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Research Article

Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition

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Pages 223-231 | Received 21 May 2011, Accepted 02 Sep 2011, Published online: 31 Oct 2011

References

  • Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease. II. Cell-based therapies. Circulation. 2004;109:2692–7.
  • Wollert KC, Drexler H. Clinical applications of stem cells for the heart. Circ Res. 2005;96:151–63.
  • Rosenzweig A. Cardiac cell therapy: mixed results from mixed cells. N Engl J Med. 2006;355:1274–7.
  • Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668–73.
  • Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, . Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 2001;107:1395–402.
  • Janssens S, Theunissen K, Boogaerts M, Van de Werf F. Bone marrow cell transfer in acute myocardial infarction. Nat Clin Pract Cardiovasc Med. 2006;3(Suppl 1):S69–72.
  • Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, . Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001;7:430–6.
  • Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, . Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–8.
  • Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, . Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA. 2001;98:10344–9.
  • Wong SS, Bernstein HS. Cardiac regeneration using human embryonic stem cells: producing cells for future therapy. Regen Med. 2010;5:763–75.
  • Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, Gepstein A, . Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest. 2001;108:407–14.
  • Xu C, Police S, Rao N, Carpenter MK. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res. 2002;91:501–8.
  • Gaur M, Ritner C, Sievers R, Pedersen A, Prasad M, Bernstein HS, . Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. Cytotherapy. 2010;12:807–17.
  • Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, . Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007;292:H1187–92.
  • Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, . Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009;17:1250–6.
  • Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, . Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005;289: H1307–14.
  • King FW, Ritner C, Liszewski W, Kwan HC, Pedersen A, Leavitt AD, . Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures. Stem Cells Dev. 2009;18:1441–50.
  • Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, . An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PLoS One. 2011;6:e16004.
  • Nicholas CR, Gaur M, Wang S, Pera RA, Leavitt AD. A method for single-cell sorting and expansion of genetically modified human embryonic stem cells. Stem Cells Dev. 2007;16:109–17.
  • King FW, Liszewski W, Ritner C, Bernstein HS. High-throughput tracking of pluripotent human embryonic stem cells with dual fluorescence resonance energy transfer molecular beacons. Stem Cells Dev. 2011;20:475–84.
  • Ritner C, Bernstein HS. Fate mapping of human embryonic stem cells by teratoma formation. J Vis Exp. 2010:2036.
  • Graichen R, Xu X, Braam SR, Balakrishnan T, Norfiza S, Sieh S, . Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation. 2008;76:357–70.
  • van Laake LW, Passier R, Monshouwer-Kloots J, Verkleij AJ, Lips DJ, Freund C, . Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res. 2007;1:9–24.
  • van Laake LW, Passier R, Monshouwer-Kloots J, Nederhoff MG, Ward-van Oostwaard D, Field LJ, . Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction. Nat Protoc. 2007;2:2551–67.
  • van Laake LW, Passier R, Doevendans PA, Mummery CL. Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents. Circ Res. 2008;102:1008–10.
  • Leor J, Gerecht S, Cohen S, Miller L, Holbova R, Ziskind A, . Human embryonic stem cell transplantation to repair the infarcted myocardium. Heart. 2007;93:1278–84.
  • Kofidis T, Lebl DR, Swijnenburg RJ, Greeve JM, Klima U, Robbins RC. Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. Eur J Cardiothorac Surg. 2006;29:50–5.
  • Caspi O, Huber I, Kehat I, Habib M, Arbel G, Gepstein A, . Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts. J Am Coll Cardiol. 2007;50:1884–93.
  • Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, . Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 2007;25:1015–24.
  • Nakanishi C, Yamagishi M, Yamahara K, Hagino I, Mori H, Sawa Y, . Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells. Biochem Biophys Res Commun. 2008;374:11–6.
  • Loffredo FS, Steinhauser ML, Gannon J, Lee RT. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell. 2011;8:389–98.
  • Ohnishi S, Sumiyoshi H, Kitamura S, Nagaya N. Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett. 2007;581:3961–6.
  • Takahashi M, Li TS, Suzuki R, Kobayashi T, Ito H, Ikeda Y, . Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol. 2006;291:H886–93.
  • Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, . Human cardiovascular progenitor cells develop from a KDR+ embryonic stem cell-derived population. Nature. 2008;453:524–8.
  • Rubart M, Field LJ. Stem cell differentiation: cardiac repair. Cells Tissues Organs. 2008;188:202–11.
  • Yoshida Y, Yamanaka S. Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration. Circulation. 2010;122:80–7.

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