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Research Article

Exposure of Aspergillus fumigatus to caspofungin results in the release, and de novo biosynthesis, of gliotoxin

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Pages 121-127 | Received 12 Jan 2012, Accepted 21 Apr 2012, Published online: 16 Jan 2013

References

  • Deresinski S, Stevens DA. Caspofungin. Clin Infect Dis 2003; 36: 1445–1457.
  • Maertens J, Raad I, Petrikkos G, . Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin Infect Dis 2004; 39: 1563–1571.
  • Zaoutis TE, Jafri HS, Huang LM, . A prospective, multicenter study of caspofungin for the treatment of documented Candida or Aspergillus infections in pediatric patients. Pediatrics 2009; 123: 877–884.
  • Walsh TJ, Teppler H, Donowitz GR, . Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. N Engl J Med 2004; 351: 1391–402.
  • Denning DW. Echinocandin antifungal drugs. Lancet 2003; 362: 1142–1151.
  • Brookman JL, Denning DW. Molecular genetics in Aspergillus fumigatus. Curr Opin Microbiol 2000; 3: 468–474.
  • Denning DW. Aspergillosis: diagnosis and treatment. Int J Antimicrob Agents 1996; 6: 161–168.
  • Denning DW. Therapeutic outcome in invasive aspergillosis. Clin Inf Dis 1996; 23: 608–615.
  • Denning DW. Invasive aspergillosis. Clin Inf Dis 1998; 26: 781–805.
  • Amitani R, Murayama T, Nawada, . Aspergillus culture filtrates and sputum sols from patients with pulmonary aspergillosis cause damage to human respiratory ciliated epithelium in vitro. Eur Resp J 1995; 8: 1681–1688.
  • Comera C, Andre K, Laffitte K, . Gliotoxin from Aspergillus fumigatus affects phagocytosis and organization of the actin cytoskeleton by distinct signaling pathways in human neutrophils. Microb Infect 2007; 9: 47–54.
  • Rementeria A, López-Molina N, Ludwig A, . Genes and molecules involved in Aspergillus fumigatus virulence. Rev Iberoam Micol 2005; 22: 1–23.
  • Waring P, Beaver J. Gliotoxin and related epipolythiodioxopiperazines. Gen Pharm 1996; 27: 1311–1316.
  • Sutton P, Moreland A, Hutchinson IV, Mullbacher A. Investigation of the potential use immunosuppressive agent gliotoxin in organ transplantation. Transplant 1995; 60: 900–902.
  • Sutton P, Waring P, Mullbacher A. Exacerbation of invasive aspergillosis by the immunosuppressive fungal metabolite, gliotoxin. Immunol Cell Biol 1996; 74: 318–322.
  • Tsunawaki S, Yoshida L, Nishida S, Kobayashi T, Shimoyama T. Fungal metabolite gliotoxin inhibits assembly of the human respiratory burst NADPH oxidase. Infect Immun 2004; 72: 3373–3382.
  • Tekaia F, Latgé JP. Aspergillus fumigatus: saprophyte or pathogen Curr Opin Microbiol 2005; 8: 385–392.
  • Lewis RE, Wiederhold NP, Chi J, . Detection of gliotoxin in experimental and human aspergillosis. Infect Immun 2005; 73: 635–637.
  • Fraser RS. Pulmonary aspergillosis: pathologic and pathogenetic features. Pathol Ann 1993; 28: 231–277.
  • Reeves EP, Murphy T, Daly P, Kavanagh K. Amphotericin B enhances the synthesis and release of the immunosuppressive agent gliotoxin from the pulmonary pathogen Aspergillus fumigatus. J Med Microbiol 2004; 53: 719–725.
  • Kelly J, Kavanagh K. Proteomic analysis of proteins released from growth-arrested Candida albicans following exposure to caspofungin. Med Mycol 2010; 48: 598–605.
  • Ghosh A, Ghosh JJ. Release of intracellular constituents of Candida albicans in presence of polyene antibiotics. Ann Biochem Exper Med 1963; 23: 612–626.
  • Betts R, Glasmacher A, Maertens J, . Efficacy of caspofungin against Candida or invasive Aspergillus infections in neutropenic patients. Cancer 2006; 106: 466–473.
  • Kwon-Chung KJ, Sugui JA. What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? Med Mycol 2009; 47: S97–103.
  • Schrettl M, Carberry S, Kavanagh K, . Self-protection against gliotoxin – a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin. PLOS Pathogens 2010; 6: e1000952.
  • Kelly J, Rowan R, McCann M, Kavanagh K. Exposure to caspofungin activates Cap and Hog pathways in Candida albicans. Med Mycol 2009; 47: 697–706.
  • Liao RS, Rennie RP, Talbot JA. Assessment of the effect of Amphotericin B on the vitality of Candida albicans. Antimicrob Agent Chemother 1999; 43: 1034–1041.

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