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Cytotherapy Volume 12, 2010 - Issue 4
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Letter

Transplantation of allogeneic bone marrow mesenchymal stromal cell-derived hepatocyte-like cells in homozygous familial hypercholesterolemia

Mehdi Mohamadnejad Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Behshad Pournasr Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran
,
Mohammad Bagheri Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Naser Aghdami Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran
,
Mansoureh Shahsavani Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran
,
Leila Abdollahzadeh Hosseini Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Ehsan Taghiabadi Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran
,
Hossein Azizi Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran
,
Iraj Heidari Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
,
Shahram Akhlaghpoor Department of Computed Tomography, Noor Medical Imaging Center, Tehran, Iran
,
Sebastiano Calandra Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
,
Reza Malekzadeh Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, IranCorrespondence[email protected].
[email protected]
&
Hossein Baharvand Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, IranCorrespondence[email protected].
 show all
Pages 566-568 | Received 06 May 2009, Accepted 25 Nov 2009, Published online: 18 Jan 2010

References

  • Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest. 2003;111:1795–803.
  • Valdivielso P, Escolar JL, Cuervas-Mons V, Pulpon LA, Chaparro MA, Gonzalez-Santos P. Lipids and lipoprotein changes after heart and liver transplantation in a patient with homozygous familial hypercholesterolemia. Ann Intern Med. 1988;108:204–6.
  • Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, . Treatment of the Crigler–Najjar syndrome type I with hepatocyte transplantation. N Engl J Med. 1998;338:1422–6.
  • Lee KD, Kuo TK, Whang-Peng J, Chung YF, Lin CT, Chou SH, . In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology. 2004;40:1275–84.
  • Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells. 2006;24:462–71.
  • Snykers S, Vanhaecke T, Papeleu P, Luttun A, Jiang Y, Vander Heyden Y, . Sequential exposure to cytokines reflecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells. Toxicol Sci. 2006;94:330–41.
  • Muraca M, Ferraresso C, Vilei MT, Granato A, Quarta M, Cozzi E, . Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat. Gut. 2007;56:1725–35.
  • Dhawan A, Mitry RR, Hughes RD, Lehec S, Terry C, Bansal S, . Hepatocyte transplantation for inherited factor VII deficiency. Transplantation. 2004;78:1812–4.

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