1,729
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice

, , , , , , , & show all
Pages 1144-1149 | Received 26 Oct 2012, Accepted 27 Feb 2013, Published online: 25 Jun 2013

References

  • Almeida RN, Motta SC, Faturi CB, et al. (2004). Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats. Pharmacol Biochem Behav 77:361–4
  • Alves D, Duarte I. (2002). Involvement of ATP-sensitive K (+) channels in the peripheral antinociceptive effect induced by dipyrone. Eur J Pharmacol 444:47–52
  • Bonjardim LR, Silva AM, Oliveira MGB, et al. (2011). Sida cordifolia leaf extract reduces the orofacial nociceptive response in mice. Phytother Res 25:1236–41
  • Botelho MA, Martins JG, Ruela RS, et al. (2009). Protective effect of locally applied carvacrol gel on ligature-induced periodontitis in rats: A tapping mode AFM study. Phytother Res 23:1439–48
  • Brown KA, Brain SD, Edgeworth JD, et al. (2006). Neutrophils in development of multiple organ failure in sepsis. Lancet 368:157–69
  • Coutaux A, Adam F, Willer JC, Le Bars D. (2005). Hyperalgesia and allodynia: Peripheral mechanisms. Joint Bone Spine 72:359–71
  • Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH. (1992). The pivotal role of tumor necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107:660–4
  • Cunha TM, Verri WA Jr, Vivancos GG, et al. (2004). An electronic pressure-meter nociception paw test for mice. Braz J Med Biol Res 37:401–7
  • Cunha TM, Verri WA Jr, Silva JS, et al. (2005). A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Nat Acad Sci USA 102:1755–60
  • Cunha TM, Poole S, Ferreira SH, Cunha FQ. (2008a). Role of cytokines in mediating mechanical hypernociception in a model of delayed-type hypersensitivity in mice. Eur J Pain 12:1059–68
  • Cunha TM, Verri WA Jr, Schivo IR, et al. (2008b). Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol 83:824–32
  • Cunha TM, Roman-Campos D, Lotufo CM, et al. (2010). Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/K+ATP signaling pathway. Proc Nat Acad Sci USA 107:4442–7
  • De Sousa DP, Oliveira FS, Almeida RN. (2006a). Evaluation of the central activity of hydroxydihydrocarvone. Biol Pharm Bull 29:811–12
  • De Sousa DP, Gonçalves JCR, Quintans-Júnior LJ, et al. (2006b). Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. Neurosci Lett 401:231–5
  • De Sousa DP, Schefer RR, Brocksom U, Brocksom TJ. (2006c). Synthesis and antidepressant evaluation of three parabenzoquinone mono-oximes and their oxy derivatives. Molecules 11:148–55
  • De Sousa DP, Quintans-Júnior LJ, Almeida RN. (2007). Evolution of the anticonvulsant activity of α-terpineol. Pharm Biol 45:69–70
  • De Sousa DP, Camargo EA, Oliveira FS, Almeida RN. (2010). Anti-inflammatory activity of hydroxydihydrocarvone. Z Naturforsch C 65:543–50
  • Duarte ID, Nakamura M, Ferreira SH. (1988). Participation of the sympathetic system in acetic acid-induced writhing in mice. Braz J Med Biol Res 21:341–3
  • Edris AE. (2007). Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A review. Phytother Res 21:308–23
  • Elisabetsky E, Coelho-De-Souza GP, Santos MAC, et al. (1995). Sedative properties of linalool. Fitoterapia 66:407–14
  • Guimarães AG, Oliveira GF, Melo MS, et al. (2010). Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol. Basic Clin Pharmacol Toxicol 107:949–57
  • Guimarães AG, Xavier MA, Santana MT, et al. (2012). Carvacrol attenuates mechanical hypernociception and inflammatory response. Naunyn-Schmiedeberg's Arch Pharmacol 385:253–63
  • Guimarães AG, Quintans JSS, Quintans-Júnior LJ. (2013). Monoterpenes with analgesic activity: A systematic review. Phytother Res 27:1–15
  • Hernández-Pacheco A, Araiza-Saldaña CI, Granados-Soto V, Mixcoatl-Zecuat T. (2008). Possible participation of the nitric oxide-cyclic GMP-protein kinase G K+ channels pathway in the peripheral antinociception of melatonin. Eur J Pharmacol 596:70–6
  • Lenardão EJ, Botteselle GV, Azambuja F, et al. (2007). Citronellal as key compound in organic synthesis. Tetrahedron 63:6671–712
  • Lima FQ, Souza GR, Verri WA Jr, et al. (2010). Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: Involvement of the NO/cGMP/PKG/K+ATP signaling pathway. Pain 151:506–15
  • Melo MS, Sena LCS, Barreto FJN, et al. (2010). Antinociceptive effect of citronellal in mice. Pharm Biol 48:411–16
  • Melo MS, Guimarães AG, Santana MF, et al. (2011). Anti-inflammatory and redox-protective activities of citronellal. Biol Res 44:363–8
  • Morris CJ. (2003). Carrageenan-induced paw edema in the rat and mouse. Methods Mol Biol 225:115–21
  • Nguelefack TB, Dutra RC, Paszcuk AF, et al. (2010). Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO--cGMP--ATP-sensitive-K(+) channel activation. J Ethnopharmacol 128:567–74
  • Obreja O, Rathee PK, Lips KS, et al. (2002). IL-1 beta potentiates heat-activated currents in rat sensory neurons: Involvement of IL-1RI, tyrosine kinase and protein kinase C. FASEB J 16:1497–503
  • Passos CS, Arbo MD, Rates SMK, Poser GLV. (2009). Terpenoids with activity in the central nervous system (CNS). Braz J Pharmacogn 19:140–9
  • Paixão MS, Melo MS, Oliveira MG, et al. (2013). Hyptis pectinata: Redox protection and orofacial antinociception. Phytother Res DOI: 10.1002/ptr.4869
  • Quintans-Júnior LJ, Souza TT, Leite BS, et al. (2008). Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine 15:619–24
  • Quintans-Júnior LJ, Melo MS, De Sousa DP, et al. (2010). Antinociceptive activity of citronellal in formalin-, capsaicin- and glutamate-induced orofacial pain in rodents and its action on nerve excitability. J Orofac Pain 24:305–12
  • Quintans-Júnior LJ, Oliveira MG, Santana MF, et al. (2011a). α-Terpineol reduces nociceptive behavior in mice. Pharm Biol 49:583–6
  • Quintans-Júnior LJ, Guimarães AG, Santana MT, et al. (2011b). Citral reduces nociceptive and inflammatory response in rodents. Braz J Pharmacog 21:497–502
  • Quintans-Júnior LJ, Rocha RF, Ceregnato FF, et al. (2011c). Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. J Med Food 14:630–9
  • Ribas CM, Meotti FC, Nascimento FP, et al. (2008). Antinociceptive effect of the Polygala sabulosa hydroalcoholic extract in mice: Evidence for the involvement of glutamatergic receptors and cytokine pathways. Basic Clin Pharmacol Toxicol 103:43–7
  • Rodrigues ARA, Duarte IDG. (2000). The peripheral antinociceptive effect induced by morphine is associated with ATP-sensitive K+ channels. Br J Pharmacol 129:110–14
  • Sachs D, Cunha FQ, Ferreira SH. (2004). Peripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci USA 101:3680–5
  • Silva J. (2003). Analgesic and anti-inflammatory effects of essential oils of Eucaliptus. J Ethnopharmacol 89:277–83
  • Silva MIG, Neto MRA, Neto PFT, et al. (2007). Central nervous system activity of acute administration of isopulegol. Pharmacol Bio Chem Behav 88:141–7
  • Verri AW Jr, Cunha TM, Parada CA, et al. (2006). Hypernociceptive role of cytokines and chemokines: Targets for analgesic drug development? Pharmacol Therap 112:116–38
  • Verri WA Jr, Cunha TM, Poole S, et al. (2007). Cytokine inhibitors and pain control. Braz J Rheumatol 47:341–53
  • Villarreal CF, Funez MI, Figueiredo F, et al. (2009). Acute and persistent nociceptive paw sensitisation in mice: The involvement of distinct signalling pathways. Life Sci 85:822–9
  • Zimmermann M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109–10

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.