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Review Article

Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on

&
Pages 256-262 | Received 16 Dec 2011, Accepted 20 Jan 2012, Published online: 22 May 2012

References

  • Rossouw JE, Anderson GL, Prentice RL, . Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–33
  • Anderson GL, Limacher M, Assaf AR, . Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004;291:1701–12
  • Plassman BL, Langa KM, Fisher GG, . Prevalence of dementia in the United States: the Aging, Demographics, and Memory Study. Neuroepidemiology 2007;29:125–32
  • Lobo A, Launer LJ, Fratiglioni L, . Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000;54 (Suppl 5):S4–9
  • Larson EB, Shadlen MF, Wang L, . Survival after initial diagnosis of Alzheimer disease. Ann Intern Med 2004;140:501–9
  • Launer LJ, Andersen K, Dewey ME, . Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. Neurology 1999;52:78–84
  • Plassman BL, Langa KM, McCammon RJ, . Incidence of dementia and cognitive impairment, not dementia in the United States. Ann Neurol 2011;70:418–26
  • Edland SD, Rocca WA, Petersen RC, Cha RH, Kokmen E. Dementia and Alzheimer disease incidence rates do not vary by sex in Rochester, Minn. Arch Neurol 2002;59:1589–93
  • Henderson VW, Buckwalter JG. Cognitive deficits of men and women with Alzheimer's disease. Neurology 1994;44:90–6
  • Ripich DN, Petrill SA, Whitehouse PJ, Ziol EW. Gender differences in language of AD patients: a longitudinal study. Neurology 1995;45:299–302
  • Tang M-X, Jacobs D, Stern Y, . Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996;348:429–32
  • Paganini-Hill A, Henderson VW. Estrogen replacement therapy and risk of Alzheimer's disease. Arch Intern Med 1996;156: 2213–17
  • Kawas C, Gray S, Brookmeyer R, Fozard J, Zonderman A. Age-specific incidence rates of Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 2000;54:2072–7
  • Zandi PP, Carlson MC, Plassman BL, . Hormone replacement therapy and incidence of Alzheimer's disease in older women: the Cache County study. JAMA 2002;288:2123–9
  • Hogervorst E, Williams J, Budge M, Riedel W, Jolles J. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis. Neuroscience 2000;101:485–512
  • LeBlanc ES, Janowsky J, Chan BKS, Nelson HD. Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA 2001;285:1489–99
  • Liu L, Zhao L, She H, . Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology 2010;151:5782–94
  • Nilsen J, Deng J, Brinton RD. Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved. Drug News Perspect 2005;18:545–53
  • Morrison JH, Brinton RD, Schmidt PJ, Gore AC. Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. J Neurosci 2006;26:10332–48
  • Henderson VW, Watt L, Buckwalter JG. Cognitive skills associated with estrogen replacement in women with Alzheimer's disease. Psychoneuroendocrinology 1996;21:421–30
  • Schneider LS, Farlow MR, Henderson VW, Pogoda JM. Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease. Neurology 1996;46:1580–4
  • Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, Reuning-Scherer J, Gulanski B. The Alzheimer's disease assessment scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology 1997;48:1511–17
  • Henderson VW, Paganini-Hill A, Miller BL, . Estrogen for Alzheimer's disease in women: randomized, double-blind, placebo-controlled trial. Neurology 2000;54:295–301
  • Mulnard RA, Cotman CW, Kawas C, . Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. JAMA 2000;283:1007–15
  • Women's Health Initiative Study Group. Design of the Women's Health Initiative clinical trial and observational study. Control Clin Trials 1998;19:61–109
  • Shumaker SA, Legault C, Rapp SR, . Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study (WHIMS). JAMA 2003;289:2651–62
  • Shumaker SA, Legault C, Kuller L, . Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004;291:2947–58
  • Rapp SR, Legault C, Henderson VW, . Subtypes of mild cognitive impairment in older postmenopausal women: the Women's Health Initiative Memory Study. Alzheimer Dis Assoc Disord 2010;24:248–55
  • Gauthier S, Reisberg B, Zaudig M, . Mild cognitive impairment. Lancet 2006;367:1262–70
  • Coker LH, Hogan PE, Bryan NR, . Postmenopausal hormone therapy and subclinical cerebrovascular disease: the WHIMS-MRI Study. Neurology 2009;72:125–34
  • Resnick SM, Espeland MA, Jaramillo SA, . Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI study. Neurology 2009;72:135–42
  • Jaramillo SA, Felton D, Andrews L, . Enrollment in a brain magnetic resonance study: results from the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI). Acad Radiol 2007;14:603–12
  • Espeland MA, Tindle HA, Bushnell CA, . Brain volumes, cognitive impairment, and conjugated equine estrogens. J Gerontol A Biol Sci Med Sci 2009;64:1243–50
  • Lord C, Buss C, Lupien SJ, Pruessner JC. Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: a possible window of opportunity effect. Neurobiol Aging 2008;29:95–101
  • Resnick SM, Henderson VW. Hormone therapy and risk of Alzheimer disease: a critical time. JAMA 2002;288:2170–2
  • Brett KM, Chong Y. Hormone Replacement Therapy: Knowledge and Use in the United States. Hyattsville, MD: National Center for Health Statistics, 2001
  • Henderson VW, Benke KS, Green RC, Cupples LA, Farrer LA. Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age. J Neurol Neurosurg Psychiatry 2005;76:103–5
  • Henderson VW, Espeland MA, Hogan PE, . Prior use of hormone therapy and incident Alzheimer's disease in the Women's Health Initiative Memory Study. Neurology 2007;68(Suppl 1):A205 (abstract)
  • Whitmer RA, Quesenberry CP, Zhou J, Yaffe K. Timing of hormone therapy and dementia: the critical window theory revisited. Ann Neurol 2011;69:163–9
  • Henderson VW. Estrogen-containing hormone therapy and Alzheimer's disease risk: understanding discrepant inferences from observational and experimental research. Neuroscience 2006;138:1031–9
  • Rocca WA, Cha RH, Waring SC, Kokmen E. Incidence of dementia and Alzheimer's disease: a reanalysis of data from Rochester, Minnesota, 1975–1984. Am J Epidemiol 1998;148: 51–62
  • Yaffe K, Krueger K, Cummings SR, . Effect of raloxifene on the prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial. Am J Psychiatry 2005;162:683–90
  • Resnick SM, Coker LH, Maki PM, Rapp SR, Espeland MA, Shumaker SA. The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline. Clin Trials 2004;1:440–50
  • Resnick SM, Maki PM, Rapp SR, . Effects of combination estrogen plus progestin hormone treatment on cognition and affect. J Clin Endocrinol Metab 2006;91:1802–10
  • Resnick SM, Espeland MA, An Y, . Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy. J Clin Endocrinol Metab 2009; 94:4152–61
  • Grady D, Yaffe K, Kristof M, Lin F, Richards C, Barrett-Connor E. Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med 2002;113:543–8
  • Linn RT, Wolf PA, Bachman DL, . The ‘preclinical phase’ of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort. Arch Neurol 1995;52:485–90
  • Tierney MC, Yao C, Kiss A, McDowell I. Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology 2005;64:1853–9
  • Yaffe K, Vittinghoff E, Ensrud KE, . Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of life. Arch Neurol 2006;63:945–50
  • Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: results from the Women's Estrogen for Stroke Trial (WEST). Am J Obstet Gynecol 2005;192:387–93
  • Almeida OP, Lautenschlager NT, Vasikaran S, Leedman P, Gelavis A, Flicker L. A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and older: effect on mood, cognition and quality of life. Neurobiol Aging 2006; 27:141–9
  • Pefanco MA, Kenny AM, Kaplan RF, . The effect of 3-year treatment with 0.25 mg/day of micronized 17beta-estradiol on cognitive function in older postmenopausal women. J Am Geriatr Soc 2007;55:426–31
  • Sherwin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988;13:345–57
  • Phillips SM, Sherwin BB. Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 1992;17:485–95
  • Maki PM, Sundermann E. Hormone therapy and cognitive function. Hum Reprod Update 2009;15:874–86
  • Joffe H, Hall JE, Gruber S, . Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women. Menopause 2006;13:411–22
  • Maki PM, Gast MJ, Vieweg AJ, Burriss SW, Yaffe K. Hormone therapy in menopausal women with cognitive complaints: a randomized, double-blind trial. Neurology 2007;69:1322–30
  • Maki PM, Rubin LH, Fornelli D, . Effects of botanicals and combined hormone therapy on cognition in postmenopausal women. Menopause 2009;16:1167–77
  • Yaffe K, Krueger K, Sarkar S, . Cognitive function in postmenopausal women treated with raloxifene. N Engl J Med 2001;344:1207–13
  • Jacobsen DE, Samson MM, Emmelot-Vonk MH, Verhaar HJ. Raloxifene improves verbal memory in late postmenopausal women: a randomized, double-blind, placebo-controlled trial. Menopause 2010;17:309–14
  • Neele SJ, Rombouts SA, Bierlaagh MA, Barkhof F, Scheltens P, Netelenbos JC. Raloxifene affects brain activation patterns in postmenopausal women during visual encoding. J Clin Endocrinol Metab 2001;86:1422–4
  • Goekoop R, Barkhof F, Duschek EJ, . Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males. Neuropsychopharmacology 2006;31:1508–18
  • Legault C, Maki PM, Resnick SM, . Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene. J Clin Oncol 2009;27:5144–52
  • Espeland MA, Shumaker SA, Limacher M, . Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. J Womens Health (Larchmt) 2010;19:371–9
  • Espeland M, Rapp S, Shumaker S, . Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004;291:2959–68
  • Resnick SM, Espeland MA, Jaramillo SA, . Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study. Neurology 2009;72:135–42
  • Brinton RD. Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action. Ann NY Acad Sci 2005;1052:57–74

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