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Review Article

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Pages 616-642 | Received 04 Jul 2010, Accepted 07 Dec 2010, Published online: 22 Mar 2011

References

  • Sultana N, Ata A. Oleanolic acid and related derivatives as medicinally important compounds. J Enzyme Inhib Med Chem 2008;23:739–756.
  • Sultana N, Farheen SZ. Naturforsch 2010 (Submitted).
  • Park SH, Oh SR, Jung KY, Lee IS, Ahn KS, Kim JG et al. Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated from Tiarella polyphylla. Arch Pharm Res 1999;22:428–431.
  • Yoshimura H, Sugawara K, Saito M, Saito S, Murakami S, Miyata N et al. In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus. Planta Med 2003;69:673–675.
  • Banno N, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem 2004;68:85–90.
  • Ohigashi H, Takamura H, Koshimizu K, Tokuda H, Ito Y. Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein–Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. Cancer Lett 1986;30:143–151.
  • Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies Africana leaves. J Ethnopharmacol 2003;84:299–305.
  • Somova LI, Shode FO, Mipando M. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine 2004;11:121–129.
  • Chaturvedula PVS, Gao Z, Hecht SM, Jones SH, Kingston DG. A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase B. J Nat Prod 2003;66:1463–5.
  • Dat NT, Lee IS, Cai XF, Shen G, Kim YH. Oleanane triterpenoids with inhibitory activity against NFAT transcription factor from Liquidambar formosana. Biol Pharm Bull 2004;27:426–428.
  • Giner-Larza EM, Manez S, Recio MC, Giner RM, Prieto JM, Cerda-Nicolas M, Rios J. Eur J Pharmacol 2001;28:137–43.
  • Jovel EM, Zhou XL, Ming DS, Wahbe TR, Towers GH. Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. Can J Physiol Pharmacol 2007;85:865–871.
  • Tin-Wa M, Farnsworth NR, Fong HH, Trojanek J. Catharanthus alkaloids. XXV. Isolation of leurosine and ursolic acid from C. pusillus. Lloydia 1970;33:261–263.
  • Nacken M, Pachaly P, Zymalkowski F. Aminoacylation of emetine. Arch Pharm Ber Dtsch Pharm Ges 1970;303:122–133.
  • Silva M. Ursolic acid in Retanilla ephedra. J Pharm Sci 1967;56:908–909.
  • Brieskorn CH, Huber KK. Description and properties of ursolic acid glucoside. Arch Pharm Ber Dtsch Pharm Ges 1966;299:792–796.
  • Plouvier V. Presence of ursolic acid in the blossoms of Viburnum opulus l. var. sterile dc (Caprifoliaceae). Ann Pharm Fr 1964;22:313–314.
  • Cucu V, Rosca M, Grecu L, Cioaca C. Isolation of ursolic acid from Viburnum latana L. Pharmazie 1977;32:542–543.
  • Takahashi T. Presence of ursolic acid in the leaves of Funtumia latifolia Stapf. Ann Pharm Fr 1961;19:520–522.
  • Holtzem H. Incidence of ursolic acid in the leaves of Pyrus communis L. Arch Pharm Ber Dtsch Pharm Ges 1958;291/63:308–310.
  • Hammouda Y, Le Men J. Study of the benzene extract of the leaves of little periwinkle: Vinca minor, presence of ursolic acid, ornol, beta-sitosterol and triacontane. Ann Pharm Fr 1956;14:344–347.
  • Schindler H, Herb M. Chemistry of Ilex aquifolium L. I. Isolation of ursolic acid and rutin from leaves. Arch Pharm Ber Dtsch Pharm Ges 1955;288:372–377.
  • Prakash Chaturvedula VS, Schilling JK, Johnson RK, Kingston DG. New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. J Nat Prod 2003;66:419–422.
  • Wu ZJ. Lipid chemical constituents of Salvia sochifolia C. Y. Wu. Zhongguo Zhong Yao Za Zhi 2001;26:264–265.
  • Xu XZ, Tian X. Studies on chemical components of Gentiana tizuensis Franch. (I). Zhongguo Zhong Yao Za Zhi 2000;25:225–226.
  • Riaz N, Anis I, Khan PM, Shah R, Malik A. Alysinol–a new triterpene from Alysicarpus monolifer. Nat Prod Lett 2002;16:415–418.
  • Pires VS, Gosmann G, Guillaume D, Schenkel EP. Triterpenes and saponins from Ilex psammophila. Nat Prod Lett 2002;16:401–406.
  • Akbar E, Malik A. Antimicrobial triterpenes from Debregeasia salicifolia. Nat Prod Lett 2002;16:339–344.
  • Yang J, Song CQ, Hu ZB. Studies on constituents in Uncaria macrophylla Wall. Zhongguo Zhong Yao Za Zhi 2000;25:484–485.
  • Zhang N, Li C, Yi X. Study on the chemical components of Rabdosia excisa. Zhong Yao Cai 1998;21:347–349.
  • Zhang L, Feng Y, Ding A. The research on the chemical components of Schizonepeta tenuifolia Briq. Zhong Yao Cai 2001;24:183–184.
  • Cheng L, Liu Y, Chen L, Luo J. Studies on the triterpenoidal saponins from flowers of Eriobotrya japonica. Hua Xi Yi Ke Da Xue Xue Bao 2001;32:283–285.
  • Park JH, Son KH, Kim SW, Chang HW, Bae K, Kang SS et al. Anti-inflammatory activity of Synurus deltoides. Phytother Res 2004;18:930–933.
  • Vági E, Rapavi E, Hadolin M, VásárhelyinéPerédi K, Balázs A, Blázovics A, Simándi B. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. J Agric Food Chem 2005;12:17–21.
  • Urech K, Scher JM, Hostanska K, Becker H. Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. J Pharm Pharmacol 2005;57:101–109.
  • Brieskorn CH, Keskin M. Triterpenes in the bark, peel and leaf of Punica granatum L. 5. Knowledge of biochemistry of triterpenes. Pharm Acta Helv 1954;29:338–340.
  • Chien MM, Svoboda GH, Schiff PL Jr, Slatkin DJ, Knapp JE. Chemical constituents of Echites hirsuta (Apocynaceae). J Pharm Sci 1979;68:247–249.
  • Karikas Z, Euerby MR, Waigh RD. Chemical constituents of Rabdosia japonica var. glaucocalyx. Planta Med. 1987;12:38–9.
  • Karikas GA, Euerby MR, Waigh RD. Constituents of the stems of Arbutus unedo. Planta Med 1987;53:223–224.
  • Zou X, Liang J, Ding LS, Peng SL. Studies on chemical constituents of Paederia scandense. Zhongguo Zhong Yao Za Zhi 2006;31:1436–1441.
  • Wang QH, Li ZY, Shen Y, Lin HW, Shu W, Zhou JB. Studies on triterpenoids from Potentilla chinensis. Zhongguo Zhong Yao Za Zhi 2006;31:1434–1436.
  • Lou FM, Yang J, Bai ZC, Wu BF. Studies on chemical constituents in rhizome of Elaeagnus bockii I. Zhongguo Zhong Yao Za Zhi 2006;31:988–989.
  • Zhang YH, Zhou L, Shi RB, Guo YJ, Dong Y. Studies on chemical constituents in spikes of Schizonepeta tenuifolia. Zhongguo Zhong Yao Za Zhi 2006;31:1247–1249.
  • Zeng JW, Qian SH, Wu JZ, Yang NY. Studies on involatile constituents of Mentha haplocalyx. Zhongguo Zhong Yao Za Zhi 2006;31:400–402.
  • Wang MY, Yang L, Tu YY. Studies on the chemical constituents from stem of Chirita longgangensis var. Hongyao. Zhongguo Zhong Yao Za Zhi 2006;31:307–308.
  • Ahmed Z, Ali D, Malik A. Structure determination of ursene-type triterpenes by NMR techniques. Magn Reson Chem 2006;44:717–719.
  • Zhang YH, Zhang JG, Xie JM, Chen GL, Cheng DL. Triterpenes from root of Rhaponticum uniflorum. Zhongguo Zhong Yao Za Zhi 2005;30:1833–1836.
  • Wang FD, Ding L, Wang HQ. Studies on triterpenoid constituents from Rabdosia japonica var. galaucocalyx. Zhongguo Zhong Yao Za Zhi 2005;30:1929–1932.
  • Yan J, Yang XW. Studies on the chemical constituents in herb of Ludwigia octovalvis. Zhongguo Zhong Yao Za Zhi 2005;30:1923–1926.
  • Qi X, Yang Y, Ye Y. Study on chemical constituents from stem of Mallotus apelta. Zhong Yao Cai 2005;28:765–766.
  • Yuan G, Yi Y. Studies on chemical constituents of the roots of Salacia hainanensis. Zhong Yao Cai 2005;28:27–29.
  • Luo Y, Yi J, Li B, Zhang G. Novel ceramides and a new glucoceramide from the roots of Incarvillea arguta. Lipids 2004;39:907–913.
  • Xiang W, Li RT, Mao YL, Zhang HJ, Li SH, Song QS et al. Four new prenylated isoflavonoids in Tadehagi triquetrum. J Agric Food Chem 2005;53:267–271.
  • Tokar M, Klimek B. Isolation and identification of biologically active compounds from Forsythia viridissima flowers. Acta Pol Pharm 2004;61:191–197.
  • Ma CH, Chen B, Qi HY, Li BG, Zhang GL. Two pyranocoumarins from the seeds of Calophyllum polyanthum. J Nat Prod 2004;67:1598–1600.
  • Cao S, Guza RC, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG. Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. J Nat Prod 2004;67:986–989.
  • Raju BL, Lin SJ, Hou WC, Lai ZY, Liu PC, Hsu FL. Antioxidant iridoid glucosides from Wendlandia formosana. Nat Prod Res 2004;18:357–364.
  • Ragasa CY, Tiu F, Rideout JA. New cycloartenol esters from Ixora coccinea. Nat Prod Res 2004;18:319–323.
  • Dallavalle S, Jayasinghe L, Kumarihamy BM, Merlini L, Musso L, Scaglioni L. A new 3,4-seco-lupane derivative from Lasianthus gardneri. J Nat Prod 2004;67:911–913.
  • Jang DS, Park EJ, Kang YH, Vigo JS, Graham JG, Cabieses F et al. Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase. Arch Pharm Res 2004;27:169–172.
  • Liu S, Qin Y, Du FL. Studies on chemical constituents in leafs of Ilex kudingcha. Zhongguo Zhong Yao Za Zhi 2003;28:834–836.
  • Zhang PC, Wu Y, Yu DQ. Chemical constituents from the leaves of Dalbergia hainanensis. Zhongguo Zhong Yao Za Zhi 2003;28:527–530.
  • Guo J, Liu LH, Mei SX, Zhao JF, Ma ZR, Li L. Studies on chemical constituents from the stems of Schisandra sphaerandra. Zhongguo Zhong Yao Za Zhi 2003;28:138–140.
  • Begum S, Hassan SI, Ali SN, Siddiqui BS. Chemical constituents from the leaves of Psidium guajava. Nat Prod Res 2004;18:135–140.
  • Xue PF, Qiao L, Liang H, Zhao YY. Studies on the chemical constituents from Potentilla multifida L. Beijing Da Xue Xue Bao 2004;36:21–23.
  • Chang CI, Kuo CC, Chang JY, Kuo YH. Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. J Nat Prod 2004;67:91–93.
  • Jung HA, Chung HY, Jung JH, Choi JS. A new pentacyclic triterpenoid glucoside from Prunus serrulata var. spontanea. Chem Pharm Bull 2004;52:157–159.
  • Chen WS, Jia XM, Zhang WD, Lou ZY, Qiao CZ. Chemical constituents in the roots of Salvia przewalskii Maxim. Yao Xue Xue Bao 2003;38:354–357.
  • Skrzypek Z, Wysokinska H. Sterols and triterpenes in cell culture of Hyssopus officinalis L. Z Naturforsch, C, J Biosci 2003;58:308–312.
  • Chen B, Zhu M, Xing WX, Yang GJ, Mi HM, Wu YT. Studies on chemical constituents in fruit of Eucalyptus globulus. Zhongguo Zhong Yao Za Zhi 2002;27:596–597.
  • Ma XJ, Du CF, Zheng JH, Chen XZ. Studies on chemical constituents of Gaultheria leucocarpa var. Yunnanensis (Franch.) T. Z. Hsu R. C. & Fang. Zhongguo Zhong Yao Za Zhi 2001;26:844–845.
  • Ren FZ, Luan XH, Zhao YM, Qu HH. Studies on flavonoids from leaves of Callicarpa bodinieri Lev. Zhongguo Zhong Yao Za Zhi 2001;26:841–844.
  • Wang GL, Hou QY, Zhang J, Xu JM, Peng JF, Lin RC. Studies on the chemical constituents of the stems of Alyxia sinensis (I). Zhongguo Zhong Yao Za Zhi 2002;27:125–127.
  • Cheng J, Bai YJ, Zhao YY, Wang B, Cheng TM. Studies on the phenylpropanoids from Eucommia ulmoides. Zhongguo Zhong Yao Za Zhi 2002;27:38–40.
  • Li C, Sun YR, Sun YF. Chemical composition of fructus Liquidambaris-lulutong. Yao Xue Xue Bao 2002;37:263–266.
  • Jin YR, Gui MY, Wang BZ. Studies on chemical constituents in the roots of Rabdosia japonica (Burm.f). Hara var. Glaucocalyx (Maxin) Hara. Zhongguo Zhong Yao Za Zhi 2000;25:678–679.
  • Lee S, Ji J, Shin KH, Kim BK. Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus. Planta Med 2002;68:939–941.
  • Wen D, Zheng X, Inoue K. Studies on chemical constituents of Ilex Merr. Zhongguo Zhong Yao Za Zhi 1999;24:223–5, 255.
  • Lee S, Kim BK, Cho SH, Shin KH. Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. Arch Pharm Res 2002;25:280–284.
  • Zheng X, Xu Y, Xu J. Chemical studies on Pyrrosia gralla (Gies.) Ching. Zhongguo Zhong Yao Za Zhi 1998;23:98–9, 128.
  • Zhou F, Liang P, Zhou Q, Qin Z. Chemical constituents of the stem and root of Syzygium buxifolium Hook. Et Arn. Zhongguo Zhong Yao Za Zhi 1998;23:164–5, 192.
  • Upadhyay RK, Pandey MB, Jha RN, Pandey VB. Eclalbatin, a triterpene saponin from Eclipta alba. J Asian Nat Prod Res 2001;3:213–217.
  • Lu X, Xu W, Shen J, Han G. Chemical studies on Campylotropis hirtella (Franch. Schindl.). Zhongguo Zhong Yao Za Zhi 1997;22:680–2, 704.
  • Huang H, Zhao S, Wang M, Liu Q, Sun H. Chemical constituents in the stem and leaf of Isodon oresbius. Zhongguo Zhong Yao Za Zhi 1998;23:37–8, 62.
  • Huang J, Wang X, Ogihara Y, Shimizu N, Takeda T, Akiyama T. Latifolosides I and J, two new triterpenoid saponins from the bark of Ilex latifolia. Chem Pharm Bull 2001;49:239–241.
  • Siddiqui BS, Sultana I, Begum S. Triterpenoidal constituents from Eucalyptus camaldulensis var. obtusa leaves. Phytochemistry 2000;54:861–865.
  • Prasad D, Juyal V, Singh R, Singh V, Pant G, Rawat MS. A new secoiridoid glycoside from Lonicera angustifolia. Fitoterapia 2000;71:420–424.
  • Hou AJ, Yang H, Jiang B, Zhao QS, Lin ZW, Sun HD. A new ent-kaurane diterpenoid from Isodon phyllostachys. Fitoterapia 2000;71:417–419.
  • Chang CW, Wu TS, Hsieh YS, Kuo SC, Chao PD. Terpenoids of Syzygium formosanum. J Nat Prod 1999;62:327–328.
  • Fullas F, Hussain RA, Chai HB, Pezzuto JM, Soejarto DD, Kinghorn AD. Cytotoxic constituents of Baccharis gaudichaudiana. J Nat Prod 1994;57:801–807.
  • Shammas G, Philianos S, Verykokidou-Vitsaropoulou E. Chemical constituents of the flowers of Fraxinus ornus L. Ann Pharm Fr 1990;48:13–16.
  • Isobe T, Noda Y, Ohsaki A, Sakanaka S, Kim M, Taniguchi M. Studies on the constituents of Leucoseptrum stellipillum. Yakugaku Zasshi 1989;109:175–178.
  • Zeng X, Fang Z, Ma J. Chemical constituents of Osbeckia chinensis L. Zhongguo Zhong Yao Za Zhi 1991;16:99–101, 127.
  • Fang Z, Yang Y, Zhou G. Isolation and identification of chemical constituents from Hedyotis chrysotricha (Palib.) Merr. Zhongguo Zhong Yao Za Zhi 1992;17:98–100, 127.
  • Shi Y, Wang H. Chemical constituents of Actinidia arguta (Sieb. et Zucc.) Planch. ex Miquel. Zhongguo Zhong Yao Za Zhi 1992;17:36–8, 64.
  • González AG, Barrera JB, Pérez EM, Padrón CE. Chemical Constituents of the Lichen Ramalina hierrensis. Planta Med 1992;58:214–218.
  • Xu M, Xiong B, Cheng P, Guo Y. Chemical constituents of Isodon albopilosus (C.Y. Wu et H.W. Li) Hara. Zhongguo Zhong Yao Za Zhi 1992;17:228–30, 256.
  • Nakanishi T, Tanaka K, Murata H, Somekawa M, Inada A. Phytochemical studies of seeds of medicinal plants. III. Ursolic acid and oleanolic acid glycosides from seeds of Patrinia scabiosaefolia Fischer. Chem Pharm Bull 1993;41:183–186.
  • Bisio A, De Tommasi N, Romussi G. Triterpenoids from Salvia wagneriana. Pharmazie 2004;59:309–311.
  • Ma CM, Jia SS, Sun T, Zhang YW. Triterpenes and steroidal compounds from Cynomorium songaricum. Yao Xue Xue Bao 1993;28:152–155.
  • Pan WD, Li YJ, Mai LT, Ohtani KH, Kasai RT, Tanaka O et al. Studies on triterpenoid constituents of the roots of Lantana camara. Yao Xue Xue Bao 1993;28:40–44.
  • Ahme R, Ifza SM, Saifuddin A, Nazeer M, Pak. Studies on triterpenoid constituents of the roots of Lantana camara. J Pharm Sci 1995;8:69–71.
  • Gosmann G, Guillaume D, Taketa AT, Schenkel EP. Triterpenoid saponins from Ilex paraguariensis. J Nat Prod 1995;58:438–441.
  • Miyase T, Shiokawa KI, Zhang DM, Ueno A. Araliasaponins I-XI, triterpene saponins from the roots of Aralia decaisneana. Phytochemistry 1996;41:1411–1418.
  • Miyase T, Melek FR, El-Gindi OD, Abdel-Khalik SM, El-Gindi MR, Haggag MY, Hilal SH. Phytochemistry 1996;4:11175–9.
  • Takeoka G, Dao L, Teranishi R, Wong R, Flessa S, Harden L et al. Identification of three triterpenoids in almond hulls. J Agric Food Chem 2000;48:3437–3439.
  • Liu YQ, You S, Tashiro S, Onodera S, Ikejima T. Oridonin induced U937 cell apoptosis through ERK pathway. Zhongguo Zhong Yao Za Zhi 2005;30:1856–1859.
  • Melek FR, Miyase T, el-Gindy MR, Abdel-Khalik SM, Ghaly NS, el-Kady M. Saponins from Fagonia glutinosa. Pharmazie 2000;55:772–776.
  • Liu P, Duan HQ, Pan Q, Zhang YW, Yao Z. Triterpenes from herb of Potentilla chinesis. Zhongguo Zhong Yao Za Zhi 2006;31:1875–1879.
  • Vági E, Rapavi E, Hadolin M, VásárhelyinéPerédi K, Balázs A, Blázovics A et al. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. J Agric Food Chem 2005;53:17–21.
  • Zhao Y, Ruan JL, Wang JH, Cong Y, Song S, Cai YL et al. Chemical constituents of radix Ranunculus ternati. Nat Prod Res 2008;22:233–240.
  • Jiang T, Huang BK, Zhang QY, Han T, Zheng HC, Qin LP. Studies on chemical constituents of Liriope platyphylla. Zhong Yao Cai 2007;30:1079–1081.
  • Liu L, Chen YP, Wan Z, Li AL, Li RY, Tu PF. Studies on chemical constituents of in herb Pyrola calliatha. Zhongguo Zhong Yao Za Zhi 2007;32:1762–1765.
  • Ding LL, Wang SC, Wang ZT. Studies on chemical constituents from root of Actinidia macrosperma. Zhongguo Zhong Yao Za Zhi 2007;32:1893–1895.
  • Ji TF, Liu CH, Wang AG, Yang JB, Su YL, Yuan L et al. Studies on the chemical constituents of Urtica dioica L. grown in Tibet Autonomous Region. Zhong Yao Cai 2007;30:662–664.
  • Tang LY, Luo MH, Jiang N, Lin HH. Studies on chemical constituents of Sambucus adnata. Zhong Yao Cai 2007;30:549–551.
  • Huang L, Zhang RS, Wang CF, Zhang SF. Studies on chemical constituents of Patrinia villosa. Zhong Yao Cai 2007;30:415–417.
  • Zhang S, Geshang SL, Dawa ZM, Zhou Y, Peng SL. Studies on chemical constituents of Eriophyton wallichii. Zhongguo Zhong Yao Za Zhi 2007;32:824–826.
  • Yawer MA, Ahmed E, Malik A, Ashraf M, Rasool MA, Afza N. New lipoxygenase-inhibiting constituents from Calligonum polygonoides. Chem Biodivers 2007;4:1578–1585.
  • Begum S, Ali SN, Hassan SI, Siddiqui BS. A new ethylene glycol triterpenoid from the leaves of Psidium guajava. Nat Prod Res 2007;21:742–748.
  • Duan WD, Zhang J, Xie G, Zhang CZ, Li C. Chemical constituents from the flower of Paulownia fortunei (seem.) Hems. Zhong Yao Cai 2007;30:168–170.
  • Wei J, Zhu HY, Shen DF, Yang B, Yang XS. Studies on the chemical constituents of Vaccinium iteophyllum. Zhong Yao Cai 2007;30:47–49.
  • Yang SM, Liu XK, Qing C, Wu DG, Zhu DY. Chemical constituents from the roots of Homonoia riparia. Yao Xue Xue Bao 2007;42:292–296.
  • Wu JY, Li GC, Wang DY. Chemical constituents of the non-alkaloid fraction of Uncaria macrophylla. Nan Fang Yi Ke Da Xue Xue Bao 2007;27:226–227.
  • da Silva VC, de Carvalho MG, Alves AN. Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). J Nat Med 2008;62:356–357.
  • Qi SH, Wu DG, Zhang S, Luo XD. Constituents of Carapa guianensis Aubl. (Meliaceae). Pharmazie 2004;59:488–490.
  • Huang H, Chao QR, Tan RX, Sun HD, Wang DC, Ma J et al. A new rosmarinic acid derivative from Isodon oresbius. Planta Med 1999;65:92–93.
  • Liu RH, Yu BY. Study on the chemical constituents of the leaves from Crataegus pinnatifida Bge. var. major N. E. Br. Zhong Yao Cai 2006;29:1169–1173.
  • Moghaddam FM, Farimani MM, Salahvarzi S, Amin G. Chemical constituents of dichloromethane extract of cultivated Satureja khuzistanica. Evid Based Complement Alternat Med 2007;4:95–98.
  • Khaliq S, Volk FJ, Frahm AW. Phytochemical investigation of Perovskia abrotanoides. Planta Med 2007;73:77–83.
  • Liao QF, Xie SP, Chen XH, Bi KS. Study on the chemical constituents of Sambucus chinensis Lindl. Zhong Yao Cai 2006;29:916–918.
  • Gören AC, Zhou BN, Topçu G, Kökdil G, Kingston DG. DNA-damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside. Nat Prod Res 2005;19:457–460.
  • Wang L, Wang HQ, Chen RY. Studies on chemical constituents from bark of Morus nigra. Zhongguo Zhong Yao Za Zhi 2007;32:2497–2499.
  • Jiang X, Zhang JC, Liu YW, Fang Y. Studies on chemical constituents of Valeriana officinalis. Zhong Yao Cai 2007;30:1391–1393.
  • Zhao DB, Yang YX, Liu XH, Wang HQ. Studies on chemical constituents in herb of Chondrilla piptocoma. Zhongguo Zhong Yao Za Zhi 2005;30:588–590.
  • Wang B, Liu P, Shen YM, Dai C. Studies on the chemical constituents from herb of Rhodobryum roseum. Zhongguo Zhong Yao Za Zhi 2005;30:895–897.
  • Rana VS, Rawat MS. A new xanthone glycoside and antioxidant constituents from the rhizomes of Swertia speciosa. Chem Biodivers 2005;2:1310–1315.
  • Khan MI, Ahmed N, Haqqani MH. Xanthones and ursolic acid from Swertia species. Planta Med 1977;32:280–281.
  • Said IM, Chun NC, Houghton PJ. Ursolic acid from Mitragyna speciosa. Planta Med 1991;57:398.
  • Fang X, Nanayakkara NP, Phoebe CH Jr, Pezzuto JM, Kinghorn AD, Farnsworth NR. Plant Anticancer agents XXXVII. Constituents of Amanoa oblongifolia1. Planta Med 1985;51:346–347.
  • Lee I, Lee J, Lee YH, Leonard J. Ursolic acid-induced changes in tumor growth, O2 consumption, and tumor interstitial fluid pressure. Anticancer Res 2001;21:2827–2833.
  • Zheng QF, Sun HX, He QJ, Ye YP. Induction of apoptosis in HeLa cells by 3beta-hydroxyurs-12-en-27-oic acid. Chem Biodivers 2006;3:742–753.
  • Tokuda H, Ohigashi H, Koshimizu K, Ito Y. Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett 1986;33:279–285.
  • Yarosh DB, Both D, Brown D. Liposomal ursolic acid (Merotaine) increases ceramides and collagen in human skin. Horm Res 2000;54:318–321.
  • Both DM, Goodtzova K, Yarosh DB, Brown DA. Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells. Arch Dermatol Res 2002;293:569–575.
  • Shin KM, Kim RK, Azefack TL, David L, Luc SB, Choudhary MI et al. In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells. Planta Med 2004;70:803–807.
  • Yim EK, Lee MJ, Lee KH, Um SJ, Park JS. Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. Int J Gynecol Cancer 2006;16:2023–2031.
  • Liu Z, Ma R, Wang Y. Study on the extracting of ursolic acid by uniform design. Zhong Yao Cai 2005;28:425–427.
  • Brieskorn CH, Hofmann H. On the quantitative determination of ursolic acid and oleanolic acid by means of the Liebermann–Burchard reaction. Arch Pharm 1962;295/67:505–509.
  • Shi HM, Long BS, Cui XM, Min ZD. A new bisabolane sesquiterpenoid from Euphorbia chrysocoma. J Asian Nat Prod Res 2005;7:857–860.
  • Zhou C, Chen K, Sun C, Chen Q, Zhang W, Li X. Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC. Biomed Chromatogr 2007;21:755–761.
  • Chen JH, Xia ZH, Tan RX. High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens. J Pharm Biomed Anal 2003;32:1175–1179.
  • Yang P, Li Y, Liu X, Jiang S. Determination of free isomeric oleanolic acid and ursolic acid in Pterocephalus hookeri by capillary zone electrophoresis. J Pharm Biomed Anal 2007;43:1331–1334.
  • Ding H, Wang Y, Wang S, You W. Quantitative determination of ursolic acid in Herba cynomorii by ultraviolet spectrophotometry. Zhongguo Zhong Yao Za Zhi 1998;23:102–3, inside back cover.
  • Song LL, Fan BY, Xu XJ, Lu PW, Xiang BR. Determination of ursolic acid of Liuwei Dihuangwan simulation samples by NIR. Zhongguo Zhong Yao Za Zhi 2006;31:1590–1593.
  • Guo Y, Cui Y, Zhou J, Yan Y, Yuan P. Quantitative determination of ursolic acid in Folium ilicis cornutae (gouguye) gathered in different and periods. Zhongguo Zhong Yao Za Zhi 1995;20:591–2, 638.
  • Jia YY, Yan XS, Nie K. Comparative analysis of ursolic acid in Crataegus pinnatifida Bge. var. major N.E. Br. before and after processing. Zhongguo Zhong Yao Za Zhi 1989;14:466–8, 510.
  • Jung SH, Ha YJ, Shim EK, Choi SY, Jin JL, Yun-Choi HS et al. Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. Biochem J 2007;403:243–250.
  • Novotny L, Abdel-Hamid ME, Hamza H, Masterova I, Grancai D. Development of LC-MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl. J Pharm Biomed Anal 2003;31:961–968.
  • Liao Q, Yang W, Jia Y, Chen X, Gao Q, Bi K. LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional Chinese medicinal preparation Lu-Ying extract. Yakugaku Zasshi 2005;125:509–515.
  • Lee WS, Im KR, Park YD, Sung ND, Jeong TS. Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. Biol Pharm Bull 2006;29:382–384.
  • Huang L, Chen T, Ye Z, Chen G. Use of liquid chromatography-atmospheric pressure chemical ionization-ion trap mass spectrometry for identification of oleanolic acid and ursolic acid in Anoectochilus roxburghii (wall.) Lindl. J Mass Spectrom 2007;42:910–917.
  • Gu JQ, Wang Y, Franzblau SG, Montenegro G, Timmermann BN. Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS. Phytochem Anal 2006;17:102–106.
  • Klimek B, Modnicki D. Terpenoids and sterols from Nepeta cataria L. var. citriodora (Lamiaceae). Acta Pol Pharm 2005;62:231–235.
  • Wang HB, Zhang ZY, Zia ZX, Su Z, Li CK. Qualitative analysis of Chinese drug xiakucao (Prunella). Zhongguo Zhong Yao Za Zhi 1993;7:702.
  • Gu BP, Zhu L, Ke WZ, Chen JW. Comparative study of the spectral characteristics of ursolic acid between laser Raman spectra and IR spectrum. Guang Pu Xue Yu Guang Pu Fen Xi 2002;22:970–972.
  • Fang X, Nanayakkara NP, Phoebe CH Jr, Pezzuto JM, Kinghorn AD, Farnsworth NR. Plant Anticancer agents XXXVII. Constituents of Amanoa oblongifolia1. Planta Med 1985;51:346–347.
  • Trumbull ER, Bianchi E, Eckert DJ, Wiedhopf RM, Cole JR. Tumor inhibitory agents from Vauquelinia corymbosa (Rosaceae). J Pharm Sci 1976;65:1407–1408.
  • Shen YM, Zhu X, Zhang KH, Xie Y, Chen J, Dai Y et al. Effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells in vitro. Zhonghua Gan Zang Bing Za Zhi 2008;16:298–301.
  • Kang WY, Du ZZ, Yang XS, Hao XJ. A new triterpene from Luculia pinciana Hook. J Asian Nat Prod Res 2005;7:91–94.
  • Miceli N, Taviano MF, Giuffrida D, Trovato A, Tzakou O, Galati EM. Anti-inflammatory activity of extract and fractions from Nepeta sibthorpii Bentham. J Ethnopharmacol 2005;97:261–266.
  • Chattopadhyay D, Arunachalam G, Mandal SC, Bhadra R, Mandal AB. CNS activity of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: an ethnomedicine of Onge. J Ethnopharmacol 2003;85:99–105.
  • Chattopadhyay D, Dungdung SR, Mandal AB, Majumder GC. A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract. Contraception 2005;71:372–378.
  • Zhang P, Li X, Li N, Xu J, Li ZL, Wang Y et al. Antibacterial constituents from fruit bodies of Ascomyce Bulgaria inquinans. Arch Pharm Res 2005;28:889–891.
  • Chattopadhyay D, Arunachalam G, Ghosh L, Rajendran K, Mandal AB, Bhattacharya SK. Antipyretic activity of Alstonia macrophylla Wall ex A. DC: an ethnomedicine of Andaman Islands. J Pharm Pharm Sci 2005;8:558–564.
  • Ali H, Houghton PJ, Soumyanath A. alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J Ethnopharmacol 2006;107:449–455.
  • Chaturvedula VS, Gao Z, Jones SH, Feng X, Hecht SM, Kingston DG. A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase. J Nat Prod 2004;67:899–901.
  • Chiang LC, Ng LT, Cheng PW, Chiang W, Lin CC. Antiviral activities of extracts and ursolic acid constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol. 2005;32:811–816.
  • Cipak L, Grausova L, Miadokova E, Novotny L, Rauko P. Dual activity of triterpenoids: apoptotic versus antidifferentiation effects. Arch Toxicol 2006;80:429–435.
  • Chiang YM, Chang JY, Kuo CC, Chang CY, Kuo YH. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry 2005;66:495–501.
  • Gnoatto SC, Dassonville-Klimpt A, Da Nascimento S, Galéra P, Boumediene K, Gosmann G, Sonnet P, Moslemi S. Antioxidant, anti-inflammatory, and anticancer activities of extracts from Ledum groenlandicum Retzius. Eur J Med Chem 2007;7.
  • Muto Y, Ninomiya M, Fujiki H. Present status of research on cancer chemoprevention in Japan. Jpn J Clin Oncol 1990;20:219–224.
  • Ikeda Y, Murakami A, Ohigashi H. Ursolic acid: an anti- and pro-inflammatory triterpenoid. Mol Nutr Food Res 2008;52:26–42.
  • Lim SW, Hong SP, Jeong SW, Kim B, Bak H, Ryoo HC et al. Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. J Dermatol 2007;34:625–634.
  • Yin MC, Chan KC. Non-enzymatic antioxidative and antiglycative effects of oleanolic acid and ursolic acid. J Agric Food Chem 2007;55:7177–7181.
  • Andersson D, Cheng Y, Duan RD. Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. J Cancer Res Clin Oncol 2008;134:101–107.
  • Vidya SM, Krishna V, Manjunatha BK, Mankani KL, Ahmed M, Singh SD. Indian Evaluation of hepatoprotective activity of Clerodendrum serratum L., Indian J Exp Biol 2007;45:538–542.
  • Balanehru S, Nagarajan B. Protective effect of oleanolic acid and ursolic acid against lipid peroxidation. Biochem Int 1991;24:981–990.
  • Ovesná Z, Kozics K, Slamenová D. Protective effects of ursolic acid and oleanolic acid in leukemic cells. Mutat Res 2006;600:131–137.
  • Sultana N, Choudhary MI, Khan A. Protein glycation inhibitory activities of Lawsonia inermis and its active principles. J Enzyme Inhib Med Chem 2009;24:257–261.
  • Vidya SM, Krishna V, Manjunatha BK, Mankani KL, Ahmed M, Singh SD. Evaluation of hepatoprotective activity of Clerodendrum serratum L. Indian J Exp Biol 2007;45:538–542.
  • Senthil S, Chandramohan G, Pugalendi KV. Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. Int J Cardiol 2007;119:131–133.
  • Achiwa Y, Hasegawa K, Udagawa Y. Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells. Biosci Biotechnol Biochem 2007;71:31–37.
  • Kassi E, Papoutsi Z, Pratsinis H, Aligiannis N, Manoussakis M, Moutsatsou P. Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells. J Cancer Res Clin Oncol 2007;133:493–500.
  • He X, Liu RH. Cranberry phytochemicals: isolation, structure elucidation, and their antiproliferative and antioxidant activities. J Agric Food Chem 2006;54:7069–7074.
  • Es-Saady D, Simon A, Jayat-Vignoles C, Chulia AJ, Delage C. MCF-7 cell-cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. Anticancer Res 1996;16:481–486.
  • Saravanan R, Pugalendi V. Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart. Pharmacol Rep 2006;58:41–47.
  • Lu J, Zheng YL, Wu DM, Luo L, Sun DX, Shan Q. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by d-galactose. Biochem Pharmacol 2007;74:1078–1090.
  • Jayaprakasam B, Olson LK, Schutzki RE, Tai MH, Nair MG. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 2006;54:243–248.
  • Lee CJ, Seok JH, Hur GM, Lee JH, Park JS, Seol IC et al. Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells. Planta Med 2004;70:1119–1122.
  • Kim KA, Lee JS, Park HJ, Kim JW, Kim CJ, Shim IS et al. Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. Life Sci 2004;74:2769–2779.
  • Harmand PO, Duval R, Liagre B, Jayat-Vignoles C, Beneytout JL, Delage C et al. Ursolic acid induces apoptosis through caspase-3 activation and cell-cycle arrest in HaCaT cells. Int J Oncol 2003;23:105–112.
  • Lauthier F, Taillet L, Trouillas P, Delage C, Simon A. Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. Anticancer Drugs 2000;11:737–745.
  • Martín-Cordero C, Reyes M, Ayuso MJ, Toro MV. Cytotoxic triterpenoids from Erica andevalensis. Z Naturforsch, C, J Biosci 2001;56:45–48.
  • Hsu YL, Kuo PL, Lin CC. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci 2004;75:2303–2316.
  • Achiwa Y, Hasegawa K, Komiya T, Udagawa Y. Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. Oncol Rep 2005;13:51–57.
  • Yim EK, Lee KH, Namkoong SE, Um SJ, Park JS. Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells. Cancer Lett 2006;235:209–220.
  • Achiwa Y, Hasegawa K, Udagawa Y. Molecular mechanism of ursolic acid-induced apoptosis in poorly differentiated endometrial cancer HEC108 cells. Oncol Rep 2005;14:507–512.
  • Tang X, Gao J, Chen J, Fang F, Wang Y, Dou H et al. Inhibition by (corrected) ursolic acid of (corrected) calcium-induced mitochondrial permeability transition and release of two pro-apoptotic proteins. Biochem Biophys Res Commun 2005;337:320–324.
  • Harmand PO, Duval R, Delage C, Simon A. Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. Int J Cancer 2005;114:1–11.
  • Choi YH, Baek JH, Yoo MA, Chung HY, Kim ND, Kim KW. Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. Int J Oncol 2000;17:565–571.
  • Kim DK, Baek JH, Kang CM, Yoo MA, Sung JW, Chung HY et al. Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. Int J Cancer 2000;87:629–636.
  • Zhang YY, Deng T, Hu ZF, Zhang QP, Zhang J, Jiang H. Mechanisms of inhibiting proliferation and inducing apoptosis of human gastric cancer cell line SGC7901 by ursolic acid. Ai Zheng 2006;25:432–437.
  • Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 2007;5:943–955.
  • Martin-Aragón S, de las Heras B, Sanchez-Reus MI, Benedi J. Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. Exp Toxicol Pathol 2001;53:199–206.
  • Liu J, Liu Y, Mao Q, Klaassen CD. The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol 1994;22:34–40.
  • Ryu SY, Oak MH, Yoon SK, Cho DI, Yoo GS, Kim TS et al. Antiallergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Planta Med 2000;66:358–360.
  • Min BS, Jung HJ, Lee JS, Kim YH, Bok SH, Ma CM et al. Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease. Planta Med 1999;65:374–375.
  • Liu XS, Jiang J. Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells. Planta Med 2007;73:1192–1194.
  • Slamenová D, Horváthová E, Bartková M, Krajcovicová Z, Lábaj J, Kosíková B et al. Reduction of DNA-damaging effects of anti-HIV drug 3′-azido-3′-dideoxythymidine on human cells by ursolic acid and lignin biopolymer. Neoplasma 2006;53:485–491.
  • Steele JC, Warhurst DC, Kirby GC, Simmonds MS. In vitro and in vivo evaluation of betulinic acid as an antimalarial. Phytother Res 1999;13:115–119.
  • Paik KJ, Jeon SS, Chung HY, Lee KH, Kim KW, Chung JK et al. Induction of differentiation of the cultured rat mammary epithelial cells by triterpene acids. Arch Pharm Res 1998;21:398–405.
  • Tan GT, Lee S, Lee IS, Chen J, Leitner P, Besterman JM et al. Natural-product inhibitors of human DNA ligase I. Biochem J 1996;314 (Pt 3):993–1000.
  • Sohn KH, Lee HY, Chung HY, Young HS, Yi SY, Kim KW. Anti-angiogenic activity of triterpene acids. Cancer Lett 1995;94:213–218.
  • Cárdenas C, Quesada AR, Medina MA. Effects of ursolic acid on different steps of the angiogenic process. Biochem Biophys Res Commun 2004;320:402–408.
  • Jeong GS, An RB, Pae HO, Oh GS, Chung HT, Kim YC. Heme oxygenase-1 inducing constituent of Prunella vulgaris in HepG2 cells. Biol Pharm Bull 2008;31:531–533.
  • Bonaccorsi I, Altieri F, Sciamanna I, Oricchio E, Grillo C, Contartese G et al. Endogenous reverse transcriptase as a mediator of ursolic acid’s antiproliferative and differentiating effects in human cancer cell lines. Cancer Lett 2008;263:130–139.
  • Ramos AA, Lima CF, Pereira ML, Fernandes-Ferreira M, Pereira-Wilson C. Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay. Toxicol Lett 2008;177:66–73.
  • Horiuchi K, Shiota S, Hatano T, Yoshida T, Kuroda T, Tsuchiya T. Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). Biol Pharm Bull 2007;30:1147–1149.
  • Steinkamp-Fenske K, Bollinger L, Völler N, Xu H, Yao Y, Bauer R et al. Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Atherosclerosis 2007;195:e104–e111.
  • Huang J, Sun Y, Lu S. Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells. Zhongguo Zhong Xi Yi Jie He Za Zhi 1999;19:296–298.
  • Andersson D, Liu JJ, Nilsson A, Duan RD. Ursolic acid inhibits proliferation and stimulates apoptosis in HT-29 cells following activation of alkaline sphingomyelinase. Anticancer Res 2003;23:3317–3322.
  • Nataraju A, Raghavendra Gowda CD, Rajesh R, Vishwanath BS. Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule. Curr Top Med Chem 2007;7:801–809.
  • Ikeda Y, Murakami A, Fujimura Y, Tachibana H, Yamada K, Masuda D et al. Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. j Immunol 2007;178:4854–4864.
  • Lai MY, Leung HW, Yang WH, Chen WH, Lee HZ. Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. Anticancer Res 2007;27:145–153.
  • Ali MS, Ibrahim SA, Jalil S, Choudhary MI. Ursolic acid: a potent inhibitor of superoxides produced in the cellular system. Phytother Res 2007;21:558–561.
  • Jedinák A, Mucková M, Kost’álová D, Maliar T, Masterova I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch, C, J Biosci 2006;61:777–782.
  • Heo HJ, Kim C, Lee HJ, Kim YS, Kang SS, Seo UK et al. Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells. Phytother Res 2007;21:462–465.
  • Ikeda Y, Murakami A, Nishizawa T, Ohigashi H. Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin. Biosci Biotechnol Biochem 2006;70:1033–1037.
  • Aguirre-Crespo F, Vergara-Galicia J, Villalobos-Molina R, Javier López-Guerrero J, Navarrete-Vázquez G, Estrada-Soto S. Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta. Life Sci 2006;79:1062–1068.
  • Moon HK, Yang ES, Park JW. Protection of peroxynitrite-induced DNA damage by dietary antioxidants. Arch Pharm Res 2006;29:213–217.
  • Thuong PT, Min BS, Jin W, Na M, Lee J, Seong R et al. Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis. Biol Pharm Bull 2006;29:830–833.
  • Zhang GP, Lu YY, Lv JC, Ou HJ. Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells. Zhongguo Zhong Yao Za Zhi 2006;31:141–144.
  • Na M, Yang S, He L, Oh H, Kim BS, Oh WK et al. Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata. Planta Med 2006;72:261–263.
  • Ahmad SF, Khan B, Bani S, Suri KA, Satti NK, Qazi GN. Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. Pharmacol Res 2006;53:233–240.
  • Oh CJ, Kil IS, Park CI, Yang CH, Park JW. Ursolic acid regulates high glucose-induced apoptosis. Free Radic Res 2007;41:638–644.
  • Ikeda Y, Murakami A, Ohigashi H. Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages. Biochem Pharmacol 2005;70:1497–1505.
  • Chiang LC, Ng LT, Cheng PW, Chiang W, Lin CC. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol 2005;32:811–816.
  • Saravanan R, Viswanathan P, Pugalendi KV. Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci 2006;78:713–718.
  • Ren D, Zuo R, González Barrios AF, Bedzyk LA, Eldridge GR, Pasmore ME et al. Differential gene expression for investigation of Escherichia coli biofilm inhibition by plant extract ursolic acid. Appl Environ Microbiol 2005;71:4022–4034.
  • Saeidnia S, Gohari AR, Uchiyama N, Ito M, Honda G, Kiuchi F. Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi. Chem Pharm Bull 2004;52:1249–1250.
  • Rocha AD, de Oliveira AB, de Souza Filho JD, Lombardi JA, Braga FC. Antifungal constituents of Clytostoma ramentaceum and Mansoa hirsuta. Phytother Res 2004;18:463–467.
  • Gu JQ, Wang Y, Franzblau SG, Montenegro G, Yang D, Timmermann BN. Antitubercular constituents of Valeriana laxiflora. Planta Med 2004;70:509–514.
  • Shih YH, Chein YC, Wang JY, Fu YS. Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats. Neurosci Lett 2004;362:136–140.
  • Jin JL, Lee YY, Heo JE, Lee S, Kim JM, Yun-Choi HS. Anti-platelet pentacyclic triterpenoids from leaves of Campsis grandiflora. Arch Pharm Res 2004;27:376–380.
  • Murakami S, Takashima H, Sato-Watanabe M, Chonan S, Yamamoto K, Saitoh M et al. Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. FEBS Lett 2004;566:55–59.
  • Soo Lee Y, Jin DQ, Beak SM, Lee ES, Kim JA. Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. Eur J Pharmacol 2003;476:173–178.
  • Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase-2, matrix metalloproteinase-9, and cyclin D1. Cancer Res 2003;63:4375–4383.
  • Li Y, Ishibashi M, Satake M, Chen X, Oshima Y, Ohizumi Y. Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity. J Nat Prod 2003;66:696–698.
  • Satomi Y, Nishino H, Shibata S. Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. Anticancer Res 2005;25:4043–4047.
  • Andrikopoulos NK, Kaliora AC, Assimopoulou AN, Papapeorgiou VP. Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytother Res 2003;17:501–507.
  • Somova LO, Nadar A, Rammanan P, Shode FO. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine 2003;10:115–121.
  • Chiang LC, Chiang W, Chang MY, Ng LT, Lin CC. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med 2003;31:37–46.
  • Jiwajinda S, Santisopasri V, Murakami A, Kim OK, Kim HW, Ohigashi H. Suppressive effects of edible thai plants on superoxide and nitric oxide generation. Asian Pac J Cancer Prev 2002;3:215–223.
  • Tapondjou LA, Lontsi D, Sondengam BL, Choi J, Lee KT, Jung HJ et al. In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. Arch Pharm Res 2003;26:143–146.
  • Chandramu C, Manohar RD, Krupadanam DG, Dashavantha RV. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother Res 2003;17:129–134.
  • Lee S, Min B, Kho Y. Brine shrimp lethality of the compounds from Phryma leptostachya L. Arch Pharm Res 2002;25:652–654.
  • Wang Q, Fan M, Bian Z, Nie M, Chen Z. Extract and identify ingredient from Ligustrum Lucidum Ait and study its effect to periodontal pathogen. Zhonghua Kou Qiang Yi Xue Za Zhi 2002;37:388–390.
  • Abe F, Yamauchi T, Nagao T, Kinjo J, Okabe H, Higo H et al. Ursolic acid as a trypanocidal constituent in rosemary. Biol Pharm Bull 2002;25:1485–1487.
  • Mitaine-Offer AC, Hornebeck W, Sauvain M, Zèches-Hanrot M. Triterpenes and phytosterols as human leucocyte elastase inhibitors. Planta Med 2002;68:930–932.
  • Li J, Guo WJ, Yang QY. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT-15. World J Gastroenterol 2002;8:493–495.
  • Heo HJ, Cho HY, Hong B, Kim HK, Heo TR, Kim EK et al. Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. Mol Cells 2002;13:5–11.
  • Chung YK, Heo HJ, Kim EK, Kim HK, Huh TL, Lim Y et al. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol Cells 2001;11:137–143.
  • Hollósy F, Mészáros G, Bökönyi G, Idei M, Seprödi A, Szende B et al. Cytostatic, cytotoxic and protein tyrosine kinase inhibitory activity of ursolic acid in A431 human tumor cells. Anticancer Res 2000;20:4563–4570.
  • Díaz AM, Abad MJ, Fernández L, Recuero C, Villaescusa L, Silván AM et al. In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. Biol Pharm Bull 2000;23:1307–1313.
  • Begum S, Farhat F, Sultana I, Siddiqui BS, Shaheen F, Gilani AH. Spasmolytic constituents from Eucalyptus camaldulensis var. obtusa leaves. J Nat Prod 2000;63:1265–1268.
  • Mizushina Y, Iida A, Ohta K, Sugawara F, Sakaguchi K. Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem J 2000;350 Pt 3:757–763.
  • Wen ZM, Xu LX. Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I). Zhongguo Zhong Yao Za Zhi 2001;26:406–408.
  • Setzer WN, Rozmus GF, Setzer MC, Schmidt JM, Vogler B, Reeb S et al. Bioactive principles in the bark of Pilidiostigma tropicum. J Mol Model 2006;12:703–711.
  • Kim YK, Yoon SK, Ryu SY. Cytotoxic triterpenes from stem bark of Physocarpus intermedius. Planta Med 2000;66:485–486.
  • Min BS, Kim YH, Lee SM, Jung HJ, Lee JS, Na MK et al. Cytotoxic triterpenes from Crataegus pinnatifida. Arch Pharm Res 2000;23:155–158.
  • Vasconcelos MA, Royo VA, Ferreira DS, Crotti AE, Andrade e Silva ML, Carvalho JC et al. In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanoic acid from Miconia albicans (Melastomataceae). Z Naturforsch, C, J Biosci 2006;61:477–482.
  • Saraswat B, Visen PK, Agarwal DP. Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. Phytother Res 2000;14:163–166.
  • Subbaramaiah K, Michaluart P, Sporn MB, Dannenberg AJ. Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Cancer Res 2000;60:2399–2404.
  • Choi BM, Park R, Pae HO, Yoo JC, Kim YC, Jun CD et al. Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol 2000;86:53–58.
  • Deng JZ, Starck SR, Hecht SM. DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod 1999;62:1624–1626.
  • Traore-Keita F, Gasquet M, Di Giorgio C, Ollivier E, Delmas F, Keita A et al. Antimalarial activity of four plants used in traditional medicine in Mali. Phytother Res 2000;14:45–47.
  • Jeong TS, Hwang EI, Lee HB, Lee ES, Kim YK, Min BS et al. Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. Planta Med 1999;65:261–263.
  • Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L. Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 1998;61:1212–1215.
  • Cha HJ, Park MT, Chung HY, Kim ND, Sato H, Seiki M et al. Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Oncogene 1998;16:771–778.
  • Baek JH, Lee YS, Kang CM, Kim JA, Kwon KS, Son HC et al. Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. Int J Cancer 1997;73:725–728.
  • Hsu HY, Yang JJ, Lin CC. Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. Cancer Lett 1997;111:7–13.
  • Es-saady D, Simon A, Ollier M, Maurizis JC, Chulia AJ, Delage C. Inhibitory effect of ursolic acid on B16 proliferation through cell-cycle arrest. Cancer Lett 1996;106:193–197.
  • Cha HJ, Bae SK, Lee HY, Lee OH, Sato H, Seiki M et al. Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. Cancer Res 1996;56:2281–2284.
  • Shen H, Cheng T, Qiao C, Su Z, Li C. Antitumor effect in vitro and immuno-response in vivo of Fructus mume. Zhongguo Zhong Yao Za Zhi 1995;20:365–8, inside back cover.
  • Young HS, Chung HY, Lee CK, Park KY, Yokozawa T, Oura H. Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system. Biol Pharm Bull 1994;17:990–992.
  • Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K et al. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 1994;54:701–708.
  • Tokuda H, Ohigashi H, Koshimizu K, Ito Y. Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett 1986;33:279–285.
  • Liu J, Liu Y, Mao Q, Klaassen CD. The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol 1994;22:34–40.
  • Lee HY, Chung HY, Kim KH, Lee JJ, Kim KW. Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. J Cancer Res Clin Oncol 1994;120:513–518.
  • Balanehru S, Nagarajan B. Intervention of adriamycin induced free radical damage. Biochem Int 1992;28:735–744.
  • Varanda EM, Zúñiga GE, Salatino A, Roque NF, Corcuera LJ. Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum. J Nat Prod 1992;55:800–803.
  • Simon A, Najid A, Chulia AJ, Delage C, Rigaud M. Inhibition of lipoxygenase activity and HL-60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris). Biochim Biophys Acta 1992;1125:68–72.
  • Najid A, Simon A, Cook J, Chable-Rabinovitch H, Delage C, Chulia AJ et al. Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL-60 leukemic cells. FEBS Lett 1992;299:213–217.
  • Ying QL, Rinehart AR, Simon SR, Cheronis JC. Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes. Biochem J 1991;277 (Pt 2):521–526.
  • Kowalewski Z, Kortus M, Kedzia W, Koniar H. Antibiotic action of beta-ursolic acid. Arch Immunol Ther Exp (Warsz) 1976;24:115–119.
  • Kikuko T, Shigemi S, Masahiro S, and Tatsu M. 1993; Hair-raising cosmetic. Japanese Patent no. 05286835.
  • Sultana N, Saleem M, Iqbal J, Iqbal L, Afza N. Isolation and structure characterization of three new triterpenes from alstonia scholaris flowers. Z Naturforsch 2010 (Submitted).
  • Sultana N, Saleem M. Phytochemical studies on Alstonia scholaris Z Naturforsch B 2010;65b:203–210.
  • Cunha WR, Crevelin EJ, Arantes GM, Crotti AE, Andrade e Silva ML, Furtado NA et al. A study of the trypanocidal activity of triterpene acids isolated from Miconia species. Phytother Res 2006;20:474–478.
  • Tan N, Kaloga M, Radtke OA, Kiderlen AF, Oksüz S, Ulubelen A et al. Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities. Phytochemistry 2002;61:881–884.
  • Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorg Med Chem Lett 2008;18:2633–2639.
  • Dufour D, Pichette A, Mshvildadze V, Bradette-Hébert ME, Lavoie S, Longtin A et al. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. J Ethnopharmacol 2007;111:22–28.
  • Mallavadhani UV, Mahapatra A, Jamil K, Reddy PS. Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains. Biol Pharm Bull 2004;27:1576–1579.
  • Ogawa S, Hosoi K, Ikeda N, Makino M, Fujimoto Y, Iida T. Oxyfunctionalization products of terpenoids with dimethyldioxirane and their biological activity. Chem Pharm Bull 2007;55:247–250.
  • Hasan S, Beatrice R, Eckart-roderich S, Hermann PTA. Inhibition by boswellic acids of human leukocyte elastase. The journal of pharmacology and experimental therapeutics 1997;281:460–463.
  • Syrovets T, Büchele B, Gedig E, Slupsky JR, Simmet T. Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha. Mol Pharmacol 2000;58:71–81.
  • D’Abrosca B, Fiorentino A, Monaco P, Pacifico S. Radical-scavenging activities of new hydroxylated ursane triterpenes from cv. Annurca apples. Chem Biodivers 2005;2:953–958.
  • Leite JP, Oliveira AB, Lombardi JA, Filho JD, Chiari E. Trypanocidal activity of triterpenes from Arrabidaea triplinervia and derivatives. Biol Pharm Bull 2006;29:2307–2309.
  • Jang DS, Su BN, Pawlus AD, Kang YH, Kardono LB, Riswan S et al. Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. Phytochemistry 2006;67:1832–1837.
  • Ma CM, Cai SQ, Cui JR, Wang RQ, Tu PF, Hattori M et al. The cytotoxic activity of ursolic acid derivatives. Eur J Med Chem 2005;40:582–589.
  • Cunha WR, Martins C, da Silva Ferreira D, Crotti AE, Lopes NP, Albuquerque S. In vitro trypanocidal activity of triterpenes from Miconia species. Planta Med 2003;69:470–472.
  • Tanud T, John BB, Ratchanaporn C, Apichart S. Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic, and ursolic acids Chem Pharm Bull 2008;56:194–198.
  • Tian Z, Lin G, Zheng RX, Huang F, Yang MS, Xiao PG. Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana. World J Gastroenterol 2006;12:874–879.
  • Andrikopoulos NK, Kaliora AC, Assimopoulou AN, Papageorgiou VP. Inhibitory activity of minor polyphenolic and non-polyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. J Med Food 2002;5:1–7.
  • Fatima N, Tapondjou LA, Lontsi D, Sondengam BL, Atta-Ur-Rahman, Choudhary MI. Quinovic acid glycosides from Mitragyna stipulosa — first examples of natural inhibitors of snake venom phosphodiesterase I. Nat Prod Lett 2002;16:389–393.
  • Tapondjou LA, Lontsi D, Sondengam BL, Choudhary MI, Park HJ, Choi J et al. Structure-activity relationship of triterpenoids isolated from Mitragyna stipulosa on cytotoxicity. Arch Pharm Res 2002;25:270–274.
  • Collins DO, Ruddock PL, Chiverton de Grasse J, Reynolds WF, Reese PB. Microbial transformation of cadina-4,10(15)-dien-3-one, aromadendr-1(10)-en-9-one and methyl ursolate by Mucor plumbeus ATCC 4740. Phytochemistry 2002;59:479–488.
  • Hollósy F, Idei M, Csorba G, Szabó E, Bökönyi G, Seprödi A, Mészáros G, Szende B, Kéri G. Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis. Anticancer Res 2001;2:13485–13491.
  • Kashiwada Y, Nagao T, Hashimoto A, Ikeshiro Y, Okabe H, Cosentino LM et al. Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. J Nat Prod 2000;63:1619–1622.
  • Suruga T, Chun Y, Ebizuka Y, Sankawa U. Biologically active constituents of Melaleuca leucadendron: inhibitors of induced histamine release from rat mast cells. Chem Pharm Bull 1999;139:3276–3278.
  • Ma C, Nakamura N, Miyashiro H, Hattori M, Shimotohno K. Inhibitory effects of constituents from Cynomorium songaricum and related triterpene derivatives on HIV-1 protease. Chem Pharm Bull 1999;47:141–145.
  • Farina C, Pinza M, Pifferi G. Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. Farmaco 1998;53:22–32.
  • Mallavadhani UV, Mahapatra A, Raja SS, Manjula C. Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues. J Agric Food Chem 2003;51:1952–1955.
  • Kashiwada Y, Wang HK, Nagao T, Kitanaka S, Yasuda I, Fujioka T et al. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. J Nat Prod 1998;61:1090–1095.
  • Benyahia S, Benayache S, Benayache F, León F, Quintana J, López M et al. Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity. Phytochemistry 2005;66:627–632.
  • Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD et al. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. J Nat Prod 2004;67:994–998.
  • Suh N, Honda T, Finlay HJ, Barchowsky A, Williams C, Benoit NE et al. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res 1998;58:717–723.
  • Takechi M, Tanaka Y. Structure-activity relationships of synthetic methyl ursolate glycosides. Phytochemistry 1993;34:675–677.
  • Ovesná Z, Vachálková A, Horváthová K, Tóthová D. Pentacyclic triterpenoic acids: new chemoprotective compounds. Mini review. Neoplasma 2004;51:327–333.
  • Liao LP, Li SL, Li P. Simultaneous determination of seven triterpenoids and triterpenoid saponins in Folium llicis Purpureae by high performance liquid chromatography coupled with evaporative light scattering detection. J Sep Sci 2005;28:2061–2066.
  • Yan H, Zhao L, Zhu D, Ding L. Determination of oleanolic acid and ursolic acid in Spica prunellae by derivative GC method. Zhongguo Zhong Yao Za Zhi 1999;24:744–5, 764.
  • Kriwacki RW, Pitner TP. Current aspects of practical two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy: applications to structure elucidation. Pharm Res 1989;6:531–554.
  • Lopes SO, Moreno PR, Henriques AT. Growth characteristics and chemical analysis of Psychotria carthagenensis cell suspension cultures. Enzyme Microb Technol 2000;26:259–264.
  • He X, Liu RH. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity. J Agric Food Chem 2007;55:4366–4370.
  • Sultana N, Khalid A. A new fatty ester and a new triterpene from Skimmia laureola. Nat Prod Res 2008;22:37–47.
  • Sultana N, Khalid A. A new fatty ester and a new triterpene from Skimmia laureola. Nat Prod Res 2008;22:37–47.
  • Han SK, Ko YI, Park SJ, Jin IJ, Kim YM. Oleanolic acid and ursolic acid stabilize liposomal membranes. Lipids 1997;32:769–773.
  • Lin CN, Lu CM, Cheng MK, Gan KH, Won SJ. The cytotoxic principles of Solanum incanum. J Nat Prod 1990;53:513–516.
  • Kozai K, Miyake Y, Kohda H, Kametaka S, Yamasaki K, Suginaka H et al. Inhibition of glucosyltransferase from Streptococcus mutans by oleanolic acid and ursolic acid. Caries Res 1987;21:104–108.

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