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Research Article

The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism

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Pages 1215-1227 | Received 26 Feb 2012, Accepted 02 Jul 2012, Published online: 27 Aug 2012

References

  • Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17:1503–20.
  • Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol. 2003;14(Suppl 1):S55–61.
  • Macedo E, Bouchard J, Mehta RL. Renal recovery following acute kidney injury. Curr Op Crit Care. 2008;14:660–5.
  • Baer PC, Geiger H. Mesenchymal stem cell interactions with growth factors on kidney repair. Curr Opin Nephrol Hypertens. 2010;19:1–6.
  • Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, . Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest. 2005;115:1743–55.
  • Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation- independent mechanisms. Am J Physiol Renal Physiol. 2005;289:F31–42.
  • Bi B, Schmitt R, Israilova M, Nishio H, Cantley LG. Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol. 2007;18:2486–96.
  • Togel FE, Westenfelder C. Mesenchymal stem cells: a new therapeutic tool for AKI. Nature Rev Nephrol. 2010;6:179–83.
  • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98:1076–84.
  • Rao MS, Mattson MP. Stem cells and aging: expanding the possibilities. Mech Ageing Dev. 2001;122:713–34.
  • Can A, Karahuseyinoglu S. Concise review. Human umbilical cord stroma with regard to the source of fetus-derived stem cells. Stem Cells. 2007;25:2886–95.
  • Mitchell KE, Weiss ML, Mitchell BM, Martin P, Davis D, Morales L, . Matrix cells from Wharton's jelly form neurons and glia. Stem Cells. 2003;21:50–60.
  • Troyer DL, Weiss ML. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells. 2008;26:591–9.
  • Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, VanderWerff I, . Immune properties of human umbilical cord Wharton's jelly-derived cells. Stem Cells. 2008; 26:2865–74.
  • Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells. 2007;25:1384–92.
  • Boor P, Ostendorf T, Floege J. Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol. 2010;6:643–56.
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–7.
  • Bonegio R, Lieberthal W. Role of apoptosis in the pathogenesis of acute renal failure. Curr Opin Nephrol Hypertens. 2002;11:301–8.
  • Kunter U, Rong S, Djuric Z, Boor P, Muller-Newen G, Yu D, . Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. J Am Soc Nephrol. 2006;17:2202–12.
  • Morigi M, Introna M, Imberti B, Corna D, Abbate M, Rota C, . Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells. 2008;26:2075–82.
  • Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int. 2004;66:480–5.
  • Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006;86:583–650.
  • Deng J, Kohda Y, Chiao H, Wang Y, Hu X, Hewitt SM, . Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int. 2001;60:2118–28.
  • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999;13:2905–27.
  • Xie L, Zheng X, Qin J, Chen Z, Jin Y, Ding W. Role of PI3-kinase/Akt signalling pathway in renal function and cell proliferation after renal ischaemia/reperfusion injury in mice. Nephrology (Carlton). 2006;11:207–12.
  • Lieberthal W, Fuhro R, Andry CC, Rennke H, Abernathy VE, Koh JS, . Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol. 2001;281:F693–706.
  • Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, . Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008;2:284–91.
  • Humphreys BD, Czerniak S, Dirocco DP, Hasnain W, Cheema R, Bonventre JV. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci USA. 2011;108:9226–31.
  • Liu KD, Brakeman PR. Renal repair and recovery. Crit Care Med. 2008;36:S187–92.
  • Hammerman MR, Miller SB. Therapeutic use of growth factors in renal failure. J Am Soc Nephrol. 1994;5:1–11.
  • Nigam S, Lieberthal W. Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair. Am J Physiol Renal Physiol. 2000;279:F3–11.
  • Liu Y. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am J Physiol. 1999;277:F624–33.
  • Vargas GA, Hoeflich A, Jehle PM. Hepatocyte growth factor in renal failure: promise and reality. Kidney Int. 2000; 57:1426–36.
  • Liu Y. Hepatocyte growth factor and the kidney. Curr Opin Nephrol Hypertens. 2002;11:23–30.
  • Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol. 2008;173:30–41.
  • Mizuno S, Nakamura T. Prevention of neutrophil extravasation by hepatocyte growth factor leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys. Am J Pathol. 2005;166:1895–905.
  • Kamimoto M, Mizuno S, Matsumoto K, Nakamura T. Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-1- dependent mechanism. Biochem Biophys Res Comm. 2009;380:333–7.
  • Rutella S, Bonanno G, Procoli A, Mariotti A, de Ritis DG, Curti A, . Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10 + IL-12low/neg accessory cells with dendritic-cell features. Blood. 2006;108:218–27.
  • Liu Y. Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol. 2004;287:F7–16.
  • Nakamura T, Mizuno S. The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. Proc Japan Acad Series B. 2010;86:588–610.
  • Morigi M, Rota C, Montemurro T, Montelatici E, Lo Cicero V, Imberti B, . Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury. Stem Cells. 2010;28:513–22.
  • Ratajczak MZ, Kucia M, Jadczyk T, Greco NJ, Wojakowski W, Tendera M, . Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? 2011;26:1166–1173.
  • Camussi G, Deregibus MC, Tetta C. Paracrine/endocrine mechanism of stem cells on kidney repair: role of microvesicle-mediated transfer of genetic information. Curr Opin Nephrol Hyperten. 2010;19:7–12.
  • Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, . Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20:223–8.
  • Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, Ilancheran S, . Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol. 2009;175:303–13.

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