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ORIGINAL ARTICLES

Soybean isoflavones attenuate the expression of genes related to endometrial cancer risk

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Pages 389-398 | Received 28 Jul 2014, Accepted 08 Sep 2014, Published online: 27 Nov 2014

References

  • Han KK, Soares JM Jr, Haidar MA, et al. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol 2002;99:389–94
  • Kaari C, Haidar MA, Júnior JM, et al. Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study. Maturitas 2006;53:49–58
  • Moreira AC, Silva AM, Santos MS, et al. Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown. J Steroid Biochem Mol Biol 2014;143:61–71
  • Francisco AM, Carbonel AF, Simões RS, et al. Do extracts of oral soybean augment the trophic effect of estrogen on the rat uterus? Climacteric 2013;16:161–8
  • del Giorno C, Fonseca AM, Bagnoli VR, et al. Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause women. Rev Assoc Med Bras 2010;56:558–62
  • Wang Q, Ge X, Tian X, Zhang Y, Zhang J, Zhang P. Soy isoflavone: the multipurpose phytochemical. Biomed Rep 2013;1: 697–701
  • Bedell S, Nachtigall M, Naftolin F. The pros and cons of plant estrogens for menopause. J Steroid Biochem Mol Biol 2014;139:225–36
  • Berwick DM. Broadening the view of evidence-based medicine. Qual Saf Health Care 2005;14:315–16
  • Yuguchi H, Tanabe A, Hayashi A, et al. The expression status of G protein-coupled receptor GPR30 is associated with the clinical characteristics of endometriosis. Endocr Res 2013;38:223–31
  • Pavese JM, Farmer RL, Bergan RC. Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev 2010;29:465–82
  • Nadal-Serrano M, Pons DG, Sastre-Serra J, et al. Genistein modulates oxidative stress in breast cancer cell lines according to ERα/ERβ ratio: effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes. Int J Biochem Cell Biol 2013;45:2045–51
  • Bosviel R, Dumollard E, Déchelotte P, et al. Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? OMICS 2012;16:235–44
  • Lichtenstein AH. Soy protein, isoflavonoids, and risk of developing coronary heart disease. Curr Atheroscler Rep 1999;1:210–14
  • Horiuchi T, Weller PF. Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5. Am J Respir Cell Mol Biol 1997;17:70–7
  • Zhen P, Zhao Q, Hou D, et al. Genistein attenuates vascular endothelial impairment in ovariectomized hyperhomocysteinemic rats. J Biomed Biotechnol 2012;2012:730462
  • Adlercreutz H, Hämäläinen E, Gorbach S, et al. Dietary phyto-oestrogens and the menopause in Japan. Lancet 1992;339:1233
  • Carbonel AA, Baracat MC, Simões RS, et al. The soybean concentrated extract proliferates the vagina of adult rats. Menopause 2011;18:93–101
  • Rimoldi G, Christoffel J, Seidlova-Wuttke D, et al. Effects of chronic genistein treatment in mammary gland, uterus, and vagina. Environ Health Perspect 2007;115(Suppl 1):62–8
  • Calió ML, Marinho DS, Carbonel AF, et al. Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. Free Radic Biol Med 2014;70:141–54
  • Stachenfeld NS. Hormonal changes during menopause and the impact on fluid regulation. Reprod Sci 2014;21:555–61
  • Hodis HN, Collins P, Mack WJ, et al. The timing hypothesis for coronary heart disease prevention with hormone therapy: past, present and future in perspective. Climacteric 2012;15: 217–28
  • Carbonel AA, Simões RS, Santos RH, et al. Effects of high-dose isoflavones on rat uterus. Rev Assoc Med Bras 2011;57:534–9
  • Setchell KD, Cassidy A. Dietary isoflavones: biological effects and relevance to human health. J Nutr 1999;129:758–67S
  • Moiseeva EP, Almeida GM, Jones GD, et al. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther 2007;6:3071–9
  • Touny LH, Banerjee PP. Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein. Prostate 2006;66:1542–55
  • Lim S, Kaldis P. Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development 2013;140:3079–93
  • Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause 2004;11:400–4
  • Inoue A, Takeuchi S, Takahashi S. Insulin-like growth factor-I stimulated DNA replication in mouse endometrial stromal cells. J Reprod Dev 2005;51:305–13
  • Unfer V, Casini ML, Costabile L, et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004;82:145–8
  • Murray MJ, Meyer WR, Lessey BA, et al. Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: a pilot trial. Menopause 2003;10:456–64
  • Kuiper GG, Carlsson B, Grandien K, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997; 138:863–70
  • García-Pérez MA, Del Val R, Noguera I, et al. Estrogen receptor agonists and immune system in ovariectomized mice. Int J Immunopathol Pharmacol 2006;19:807–19
  • Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000;182:311–22
  • Kypreos KE, Zafirovic S, Petropoulou PI, et al. Regulation of endothelial nitric oxide synthase and high-density lipoprotein quality by estradiol in cardiovascular pathology. J Cardiovasc Pharmacol Ther 2014;19:256–68
  • Tee MK, Rogatsky I, Tzagarakis-Foster C, et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors α and β. Mol Biol Cell 2004;15:1262–72
  • Lynch JF 3rd, Dejanovic D, Winiecki P, et al. Activation of ERβ modulates fear generalization through an effect on memory retrieval. Horm Behav 2014;66:421–9
  • Hyder SM, Huang JC, Nawaz Z, et al. Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environ Health Perspect 2000;108:785–90
  • Hyder SM, Chiappetta C, Murthy L, et al. Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780. Cancer Res 1997;57:2547–9
  • Hilakivi-Clarke L, Andrade JE, Helferich W. Is soy consumption good or bad for the breast? J Nutr 2010;140:2326–34S
  • Jarzabek K, Koda M, Walentowicz-Sadlecka M, et al. Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology. Tumour Biol 2013;34:4007–16

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