubMed Web of Science ®Google Scholar
• Hsich E, Segal BH, Pagano PJ, . Vascular effects following homozygous disruption of p47(phox): an essential component of NADPH oxidase. Circulation 2000; 101: 1234–1236.
   PubMed Web of Science ®Google Scholar
• Geiszt M, Leto TL. The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem 2004; 279: 51715–51718.
   PubMed Web of Science ®Google Scholar
• Nauseef WM. Biological roles for the NOX family NADPH oxidases. J Biol Chem 2008; 283: 16961–16965.
   PubMed Web of Science ®Google Scholar