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Original Article

Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats

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Pages 167-173 | Received 18 Dec 2013, Accepted 03 Apr 2014, Published online: 22 Sep 2014

References

  • Adzet T, Camarasa J, Laguna JC. (1987). Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. J Nat Prod 50:612–17
  • Carlberg I, Mannervik B. (1985). Glutathione reductase. Meth Enzymol 113:485–90
  • Chen C, Hennig GE, Manautou JE. (2003). Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats. Drug Metab Dispos 31:798–804
  • Cover C, Mansouri A, Knight TR, et al. (2005). Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther 315:879–87
  • Czeczot H, Ścibior D, Skrzycki M, Podsiad M. (2006). Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma. Acta Biochim Pol 53:237–41
  • Davidson DG, Eastham WN. (1966). Acute liver necrosis following overdose of paracetamol. Br Med J 2:497–9
  • Dybing E, Holme JA, Gordon WP, et al. (1984). Genotoxicity studies with paracetamol. Mutat Res 138:21–32
  • Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–7
  • Fantini N, Colombo G, Giori A, et al. (2011). Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytother Res 25:463–6
  • Galal RM, Zaki HF, Seif El-Nasr MM, Agha AM. (2012). Potential protective effect of honey against paracetamol-induced hepatotoxicity. Arch Iran Med 15:674–80
  • Gebhardt R. (1997). Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol 144:279–86
  • Gupta AK, Misra N. (2006). Hepatoprotective activity of aqueous ethanolic extract of chamomile capitula in paracetamol intoxicated albino rats. Am J Pharmacol Toxicol 1:17–20
  • Gurel E, Caner M, Bayraktar L, et al. (2007). Effects of artichoke extract supplementation on gonads of cadmium-treated rats. Biol Trace Elem Res 119:51–9
  • Habig WH, Pabst MJ, Jakoby WB. (1974). Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130–9
  • Heidarian E, Rafieian-Kopaei M. (2013). Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Pharm Biol 51:1104–9
  • Hinson JA, Pike SL, Pumford NR, Mayeux PR. (1998). Nitrotyrosine protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol 11:604–7
  • Jaeschke H, Knight TR, Bajt ML. (2003). The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 144:279–88
  • James LP, Mayeux PR, Hinson JA. (2003). Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 31:1499–506
  • Jollow DJ, Mitchell JR, Potter WZ, et al. (1973). Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 187:195–202
  • Lauterburg BH, Mitchell JR. (1982). Toxic doses of acetaminophen suppress hepatic glutathione synthesis in rats. Hepatology 2:8–12
  • Lee WM. (2004). Acetaminophen and the U.S. acute liver failure study group: Lowering the risks of hepatic failure. Hepatology 40:6–9
  • Li H, Xia N, Brausch I, et al. (2004). Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J Pharmacol Exp Ther 310:926–32
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75
  • Mant TG, Tempowski JH, Volans GN, Talbot JC. (1984). Adverse reactions to acetylcysteine and effects of overdose. Br Med J 289:217–19
  • Mehmetçik G, Ozdemirler G, Koçak-Toker N, et al. (2008). Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Exp Toxicol Pathol 60:475–80
  • Metwally NS, Kholeif TE, Ghanem KZ, et al. (2011). The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. Eur Rev Med Pharmacol Sci 15:1429–44
  • Mihara M, Uchiyama M. (1978). Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271–8
  • Mileo AM, Di Venere D, Linsalata V, et al. (2012). Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231. J Cell Physiol 227:3301–9
  • Miranda KM, Espey MG, Wink DA. (2001). A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5:62–71
  • Mitchell JR, Jollow DJ, Potter WZ, et al. (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187:211–17
  • Mladenović D, Radosavljević T, Ninković M, et al. (2009). Liver antioxidant capacity in the early phase of acute paracetamol-induced liver injury in mice. Food Chem Toxicol 47:866–70
  • Nassar MI, Mohamed TK, Elshamy AI, et al. (2013). Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads. J Sci Food Agric 93:2494–501
  • Nelson SD. (1990). Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 10:267–78
  • Olmos A, Giner RM, Recio MC, et al. (2008). Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species. Arch Biochem Biophys 475:66–71
  • Oshida K, Iwanaga E, Miyamoto-Kuramitsu K, Miyamoto Y. (2008). An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry. J Toxicol Sci 33:515–24
  • Pigeolet E, Corbisier P, Houbion A, et al. (1990). Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 51:283–97
  • Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H. (2011). The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 251:226–33
  • Ramsay RR, Rashed MS, Nelson SD. (1989). In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria. Arch Biochem Biophys 273:449–57
  • Robak J, Gryglewski RJ. (1988). Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 37:837–41
  • Rondanelli M, Giacosa A, Opizzi A, et al. (2013). Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: A double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr 64:7–15
  • Roušar T, Pařík P, Kučera O, et al. (2010). Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro. Physiol Res 59:225–32
  • Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–91
  • Squadrito GL, Pryor WA. (1998). Oxidative chemistry of nitric oxide: The roles of superoxide, peroxynitrite and carbon dioxide. Free Radic Biol Med 25:392–403
  • Tripathi KD. (2008). Essentials of Medical Pharmacology. 6th ed. New Delhi, India: Jaypee Brothers Medical Publishers (P) Ltd
  • Wong PS, Eiserich JP, Reddy S, et al. (2001). Inactivation of glutathione-S-transferases by nitric oxide-derived oxidants: Exploring a role for tyrosine nitration. Arch Biochem Biophys 394:216–28
  • Zelko IN, Mariani TJ, Folz RJ. (2002). Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 33:337–49

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