Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 27, 2012 - Issue 1
Submit an article Journal homepage
1,270
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Namki ChoCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of Korea
,
Jungmoo HuhCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of Korea
,
Heejung YangCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of Korea
,
Eun Ju JeongCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of Korea
,
Young Choong KimCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of Korea
,
Jinwoong KimCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of KoreaCorrespondence[email protected] [email protected]
&
Sang Hyun SungCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul, Republic of KoreaCorrespondence[email protected] [email protected]
 show all
Pages 1-4 | Received 22 Dec 2010, Accepted 07 Feb 2011, Published online: 08 Jul 2011

References

  • Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 1994;63:175–195.
  • Bugnon O, Schaad NC, Schorderet M. Nitric oxide modulates endogenous dopamine release in bovine retina. Neuroreport 1994;5:401–404.
  • Bolaños JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB et al. Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem 1997;68:2227–2240.
  • Fernández-Vizarra P, Fernández AP, Castro-Blanco S, Encinas JM, Serrano J, Bentura ML et al. Expression of nitric oxide system in clinically evaluated cases of Alzheimer’s disease. Neurobiol Dis 2004;15:287–305.
  • Good PF, Hsu A, Werner P, Perl DP, Olanow CW. Protein nitration in Parkinson’s disease. J Neuropathol Exp Neurol 1998;57:338–342.
  • Jiang Y, Tu PF. Xanthone O-glycosides from Polygala tenuifolia. Phytochemistry 2002;60:813–816.
  • Sakuma S, Shoji J. Studies on the constituents of the root of Polygala tenuifolia Willdenow. 1. Isolation of saponins and the structures of Onjisaponin-G and Onjisaponin-F. Chem Pharm Bull 1981;29:2431–2441.
  • Pinto MM, Sousa ME, Nascimento MS. Xanthone derivatives: new insights in biological activities. Curr Med Chem 2005;12:2517–2538.
  • Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 1990;27:229–237.
  • Ischiropoulos H, Beckman JS. Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest 2003;111:163–169.
  • Norris PJ, Faull RL, Emson PC. Neuronal nitric oxide synthase (nNOS) mRNA expression and NADPH-diaphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer’s disease brains. Brain Res Mol Brain Res 1996;41:36–49.
  • Fujita T, Liu DY, Ueda S, Takeda Y. Xanthones from Polygala tenuifolia. Phytochemistry 1992;31:3997–4000.
  • Mao SL, Liao SX, Wu JH, Ling N, Chen H, Liang HQ et al. [Studies on chemical constituents of Polygala arillata buch-ham]. Yao Xue Xue Bao 1997;32:360–362.
  • Ikeya Y, Sugama K, Okada M, Mitsuhashi H. 2 Xanthones from Polygala tenuifolia. Phytochemistry 1991;30:2061–2065.
  • Bashir A, Hamburger M, Msonthi JD, Hostettmann K. Sinapic acid esters from Polygala virgata. Phytochemistry 1993;32:741–745.
  • Pinheiro TR, Cechinel V, Santos ARS, Calixto JB, Monache FD, Pizzolatti MG, Yunes RA. Three xanthones from Polygala cyparissias. Phytochemistry 1998;48:725–728.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.