137
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Clinicopathologic findings following intra-articular injection of autologous and allogeneic placentally derived equine mesenchymal stem cells in horses

, , , , , , , , & show all
Pages 419-430 | Received 17 May 2010, Accepted 07 Oct 2010, Published online: 25 Nov 2010

References

  • Arnhold SJ, Goletz I, Klein H, Stumpf G, Beluche LA, Rohde C, . Isolation and characterization of bone marrow-derived equine mesenchymal stem cells. Am J Vet Res. 2007;68:1095–105.
  • Fortier LA, Nixon AJ, Williams J, Cable CS. Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res. 1998;59:1182–7.
  • Toupadakis CA, Wong A, Gentos DC, Cheung WK, Borjeson DL, Ferraro GL, . Comparison of the osteogenic potential of mesenchymal stem cells from equine bone marrow, adipose tissue, umbilical cord blood and umbilical cord tissue and optimization of expansion conditions for clinical use. Am J Vet Res; 2010;71:1237–1245.
  • Vidal MA, Kilroy GE, Johnson JR, Lopez MJ, Moore RM, Gimble JM. Cell growth characteristics and differentiation frequency of adherent equine bone marrow-derived mesenchymal stromal cells: adipogenic and osteogenic capacity. Vet Surg. 2006;35:601–10.
  • da Silva Meirelles L, Sand TT, Harman RJ, Lennon DP, Caplan AI. MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Eng. 2009;15:221–9.
  • Vidal MA, Kilroy GE, Lopez MJ, Johnson JR, Moore RM, Gimble JM. Characterization of equine adipose tissue-derived stromal cells: adipogenic and osteogenic capacity and comparison with bone marrow-derived mesenchymal stromal cells. Vet Surg. 2007;36:613–22.
  • Passeri S, Nocchi F, Lamanna R, Lapi S, Miragliotta V, Giannessi E, . Isolation and expansion of equine umbilical cord-derived matrix cells (EUCMCs). Cell Biol Int. 2009;33:100–5.
  • Koch TG, Heerkens T, Thomsen PD, Betts DH. Isolation of mesenchymal stem cells from equine umbilical cord blood. BMC Biotechnol. 2007;7:26–35.
  • Koch TG, Thomsen PD, Betts DH. Improved isolation protocol for equine cord blood-derived mesenchymal stromal cells. Cytotherapy. 2009;11:443–7.
  • Schuh EM, Friedman MS, Carrade DD, Li J, Heeke D, Oyserman SM, . Identification of variables that optimize isolation and culture of multipotent mesenchymal stem cells from equine umbilical-cord blood. Am J Vet Res.2009;70: 1526–35.
  • Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24: 1294–301.
  • Bartholemew S, Owens SD, Ferraro GL, Carrade DD, Lara DJ, Librach F, . Collection of equine cord blood and placental tissues in forty thoroughbred mares. Equ Vet J. 2009;41: 724–8.
  • Berg L, Koch T, Heerkens T, Bessonov K, Thomsen P, Betts D. Chondrogenic potential of mesenchymal stromal cells derived from equine bone marrow and umbilical cord blood. Vet Comp Orthop Traumatol. 2009;22:363–70.
  • Koch T, Berg L, Betts D. Concepts for the clinical use of stem cells in equine medicine. Can Vet J. 2008;49:1009–17.
  • Frisbie D, Smith R. Clinical update on the use of mesenchymal stem cells in equine orthopaedics. Equ Vet J. 2010;42: 86–9.
  • Agung M, Ochi M, Yanada S, Adachi N, Izuta Y, Yamasaki T, . Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration. Knee Surg Sports Traumatol Arthrosc. 2006;14:1307–14.
  • Black LL, Gaynor J, Adams C, Dhupa S, Sams AE, Taylor R, . Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther. 2008;9:192–200.
  • Frisbie DD, Kisiday JD, Kawcak CE, Werpy NM, McIlwraith CW. Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis. J Orthop Res. 2009;27(12):1675–80.
  • Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003;48:3464–74.
  • Newman RE, Yoo D, LeRoux MA, Danilkovitch-Miagkova A. Treatment of inflammatory diseases with mesenchymal stem cells. Inflamm Allerg Drug Targ. 2009;8:110–23.
  • Sotiropoulou PA, Papamichail M. Immune properties of mesenchymal stem cells. Meth Mol Biol. 2007;407:225–43.
  • Kode JA, Mukherjee S, Joglekar MV, Hardikar AA. Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy. 2009;11: 377–91.
  • Koppula PR, Chelluri LK, Polisetti N, Vemuganti GK. Histocompatibility testing of cultivated human bone marrow stromal cells: a promising step towards pre-clinical screening for allogeneic stem cell therapy. Cell Immunol. 2009;259(1): 61–65.
  • Batten P, Sarathchandra P, Antoniw JW, Tay SS, Lowdell MW, Taylor PM, . Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves. Tissue Eng. 2006;12:2263–73.
  • Chang CJ, Yen ML, Chen YC, Chien CC, Huang HI, Bai CH, . Placenta-derived multipotent cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-gamma. Stem Cells. 2006;24:2466–77.
  • Keyser KA, Beagles KE, Kiem HP. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation. Cell Transplant. 2007;16:555–62.
  • Prevosto C, Zancolli M, Canevali P, Zocchi MR, Poggi A. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica. 2007;92:881–8.
  • Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, . Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;30:42–8.
  • Cui L, Yin S, Liu W, Li N, Zhang W, Cao Y. Expanded adipose-derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng. 2007;13: 1185–95.
  • Nasef A, Chapel A, Mazurier C, Bouchet S, Lopez M, Mathieu N, . Identification of IL-10 and TGF beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells. Gene Expr. 2007;13:217–26.
  • Yang SH, Park MJ, Yoon IH, Kim SY, Hong SH, Shin JY, . Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10. Exp Mol Med. 2009;41:315–24.
  • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005, 2005;105:1815–22.
  • Cho PS, Messina DJ, Hirsh EL, Chi N, Goldman SN, Lo DP, . Immunogenicity of umbilical cord tissue derived cells. Blood. 2008;111:430–8.
  • Li C, Zhang W, Jiang X, Mao N. Human-placenta-derived mesenchymal stem cells inhibit proliferation and function of allogeneic immune cells. Cell Tissue Res. 2007;330: 437–46.
  • Wang M, Yang Y, Yang D, Luo F, Liang W, Guo S, . The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro. Immunology. 2009; 126:220–32.
  • Nauta AJ, Westerhuis G, Kruisselbrink AB, Lurvink EG, Willemze R, Fibbe WE. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood. 2006;108:2114–20.
  • Poncelet AJ, Vercruysse J, Saliez A, Gianello P. Although pig allogeneic mesenchymal stem cells are not immunogenic in vitro, intracardiac injection elicits an immune response in vivo. Transplantation. 2007;83:783–90.
  • Perin EC, Silva GV, Assad JA, Vela D, Buja LM, Sousa AL, . Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction. J Mol Cell Cardiol. 2008;44: 486–95.
  • Wolf D, Reinhard A, Seckinger A, Katus HA, Kuecherer H, Hansen A. Dose-dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart. Stem Cells Dev. 2009;18:321–9.
  • Togel F, Cohen A, Zhang P, Yang Y, Hu Z, Westenfelder C. Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev. 2009;18:475–85.
  • Planka L, Gal P, Kecova H, Klima J, Hlucilova J, Filova E, . Allogeneic and autogenous transplantations of MSCs in treatment of the physeal bone bridge in rabbits. BMC Biotechnol. 2008;8:70–79.
  • Arinzeh TL, Peter SJ, Archambault MP, van den Bos C, Gordon S, Kraus K, . Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect. J Bone Joint Surg Am. 2003;85A:1927–35.
  • Prigozhina TB, Khitrin S, Elkin G, Eizik O, Morecki S, Slavin S. Mesenchymal stromal cells lose their immunosuppressive potential after allotransplantation. Exp Hematol. 2008;36: 1370–6.
  • Guest DJ, Smith MR, Allen WR. Monitoring the fate of autologous and allogeneic mesenchymal progenitor cells injected into the superficial digital flexor tendon of horses: preliminary study. Equine Vet J. 2008;40:178–81.
  • Rubinstein P, Dobrila L, Rosenfield RE, Adamson JW, Migliaccio G, Migliaccio AR, . Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA.1995;92: 10119–22.
  • Anonymous. Definition and classification of lameness. Kester, WO. Guide for Veterinary Service and Judging Of Equestrian Events. Lexington: AAEP; 1991. 19.
  • Lindegaard C, Gleerup KB, Thomsen MH, Martinussen T, Jacobsen S, Andersen PH. Anti-inflammatory effects of intra-articular administration of morphine in horses with experimentally induced synovitis. Am J Vet Res. 2010;71: 69–75.
  • Kay AT, Bolt DM, Ishihara A, Rajala-Schultz PJ, Bertone AL. Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetonide, mepivacaine hydrochloride, or both on lipopolysaccharide induced lameness in horses. Am J Vet Res. 2008;69:1646–54.
  • Oh W, Kim DS, Yang YS, . Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol 2008;251:116–123.
  • Zhang ZY, Teoh SH, Chong MS, . Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells. Stem Cells 2009;27:126–137.
  • Hu X, Wang J, Chen J, . Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg 2007;31:438–443.
  • Del Bue M, Ricco S, Ramoni R, . Equine adipose-tissue derived mesenchymal stem cells and platelet concentrates: their association in vitro and in vivo. Vet Res Commun 2008;32:S51–5.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.