Treating vulvovaginal atrophy/genitourinary syndrome of menopause: how important is vaginal lubricant and moisturizer composition?

References

• Dunn KM, Croft PR, Hackett GI. Sexual problems: a study of the prevalence and need for health care in the general population. Fam Pract 1998;15:519–24
   PubMed Web of Science ®Google Scholar
• Leiblum SR, Hayes RD, Wanser RA, Nelson JS. Vaginal dryness: a comparison of prevalence and interventions in 11 countries. J Sex Med 2009;6:2425–33
   PubMed Web of Science ®Google Scholar
• Palacios S. Managing urogenital atrophy. Maturitas 2009;63:315–18
   PubMed Web of Science ®Google Scholar
• Panay N, Fenton A. Vulvovaginal atrophy – a tale of neglect. Climacteric 2014;17:1–2
   Web of Science ®Google Scholar
• Portman DJ, Gass ML, Vulvovaginal Atrophy Terminology Consensus Conference Panel. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and The North American Menopause Society. Climacteric 2014;17:557–63
   PubMed Web of Science ®Google Scholar
• Panay N. Genitourinary syndrome of the menopause – dawn of a new era. Climacteric 2015;18(Suppl 1):13–17
   Google Scholar
• Braunstein S, van de Wijgert J. Preferences and practices related to vaginal lubrication: implications for microbicide acceptability and clinical testing. J Womens Health (Larchmt) 2005;14:424–33
   PubMed Web of Science ®Google Scholar
• Jozkowski KN, Herbenick D, Schick V, Reece M, Sanders SA, Fortenberry JD. Women's perceptions about lubricant use and vaginal wetness during sexual activities. J Sex Med 2013;10:484–92
   PubMed Web of Science ®Google Scholar
• Andelloux M. Products for sexual lubrication: understanding and addressing options with your patients. Nurs Womens Health 2011;15:253–7
   PubMedGoogle Scholar
• Cordeau D, Courtois F. Sexual disorders in women with MS: assessment and management. Ann Phys Rehabil Med 2014;57:337–47
   PubMedGoogle Scholar
• Kennedy SH, Rizvi S. Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 2009;29:157–64
   PubMed Web of Science ®Google Scholar
• Sutton KS, Boyer SC, Goldfinger C, Ezer P, Pukall CF. To lube or not to lube: experiences and perceptions of lubricant use in women with and without dyspareunia. J Sex Med 2012;9:240–50
   PubMed Web of Science ®Google Scholar
• Jamieson DJ, Steege JF. The prevalence of dysmenorrhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol 1996;87:55–8
   PubMed Web of Science ®Google Scholar
• Seehusen DA, Baird DC, Bode DV. Dyspareunia in women. Am Fam Physician 2014;90:465–70
   PubMed Web of Science ®Google Scholar
• Berman JR, Adhikari SP, Goldstein I. Anatomy and physiology of female sexual function and dysfunction: classification, evaluation and treatment options. Eur Urol 2000;38:20–9
   PubMed Web of Science ®Google Scholar
• Lev-Sagie A. Vulvar and vaginal atrophy: physiology, clinical presentation, and treatment considerations. Clin Obstet Gynecol 2015;58:476–91
   PubMed Web of Science ®Google Scholar
• Kingsberg SA, Wysocki S, Magnus L, Krychman ML. Vulvar and vaginal atrophy in postmenopausal women: findings from the REVIVE (REal Women's VIews of Treatment Options for Menopausal Vaginal ChangEs) survey. J Sex Med 2013;10:1790–9
   PubMed Web of Science ®Google Scholar
• Goldstein AT, Burrows LJ. Sexual Pain Disorders in Women 2009 [7 July 2015]. Available from: http://www.issm.info/news/review-reports/sexual-pain-disorders-in-women/
   Google Scholar
• Sturdee DW, Panay N. Recommendations for the management of postmenopausal vaginal atrophy. Climacteric 2010;13:509–22
   PubMed Web of Science ®Google Scholar
• The North American Menopause Society. Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. Menopause 2013;20:888–902
   PubMed Web of Science ®Google Scholar
• Chen J, Geng L, Song X, Li H, Giordan N, Liao Q. Evaluation of the efficacy and safety of hyaluronic acid vaginal gel to ease vaginal dryness: a multicenter, randomized, controlled, open-label, parallel-group, clinical trial. J Sex Med 2013;10:1575–84
   PubMed Web of Science ®Google Scholar
• Bachmann GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician 2000;61:3090–6
   PubMed Web of Science ®Google Scholar
• Sinha A, Ewies AA. Non-hormonal topical treatment of vulvovaginal atrophy: an up-to-date overview. Climacteric 2013;16:305–12
   PubMed Web of Science ®Google Scholar
• Lammerink EA, de Bock GH, Schroder CP, Mourits MJ. The management of menopausal symptoms in breast cancer survivors: case-based approach. Maturitas 2012;73:265–8
   PubMed Web of Science ®Google Scholar
• Derzko C, Elliott S, Lam W. Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol 2007;14(Suppl 1):S20–40
   PubMedGoogle Scholar
• Pruthi S, Simon JA, Early AP. Current overview of the management of urogenital atrophy in women with breast cancer. Breast J 2011;17:403–8
   PubMed Web of Science ®Google Scholar
• Simon JA, Kokot-Kierepa M, Goldstein J, Nappi RE. Vaginal health in the United States: results from the Vaginal Health: Insights, Views & Attitudes survey. Menopause 2013;20:1043–8
   PubMed Web of Science ®Google Scholar
• Barlow DH, Cardozo LD, Francis RM, et al. Urogenital ageing and its effect on sexual health in older British women. Br J Obstet Gynaecol 1997;104:87–91
   PubMedGoogle Scholar
• Herbenick D, Reece M, Hensel D, Sanders S, Jozkowski K, Fortenberry JD. Association of lubricant use with women's sexual pleasure, sexual satisfaction, and genital symptoms: a prospective daily diary study. J Sex Med 2011;8:202–12
   PubMed Web of Science ®Google Scholar
• World Health Organization. Use and procurement of additional lubricants for male and female condoms: WHO/UNFPA/FHI360 advisory note 2012 [7 July 2015]. Available from: http://apps.who.int/iris/bitstream/10665/76580/1/WHO_RHR_12.33_eng.pdf
   Google Scholar
• Willhite LA, O’Connell MB. Urogenital atrophy: prevention and treatment. Pharmacotherapy 2001;21:464–80
   PubMed Web of Science ®Google Scholar
• Herbenick D, Reece M, Schick V, Sanders SA, Fortenberry JD. Women's use and perceptions of commercial lubricants: prevalence and characteristics in a nationally representative sample of American adults. J Sex Med 2014;11:642–52
   PubMed Web of Science ®Google Scholar
• Cribby S, Taylor M, Reid G. Vaginal microbiota and the use of probiotics. Interdiscip Perspect Infect Dis 2008;2008:256490
   PubMedGoogle Scholar
• Raz R. Urinary tract infection in postmenopausal women. Korean J Urol 2011;52:801–8
   PubMedGoogle Scholar
• Adriaens E, Remon JP. Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex Transm Dis 2008;35:512–16
   PubMed Web of Science ®Google Scholar
• Agarwal A, Deepinder F, Cocuzza M, Short RA, Evenson DP. Effect of vaginal lubricants on sperm motility and chromatin integrity: a prospective comparative study. Fertil Steril 2008;89:375–9
   PubMed Web of Science ®Google Scholar
• Dezzutti CS, Brown ER, Moncla B, et al. Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity. PLoS One 2012;7:e48328
   PubMedGoogle Scholar
• Fuchs EJ, Lee LA, Torbenson MS, et al. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis 2007;195:703–10
   PubMed Web of Science ®Google Scholar
• Cunha AR, Machado RM, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, das Neves J, Palmeira-de-Oliveira R. Characterization of commercially available vaginal lubricants: a safety perspective. Pharmaceutics 2014;6:530–42
   PubMedGoogle Scholar
• Bledzka D, Gromadzinska J, Wasowicz W. Parabens. From environmental studies to human health. Environ Int 2014;67:27–42
   PubMed Web of Science ®Google Scholar
• Karpuzoglu E, Holladay SD, Gogal RM Jr. Parabens: potential impact of low-affinity estrogen receptor binding chemicals on human health. J Toxicol Environ Health B Crit Rev 2013;16:321–35
   PubMed Web of Science ®Google Scholar
• Nohynek GJ, Borgert CJ, Dietrich D, Rozman KK. Endocrine disruption: fact or urban legend? Toxicol Lett 2013;223:295–305
   PubMed Web of Science ®Google Scholar
• Harvey PW, Everett DJ. Significance of the detection of esters of p-hydroxybenzoic acid (parabens) in human breast tumours. J Appl Toxicol 2004;24:1–4
   PubMed Web of Science ®Google Scholar
• Moench TR, Mumper RJ, Hoen TE, Sun M, Cone RA. Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse. BMC Infect Dis 2010;10:331
   PubMed Web of Science ®Google Scholar
• Fashemi B, Delaney ML, Onderdonk AB, Fichorova RN. Effects of feminine hygiene products on the vaginal mucosal biome. Microb Ecol Health Dis 2013;24 doi: 10.3402/mehd.v24i0.19703. eCollection 2013
   PubMedGoogle Scholar
• Brotman RM, Ravel J, Cone RA, Zenilman JM. Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis. Sex Transm Infect 2010;86:297–302
   PubMed Web of Science ®Google Scholar
• Kabara JJ, Orth DS. Preservative-Free and Self-Preserving Cosmetics and Drugs. Principles and Practice. New York: Marcel Dekker, Inc.,1997
   Google Scholar
• Dayal MB, Wheeler J, Williams CJ, Barnhart KT. Disruption of the upper female reproductive tract epithelium by nonoxynol-9. Contraception 2003;68:273–9
   PubMed Web of Science ®Google Scholar
• Phillips DM, Zacharopoulos VR. Nonoxynol-9 enhances rectal infection by herpes simplex virus in mice. Contraception 1998;57:341–8
   PubMed Web of Science ®Google Scholar
• Phillips DM, Taylor CL, Zacharopoulos VR, Maguire RA. Nonoxynol-9 causes rapid exfoliation of sheets of rectal epithelium. Contraception 2000;62:149–54
   PubMed Web of Science ®Google Scholar
• Cone RA, Hoen T, Wong X, Abusuwwa R, Anderson DJ, Moench TR. Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect Dis 2006;6:90
   PubMed Web of Science ®Google Scholar
• Dhondt MM, Adriaens E, Remon JP. The evaluation of the local tolerance of vaginal formulations, with or without nonoxynol-9, using the slug mucosal irritation test. Sex Transm Dis 2004;31:229–35
   PubMed Web of Science ®Google Scholar
• Phillips DM, Sudol KM, Taylor CL, Guichard L, Elsen R, Maguire RA. Lubricants containing N-9 may enhance rectal transmission of HIV and other STIs. Contraception 2004;70:107–10
   PubMed Web of Science ®Google Scholar
• Achilles SL, Shete PB, Whaley KJ, Moench TR, Cone RA. Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis. Sex Transm Dis 2002;29:655–64
   PubMed Web of Science ®Google Scholar
• Begay O, Jean-Pierre N, Abraham CJ, et al. Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro. AIDS Res Hum Retroviruses 2011;27:1019–24
   PubMed Web of Science ®Google Scholar
• Steiner AZ, Long DL, Tanner C, Herring AH. Effect of vaginal lubricants on natural fertility. Obstet Gynecol 2012;120:44–51
   PubMed Web of Science ®Google Scholar
• Anderson L, Lewis SE, McClure N. The effects of coital lubricants on sperm motility in vitro. Hum Reprod 1998;13:3351–6
   PubMed Web of Science ®Google Scholar
• Frishman GN, Luciano AA, Maier DB. Evaluation of Astroglide, a new vaginal lubricant: effects of length of exposure and concentration on sperm motility. Fertil Steril 1992;58:630–2
   PubMed Web of Science ®Google Scholar
• Kutteh WH, Chao CH, Ritter JO, Byrd W. Vaginal lubricants for the infertile couple: effect on sperm activity. Int J Fertil Menopausal Stud 1996;41:400–4
   PubMedGoogle Scholar
• Sandhu RS, Wong TH, Kling CA, Chohan KR. In vitro effects of coital lubricants and synthetic and natural oils on sperm motility. Fertil Steril 2014;101:941–4
   PubMed Web of Science ®Google Scholar
• Mowat A, Newton C, Boothroyd C, Demmers K, Fleming S. The effects of vaginal lubricants on sperm function: an in vitro analysis. J Assist Reprod Genet 2014;31:333–9
   PubMed Web of Science ®Google Scholar
• Amelar RD, Dubin L, Schoenfeld C. Sperm motility. Fertil Steril 1980;34:197–215
   PubMed Web of Science ®Google Scholar
• World Health Organization. WHO laboratory manual for the examination and processing of human semen, 5th edition 2010 [7 July 2015]. Available from: http://whqlibdoc.who.int/publications/2010/9789241547789_eng.pdf
   Google Scholar
• Peek JC, Matthews CD. The pH of cervical mucus, quality of semen, and outcome of the post-coital test. Clin Reprod Fertil 1986;4:217–25
   PubMedGoogle Scholar
• Rossato M, Balercia G, Lucarelli G, Foresta C, Mantero F. Role of seminal osmolarity in the reduction of human sperm motility. Int J Androl 2002;25:230–5
   PubMedGoogle Scholar
• Connor CJ, Eppsteiner EE. Vulvar contact dermatitis. Proc Obstet Gynecol 2014;4:1
   Google Scholar
• Majerovich JA, Canty A, Miedema B. Chronic vulvar irritation: could toilet paper be the culprit? Can Fam Physician 2010;56:350–2
   PubMed Web of Science ®Google Scholar
• Wolf LK. Studies raise questions about safety of personal lubricants. Chem Eng News 2012;90:46–7
   Google Scholar